Title:
2-(SUBSTITUTED BENZENE MATRIX) AROMATIC FORMATE FTO INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/157843
Kind Code:
A1
Abstract:
The preparation method provides 2-(substituted benzene matrix) aromatic formate FTO inhibitor, a preparation method therefor, and applications thereof. Specifically, disclosed in the present invention are a 2-(substituted benzene matrix) aromatic formate compound represented by the following formula (I), and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, which can be used as an FTO target inhibitor for treating diseases associated with FTO targets, obesity, metabolic syndrome (MS), type 2 diabetes (T2D), Alzheimer's diseases, breast cancers, small-cell lung cancers, a human bone marrow striated muscle cancer, a pancreatic cancer, malignant glioblastoma and the like.
Inventors:
YANG CAIGUANG (CN)
HUANG YUE (CN)
DONG ZE (CN)
ZHANG TAO (CN)
XU HONGJIAO (CN)
HUANG YUE (CN)
DONG ZE (CN)
ZHANG TAO (CN)
XU HONGJIAO (CN)
Application Number:
PCT/CN2018/077795
Publication Date:
September 07, 2018
Filing Date:
March 01, 2018
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07C229/58; A61K31/41; A61P3/00; A61P9/00; A61P35/00; C07D231/12; C07D239/26; C07D333/20; C07D413/12
Domestic Patent References:
| WO2006098308A1 | 2006-09-21 |
Foreign References:
| US20110129445A1 | 2011-06-02 | |||
| CN101568521A | 2009-10-28 | |||
| CN104069092A | 2014-10-01 |
Other References:
J. SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3590920A4
See also references of EP 3590920A4
Attorney, Agent or Firm:
XU AND PARTNERS, LLC. (CN)
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