Title:
2-HYDROXYPHENYLALKYLAMINE DERIVATIVES AND MAILLARD REACTION INHIBITORS
Document Type and Number:
WIPO Patent Application WO/1996/036591
Kind Code:
A1
Abstract:
2-Hydroxyphenylalkylamine derivatives having the activity of inhibiting Maillard reaction and represented by general formula (I) and pharmacologically acceptable salts thereof: wherein R1, R2, R3 and R4 may be the same or different and each represents hydrogen, lower alkyl, lower alkoxy, hydroxy, mercapto, halogeno, nitro, amino, acylamino, acyl or hydroxy(lower alkyl); R5 represents hydrogen or lower alkyl; A represents a single bond or lower alkylene or lower alkenylene optionally substituted by hydroxy; Y represents a single bond or lower alkylene; and Z represents carboxy, lower alkoxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl, carbamoyl, etc.
Inventors:
SATOH FUMIYASU (JP)
HARADA HIROMU (JP)
KUSAMA HIROSHI (JP)
IYOBE AKIRA (JP)
KOIZUMI TAKASHI (JP)
KAMATA KOJI (JP)
KATSUNO KENJI (JP)
KOBAYASHI MIHO (JP)
HARADA HIROMU (JP)
KUSAMA HIROSHI (JP)
IYOBE AKIRA (JP)
KOIZUMI TAKASHI (JP)
KAMATA KOJI (JP)
KATSUNO KENJI (JP)
KOBAYASHI MIHO (JP)
Application Number:
PCT/JP1996/001261
Publication Date:
November 21, 1996
Filing Date:
May 14, 1996
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
SATOH FUMIYASU (JP)
HARADA HIROMU (JP)
KUSAMA HIROSHI (JP)
IYOBE AKIRA (JP)
KOIZUMI TAKASHI (JP)
KAMATA KOJI (JP)
KATSUNO KENJI (JP)
KOBAYASHI MIHO (JP)
SATOH FUMIYASU (JP)
HARADA HIROMU (JP)
KUSAMA HIROSHI (JP)
IYOBE AKIRA (JP)
KOIZUMI TAKASHI (JP)
KAMATA KOJI (JP)
KATSUNO KENJI (JP)
KOBAYASHI MIHO (JP)
International Classes:
C07C229/34; C07C229/36; C07C237/20; C07D231/36; C07D237/20; (IPC1-7): C07C229/36; A61K31/165; A61K31/195; A61K31/215; C07C237/20; C07C309/24; C07C311/35; C07C317/28
Foreign References:
| JPH02765A | 1990-01-05 | |||
| JPH06329637A | 1994-11-29 | |||
| JPS472872A | ||||
| JPS467875A |
Other References:
THE JOURNAL OF ANTIBIOTICS, May 1990, Vol. 43, No. 5, BEST DESMOND J. et al., "Structure-Activity Relationships of Some Arylglycine Analogues and Catechol Isosteres of BRL 36650, a 6alpha-Formamido Penicillin", pages 574-577.
See also references of EP 0839799A4
See also references of EP 0839799A4
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