Title:
21908 AND 21911, HUMAN GUANYLATE KINASE FAMILY MEMBERS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2002048330
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acid molecules, designated MAGK nucleic acid molecules, which encode novel guanylate kinase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MAGK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a MAGK gene has been introduced or disrupted. The invention still further provides isolated MAGK proteins, fusion proteins, antigenic peptides and anti-MAGK antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
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Inventors:
KAPELLER-LIBERMANN ROSANNA
Application Number:
PCT/US2001/044344
Publication Date:
March 13, 2003
Filing Date:
November 26, 2001
Export Citation:
Assignee:
MILLENIUM PHARMACEUTICALS INC (US)
International Classes:
C12N9/12; (IPC1-7): C12N15/00; C12N15/10; C12N5/10; C12N9/12; C07K16/18; C12Q1/68; G01N33/68
Foreign References:
| US5401835A | 1995-03-28 |
Other References:
INAGAKI H ET AL: "rDLG6: A novel homolog of Drosophila DLG expressed in rat brain", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 265, Q9QYH1, - 1999, pages 462 - 469, XP002204245
BRADY W A ET AL: "Cloning, characterization, and modeling of mouse and human guanylate kinases", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 28, 12 July 1996 (1996-07-12), pages 16734 - 16740, XP002188875, ISSN: 0021-9258
FITZGIBBON JUDE ET AL: "Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation.", FEBS LETTERS, vol. 385, no. 3, 1996, pages 185 - 188, XP002204145, ISSN: 0014-5793
KIM ANTHONY C ET AL: "Complete genomic organization of the human erythroid p55 gene (MPP1), a membrane-associated guanylate kinase homologue.", GENOMICS, vol. 31, no. 2, 1996, pages 223 - 229, XP002204146, ISSN: 0888-7543
DIMITRATOS S D ET AL: "SIGNALING PATHWAYS ARE FOCUSED AT SPECIALIZED REGIONS ON THE PLASMA MEMBRANE BY SCAFFOLDING PROTEINS OF THE MAGUK FAMILY", BIOESSAYS, CAMBRIDGE, GB, vol. 21, no. 11, 1999, pages 912 - 921, XP001053275, ISSN: 0265-9247
GONZALEZ-MARISCAL LORENZA ET AL: "MAGUK proteins: Structure and role in the tight junction.", SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, vol. 11, no. 4, August 2000 (2000-08-01), pages 315 - 324, XP002204147, ISSN: 1084-9521
BRADY W A ET AL: "Cloning, characterization, and modeling of mouse and human guanylate kinases", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 28, 12 July 1996 (1996-07-12), pages 16734 - 16740, XP002188875, ISSN: 0021-9258
FITZGIBBON JUDE ET AL: "Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation.", FEBS LETTERS, vol. 385, no. 3, 1996, pages 185 - 188, XP002204145, ISSN: 0014-5793
KIM ANTHONY C ET AL: "Complete genomic organization of the human erythroid p55 gene (MPP1), a membrane-associated guanylate kinase homologue.", GENOMICS, vol. 31, no. 2, 1996, pages 223 - 229, XP002204146, ISSN: 0888-7543
DIMITRATOS S D ET AL: "SIGNALING PATHWAYS ARE FOCUSED AT SPECIALIZED REGIONS ON THE PLASMA MEMBRANE BY SCAFFOLDING PROTEINS OF THE MAGUK FAMILY", BIOESSAYS, CAMBRIDGE, GB, vol. 21, no. 11, 1999, pages 912 - 921, XP001053275, ISSN: 0265-9247
GONZALEZ-MARISCAL LORENZA ET AL: "MAGUK proteins: Structure and role in the tight junction.", SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, vol. 11, no. 4, August 2000 (2000-08-01), pages 315 - 324, XP002204147, ISSN: 1084-9521
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