Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
2-AMINOBUTANOL COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
Document Type and Number:
WIPO Patent Application WO/2007/126042
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a novel compound having few adverse side-effects such as bradycardia and also having an excellent effect of reducing the number of lymphocytes in the peripheral blood. [MEANS FOR SOLVING PROBLEMS] Disclosed is a 2-aminobutanol compound represented by the general formula (I) shown below, a pharmaceutically acceptable acid addition salt thereof, or a hydrate or solvate of the compound or the acid addition salt. Also disclosed is a process for production of the 2-aminobutanol compound. (I) wherein R1 represents a hydrogen atom or P(=O)(OH)2; R2 represents an alkyl having 1 to 4 carbon atoms which may be substituted by a hydroxyl group or a halogen atom; R3 represents a hydrogen atom, a halogen atom, a cyano, an alkyl having 1 to 4 carbon atoms which may be substituted by a halogen atom, or an acyl having 2 to 5 carbon atoms which may be subsituted by a halogen atom; X represents an oxygen atom, a sulfur atom, a carbonyl or NR4 (wherein R4 represents a hydrogen atom or an alkyl having 1 to 4 carbon atoms; Ar1 represents an arylene which may be substituted or a heteroarylene which may be substituted; and Ar2 represents an aryl which may be substituted or a hateroaryl which may be subsituted, provided that, when X represents an oxygen atom, Ar1 represents a phenylene and Ar2 represents a phenyl group, the phenyl group corresponding to Ar2 is substituted.

Inventors:
KIUCHI, Masatoshi (Tokyo Office 2-6, Nihonbashi-honcho 2-chome, Chuo-k, Tokyo 05, 1038405, JP)
城内 正壽 (〒05 東京都中央区日本橋本町二丁目2番6号 三菱ウェルファーマ株式会社 東京オフィス内 Tokyo, 1038405, JP)
NAKAMURA, Mitsuharu (Tokyo Office 2-6, Nihonbashi-honcho 2-chome, Chuo-k, Tokyo 05, 1038405, JP)
中村 光治 (〒05 東京都中央区日本橋本町二丁目2番6号 三菱ウェルファーマ株式会社 東京オフィス内 Tokyo, 1038405, JP)
Application Number:
JP2007/059150
Publication Date:
November 08, 2007
Filing Date:
April 27, 2007
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
MITSUBISHI PHARMA CORPORATION (6-9 Hiranomachi 2-chome, Chuo-ku Osaka-shi Osaka, 46, 5410046, JP)
三菱ウェルファーマ株式会社 (〒46 大阪府大阪市中央区平野町二丁目6番9号 Osaka, 5410046, JP)
KIUCHI, Masatoshi (Tokyo Office 2-6, Nihonbashi-honcho 2-chome, Chuo-k, Tokyo 05, 1038405, JP)
城内 正壽 (〒05 東京都中央区日本橋本町二丁目2番6号 三菱ウェルファーマ株式会社 東京オフィス内 Tokyo, 1038405, JP)
NAKAMURA, Mitsuharu (Tokyo Office 2-6, Nihonbashi-honcho 2-chome, Chuo-k, Tokyo 05, 1038405, JP)
International Classes:
C07C217/64; A61K31/135; A61K31/145; A61K31/381; A61K31/661; A61P37/06; C07C225/10; C07C323/32; C07C323/38; C07D333/22; C07D333/34; C07F9/09
Domestic Patent References:
WO2003029205A1
WO1994008943A1
WO1996006068A1
WO1998045429A2
WO2003099192A2
WO2003029184A1
Foreign References:
JP2005527612A
JP2004307440A
Other References:
See also references of EP 2017257A1
SCIENCE vol. 296, 2002, pages 346 - 349
NATURE vol. 427, 2004, pages 355 - 360
ORGANIC LETTERS vol. 5, 2003, pages 4017 - 4020
'Organic Letters', vol. 5, 2003 pages 4017 - 4020
CIRCULATION vol. 111, 2005, pages 222 - 229
Download PDF: