2-AMINOBUTANOL COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES

WIPO Patent Application WO/2007/126042

A1

[PROBLEMS] To provide a novel compound having few adverse side-effects such as bradycardia and also having an excellent effect of reducing the number of lymphocytes in the peripheral blood. [MEANS FOR SOLVING PROBLEMS] Disclosed is a 2-aminobutanol compound represented by the general formula (I) shown below, a pharmaceutically acceptable acid addition salt thereof, or a hydrate or solvate of the compound or the acid addition salt. Also disclosed is a process for production of the 2-aminobutanol compound. (I) wherein R1 represents a hydrogen atom or P(=O)(OH)2; R2 represents an alkyl having 1 to 4 carbon atoms which may be substituted by a hydroxyl group or a halogen atom; R3 represents a hydrogen atom, a halogen atom, a cyano, an alkyl having 1 to 4 carbon atoms which may be substituted by a halogen atom, or an acyl having 2 to 5 carbon atoms which may be subsituted by a halogen atom; X represents an oxygen atom, a sulfur atom, a carbonyl or NR4 (wherein R4 represents a hydrogen atom or an alkyl having 1 to 4 carbon atoms; Ar1 represents an arylene which may be substituted or a heteroarylene which may be substituted; and Ar2 represents an aryl which may be substituted or a hateroaryl which may be subsituted, provided that, when X represents an oxygen atom, Ar1 represents a phenylene and Ar2 represents a phenyl group, the phenyl group corresponding to Ar2 is substituted.

KIUCHI MASATOSHI (JP)
NAKAMURA MITSUHARU (JP)
HAMADA MAIKO (JP)
SUGAHARA KUNIO (JP)

PCT/JP2007/059150

November 08, 2007

April 27, 2007

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MITSUBISHI PHARMA CORP (JP)
KIUCHI MASATOSHI (JP)
NAKAMURA MITSUHARU (JP)
HAMADA MAIKO (JP)
SUGAHARA KUNIO (JP)

C07C217/64; A61K31/135; A61K31/145; A61K31/381; A61K31/661; A61P37/06; C07C225/10; C07C323/32; C07C323/38; C07D333/22; C07D333/34; C07F9/09

WO2003029205A1	2003-04-10
WO1994008943A1	1994-04-28
WO1996006068A1	1996-02-29
WO1998045429A2	1998-10-15
WO2003099192A2	2003-12-04
WO2003029184A1	2003-04-10

JP2005527612A	2005-09-15
JP2004307440A	2004-11-04

See also references of EP 2017257A4
SCIENCE, vol. 296, 2002, pages 346 - 349
NATURE, vol. 427, 2004, pages 355 - 360
ORGANIC LETTERS, vol. 5, 2003, pages 4017 - 4020
"Organic Letters", vol. 5, 2003, pages: 4017 - 4020
CIRCULATION, vol. 111, 2005, pages 222 - 229

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