1H-IMIDAZO[4,5-B]PYRIDINYL AND 2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDINYL HETEROCYCLIC BET BROMODOMAIN INHIBITORS

Title:

1H-IMIDAZO[4,5-B]PYRIDINYL AND 2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDINYL HETEROCYCLIC BET BROMODOMAIN INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2017/103670

Kind Code:

A8

Abstract:

Substituted 1H-imidazo[4,5-b]pyridinyl and 2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridinyl heterocyclic compounds, which are useful as inhibitors of BET protein function by binding to bromodomains, compositions comprising said compounds, and their use in therapy are disclosed herein. These compounds are useful in the treatment of diseases and conditions, such as, cancer, autoimmune diseases, inflammation and cardiovascular diseases.

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Inventors:

BROWN SAMUEL DAVID (US)
KHARENKO OLESYA (CA)

Application Number:

PCT/IB2016/001874

Publication Date:

January 18, 2018

Filing Date:

December 14, 2016

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Assignee:

ZENITH EPIGENETICS LTD (CA)

International Classes:

C07D471/04; A61K31/437; A61K31/46; A61P35/00

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