Title:
2'-GUANIDINYL-SUBSTITUTED OLIGONUCLEOTIDES AND GENE EXPRESSION MODULATION THEREWITH
Document Type and Number:
WIPO Patent Application WO2001002423
Kind Code:
A9
Abstract:
The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.
Inventors:
MANOHARAN MUTHIAH (US)
COOK PHILLIP DAN (US)
PRAKASH THAZHA P (US)
MOHAN VENKATRAMAN (US)
COOK PHILLIP DAN (US)
PRAKASH THAZHA P (US)
MOHAN VENKATRAMAN (US)
Application Number:
PCT/US2000/018609
Publication Date:
May 02, 2002
Filing Date:
July 07, 2000
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
MANOHARAN MUTHIAH (US)
COOK PHILLIP DAN (US)
PRAKASH THAZHA P (US)
MOHAN VENKATRAMAN (US)
MANOHARAN MUTHIAH (US)
COOK PHILLIP DAN (US)
PRAKASH THAZHA P (US)
MOHAN VENKATRAMAN (US)
International Classes:
A61K31/712; A61K48/00; A61P35/00; C07C335/38; C07F9/24; C07H21/00; C07H21/04; C07H21/02; (IPC1-7): C12Q1/68; A61K31/70; C07H19/067; C07H19/073; C07H19/10; C07H19/167; C07H19/173; C07H19/20; C07H21/00; C07H21/02; C07H21/04
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