Title:
2-THIOETHENYL CARBAPENEM DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2006/109823
Kind Code:
A1
Abstract:
A 2-ethenylthio carbapenem derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof. This compound has a potent antibacterial effect and a broad antibacterial spectrum against pneumococci including penicillin-resistant Streptococcus pneumoniae (PRSP), influenza viruses including β-lactamase-non-producing ampicillin-resistant Haemophilus influenzae (BLNAR), Moraxella catarrhalis and the like.
Inventors:
MARUYAMA TAKAHISA (JP)
KANO YUKO (JP)
ANDO TAKASHI (JP)
SASAKI TOSHIRO (JP)
SAWABE TAKEHIKO (JP)
BABA NOBUYOSHI (JP)
TAKATA HIROMI (JP)
SUZUKI HISASHI (JP)
AIHARA KAZUHIRO (JP)
FUJITA TOSHIKI (JP)
KANO YUKO (JP)
ANDO TAKASHI (JP)
SASAKI TOSHIRO (JP)
SAWABE TAKEHIKO (JP)
BABA NOBUYOSHI (JP)
TAKATA HIROMI (JP)
SUZUKI HISASHI (JP)
AIHARA KAZUHIRO (JP)
FUJITA TOSHIKI (JP)
Application Number:
PCT/JP2006/307698
Publication Date:
October 19, 2006
Filing Date:
April 12, 2006
Export Citation:
Assignee:
MEIJI SEIKA KAISHA (JP)
MARUYAMA TAKAHISA (JP)
KANO YUKO (JP)
ANDO TAKASHI (JP)
SASAKI TOSHIRO (JP)
SAWABE TAKEHIKO (JP)
BABA NOBUYOSHI (JP)
TAKATA HIROMI (JP)
SUZUKI HISASHI (JP)
AIHARA KAZUHIRO (JP)
FUJITA TOSHIKI (JP)
MARUYAMA TAKAHISA (JP)
KANO YUKO (JP)
ANDO TAKASHI (JP)
SASAKI TOSHIRO (JP)
SAWABE TAKEHIKO (JP)
BABA NOBUYOSHI (JP)
TAKATA HIROMI (JP)
SUZUKI HISASHI (JP)
AIHARA KAZUHIRO (JP)
FUJITA TOSHIKI (JP)
International Classes:
C07D477/00; A61K31/407; A61P31/04
Domestic Patent References:
| WO2003089431A1 | 2003-10-30 |
Foreign References:
| JPH09249667A | 1997-09-22 | |||
| JPH0812676A | 1996-01-16 | |||
| JPS5740487A | 1982-03-06 | |||
| JPH0625196A | 1994-02-01 | |||
| JP2002332288A | 2002-11-22 |
Other References:
YOKOO C. ET AL.: "Studies on cephalosporin antibiotics. IV. Synthesis, antibacterial activity and oral absorption of new 3-(2-substituted-vinylthio)-7b-[(Z)-2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]cephalosporins", JOURNAL OF ANTIBIOTICS, vol. 44, no. 12, 1991, pages 1422 - 1431, XP003006107
NISHIMURA S. ET AL.: "Synthesis and biological activity of 3-vinylthio- and 3-vinylthiomethylcephem derivatives", JOURNAL OF ANTIBIOTICS, vol. 43, no. 9, 1990, pages 1160 - 1168, XP003006108
See also references of EP 1870412A4
NISHIMURA S. ET AL.: "Synthesis and biological activity of 3-vinylthio- and 3-vinylthiomethylcephem derivatives", JOURNAL OF ANTIBIOTICS, vol. 43, no. 9, 1990, pages 1160 - 1168, XP003006108
See also references of EP 1870412A4
Attorney, Agent or Firm:
Yoshitake, Kenji (Room 323 Fuji Bldg., 2-3, Marunouchi 3-chom, Chiyoda-ku Tokyo 05, JP)
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