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Title:
2-AMINOETHYL SUBSTITUTED PYRIMIDIN-2-ONES, CYCLOPROPANES, PYRAZOLINES, PYRIMIDINES AND BENZOTHIAZEPINES AND THEIR USE AS UROTENSIN II AND SOMATOSTATIN 5 RECEPTOR LIGANDS
Document Type and Number:
WIPO Patent Application WO2004073642
Kind Code:
A3
Abstract:
The present invention provides a combinatorial approach to a library of novel compounds having four diversity points. The compounds provide for the mapping of urotensin II and somatostatin 5 receptors by differential binding of said receptors. Accordingly, the invention relates in a first aspect to novel compounds of the general formula I to V or salts thereof, The present invention further relates to a method of treating diseases for which modulation of the urotensin II receptor produces a physiologically beneficial response in said disease, such as those associated with CNS function and cardiovascular diseases. The present invention further relates to pharmaceutical compositions comprising these agents for the -treatment of these diseases adapted to modulate the urotensin II receptor.

Inventors:
OLSSON ROGER (SE)
Application Number:
PCT/US2004/004765
Publication Date:
March 17, 2005
Filing Date:
February 18, 2004
Export Citation:
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Assignee:
ACADIA PHARM INC (US)
OLSSON ROGER (SE)
International Classes:
C07C225/18; C07D231/06; C07D239/22; C07D239/26; C07D281/10; (IPC1-7): C07D239/22; A61K31/513; C07C225/18; C07D231/06; C07D239/26; C07D281/10; A61K31/135; A61K31/415; A61K31/505; A61K31/554
Other References:
CROSTON G E ET AL: "Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954)", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 23, 7 November 2002 (2002-11-07), pages 4950 - 4953, XP001153553, ISSN: 0022-2623
BERTOZZI F ET AL: "A Combinatorial Scaffold Approach Based upon a Multicomponent Reaction", ORGANIC LETTERS, vol. 5, no. 9, 1 May 2003 (2003-05-01), pages 1551 - 1554, XP002292429
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