Title:
2-AMINO- AND 2-THIO-SUBSTITUTED 1,3-DIAMINOPROPANES
Document Type and Number:
WIPO Patent Application WO2005095326
Kind Code:
A8
Abstract:
Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
Inventors:
HOM ROY (US)
TUCKER JOHN (US)
JOHN VARGHESE (US)
SHAH NEERAV (US)
TUCKER JOHN (US)
JOHN VARGHESE (US)
SHAH NEERAV (US)
Application Number:
PCT/US2005/009920
Publication Date:
October 12, 2006
Filing Date:
March 25, 2005
Export Citation:
Assignee:
ELAN PHARM INC (US)
PHARMACIA & UP JOHN COMPANY LL (US)
HOM ROY (US)
TUCKER JOHN (US)
JOHN VARGHESE (US)
SHAH NEERAV (US)
PHARMACIA & UP JOHN COMPANY LL (US)
HOM ROY (US)
TUCKER JOHN (US)
JOHN VARGHESE (US)
SHAH NEERAV (US)
International Classes:
C07C233/36; A61K31/16; A61K31/353; A61K31/382; A61K31/47; C07C235/10; C07C271/24; C07C311/05; C07C323/41; C07C327/42; C07D213/38; C07D215/38; C07D215/46; C07D303/36; C07D307/52; C07D311/68; C07D311/76; C07D317/72; C07D333/20; C07D335/04; C07D335/06; C07D405/04
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