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Title:
17-DESMETHYLRAPAMYCIN AND ANALOGUES THEREOF, METHODS FOR THEIR RODUCTION AND THEIR USE AS IMMUNOSUPRESSANTS, ANTICANCER AGENTS, ANTIFUNGAL AGENTS, ETC.
Document Type and Number:
WIPO Patent Application WO2006016167
Kind Code:
A3
Abstract:
The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in. one aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods_ for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17­desinethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections,. transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.

Inventors:
GREGORY MATTHEW ALAN (GB)
MARTIN CHRISTINE JANET (GB)
Application Number:
GB2005003158W
Publication Date:
April 13, 2006
Filing Date:
August 11, 2005
Export Citation:
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Assignee:
BIOTICA TECHNOLOGY LIMITED
GREGORY, MATTHEW, ALAN
MARTIN, CHRISTINE, JANET
International Classes:
C07D498/18; A61K31/436; C07D221/00; C07D273/00; C07D311/00; C12N15/00
Domestic Patent References:
WO2004007709A22004-01-22
WO2001034816A12001-05-17
WO1998054308A21998-12-03
Foreign References:
EP0589703A11994-03-30
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