Title:
2,4-DIAMINOPYRIMIDINE DERIVATIVE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/135488
Kind Code:
A1
Abstract:
The present invention relates to a 2,4-diaminopyrimidine derivative, pharmaceutically acceptable salts thereof, hydrates, solvates or stereoisomers, and a preparation method thereof and an application of the compound used separately or in combination with other drugs in treatment of diseases having ALK2 kinase-mediated pathological features. （I）
Inventors:
ZHANG LEI (CN)
Application Number:
PCT/CN2019/128245
Publication Date:
July 02, 2020
Filing Date:
December 25, 2019
Export Citation:
Assignee:
SHANGHAI ZHEYE BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07D401/14; A61K31/506; A61K31/5377; A61P35/00; C07D401/12; C07D409/14
Domestic Patent References:
| WO2003095448A1 | 2003-11-20 | |||
| WO2016033100A1 | 2016-03-03 | |||
| WO2014151871A2 | 2014-09-25 |
Foreign References:
| CN105308033A | 2016-02-03 | |||
| CN1697830A | 2005-11-16 | |||
| CN104672214A | 2015-06-03 | |||
| CN102336716A | 2012-02-01 |
Other References:
GANZ T., PHYSIOL REV., vol. 93, no. 4, 2013, pages 1721 - 1741
KRAUSE A., FEBS LETT., vol. 480, no. 2-3, 2000, pages 147 - 150
PIGEON C., J BIOL CHEM., vol. 276, no. 11, 2001, pages 7806 - 7810
HENTZE MW., CELL, vol. 142, no. 1, 2010, pages 24 - 38
NEMETH E., SCIENCE, vol. 306, no. 5704, 2004, pages 2090 - 2093
THEURL I., BLOOD, vol. 113, no. 21, 2009, pages 5277 - 5286
WEISS G., N ENGL J MED, vol. 352, no. 10, 2005, pages 1011 - 1023
WANG RH., CELL METAB, vol. 2, no. 6, 2005, pages 399 - 409
ANDRIOPOULOS B JR., NAT GENET, vol. 41, no. 4, 2009, pages 478 - 481
ZHAO N., J CLIN INVEST., vol. 123, no. 6, 2013, pages 2337 - 2343
STEINBICKER AU., BLOOD, vol. 118, no. 15, 2011, pages 4224 - 4230
See also references of EP 3904347A4
KRAUSE A., FEBS LETT., vol. 480, no. 2-3, 2000, pages 147 - 150
PIGEON C., J BIOL CHEM., vol. 276, no. 11, 2001, pages 7806 - 7810
HENTZE MW., CELL, vol. 142, no. 1, 2010, pages 24 - 38
NEMETH E., SCIENCE, vol. 306, no. 5704, 2004, pages 2090 - 2093
THEURL I., BLOOD, vol. 113, no. 21, 2009, pages 5277 - 5286
WEISS G., N ENGL J MED, vol. 352, no. 10, 2005, pages 1011 - 1023
WANG RH., CELL METAB, vol. 2, no. 6, 2005, pages 399 - 409
ANDRIOPOULOS B JR., NAT GENET, vol. 41, no. 4, 2009, pages 478 - 481
ZHAO N., J CLIN INVEST., vol. 123, no. 6, 2013, pages 2337 - 2343
STEINBICKER AU., BLOOD, vol. 118, no. 15, 2011, pages 4224 - 4230
See also references of EP 3904347A4
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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