Title:
2-ALKOXYBENZENE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/029027
Kind Code:
A1
Abstract:
To provide compounds which have further excellent antagonisms to NK¿1? receptor, NK¿2? receptor and NK¿3? receptor, have elevated oral absorbability and show favorable kinetics in vivo. [Means for Solution] Compounds represented by general formula (I) or pharmaceutically acceptable salts, ester or other derivatives of the same, wherein R?1¿ represents alkyl; R?2¿ represents optionally substituted 5-membered heteroaryl containing nitrogen or optionally substituted 5-membered heterocyclyl containing nitrogen; R?3¿ represents optionally substituted aryl or optionally substituted heteroaryl; A represents CO or SO¿2?; E represents CH¿2?, O or S; G represents an optionally substituted cycloalkane ring, an optionally substituted cycloalkene ring or an optionally substituted saturated heterocycle; Ar represents an optionally substituted aryl ring or an optionally substituted heteroaryl ring; m is 1 or 2; and n is from 2 to 4.
Inventors:
NISHI TAKAHIDE (JP)
TAKEMOTO TOSHIYASU (JP)
YAMAGUCHI TAKESHI (JP)
TAKEMOTO TOSHIYASU (JP)
YAMAGUCHI TAKESHI (JP)
Application Number:
PCT/JP2000/007344
Publication Date:
April 26, 2001
Filing Date:
October 20, 2000
Export Citation:
Assignee:
SANKYO CO (JP)
NISHI TAKAHIDE (JP)
TAKEMOTO TOSHIYASU (JP)
YAMAGUCHI TAKESHI (JP)
NISHI TAKAHIDE (JP)
TAKEMOTO TOSHIYASU (JP)
YAMAGUCHI TAKESHI (JP)
International Classes:
A61K31/4355; A61K31/4365; A61K31/438; A61K31/4545; A61K31/4738; A61K31/537; A61K31/5377; A61K31/5383; A61P1/04; A61P11/00; A61P11/06; A61P11/16; A61P13/00; A61P27/16; A61P37/08; A61P43/00; C07D471/10; C07D491/107; (IPC1-7): C07D401/06; A61K31/4355; A61K31/4365; A61K31/438; A61K31/4545; A61K31/4738; A61K31/537; A61K31/5377; A61K31/5383; A61P1/04; A61P11/00; A61P11/06; A61P11/16; A61P13/00; A61P27/16; A61P37/08; A61P43/00; C07D401/14; C07D471/10; C07D491/107; C07D495/10; C07D498/10
Domestic Patent References:
| WO1998027085A1 | 1998-06-25 |
Foreign References:
| EP0776893A1 | 1997-06-04 | |||
| US5861417A | 1999-01-19 |
Attorney, Agent or Firm:
Ohno, Akio (Limited 2-58 Hiromachi 1-chome Shinagawa-ku, Tokyo, JP)
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