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Title:
2-AMINOBENZAMIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/063925
Kind Code:
A1
Abstract:
Disclosed is a novel and excellent therapeutic or prophylactic agent for nociceptive pain, neuropathic pain, cancer pain, headache, bladder dysfunction or the like, which relies on a preventive activity on capsaicin receptor VR1 activation. It is found that a benzamide derivative having a benzene ring fused with a monocyclic ring on a nitrogen atom in the amide group and an amino group substituted by a lower alkylamino or cyclic group at a position adjacent to the amide group has a potent preventive activity on VR1 activation and an excellent pharmacological activity relying on the preventive activity, and therefore the derivative can be used as a good therapeutic or prophylactic agent for a VR1-related disease, such as nociceptive pain, neuropathic pain, cancer pain, headache and bladder dysfunction.

Inventors:
KURAMOCHI TAKAHIRO (JP)
HIRABAYASHI RYOJI (JP)
KOGANEMARU YOHEI (JP)
MUNAKATA RYOSUKE (JP)
YONEZAWA KOICHI (JP)
KISO TETSUO (JP)
Application Number:
PCT/JP2006/323863
Publication Date:
June 07, 2007
Filing Date:
November 29, 2006
Export Citation:
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Assignee:
ASTELLAS PHARMA INC (JP)
KURAMOCHI TAKAHIRO (JP)
HIRABAYASHI RYOJI (JP)
KOGANEMARU YOHEI (JP)
MUNAKATA RYOSUKE (JP)
YONEZAWA KOICHI (JP)
KISO TETSUO (JP)
International Classes:
A61K31/167; A61K31/404; A61K31/428; A61K31/4439; A61K31/454; A61K31/4704; A61K31/4709; A61K31/496; A61K31/5377; A61K31/538; A61K31/5415; A61P13/10; A61P25/02; A61P29/00; A61P43/00; C07D207/09; C07D207/14; C07D209/34; C07D211/06; C07D211/26; C07D211/58; C07D213/80; C07D215/38; C07D265/30; C07D265/36; C07D277/62; C07D277/64; C07D279/16; C07D295/12; C07D295/14; C07D307/14; C07D307/22; C07D309/14; C07D319/12; C07D401/12; C07D405/12; C07D413/12; C07D417/12
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WO2006038871A12006-04-13
WO2004039795A22004-05-13
WO2004056780A22004-07-08
WO2004005279A22004-01-15
WO2006048251A12006-05-11
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See also references of EP 1955697A4
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (3-11 Nihonbashi-Honcho 2-chom, Chuo-ku Tokyo 11, JP)
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