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Title:
2'-DEOXY-7-DEAZAPURINE NUCLEOSIDE DERIVATIVE HAVING ANTIVIRAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2018/110591
Kind Code:
A1
Abstract:
The present invention makes it clear that a nucleoside derivative which shows excellent antiviral activity against HBV and which has low cytotoxicity can be obtained by substituting specific functional groups at each of positions 2, 6, and 7 of the purine base and position 4 of the ribose sugar, in 2'-deoxy-7-deazaadenosine.

Inventors:
MITSUYA HIROAKI (JP)
YAMADA KOHEI (JP)
TOMAYA KOTA (JP)
OHNO YUTARO (JP)
Application Number:
JP2017/044684
Publication Date:
June 21, 2018
Filing Date:
December 13, 2017
Export Citation:
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Assignee:
YAMASA CORP (JP)
NAT CENTER FOR GLOBAL HEALTH AND MEDICINE (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
C07H19/14; A61K31/7064; A61P31/12
Domestic Patent References:
WO2015199136A12015-12-30
WO2005020885A22005-03-10
WO2016100569A12016-06-23
Foreign References:
US5844106A1998-12-01
US6004939A1999-12-21
JP2013159574A2013-08-19
JP2007029093A2007-02-08
JP2005514401A2005-05-19
JP2005538096A2005-12-15
US5192749A1993-03-09
Other References:
S EELA, F. ET AL.: "7-Substituted 7-deaza-2'-deoxyadenosines and 8-aza-7-deaza 2'-deoxyadenosines:Fluorescence of DNA-Base Analogues Induced by the 7-Alkynyl Side Chain", HELVETICA CHIMICA ACTA, vol. 83, 2000, pages 910 - 927, XP002318798
RAINDLOVA, V. ET AL., CHEMPLUSCHEM, vol. 77, 2012, pages 652 - 662
SEELA, F. ET AL.: "Hydrogelation and spontaneous fiber formation of 8-aza-7-deazaadenine nucleoside click conjugates", TETRAHEDRON, vol. 67, 2011, pages 7418 - 7425, XP028265664
PENG, X. ET AL., NUCLEIC ACIDS RESEARCH, vol. 34, no. 20, 2006, pages 5987 - 6000
NAUS, P. ET AL.: "Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines:20-C-methylribonucleosides, 20-deoxy-20-fluoroarabinonucleosides,arabinonucleosides and 20-deoxyribonucleosides", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, 2012, pages 5202 - 5214, XP055496940
T AKAMATSU ET AL., HEPATOLOGY, vol. 62, no. 4, 2015, pages 1024 - 1036
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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