Title:
(2-AMINOETHYL) OXIME DERIVATIVES FOR THE TREATMENT OF DEPRESSION
Document Type and Number:
WIPO Patent Application WO2001080845
Kind Code:
A3
Abstract:
The subject invention provides compounds which are easily metabolized by the metabolic drug detoxification systems. Particularly, fluvoxamine analogs which have been designed to include esters within the structure of the compounds are taught. Also povided are methods of treating depression and affective disorders, such as obsessive compulsive disorder. Pharmaceutical compositions of the fluvoxamine analogs are also taught.
Inventors:
DRUZGALA PASCAL (US)
Application Number:
PCT/US2001/013275
Publication Date:
May 23, 2002
Filing Date:
April 24, 2001
Export Citation:
Assignee:
ARYX THERAPEUTICS (US)
DRUZGALA PASCAL (US)
DRUZGALA PASCAL (US)
International Classes:
A61P15/00; A61K31/165; A61K31/192; A61K31/215; A61K31/216; A61K31/221; A61K31/277; A61K31/4015; A61P15/10; A61P25/18; A61P25/22; A61P25/24; A61P43/00; C07C251/58; (IPC1-7): A61K31/215; A61P25/18; A61P25/24; C07C251/58
Foreign References:
| NL7610399A | 1978-03-22 | |||
| GB1533063A | 1978-11-22 |
Other References:
BOSCHMAN T A C ET AL: "IN VITRO INHIBITION OF ADP-INDUCED PLATELET AGGREGATION BY O-(AMINOALKYL) OXIME ETHERS", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 15, no. 4, 1 July 1980 (1980-07-01), pages 351 - 356, XP000577126, ISSN: 0223-5234
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