Title:
2'-SUBSTITUTED-2,2'-DEHYDRATED URIDINE OR 2'-SUBSTITUTED-2,2'-DEHYDRATED CYTIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/139602
Kind Code:
A1
Abstract:
Disclosed are 2'-substituted-2,2'-dehydrated uridine or 2'-substituted-2,2'-dehydrated cytidine compounds as represented by the following general formula I and preparation method thereof. The present invention also relates to a method of using the 2'-substituted-2,2'-dehydrated uridine or 2'-substituted-2,2'-dehydrated cytidine compounds to prepare 2'-deoxy-2'-fluorine-2'-substituted uridine or 2'-deoxy-2'-fluorine-2'-substituted cytidine or 2'-deoxy-2'-cyano-2'-substituted cytidine compounds.
Inventors:
ZHANG RONGXIA (CN)
Application Number:
PCT/CN2015/074363
Publication Date:
September 24, 2015
Filing Date:
March 17, 2015
Export Citation:
Assignee:
ZHANG RONGXIA (CN)
International Classes:
C07H19/09; C07H1/00; C07H19/073
Domestic Patent References:
| WO2014160484A1 | 2014-10-02 |
Other References:
JENKINSON, SARAH F. ET AL.: "Anomeric stereospecific synthesis of 2'-C-methyl beta -nucleosides; the Holy reaction of cyanamide with 2-C-methyl-D-arabinose", TETRAHEDRON LETTERS, vol. 48, no. 25, 30 May 2007 (2007-05-30), pages 4441, XP022093157, DOI: doi:10.1016/j.tetlet.2007.04.105
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
北京金信知识产权代理有限公司 (CN)
北京金信知识产权代理有限公司 (CN)
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