Title:
20-SUBSTITUTED CAMPTOTHECIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/098658
Kind Code:
A1
Abstract:
The present invention provides a compound having a structure shown in formula (I), an isomer thereof, a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition comprising said compound. Provided is an application of the present compound and pharmaceutical composition thereof in preparation of a drug for preventing and/or treating a cancer. The present compound has a good ex-vivo cytotoxic activity and a good in-vivo antitumor effect. The preparation method for the compound is easy and raw materials are easy to obtain. Therefore, the present compound has a wide medicinal prospect. (I)
Inventors:
JIANG TAO (CN)
ZHANG HAILIN (CN)
WU GUANZHAO (CN)
ZHANG YIXUAN (CN)
LI JING (CN)
QI XIN (CN)
ZHANG HAILIN (CN)
WU GUANZHAO (CN)
ZHANG YIXUAN (CN)
LI JING (CN)
QI XIN (CN)
Application Number:
PCT/CN2019/117646
Publication Date:
May 22, 2020
Filing Date:
November 12, 2019
Export Citation:
Assignee:
OCEAN UNIV CHINA (CN)
International Classes:
C07D491/22; A61K31/4741; A61P35/00
Domestic Patent References:
| WO2001049691A1 | 2001-07-12 | |||
| WO2001049691A1 | 2001-07-12 |
Foreign References:
| US7064202B1 | 2006-06-20 | |||
| CN108822120A | 2018-11-16 | |||
| CN104650342B | 2018-07-10 | |||
| US7064202B1 | 2006-06-20 | |||
| CN104650342B | 2018-07-10 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF: