Title:
2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY
Document Type and Number:
WIPO Patent Application WO1999040068
Kind Code:
A3
Abstract:
The present invention relates to a group of novel 2-aminoquinoline derivatives which are potent and selective agonists of the dopamine D4-receptor. The compounds have general formula (I) wherein (R1)n represents 1 or 2 substituents, which can be the same or different, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)-amino, or two groups R1 at adjacent carbon atoms together with the benzene ring may form the benzdioxane group or benzofuran group, X represents nitrogen or carbon, and the dotted line may represent a double bond, (R2)p represents 0, 1 or 2 substituents, which can be the same or different, from the group methyl and ethyl, or (R2)p is a methylene bridge or ethylene bridge, R3 is hydrogen or methyl, and (R)m represents 0, 1, or 2 substituents, which can be the same or different and can be located at all available positions of the quinolyl group, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)-amino, on the understanding that R1 cannot represent o-OCH3 when X is nitrogen, (R2)p and R3 are hydrogen, m is 0 and n is 1.
Inventors:
DEN HARTOG JACOBUS A J (NL)
VISSER GERBEN M (NL)
VAN STEEN BARTHOLOMEUS J (NL)
TULP MARTINUS T M (NL)
RONKEN ERIC (NL)
KRUSE CORNELIS G (NL)
VISSER GERBEN M (NL)
VAN STEEN BARTHOLOMEUS J (NL)
TULP MARTINUS T M (NL)
RONKEN ERIC (NL)
KRUSE CORNELIS G (NL)
Application Number:
PCT/EP1999/000855
Publication Date:
November 25, 1999
Filing Date:
February 05, 1999
Export Citation:
Assignee:
DUPHAR INT RES (NL)
HARTOG JACOBUS A J (NL)
VISSER GERBEN M (NL)
STEEN BARTHOLOMEUS J VAN (NL)
TULP MARTINUS T M (NL)
RONKEN ERIC (NL)
KRUSE CORNELIS G (NL)
HARTOG JACOBUS A J (NL)
VISSER GERBEN M (NL)
STEEN BARTHOLOMEUS J VAN (NL)
TULP MARTINUS T M (NL)
RONKEN ERIC (NL)
KRUSE CORNELIS G (NL)
International Classes:
A61K31/4709; A61K31/496; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D201/00; C07D215/38; C07D401/12; C07D405/12; (IPC1-7): C07D215/38; C07D401/12; C07D405/12; C07D405/14; A61K31/47; A61K31/495
Foreign References:
| EP0745598A1 | 1996-12-04 | |||
| US5093333A | 1992-03-03 | |||
| EP0512755A2 | 1992-11-11 |
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