Title:
15-PGDH INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2020/145250
Kind Code:
A1
Abstract:
[Problem] To provide a compound having a 15-PGDH inhibitory effect. [Solution] A compound represented by general formula (1) or a pharmacologically acceptable salt thereof.
More Like This:
Inventors:
SETO SHIGEKI (JP)
YAMADA HITOMI (JP)
SAITO YOSHIFUMI (JP)
KURASAKI HARUAKI (JP)
YAMADA HITOMI (JP)
SAITO YOSHIFUMI (JP)
KURASAKI HARUAKI (JP)
Application Number:
PCT/JP2020/000115
Publication Date:
July 16, 2020
Filing Date:
January 07, 2020
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
International Classes:
A61K31/4375; A61K31/4523; A61K31/454; A61K31/4545; A61K31/4709; A61K31/496; A61K31/4985; A61K31/502; A61K31/5025; A61K31/517; A61K31/519; A61K31/538; A61K31/5383; A61K31/5415; A61K31/55; A61K31/553; A61K31/554; A61P1/02; A61P1/04; A61P1/16; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/14; A61P19/02; A61P19/08; A61P21/00; A61P21/04; A61P25/00; A61P25/28; A61P27/02; A61P27/06; A61P27/16; A61P29/00; A61P37/02; A61P37/06; A61P43/00; C07D209/08; C07D215/48; C07D265/36; C07D267/14; C07D267/22; C07D279/16; C07D281/10; C07D413/04; C07D413/06; C07D413/14; C07D471/04; C07D498/04; C07D519/00
Domestic Patent References:
| WO2009051119A1 | 2009-04-23 | |||
| WO2008001076A1 | 2008-01-03 | |||
| WO2013158649A1 | 2013-10-24 | |||
| WO2003090699A1 | 2003-11-06 | |||
| WO2011057757A1 | 2011-05-19 |
Foreign References:
| JP2014505053A | 2014-02-27 | |||
| JP2008531542A | 2008-08-14 | |||
| JP2007099775A | 2007-04-19 | |||
| JP2014055193A | 2014-03-27 | |||
| US20130324501A1 | 2013-12-05 |
Other References:
DUVEAU, D. Y. ET AL.: "Structure-activity relationship studies and biological characterization of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, no. 2, 2014, pages 630 - 635, XP055348274, DOI: 10.1016/j.bmcl.2013.11.081
ANTCZAK, M. I. ET AL.: "Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 9, 2017, pages 3979 - 4001, XP055554244, DOI: 10.1021/acs.jmedchem.7b00271
NIESEN, F. H. ET AL.: "High-Affinity Inhibitors of Human NAD+-Dependent 15- Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure- Activity Relationships", PLOS ONE, vol. 5, no. 11, 2010, pages e13719, XP055348277, DOI: 10.1371/journal.pone.0013719
TTAI HH ET AL., PROSTAGLANDINS OTHER LIPID MEDIAT., vol. 68, no. 69, 2002, pages 483 - 493
AKESHI SHIMIZU ET AL., THE OTO-RHINO-AND LARYNGOLOGICAL CLINIC, vol. 100, no. 3, 2007, pages 157 - 166
TAKAHISA MURATA ET AL., PNAS, vol. 110, no. 13, 2013, pages 5205 - 5210
TRISTA E. NORTH ET AL., NATURE, vol. 447, no. 7147, 2007, pages 1007 - 1011
PAUL D. BOZYK ET AL., AM J RESPIR CELL MOL BIOL, vol. 45, 2011, pages 445 - 452
M. KINOSHITA ET AL., J. PHARMACOL. EXP. THER., vol. 275, no. 1, 1995, pages 494 - 501
MAKOTO ARITA ET AL., THE JOURNAL OF JAPAN RHINOLOGIC SOCIETY, vol. 51, no. 1, 2012, pages 60 - 62
ZENGLIN LIAO ET AL., RESPIRATORY RESEARCH, vol. 13, 2012, pages 110 - 121
ALLISSON FREIRE BENTO ET AL., J IMMUNOL., vol. 187, 2011, pages 1957 - 1969
XIAHONG CHEN ET AL., IMMUNOPHARMACOL. IMMUNOTOXICOL, vol. 38, no. 2, 2016, pages 61 - 67
See also references of EP 3922247A4
ANTCZAK, M. I. ET AL.: "Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 9, 2017, pages 3979 - 4001, XP055554244, DOI: 10.1021/acs.jmedchem.7b00271
NIESEN, F. H. ET AL.: "High-Affinity Inhibitors of Human NAD+-Dependent 15- Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure- Activity Relationships", PLOS ONE, vol. 5, no. 11, 2010, pages e13719, XP055348277, DOI: 10.1371/journal.pone.0013719
TTAI HH ET AL., PROSTAGLANDINS OTHER LIPID MEDIAT., vol. 68, no. 69, 2002, pages 483 - 493
AKESHI SHIMIZU ET AL., THE OTO-RHINO-AND LARYNGOLOGICAL CLINIC, vol. 100, no. 3, 2007, pages 157 - 166
TAKAHISA MURATA ET AL., PNAS, vol. 110, no. 13, 2013, pages 5205 - 5210
TRISTA E. NORTH ET AL., NATURE, vol. 447, no. 7147, 2007, pages 1007 - 1011
PAUL D. BOZYK ET AL., AM J RESPIR CELL MOL BIOL, vol. 45, 2011, pages 445 - 452
M. KINOSHITA ET AL., J. PHARMACOL. EXP. THER., vol. 275, no. 1, 1995, pages 494 - 501
MAKOTO ARITA ET AL., THE JOURNAL OF JAPAN RHINOLOGIC SOCIETY, vol. 51, no. 1, 2012, pages 60 - 62
ZENGLIN LIAO ET AL., RESPIRATORY RESEARCH, vol. 13, 2012, pages 110 - 121
ALLISSON FREIRE BENTO ET AL., J IMMUNOL., vol. 187, 2011, pages 1957 - 1969
XIAHONG CHEN ET AL., IMMUNOPHARMACOL. IMMUNOTOXICOL, vol. 38, no. 2, 2016, pages 61 - 67
See also references of EP 3922247A4
Attorney, Agent or Firm:
MIZUNO, Katsufumi et al. (JP)
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