1'alpha',24-(OH)2-VITAMIN D3 EMULSION COMPOSITION

Title:

1'alpha',24-(OH)2-VITAMIN D3 EMULSION COMPOSITION

Document Type and Number:

WIPO Patent Application WO/1995/006482

Kind Code:

A1

Abstract:

A 1'alpha',24-(OH)2-vitamin D3 cream comprising: (a) a therapeutically available quantity of 1'alpha',24-(OH)2-vitamin D3; (b) an oily phase component comprising: (i) a solid oil component comprising 5-20 parts by weight of white vaseline and 5-15 parts by weight of a higher alcohol, and (ii) a liquid oil component comprising 3-10 parts by weight of squalane; (c) an aquous phase component; and (d) 2.5-7.5 parts by weight of two or more surfactants, wherein the ratio of the solid oil component to the liquid oil component is about 2 or above, the higher alcohol is a mixture of stearyl alcohol with cetyl alcohol with the weight ratio of stearyl alcohol to the mixture being about 0.65 to about 0.9, at least 50 % by weight of the surfactants is at least one surfactant having an HLB value of about 5 or less, and the HLB value of the surfactants as a whole is about 8 to about 18.

Inventors:

MAKINO YUJI (JP)
MATUGI HIDEO (JP)
SUZUKI YOSHIKI (JP)

Application Number:

PCT/JP1994/001443

Publication Date:

March 09, 1995

Filing Date:

September 01, 1994

Export Citation:

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Assignee:

TEIJIN LTD (JP)
MAKINO YUJI (JP)
MATUGI HIDEO (JP)
SUZUKI YOSHIKI (JP)

International Classes:

A61K9/00; A61K31/59; A61K47/00; A61K47/06; A61K47/10; A61K47/14; A61K47/44; (IPC1-7): A61K47/44

Foreign References:

JPS6226223A

1987-02-04

Other References: