Title:
2-AMINO-1-(4-HYDROXY-2-METHYLPHENYL)PROPANOL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1998/013333
Kind Code:
A1
Abstract:
2-Amino-1-(4-hydroxy-2-methylphenyl)propanol derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, wherein one of Y and Z represents -A-CO-R [wherein A represents -O-D-E (wherein D represents alkylene; and E represents a single bond or phenylene) or ethylene; and R represents hydroxy, alkyl, alkoxy, aralkoxy, amino, dialkylamino or alicyclic amino] while another represents hydrogen; and the carbon atoms marked with (R) and (S) respectively represent those of R- and S-configurations. These compounds have effects of selectively stimulating $g(b)�2?-adrenaline receptors with relieved burden on the heart, such as frequent pulse, and are useful as drugs, for example, preventives for threatened abortion or premature birth and bronchodilators.
Inventors:
KITAZAWA MAKIO (JP)
OKAZAKI KOSUKE (JP)
TAMAI TETSURO (JP)
SAITO MASARU (JP)
TANAKA NOBUYUKI (JP)
KOBAYASHI HIROAKI (JP)
KIKUCHI KEN (JP)
MURANAKA HIDEYUKI (JP)
OKAZAKI KOSUKE (JP)
TAMAI TETSURO (JP)
SAITO MASARU (JP)
TANAKA NOBUYUKI (JP)
KOBAYASHI HIROAKI (JP)
KIKUCHI KEN (JP)
MURANAKA HIDEYUKI (JP)
Application Number:
PCT/JP1997/003399
Publication Date:
April 02, 1998
Filing Date:
September 25, 1997
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
KITAZAWA MAKIO (JP)
OKAZAKI KOSUKE (JP)
TAMAI TETSURO (JP)
SAITO MASARU (JP)
TANAKA NOBUYUKI (JP)
KOBAYASHI HIROAKI (JP)
KIKUCHI KEN (JP)
MURANAKA HIDEYUKI (JP)
KITAZAWA MAKIO (JP)
OKAZAKI KOSUKE (JP)
TAMAI TETSURO (JP)
SAITO MASARU (JP)
TANAKA NOBUYUKI (JP)
KOBAYASHI HIROAKI (JP)
KIKUCHI KEN (JP)
MURANAKA HIDEYUKI (JP)
International Classes:
C07C217/60; C07C229/34; C07C235/20; (IPC1-7): C07C217/56; A61K31/135; A61K31/195; A61K31/24; C07C225/16; C07C229/34; C07C235/20; C07C235/44; C07C237/20; C07D295/02
Foreign References:
| JPS62228011A | 1987-10-06 | |||
| JPS6176446A | 1986-04-18 | |||
| JPS6067450A | 1985-04-17 | |||
| JPS56138150A | 1981-10-28 | |||
| JPS565444A | 1981-01-20 |
Other References:
FARM. AIKAK., (1973), 82(7-8), HALMEKOSKI JAAKKO, MAUKONEN LIISA, "Selective Acetylations of Terbutaline and Ritodrine", pages 111-115.
BR. J. PHARMACOL., (1993), 110(4), MARTIN CORINNE A.E., NALINE EMMANUEL, MANARA LUCIANO, ADVENIER CHARLES, "Effects of two Beta3-Adrenoceptor Agonists, SR 58611A and BRL 37344 and of Salbutamol on Cholinergic and NANC Neural Contraction in Guinea Pig Main Bronchi In Vitro", pages 1311-1316.
BR. J. CLIN. PHARMACOL., (1993), 36(6), NEWNHAM D.M., INGRAM C.G., MACKIE A., LIPWORTH B.J., "Beta-Adrenoceptor Subtypes Mediating the Airways Response to BRL 35135 in Man", pages 567-571.
BR. J. PHARMACOL., (1993), 110(4), MARTIN CORINNE A.E., NALINE EMMANUEL, MANARA LUCIANO, ADVENIER CHARLES, "Effects of two Beta3-Adrenoceptor Agonists, SR 58611A and BRL 37344 and of Salbutamol on Cholinergic and NANC Neural Contraction in Guinea Pig Main Bronchi In Vitro", pages 1311-1316.
BR. J. CLIN. PHARMACOL., (1993), 36(6), NEWNHAM D.M., INGRAM C.G., MACKIE A., LIPWORTH B.J., "Beta-Adrenoceptor Subtypes Mediating the Airways Response to BRL 35135 in Man", pages 567-571.
Attorney, Agent or Firm:
KISSEI PHARMACEUTICAL CO., LTD. (4365-1 Oaza Kashiwabara, Hotaka-mach, Minamiazumi-gun Nagano 399-83, JP)
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