Title:
2-SUBSTITUTED DIBENZO[A,E]1,2,3-TRIAZOLO[4,5-C][7]ANNULEN-8-ONES AS GROWTH HORMONE SECRETAGOGUES
Document Type and Number:
WIPO Patent Application WO2002056873
Kind Code:
A3
Abstract:
The invention relates to methods of treating or preventing diseases or conditions caused by deficiencies in growth hormone by administration of 2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones. Such diseases or conditions include osteoporosis, osteopenia and obesity. Furthermore, the invention relates to methods of stimulating the release of growth hormone in a mammal by administration of 2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones. Finally, the invention further relates to promoting bone growth in a mammal, particularly endocortical, periosteal, or cancellous bone growth, by administration of 2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones.
Inventors:
DIXON BRIAN R (US)
BAGI CEDO M (US)
SCOTT WILLIAM J (US)
RANGES GERALD (US)
BAGI CEDO M (US)
SCOTT WILLIAM J (US)
RANGES GERALD (US)
Application Number:
PCT/US2001/048258
Publication Date:
August 07, 2003
Filing Date:
December 14, 2001
Export Citation:
Assignee:
BAYER PHARMACEUTICALS CORP (US)
DIXON BRIAN R (US)
BAGI CEDO M (US)
SCOTT WILLIAM J (US)
RANGES GERALD (US)
DIXON BRIAN R (US)
BAGI CEDO M (US)
SCOTT WILLIAM J (US)
RANGES GERALD (US)
International Classes:
A61K31/4192; A61K31/454; A61K45/06; A61P3/04; A61P3/10; A61P9/04; A61P17/02; A61P19/08; A61P21/06; A61P37/00; (IPC1-7): A61K31/00; A61K31/4192; A61K31/454; A61K45/06; A61P3/04; A61P3/10; A61P9/04; A61P17/02; A61P19/08; A61P21/06; A61P37/00
Domestic Patent References:
| WO1997038991A1 | 1997-10-23 | |||
| WO2002057241A1 | 2002-07-25 |
Foreign References:
| DE1938583A1 | 1971-02-11 | |||
| US5773441A | 1998-06-30 |
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