Title:
2,3,4-BENZOTHIADIAZEPINE-2,2-DIOXIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2011/039554
Kind Code:
A3
Abstract:
The present invention relates to compounds 2,3,4-benzothiadiazepine-2,2-dioxide derivatives and enantiomers of the general Formula (I) wherein 'a' represents single or double bond, R1 and R2 represent, independently, hydrogen, halogen, cyano, alkyl, alkoxy, trifluoromethyl, or if 'a' represents single bond, R1 and R2 together form =N-S-N= group, R3 and R4 represent, independently, hydrogen, alkyl, alkenyl, cycloalkyl, aryl or aralkyl, R5 and R6 represent, independently, hydrogen, halogen, cyano, alkyl, alkoxy, trifluoromethyl and/or enantiomers and/or pharmaceutically suitable acid addition salts thereof. The invention further relates to a process for their preparation, medicaments containing said compounds and the use thereof for the treatment of disorders of the central nervous system.
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Inventors:
FETTER JOZSEF (HU)
BERTHA FERENC (HU)
MOLNAR BALAZS (HU)
SIMIG GYULA (HU)
BARKOCZY JOZSEF (HU)
VOLK BALAZS (HU)
LEVAY GYOERGY (HU)
GACSALYI ISTVAN (HU)
GIGLER GABOR (HU)
KOMPAGNE HAJNALKA (HU)
MARKO BERNADETT (HU)
NAGY KATALIN (HU)
KIRICSI PETER (HU)
HARSING LASZLO GABOR (HU)
SZENASI GABOR (HU)
BERTHA FERENC (HU)
MOLNAR BALAZS (HU)
SIMIG GYULA (HU)
BARKOCZY JOZSEF (HU)
VOLK BALAZS (HU)
LEVAY GYOERGY (HU)
GACSALYI ISTVAN (HU)
GIGLER GABOR (HU)
KOMPAGNE HAJNALKA (HU)
MARKO BERNADETT (HU)
NAGY KATALIN (HU)
KIRICSI PETER (HU)
HARSING LASZLO GABOR (HU)
SZENASI GABOR (HU)
Application Number:
PCT/HU2010/000103
Publication Date:
June 16, 2011
Filing Date:
September 29, 2010
Export Citation:
Assignee:
EGIS GYOGYSZERGYAR NYILVANOSAN MUKOEDO RESZVENYTARSAGAG (HU)
FETTER JOZSEF (HU)
BERTHA FERENC (HU)
MOLNAR BALAZS (HU)
SIMIG GYULA (HU)
BARKOCZY JOZSEF (HU)
VOLK BALAZS (HU)
LEVAY GYOERGY (HU)
GACSALYI ISTVAN (HU)
GIGLER GABOR (HU)
KOMPAGNE HAJNALKA (HU)
MARKO BERNADETT (HU)
NAGY KATALIN (HU)
KIRICSI PETER (HU)
HARSING LASZLO GABOR (HU)
SZENASI GABOR (HU)
FETTER JOZSEF (HU)
BERTHA FERENC (HU)
MOLNAR BALAZS (HU)
SIMIG GYULA (HU)
BARKOCZY JOZSEF (HU)
VOLK BALAZS (HU)
LEVAY GYOERGY (HU)
GACSALYI ISTVAN (HU)
GIGLER GABOR (HU)
KOMPAGNE HAJNALKA (HU)
MARKO BERNADETT (HU)
NAGY KATALIN (HU)
KIRICSI PETER (HU)
HARSING LASZLO GABOR (HU)
SZENASI GABOR (HU)
International Classes:
C07D285/06; A61K31/554; A61P25/00; C07D285/36; C07D309/24
Other References:
J. F. KING ET AL: "Chlorination of Heterocyclic and Acyclic Sulfonhydrazones", CAN. J. CHEM., vol. 49, no. 6, March 1971 (1971-03-01), pages 943 - 955, XP002632360, DOI: 10.1139/v71-154
Attorney, Agent or Firm:
ADVOPATENT OFFICE OF PATENT AND TRADMARK ATTORNEYS (Budapest, HU)
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