Title:
2, 6-DINITROGEN-CONTAINING SUBSTITUTED PURINE DERIVATIVES, THE PREPARATION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/128428
Kind Code:
A1
Abstract:
The present invention provides 2, 6-dinitrogen-containing substituted purine
compounds of formula (A) or their salts or their solvates or the solvates of their
salts, as well as pharmaceutical compositions containing such compounds. The
compounds of the invention have the characteristic of lower toxicity, broad
anticancer spectrum, higher anticancer activity, good stability and the like.
The compounds are useful for the manufacture of an antitumor medicament. The
present invention also provides a process for preparing these compounds.
Inventors:
WU ZHANGGUI (CN)
YE WEIDONG (CN)
YUAN JIANYONG (CN)
CHEN GANG (CN)
YE WEIDONG (CN)
YUAN JIANYONG (CN)
CHEN GANG (CN)
Application Number:
PCT/CN2008/000782
Publication Date:
October 30, 2008
Filing Date:
April 17, 2008
Export Citation:
Assignee:
ZHE JIANG MEDICINE CO LTD XINC (CN)
WU ZHANGGUI (CN)
YE WEIDONG (CN)
YUAN JIANYONG (CN)
CHEN GANG (CN)
WU ZHANGGUI (CN)
YE WEIDONG (CN)
YUAN JIANYONG (CN)
CHEN GANG (CN)
International Classes:
C07D473/16; A61K31/52; A61K31/7076; A61P35/00; C07H19/16; C07H19/173; C07H19/20
Domestic Patent References:
| WO1992001968A1 | 1992-02-06 |
Foreign References:
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Other References:
CISZEWSKI L. ET AL.: "A Practical Synthesis of 2-Arylamino-6-alkylaminopurines from 2,6-Dichloropurine", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 10, no. 4, 2006, pages 799 - 802, XP008125798
TRIVEDI B.K. ET AL.: "C2N6-Disubstituted Adenosines: Synthesis and Structure-Activity Relationships", JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 8, 1989, pages 1667 - 1673, XP002053657
YAMAGUCHI T. ET AL.: "Synthesis and biological activities of sugar-modified 2-(p-n-butylanilino)-2'-deoxyadenosine analogues", NUCLEOSIDES & NUCLEOTIDES, vol. 14, no. 3-5, 1995, pages 529 - 532, XP009088655
WRIGHT G.E. ET AL.: "Synthesis, cell-growth inhibition, and antitumor screening of 2-(p-n-butylanilino(purines and their nucleoside analogues", JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 1, 1987, pages 109 - 116, XP002135675
See also references of EP 2149574A4
J. ORG. CHEM., vol. 69, 2004, pages 3212 - 3215
J. MED. CHEM., vol. 27, 1984, pages 175 - 181
TETRAHERON LETTERS, vol. 39, 1998, pages 1827 - 1830
TRIVEDI B.K. ET AL.: "C2N6-Disubstituted Adenosines: Synthesis and Structure-Activity Relationships", JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 8, 1989, pages 1667 - 1673, XP002053657
YAMAGUCHI T. ET AL.: "Synthesis and biological activities of sugar-modified 2-(p-n-butylanilino)-2'-deoxyadenosine analogues", NUCLEOSIDES & NUCLEOTIDES, vol. 14, no. 3-5, 1995, pages 529 - 532, XP009088655
WRIGHT G.E. ET AL.: "Synthesis, cell-growth inhibition, and antitumor screening of 2-(p-n-butylanilino(purines and their nucleoside analogues", JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 1, 1987, pages 109 - 116, XP002135675
See also references of EP 2149574A4
J. ORG. CHEM., vol. 69, 2004, pages 3212 - 3215
J. MED. CHEM., vol. 27, 1984, pages 175 - 181
TETRAHERON LETTERS, vol. 39, 1998, pages 1827 - 1830
Attorney, Agent or Firm:
SHANGHAI XIN TIAN PATENT AGENCY CO., LTD (No.59Nan Chang Roa, Shanghai 0, CN)
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