Title:
2-METHOXYESTRADIOL DERIVATIVES AND MEDICAL USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/075860
Kind Code:
A1
Abstract:
The present invention relates to novel 2-Methoxyestradiol derivatives and their medical use. In particular, the novel derivatives of the present invention are useful for the treatment or prevention of liver or lung fibrosis. Accordingly, the present invention also provides medical uses of the 2-Methoxyestradiol derivatives of the present invention. The present invention also provides a method of treating or preventing liver or lung fibrosis comprising administering an effective amount of the 2-Methoxyestradiol derivatives of the present invention.
More Like This:
Inventors:
SEO HAENG RAN (KR)
CHOI INHEE (KR)
CHOI JUNGHWAN (KR)
KIM YOUNG MI (KR)
SONG YEONHWA (KR)
KIM ARAM (KR)
LEE YOON JIN (KR)
LEE HAE-JUNE (KR)
NAM JAE-KYUNG (KR)
KIM JIHEE (KR)
LEE SU-YEON (KR)
CHOI INHEE (KR)
CHOI JUNGHWAN (KR)
KIM YOUNG MI (KR)
SONG YEONHWA (KR)
KIM ARAM (KR)
LEE YOON JIN (KR)
LEE HAE-JUNE (KR)
NAM JAE-KYUNG (KR)
KIM JIHEE (KR)
LEE SU-YEON (KR)
Application Number:
PCT/KR2020/014040
Publication Date:
April 22, 2021
Filing Date:
October 14, 2020
Export Citation:
Assignee:
PASTEUR INSTITUT KOREA (KR)
KOREA INST RADIOLOGICAL & MEDICAL SCIENCES (KR)
KOREA INST RADIOLOGICAL & MEDICAL SCIENCES (KR)
International Classes:
C07J1/00; A61K31/565; A61P1/16; C07J31/00
Domestic Patent References:
| WO2008124878A1 | 2008-10-23 |
Foreign References:
| US20050014737A1 | 2005-01-20 |
Other References:
SUWANDI, L.S. ; AGOSTON, G.E. ; SHAH, J.H. ; HANSON, A.D. ; ZHAN, X.H. ; LAVALLEE, T.M. ; TRESTON, A.M.: "Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs", BIORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 19, no. 22, 15 November 2009 (2009-11-15), Amsterdam , NL, pages 6459 - 6462, XP026703828, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2009.09.009
FANG, Z. ; AGOSTON, G.E. ; LADOUCEUR, G. ; TRESTON, A.M. ; WANG, L. ; CUSHMAN, M.: "Structure elucidation by synthesis of four metabolites of the antitumor drug ENMD-1198 detected in human plasma samples", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 65, no. 51, 19 December 2009 (2009-12-19), AMSTERDAM, NL, pages 10535 - 10543, XP026765536, ISSN: 0040-4020, DOI: 10.1016/j.tet.2009.10.046
HAYASHIDA KAZUMI, SHOJI IKUO, DENG LIN, JIANG DA-PENG, IDE YOSHI-HIRO, HOTTA HAK: "17β-estradiol inhibits the production of infectious particles of hepatitis C virus : 17β-estradiol inhibits HCV virion production", MICROBIOLOGY AND IMMUNOLOGY, CENTER FOR ACADEMIC PUBLICATIONS JAPAN|, JP, vol. 54, no. 11, 1 November 2010 (2010-11-01), JP, pages 684 - 690, XP055800999, ISSN: 0385-5600, DOI: 10.1111/j.1348-0421.2010.00268.x
See also references of EP 4041744A4
FANG, Z. ; AGOSTON, G.E. ; LADOUCEUR, G. ; TRESTON, A.M. ; WANG, L. ; CUSHMAN, M.: "Structure elucidation by synthesis of four metabolites of the antitumor drug ENMD-1198 detected in human plasma samples", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 65, no. 51, 19 December 2009 (2009-12-19), AMSTERDAM, NL, pages 10535 - 10543, XP026765536, ISSN: 0040-4020, DOI: 10.1016/j.tet.2009.10.046
HAYASHIDA KAZUMI, SHOJI IKUO, DENG LIN, JIANG DA-PENG, IDE YOSHI-HIRO, HOTTA HAK: "17β-estradiol inhibits the production of infectious particles of hepatitis C virus : 17β-estradiol inhibits HCV virion production", MICROBIOLOGY AND IMMUNOLOGY, CENTER FOR ACADEMIC PUBLICATIONS JAPAN|, JP, vol. 54, no. 11, 1 November 2010 (2010-11-01), JP, pages 684 - 690, XP055800999, ISSN: 0385-5600, DOI: 10.1111/j.1348-0421.2010.00268.x
See also references of EP 4041744A4
Attorney, Agent or Firm:
PHIL & ONZI INT'L PATENT & LAW FIRM (KR)
Download PDF: