2-MERCAPTOCARBOXYLIC ACID DERIVATIVES

WIPO Patent Application WO/2000/050392

A1

2-Mercaptocarboxylic acid derivatives represented by general formula (I), pharmacologically acceptable esters of the same, or pharmacologically acceptable salts of both, which exhibit excellent antihyperglycemic and PPAR-activating effects and so on wherein A is phenyl or the like; X is a free valency or the like; W and Y are each independently alkylene or the like; and R is hydrogen or the like.

KUROBE HIROSHI (JP)
NUNOZAWA TETSUJI (JP)
SUGAWARA TOMOKAZU (JP)
MORIGUCHI KOUEI (JP)
ENDO TAKESHI (JP)

PCT/JP2000/001045

August 31, 2000

February 24, 2000

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SANKYO CO (JP)
FUJI CHEM IND CO LTD (JP)
KUROBE HIROSHI (JP)
NUNOZAWA TETSUJI (JP)
SUGAWARA TOMOKAZU (JP)
MORIGUCHI KOUEI (JP)
ENDO TAKESHI (JP)

A61K31/19; A61P3/06; A61P3/10; C07C323/52; C07C323/56; C07C327/22; C07C333/08; C07D213/30; C07D233/64; C07D277/24; (IPC1-7): C07C323/52; A61K31/192; A61K31/265; A61K31/27; A61K31/341; A61K31/343; A61K31/381; A61K31/4164; A61K31/426; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/47; A61K31/505; A61P3/06; A61P3/10; C07C323/56; C07C327/22; C07C333/04; C07D213/30; C07D213/55; C07D213/64; C07D213/65; C07D213/68; C07D213/89; C07D215/20; C07D233/64; C07D239/26; C07D277/24; C07D307/42; C07D307/80; C07D333/16; C07D333/22; C07D333/28; C07D333/32

WO1994017036A1

1994-08-04

GB2090591A	1982-07-14
JPH10306076A	1998-11-17

CORIC, PASCALE ET. AL.: "Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors", J. MED. CHEM., vol. 39, no. 6, 1996, pages 1210 - 1219, XP002929114

Nakamura, Minoru (Shin-Tokyo Building 3-1 Marunouchi 3-chome Chiyoda-ku, Tokyo, JP)

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