2-ALKYL-6-(PYRAZOLOPYRIDIN-4-YL)PYRIDAZINONE DERIVATIVE, ADDITION SALT THEREOF, AND PDE INHIBITOR COMPRISING THE DERIVATIVE OR THE SALT AS ACTIVE INGREDIENT

Title:

2-ALKYL-6-(PYRAZOLOPYRIDIN-4-YL)PYRIDAZINONE DERIVATIVE, ADDITION SALT THEREOF, AND PDE INHIBITOR COMPRISING THE DERIVATIVE OR THE SALT AS ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2008/029882

Kind Code:

A1

Abstract:

[PROBLEMS] To provide a 2-alkyl-6-(pyrazolopyridin- 4-yl)pyridazinone derivative which is useful as a pharmaceutical agent having a phosphodiesterase-inhibiting activity. [MEANS FOR SOLVING PROBLEMS] A 2-alkyl-6- (pyrazolopyridin-4-yl)pyridazinone derivative represented by the general formula (1) (a specific example: 6-(7-methoxy-2- trifluoromethylpyrazolo[1,5-a]pyridin-4-yl)-5-methyl-2-[3- [4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3- yl)phenoxy]propyl]-4,5-dihydro-2H- pyridazin-3-one).

Inventors:

KOHNO, Yasushi (Discovery Research Laboratories, Kyorin Pharmaceutical Co. Ltd., 2399-1, Nogi, Nogi-machi, Shimotsuga-gu, Tochigi 14, 3290114, JP)
河野靖志 (〒14 栃木県下都賀郡野木町野木２３９９－１杏林製薬株式会社創薬研究所内 Tochigi, 3290114, JP)
OCHIAI, Koji (Kyorin Pharmaceutical Co. Ltd., 2399-1, Nogi, Nogi-machi, Shimotsuga-gu, Tochigi 14, 3290114, JP)
落合貢司 (〒14 栃木県下都賀郡野木町野木２３９９－１杏林製薬株式会社創薬研究所内 Tochigi, 3290114, JP)

Application Number:

JP2007/067420

Publication Date:

March 13, 2008

Filing Date:

September 06, 2007

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Assignee:

KYORIN PHARMACEUTICAL CO., LTD. (5 Kanda Surugadai 2-chome, Chiyoda-ku Tokyo, 11, 1018311, JP)
杏林製薬株式会社 (〒11 東京都千代田区神田駿河台２丁目５番地 Tokyo, 1018311, JP)
KOHNO, Yasushi (Discovery Research Laboratories, Kyorin Pharmaceutical Co. Ltd., 2399-1, Nogi, Nogi-machi, Shimotsuga-gu, Tochigi 14, 3290114, JP)
河野靖志 (〒14 栃木県下都賀郡野木町野木２３９９－１杏林製薬株式会社創薬研究所内 Tochigi, 3290114, JP)
OCHIAI, Koji (Kyorin Pharmaceutical Co. Ltd., 2399-1, Nogi, Nogi-machi, Shimotsuga-gu, Tochigi 14, 3290114, JP)

International Classes:

C07D471/04; A61K31/501; A61P7/02; A61P9/10; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P25/00; A61P25/24; A61P25/28; A61P29/00; A61P31/04; A61P37/08; A61P43/00; C07F7/18; C07D471/00; A61K31/501; A61P7/00; A61P9/00; A61P11/00; A61P17/00; A61P25/00; A61P29/00; A61P31/00; A61P37/00; A61P43/00; C07F7/00

Attorney, Agent or Firm:

MIZUNO, Katsufumi et al. (721 Marunouchi-Nakadori Bldg, 2-3 Marunouchi 2-chom, Chiyoda-ku Tokyo 05, 1000005, JP)

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