2-(PHENYLETHYNYL)THIENO[3,4-B]PYRAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTING OR TREATING CANCER

WIPO Patent Application WO/2014/109530

A1

The purpose of the present invention is to provide: a novel 2-(phenylethynyl)thieno[3,4-b]pyrazine derivative represented by chemical formula 1 and having TGase 2 (Transglutaminase 2)-suppressing activity; pharmaceutically acceptable salts thereof; and a pharmaceutical composition comprising same for preventing or treating cancer.

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GONG YOUNG DAE (KR)
KIM SOO YOUL (KR)
KIM NA YEON (KR)

PCT/KR2014/000172

July 17, 2014

January 08, 2014

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UNIV DONGGUK IND ACAD COOP (KR)
NAT CANCER CT (KR)

C07D495/04; A61K31/4985; A61P35/00

US7399764B2	2008-07-15
KR101097177B1	2011-12-22

KIM, NA YEON ET AL.: "A Novel 3-Arylethynyl-substituted Thieno[2,4-b]pyrazine Derivatives as a Human Trasnglutaminase 2 inhibitor.", THE KOREAN CHEMICAL SOCIETY, 110TH GENERAL ASSEMBLY AND CONFERENCE POSTER PRESENTATION DOCUMENT., 2012, pages ABST.2012
DUVAL, E. ET AL.: "Structure-activity relationship study of novel tissue transglutaminase inhibitors.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS., vol. 15, no. ISSUE, 2005, pages 1885 - 1889
GONG, Y. D. ET AL.: "A Novel 3-Phenylethynyl-2-yl-oxy Quinoxaline Core Skeleton and Pharmacophore Model as a Hypoxia-inducible Factor Inhibitor.", NOTES., vol. 31, no. 11, 2011, pages 3441 - 3444

SON, MIN (KR)
손민 (KR)

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