Title:
2-(R²-THIO)-10-[3-(4-R1-PIPERAZIN-1-YL)PROPYL]-10H-PHENOTHIAZINE FOR TREATING A β-AMYLOIDOPATHY OR AN ALPHA-SYNUCLEOPATHY, AND METHOD FOR THE DIAGNOSIS OR PREDIAGNOSIS THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/031941
Kind Code:
A3
Abstract:
The invention relates to 2-(R2-thio)-10-[3-(4-R1-piperazin-1-yl)propyl]-10H-phenothiazine according to general formula I, for treating a β-amyloidopathy or an α-synucleinopathy accompanied by a cerebral protein deposit and a reduced activity of the cerebral ABCC1-transporter. The invention also relates to a method for the diagnosis or prediagnosis of a β-amyloidopathy or an α-synucleopathy accompanied by a cerebral protein deposit and a reduced activity of the cerebral ABCC1-transporter, or for determining the risk of a proband suffering from such an illness, the proband already having accumulated substances transported by the cerebral ABCC1 transporter.
Inventors:
PAHNKE JENS (DE)
Application Number:
PCT/EP2011/064893
Publication Date:
September 20, 2012
Filing Date:
August 30, 2011
Export Citation:
Assignee:
UNIV ROSTOCK (DE)
PAHNKE JENS (DE)
PAHNKE JENS (DE)
International Classes:
C07D417/06; A61K31/5415; A61P25/28; C07D417/14; G01N33/68
Domestic Patent References:
| WO2008092898A1 | 2008-08-07 | |||
| WO1996004915A1 | 1996-02-22 |
Other References:
CIRRITO J R ET AL: "P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, vol. 115, no. 11, 1 November 2005 (2005-11-01), pages 3285 - 3290, XP003015274, ISSN: 0021-9738, DOI: 10.1172/JCI25247
PAHNKE JENS ET AL: "Clinico-pathologic function of cerebral ABC transporters - Implications for the pathogenesis of Alzheimer's disease", CURRENT ALZHEIMER RESEARCH, vol. 5, no. 4, August 2008 (2008-08-01), pages 396 - 405, XP009160059, ISSN: 1567-2050
DEELEY R G ET AL: "Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 580, no. 4, 13 February 2006 (2006-02-13), pages 1103 - 1111, XP028030467, ISSN: 0014-5793, [retrieved on 20060213], DOI: 10.1016/J.FEBSLET.2005.12.036
MARKUS KROHN ET AL.: "Cerebral amyloid-[beta] proteostasis is regulated by the membrane transport protein ABCC1 in mice", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 121, no. 10, 1 September 2011 (2011-09-01), pages 3924 - 3931, XP055029425, ISSN: 1558-8238, Retrieved from the Internet [retrieved on 20120611], DOI: 10.1172/JCI57867DS1)
PAHNKE JENS ET AL: "Clinico-pathologic function of cerebral ABC transporters - Implications for the pathogenesis of Alzheimer's disease", CURRENT ALZHEIMER RESEARCH, vol. 5, no. 4, August 2008 (2008-08-01), pages 396 - 405, XP009160059, ISSN: 1567-2050
DEELEY R G ET AL: "Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 580, no. 4, 13 February 2006 (2006-02-13), pages 1103 - 1111, XP028030467, ISSN: 0014-5793, [retrieved on 20060213], DOI: 10.1016/J.FEBSLET.2005.12.036
MARKUS KROHN ET AL.: "Cerebral amyloid-[beta] proteostasis is regulated by the membrane transport protein ABCC1 in mice", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 121, no. 10, 1 September 2011 (2011-09-01), pages 3924 - 3931, XP055029425, ISSN: 1558-8238, Retrieved from the Internet
Attorney, Agent or Firm:
WABLAT LANGE KARTHAUS (Berlin, DE)
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