FIELD OF THE INVENTION

The present invention relates to 2,4-diaminopyrimidines and pharmaceutically acceptable salts thereof, purification methods for the same, pharmaceutical

compositions containing them, methods of obtaining and using them for the treatment of disease states, disorders, and conditions mediated by histamine H4 receptor activity. BACKGROUND OF THE INVENTION

The histamine H4 receptor (H4R) is one of the identified receptors for histamine (for reviews, see: Fung-Leung, W.-P., et al., Curr. Opin. Invest. Drugs 2004, 5(11), 1174-1183; de Esch, I.J.P., et al., Trends Pharmacol. Sci.2005, 26(9), 462-469). The receptor is found in the bone marrow and spleen and is expressed on eosinophils, basophils, mast cells (Liu, C., et al., Mol. Pharmacol.2001, 59(3), 420-426; Morse, K.L., et al., J. Pharmacol. Exp. Ther.2001, 296(3), 1058-1066; Hofstra, C.L., et al., J.

Pharmacol. Exp. Ther.2003, 305(3), 1212-1221; Lippert, U., et al., J. Invest. Dermatol. 2004, 123(1), 116-123; Voehringer, D., et al., Immunity 2004, 20(3), 267-277), CD8 ⁺ T cells (Gantner, F., et al., J. Pharmacol. Exp. Ther.2002, 303(1), 300-307), dendritic cells, and human synovial cells from rheumatoid arthritis patients (Ikawa, Y., et al., Biol. Pharm. Bull.2005, 28(10), 2016-2018). However, expression in neutrophils and monocytes is less well defined (Ling, P., et al., Br. J. Pharmacol.2004, 142(1), 161- 171). Receptor expression is at least in part controlled by various inflammatory stimuli (Coge, F., et al., Biochem. Biophys. Res. Commun.2001, 284(2), 301-309; Morse, et al., 2001), thus supporting that H4R activation influences inflammatory responses.

Because of its preferential expression on immunocompetent cells, H ₄ R is closely related with the regulatory functions of histamine during the immune response.

A biological activity of histamine in the context of immunology and autoimmune diseases is closely related with the allergic response and its deleterious effects, such as inflammation. Events that elicit the inflammatory response include physical stimulation (including trauma), chemical stimulation, infection, and invasion by a foreign body. The inflammatory response is characterized by pain, increased temperature, redness, swelling, reduced function, or a combination of these.

Mast cell degranulation (exocytosis) releases histamine and leads to an inflammatory response that may be initially characterized by a histamine-modulated wheal and flare reaction. A wide variety of immunological stimuli (e.g., allergens or antibodies) and non-immunological (e.g., chemical) stimuli may cause the activation, recruitment, and de-granulation of mast cells. Mast cell activation initiates allergic inflammatory responses, which in turn cause the recruitment of other effector cells that further contribute to the inflammatory response. It has been shown that histamine induces chemotaxis of mouse mast cells (Hofstra, et al, 2003). Chemotaxis does not occur using mast cells derived from H ₄ R knockout mice. Furthermore, the response is blocked by an H ₄ -specific antagonist, but not by Hi , H2 or H3 receptor antagonists (Hofstra, et al., 2003; Thurmond, R.L., et al., J. Pharmacol. Exp. Ther. 2004, 309(1 ), 404-413). The in vivo migration of mast cells to histamine has also been investigated and shown to be H ₄ R dependent (Thurmond, et al., 2004). The migration of mast cells may play a role in allergic rhinitis and allergy where increases in mast cell number are found (Kirby, J.G., et al., Am. Rev. Respir. Dis. 1987, 136(2), 379-383; Crimi, E., et al., Am. Rev. Respir. Dis. 1991 , 144(6), 1282-1286; Amin, K., et al., Am. J. Resp. Crit. Care Med. 2000, 162(6), 2295-2301 ; Gauvreau, G.M., et al., Am. J. Resp. Crit. Care Med. 2000, 161 (5), 1473-1478; Kassel, O., et al., Clin. Exp. Allergy 2001 , 31 (9), 1432-1440). In addition, it is known that in response to allergens there is a redistribution of mast cells to the epithelial lining of the nasal mucosa (Fokkens, W.J., et al, Clin. Exp. Allergy 1992, 22(7), 701 -710; Slater, A., et al, J. Laryngol. Otol. 1996, 1 10, 929-933). These results show that the chemotactic response of mast cells is mediated by H ₄ R.

It has been shown that eosinophils can chemotax towards histamine (O'Reilly, M., et al, J. Recept. Signal Transduction 2002, 22(1 -4), 431 -448; Buckland, K.F., et al, Br. J. Pharmacol. 2003, 140(6), 1 1 17-1 127; Ling et al, 2004). Using H ₄ selective ligands, it has been shown that histamine-induced chemotaxis of eosinophils is mediated through the H ₄ R (Buckland, et al, 2003; Ling et al., 2004). Cell surface expression of adhesion molecules CD1 1 b/CD18 (LFA-1 ) and CD54 (ICAM-1 ) on eosinophils increases after histamine treatment (Ling, et al., 2004). This increase is blocked by H ₄ R antagonists but not by Hi , H2, or H3 receptor antagonists.

H ₄ R also plays a role in dendritic cells and T cells. In human monocyte-derived dendritic cells, H ₄ R stimulation suppresses IL-12p70 production and drives histamine- mediated chemotaxis (Gutzmer, R., et al., J. Immunol. 2005, 174(9), 5224-5232). A role for the H ₄ R in CD8 ⁺ T cells has also been reported. Gantner, et al., (2002) showed that both H ₄ and H2 receptors control histamine-induced IL-16 release from human CD8 ⁺ T cells. IL-16 is found in the bronchoalveolar fluid of allergen- or histamine-challenged asthmatics (Mashikian, V.M., et al, J. Allergy Clin. Immunol. 1998, 101 (6, Part 1 ), 786- 792; Krug, N., et al, Am. J. Resp. Crit. Care Med. 2000, 162(1 ), 105-1 1 1 ) and is considered important in CD4 ⁺ cell migration. The activity of the receptor in these cell types indicates an important role in adaptive immune responses such as those active in autoimmune diseases.

In vivo H ₄ R antagonists were able to block neutrophillia in zymosan-induced peritonitis or pleurisy models (Takeshita, K., et al, J. Pharmacol. Exp. Ther. 2003, 307(3), 1072-1078; Thurmond, R., et al, 2004). In addition, H ₄ R antagonists have activity in a widely used and well-characterized model of colitis (Varga, C, et al, Eur. J. Pharmacol. 2005, 522(1 -3), 130-138). These results support the conclusion that H ₄ R antagonists have the capacity to be anti-inflammatory in vivo.

Another physiological role of histamine is as a mediator of itch and Hi receptor antagonists are not completely effective in the clinic. Recently, H ₄ R has also been implicated in histamine-induced scratching in mice (Bell, J.K., et al., Br. J. Pharmacol. 2004, 142(2), 374-380). The effects of histamine could be blocked by H ₄ R antagonists. These results support the hypothesis that H ₄ R is involved in histamine-induced itch and that H ₄ R antagonists will therefore have positive effects in treating pruritus.

Modulation of H ₄ R controls the release of inflammatory mediators and inhibits leukocyte recruitment, thus providing the ability to prevent and/or treat H ₄ -mediated diseases and conditions, including the deleterious effects of allergic responses such as inflammation. Compounds according to the present invention have H ₄ R-modulating properties. Compounds according to the present invention have leukocyte recruitment inhibiting properties. Compounds according to the present invention have antiinflammatory properties.

Examples of textbooks on the subject of inflammation include: Gallin, J. I.;

Snyderman, R., Inflammation: Basic Principles and Clinical Correlates, 3rd ed.;

Lippincott Williams & Wilkins: Philadelphia, 1999; Stvrtinova, V., et al., Inflammation and Fever. Pathophysiology Principles of Diseases (Textbook for Medical Students); Academic Press: New York, 1995; Cecil; et al. Textbook Of Medicine, 18th ed.; W.B. Saunders Co., 1988; and Stedman's Medical Dictionary.

Background and review material on inflammation and conditions related with inflammation can be found in articles such as the following: Nathan, C, Nature 2002, 420(6917), 846-852; Tracey, K.J., Nature 2002, 420(6917), 853-859; Coussens, L.M., et ai, Nature 2002, 420(6917), 860-867; Libby, P., Nature 2002, 420, 868-874; Benoist, C, et al., Nature 2002, 420(6917), 875-878; Weiner, H.L., et al., Nature 2002,

420(6917), 879-884; Cohen, J., Nature 2002, 420(6917), 885-891 ; Steinberg, D., Nature Med. 2002, 8(1 1 ), 121 1 -1217.

Thus, small-molecule histamine H ₄ R modulators according to this invention control the release of inflammatory mediators and inhibit leukocyte recruitment, and may be useful in treating inflammation of various etiologies, including the following conditions and diseases: inflammatory disorders, allergic disorders, dermatological disorders, autoimmune disease, lymphatic disorders, pruritus, and immunodeficiency disorders. Diseases, disorders and medical conditions that are mediated by histamine H ₄ R activity include those referred to herein.

SUMMARY OF THE INVENTION

The invention relates to 2,4-diaminopyrimidines and pharmaceutically acceptable salts thereof, purification methods for the same, pharmaceutical compositions

containing them, methods of obtaining and using them for the treatment of disease states, disorders, and conditions mediated by the histamine H ₄ receptor activity. The 2,4-diaminopyrimidines are compounds of Formula I

wherein

R ¹ is S(0) _n R ⁴ or SF ₅ ;

n is 1 or 2;

R ⁴ is selected from the group consisting of Ci-C4 alkyl, C1-C2 perhaloalkyl, C3-C4 cycloalkyi and NR ⁵ R ⁶ ;

each of R ⁵ and R ⁶ is independently C ₁ -C ₄ alkyl or R ⁵ and R ⁶ together with the nitrogen to which they are attached form a 5-6 membered heterocyclic ring;

or

R ¹ is selected from the group consisting of halo, CF3, OCF3, C(OH)(CF3)2, CN, and C(0)NH _2;

R ² is selected from the group consisting of C ₁ -C ₅ alkyl, C2-C5 alkenyl, C3-C5 cycloalkyi, C ₁ -C ₂ perhaloalkyl, O C ₁ -C ₄ alkyl, and OC ₁ -C ₃ perhaloalkyl;

R ³ is selected from the group consisting of

wherein

said C ₂ -C ₅ alkyl is optionally substituted with one OCH3

each of Y, U, T and Z is independently H or CH3; and

X is selected from the group consisting of H, CI, and F.

DETAILED DESCRIPTION OF THE INVENTION As used herein, the terms "including", "containing" and "comprising" are used in their open, non-limiting sense.

Unless qualified specifically in particular instances of use, the term "alkyl" refers to a straight- or branched-chain alkyl group having from 1 to 8 carbon atoms in the chain. Examples of alkyl groups include methyl (Me), ethyl (Et), n-propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl (tBu), pentyl, isopentyl, tert-pentyl, hexyl, isohexyl, and groups that in light of the ordinary skill in the art and the teachings provided herein would be considered equivalent to any one of the foregoing examples. "C ₁ -C ₄ alkyl" refers to straight- or branched-chain alkyl group having from 1 to 4 carbon atoms in the chain. The term "cycloalkyl" refers to a saturated or partially saturated, monocyclic, fused polycyclic, or spiro polycyclic carbocycle having from 3 to 12 ring atoms per carbocycle. Illustrative examples of cycloalkyl groups include the following entities, in the form of properly bonded moieties:

The term "halogen" represents chlorine, fluorine, bromine, or iodine.

The term "perhaloalkyl" or "haloalkyi" refers to a straight- or branched-chain alkyl group having from 1 to 6 carbon atoms in the chain optionally substituting hydrogens with halogens. The term "C ₁ -C ₄ haloalkyi" as used here refers to a straight- or branched- chain alkyl group having from 1 to 4 carbon atoms in the chain, optionally substituting hydrogens with halogens. Examples of "perhaloalkyl", "haloalkyi" groups include trifluoromethyl (CF3), difluoromethyl (CF2H), monofluoromethyl (CH2F), pentafluoroethyl (CF2CF3), tetrafluoroethyl (CHFCFs), monofluoroethyl (CH2CH2F), trifluoroethyl

(CH2CF3), tetrafluorotrifluoromethylethyl (CF(CF3)2), and groups that in light of the ordinary skill in the art and the teachings provided herein would be considered equivalent to any one of the foregoing examples.

Those of ordinary skill in the art will recognize that the species of cycloalkyl, and heterocyclic ring groups listed or illustrated above are not exhaustive, and that additional species within the scope of these defined terms may also be selected.

The term "substituted" means that the specified group or moiety bears one or more substituents. The term "unsubstituted" means that the specified group bears no substituents. The term "optionally substituted" means that the specified group is unsubstituted or substituted by one or more substituents. Where the term "substituted" is used to describe a structural system, the substitution is meant to occur at any valency-allowed position on the system.

Any formula given herein is intended to represent compounds having structures depicted by the structural formula as well as certain variations or forms. Furthermore, certain structures may exist as geometric isomers (i.e. , cis and trans isomers), or as tautomers.

Any formula given herein is also intended to represent unlabeled forms as well as isotopically labeled forms of the compounds. Isotopically labeled compounds have structures depicted by the formulas given herein except that one or more atoms are replaced by an atom having a selected atomic mass or mass number in an enriched form. Examples of isotopes that can be incorporated into compounds of the invention in a form that exceeds natural abundances include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorous, fluorine, chlorine, and iodine, such as ² H, ³ H, ^{1 1} C, ¹³ C, ¹⁴ C, ¹⁵ N, ¹⁸ 0, ¹⁷ 0, ³¹ P, ³² P, ³⁵ S, ¹⁸ F, ³⁶ CI, and ¹²⁵ l, respectively. Such isotopically labelled compounds are useful in metabolic studies (preferably with ¹⁴ C), reaction kinetic studies (with, for example ² H or ³ H), detection or imaging techniques [such as positron emission tomography (PET) or single-photon emission computed tomography (SPECT)] including drug or substrate tissue distribution assays, or in radioactive treatment of patients. In particular, an ¹⁸ F or ¹¹ C labeled compound may be particularly preferred for PET or

SPECT studies. Further, substitution with heavier isotopes such as deuterium (i.e. , ² H) may afford certain therapeutic advantages resulting from greater metabolic stability, for example increased in vivo half-life or reduced dosage requirements. Isotopically labeled compounds of this invention can generally be prepared by carrying out the procedures disclosed in the schemes or in the examples and preparations described below by substituting a readily available isotopically labeled reagent for a non- isotopically labeled reagent.

When referring to any formula given herein, the selection of a particular moiety from a list of possible species for a specified variable is not intended to define the same choice of the species for such variable appearing elsewhere. In other words, where a variable appears more than once, the choice of the species from a specified list is independent of the choice of the species for the same variable elsewhere in the formula, unless stated otherwise.

The nomenclature "Ci-Cj" with j > i, when applied herein to a class of

substituents, is meant to refer to embodiments of this invention for which each and every one of the number of carbon members, from i to j including i and j, is

independently realized. By way of example, the term C1-C3 refers independently to embodiments that have one carbon member (Ci ), embodiments that have two carbon members (C2), and embodiments that have three carbon members (C3).

The term Cn-m alkyl refers to an aliphatic chain, whether straight or branched, with a total number N of carbon members in the chain that satisfies n < N < m, with m > n.

When the same plurality of substituents is assigned to various groups, the specific individual substituent assignment to each of such groups is meant to be independently made with respect to the specific individual substituent assignments to the remaining groups. By way of illustration, but not as a limitation, if each of groups Q and R can be H or F, the choice of H or F for Q is made independently of the choice of H or F for R, so the choice of assignment for Q does not determine or condition the choice of assignment for R, or vice-versa, unless it is expressly indicated otherwise. Illustrative claim recitation in this regard would read as "each of Q and R is

independently H or F", or "each of Q and R is independently selected form the group consisting of H and F".

"Tautomers" refer to compounds that are interchangeable forms of a particular compound structure, and that vary in the displacement of hydrogen atoms and electrons. Thus, two structures that have an H member in different positions may be in equilibrium while satisfying valency rules. For example, enols and ketones are

tautomers because they are rapidly interconverted by treatment with either acid or base.

Reference to a compound herein stands for a reference to any one of: (a) the actually recited form of such compound, and (b) any of the forms of such compound in the medium in which the compound is being considered when named. For example, reference herein to a compound such as R-COOH, encompasses reference to any one of, for example, R-COOH(s), R-COOH(sol), and R-COO-(sol). In this example, R- COOH(s) refers to the solid compound, as it could be for example in a tablet or some other solid pharmaceutical composition or preparation; R-COOH(sol) refers to the undissociated form of the compound in a solvent; and R-COO-(sol) refers to the dissociated form of the compound in a solvent, such as the dissociated form of the compound in an aqueous environment, whether such dissociated form derives from R- COOH, from a salt thereof, or from any other entity that yields R-COO- upon

dissociation in the medium being considered. In another example, an expression such as "exposing an entity to compound of formula R-COOH" refers to the exposure of such entity to the form, or forms, of the compound R-COOH that exists, or exist, in the medium in which such exposure takes place. In still another example, an expression such as "reacting an entity with a compound of formula R-COOH" refers to the reacting of (a) such entity in the chemically relevant form, or forms, of such entity that exists, or exist, in the medium in which such reacting takes place, with (b) the chemically relevant form, or forms, of the compound R-COOH that exists, or exist, in the medium in which such reacting takes place. In this regard, if such entity is for example in an aqueous environment, it is understood that the compound R-COOH is in such same medium, and therefore the entity is being exposed to species such as R-COOH(aq) and/or R-COO- (aq), where the subscript "(aq)" stands for "aqueous" according to its conventional meaning in chemistry and biochemistry. A carboxylic acid functional group has been chosen in these nomenclature examples; this choice is not intended, however, as a limitation but it is merely an illustration. It is understood that analogous examples can be provided in terms of other functional groups, including but not limited to hydroxyl, basic nitrogen members, such as those in amines, and any other group that interacts or transforms according to known manners in the medium that contains the compound. Such interactions and transformations include, but are not limited to, dissociation, association, tautomerism, solvolysis, including hydrolysis, solvation, including hydration, protonation, and deprotonation. No further examples in this regard are provided herein because these interactions and transformations in a given medium are known by any one of ordinary skill in the art.

In another example, a zwitterionic compound would be encompassed herein by referring to a compound that is known to form a zwitterion, even if it is not explicitly named in its zwitterionic form. Terms such as zwitterion, zwitterions, and their synonyms zwitterionic compound(s) are standard lUPAC-endorsed names that are well known and part of standard sets of defined scientific names. In this regard, the name zwitterion is assigned the name identification CHEBI:27369 by the Chemical Entities of Biological Interest (ChEBI) dictionary of molecular entities. As generally well known, a zwitterion or zwitterionic compound is a neutral compound that has formal unit charges of opposite sign. Sometimes these compounds are referred to by the term "inner salts". Other sources refer to these compounds as "dipolar ions", although the latter term is regarded by still other sources as a misnomer. As a specific example, aminoethanoic acid (the amino acid glycine) has the formula H2NCH2COOH, and it exists in some media (in this case in neutral media) in the form of the zwitterion

Zwitterions, zwitterionic compounds, inner salts and dipolar ions in the known and well established meanings of these terms are within the scope of this invention, as would in any case be so appreciated by those of ordinary skill in the art. Because there is no need to name each and every embodiment that would be recognized by those of ordinary skill in the art, no structures of the zwitterionic compounds that are associated with the compounds of this invention are given explicitly herein. They are, however, part of the embodiments of this invention. No further examples in this regard are provided herein because the interactions and transformations in a given medium that lead to the various forms of a given compound are known by any one of ordinary skill in the art.

When referring to any formula given herein, the selection of a particular moiety from a list of possible species for a specified variable is not intended to define the same choice of the species for the variable appearing elsewhere. In other words, where a variable appears more than once, the choice of the species from a specified list is independent of the choice of the species for the same variable elsewhere in the formula, unless stated otherwise.

By way of a first example on substituent terminology, if substituent S ¹ exam _P ie is one of Si and S2, and substituent S ² exam _P ie is one of S3 and S4, then these assignments refer to embodiments of this invention given according to the choices S ¹ exam _P ie is Si and

S ² example IS S3; S ¹ example IS Si and S ² example IS S ₄ S ¹ example IS S2 and S ² example IS S3;

S ¹ example is S2 and S ² exampie is S< and equivalents of each one of such choices. The shorter terminology "S ¹ exam _P ie is one of Si and S2, and S ² exam _P ie is one of S3 and S ₄ " is accordingly used herein for the sake of brevity, but not by way of limitation. The foregoing first example on substituent terminology, which is stated in generic terms, is meant to illustrate the various substituent assignments described herein.

Furthermore, when more than one assignment is given for any member or substituent, embodiments of this invention comprise the various groupings that can be made from the listed assignments, taken independently, and equivalents thereof. By way of a second example on substituent terminology, if it is herein described that substituent is one of Si , S2, and S3, this listing refers to embodiments of this invention for Which is is one of S ₁ and S2; is one of S ₁ and S ₃ ; is one Of S2 and S ₃ ; IS one of Si , S ₂ and S3;

and is any equivalent of each one of these choices. The shorter terminology is one of Si , S2, and S3" is accordingly used herein for the sake of brevity, but

not by way of limitation. The foregoing second example on substituent terminology, which is stated in generic terms, is meant to illustrate the various substituent

assignments described herein.

A "pharmaceutically acceptable salt" is intended to mean a salt of a free acid or base of a compound represented by Formula (I) that is non-toxic, biologically tolerable, or otherwise biologically suitable for administration to the subject. See, generally, S.M. Berge, et al., "Pharmaceutical Salts", J. Pharm. Sci., 1977, 66: 1 -19, and Handbook of Pharmaceutical Salts, Properties, Selection, and Use, Stahl and Wermuth, Eds., Wiley- VCH and VHCA, Zurich, 2002. Preferred pharmaceutically acceptable salts are those that are pharmacologically effective and suitable for contact with the tissues of patients without undue toxicity, irritation, or allergic response. A compound of Formula (I) may possess a sufficiently acidic group, a sufficiently basic group, or both types of functional groups, and accordingly react with a number of inorganic or organic bases, and inorganic and organic acids, to form a pharmaceutically acceptable salt. Examples of pharmaceutically acceptable salts include sulfates, pyrosulfates, bisulfates, sulfites, bisulfites, phosphates, monohydrogen-phosphates, dihydrogenphosphates,

metaphosphates, pyrophosphates, chlorides, bromides, iodides, acetates, propionates, decanoates, caprylates, acrylates, formates, isobutyrates, caproates, heptanoates, propiolates, oxalates, malonates, succinates, suberates, sebacates, fumarates, maleates, butyne-1 ,4-dioates, hexyne-1 ,6-dioates, benzoates, chlorobenzoates, methylbenzoates, dinitrobenzoates, hydroxybenzoates, methoxybenzoates, phthalates, sulfonates, xylenesulfonates, phenylacetates, phenylpropionates, phenylbutyrates, citrates, lactates, γ-hydroxybutyrates, glycolates, tartrates, methane-sulfonates, propanesulfonates, naphthalene-1 -sulfonates, naphthalene-2 -sulfonates, and

mandelates.

Compounds of Formula I contain at least one nitrogen of basic character, so desired pharmaceutically acceptable salts may be prepared by any suitable method available in the art, for example, treatment of the free base with an inorganic acid, such as hydrochloric acid, hydrobromic acid, sulfuric acid, sulfamic acid, nitric acid, boric acid, phosphoric acid, and the like, or with an organic acid, such as acetic acid, phenylacetic acid, propionic acid, stearic acid, lactic acid, ascorbic acid, maleic acid, hydroxymaleic acid, isethionic acid, succinic acid, valeric acid, fumaric acid, malonic acid, pyruvic acid, oxalic acid, glycolic acid, salicylic acid, oleic acid, palmitic acid, lauric acid, a pyranosidyl acid, such as glucuronic acid or galacturonic acid, an alpha-hydroxy acid, such as mandelic acid, citric acid, or tartaric acid, an amino acid, such as aspartic acid or glutamic acid, an aromatic acid, such as benzoic acid, 2-acetoxybenzoic acid, naphthoic acid, or cinnamic acid, a sulfonic acid, such as laurylsulfonic acid, p- toluenesulfonic acid, methanesulfonic acid, ethanesulfonic acid, any compatible mixture of acids such as those given as examples herein, and any other acid and mixture thereof that are regarded as equivalents or acceptable substitutes in light of the ordinary level of skill in this technology.

Illustrative embodiments of this invention are given by compounds of Formula I

wherein R ¹ is S(0) _n R ⁴ or SF ₅ ;

n is 1 or 2;

R ⁴ is selected from the group consisting of

each of R ⁵ and R ⁶ is independently C ₁ -C ₄ alkyl, or R ⁵ and R ⁶ together with the nitrogen to which they are attached form a 5-6 membered heterocyclic ring;

or

R ¹ is selected from the group consisting of halo, and C(0)NH _2;

R ² is selected from the group consisting of C

3 is selected from the group consisting of

wherein

said C2-C5 alkyl is optionally substituted with one OCH3

each of Y, U, T and Z are independently H or CH3; and

X is selected from the group consisting of H, CI, and F. An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is S(0) _n R ⁴ or SFs.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is S(0) _n R ⁴ , R ⁴ is Ci-C4 alkyl, and n is 2.

An additional illustrative embodiment of the invention is a compound of Formula

I, wherein R ¹ is S(0) _n R ⁴ , R ⁴ is CH ₃ , and n is 2.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is SFs.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is selected from the group consisting of halo, CF3, OCF3, C(OH)(CF3)2, CN, and C(0)NH ₂ .

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is selected from the group consisting of SO2CH3, SO2CF3, SFs, F, and OCFs.

An additional illustrative embodiment of the invention is a compound of Formula

I, wherein R ¹ is selected from the group consisting of SO2CH3, SO2CF3, SFs, and OCF3.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is selected from the group consisting of SO2CH3, SO2CF3, and SFs.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is selected from the group consisting of SO2CH3 and SFs.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is SO2CH3.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is SO2CF3.

An additional illustrative embodiment of the invention is a compound of Formula

I, wherein R ¹ is SFs.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is halo.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is F or CI. An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is F.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is OCF3.

An additional illustrative embodiment of the invention is a compound of Formula

I, wherein R ² is selected from the group consisting of C ₁ -C ₅ alkyI, C2-C5 alkenyl, C3-C5 cycloalkyi, C1-C2 perhaloalkyl, OCi-C4 alkyl, and OC1-C3 perhaloalkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is selected from the group consisting of C ₁ -C ₅ alkyI, C3-C5 cycloalkyi, C1-C2 perhaloalkyl, OCi-C4 alkyl, and OC1-C3 perhaloalkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is selected from the group consisting of Ci-Cs alkyl, C3-C5 cycloalkyi, C1-C2 perhaloalkyl, and OCi-C4 alkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is selected from the group consisting of Ci-Cs alkyl, C3-C5 cycloalkyi, and OCi-C4 alkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is OCi-C4 alkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is OCi-C3 alkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is OCi-C2 alkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is OCH2CH3.

An additional illustrative embodiment of the invention is a compound of Formula

I, wherein R ² is selected from the group consisting of Ci-Cs alkyl and C3-C5 cycloalkyi.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is Ci-Cs alkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is C1-C3 alkyl. An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is Ci-C2 alkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is CH3.

An additional illustrative embodiment of the invention is a compound of Formula

I, wherein R ² is CH2CH3.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is C3-C-5 cycloalkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is C3-C4 cycloalkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is cyclopropyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ² is cyclobutyl.

An additional illustrative embodiment of the invention is a compound of Formula

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ³ is selected from the group consisting of

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ³ is selected from the group consisting of

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ³ is selected from the roup consisting of

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ³ is

An additional illustrative embodiment of the invention is a compound of Formula I, wherein each of Y and Z is H, and R ³ is

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ³ is C2-Cs alkyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ³ is C2-C-3 alkyl.

An additional illustrative embodiment of the invention is a compound of Formula

I, wherein R ³ is selected from the group consisting of ethyl, n-propyl, and isopropyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ³ is ethyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ³ is isopropyl.

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is SO2CH3, R ² is cyclobutyl, and R ³ is ethyl. An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is SF ₅ , R ² is CH ₃ , and R ³ is

An additional illustrative embodiment of the invention is a compound of Formula I, wherein R ¹ is SO2CF3, R ² is cyclobutyl, and R ³ is

An additional illustrative embodiment of the invention is a compound of Formula

I, wherein R ¹ is F, R ² is OCH2CH3, and R ³ is isopropyl.

Additional illustrative embodiments of this invention are compounds or a pharmaceutically acceptable salt thereof selected from the group consisting of

(2-Ethoxy-4-fluorophenyl)-N4.-isopropylpyrimidine-2,4-diamin e;

N4.-((1 H-Pyrazol-5-yl)methyl)-N4.-(4-fluoro-2-methylphenyl)pyrimidi ne-2,4-diamine;

N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(isoxazol-4-ylmethyl)py rimidine-2,4-diamine;

N4.-Benzyl-N4.-(2-ethoxy-4-fluorophenyl)pyrimidine-2,4-di amine;

N4.-(Oxazol-4-ylmethyl)-N4.-(2-propyl-4-(trifluoromethoxy )phenyl)pyrimidine-2,4-diamine; N4.-(2-Cyclobutyl-4-(trifluoromethoxy)phenyl)-N4.-(oxazol-4- ylmethyl)pyrimidine-2,4- diamine;

N4.-(2-Methyl-4-(trifluoromethoxy)phenyl)-N4.-(oxazol-4-y lmethyl)pyrimidine-2,4-diamine; N4.-(2-lsobutyl-4-(trifluoromethoxy)phenyl)-N4.-(oxazol-4-yl methyl)pyrimidine-2,4- diamine;

2-(4-((2-Aminopyrimidin-4-yl)(oxazol-4-ylmethyl)amino)-3-eth ylphenyl)-1 , 1 , 1 , 3,3,3- hexafluoropropan-2-ol;

N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(oxazol-2-ylmethyl)pyri midine-2,4-diamine;

N4.-((1 H-Pyrazol-3-yl)methyl)-N4.-(2-ethoxy-4-fluorophenyl)pyrimidi ne-2,4-diamine;

N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(oxazol-4-ylmethyl)pyri midine-2,4-diamine; N4.-((4-Chloro-1 H-pyrazol-3-yl)methyl)-N4.-(2-ethoxy-4-fluorophenyl)pyrimidi ne-2,4- diamine;

N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(isoxazol-3-ylmethyl)pyrim idine-2,4-diamine;

N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(thiazol-5-ylmethyl)pyrimi dine-2,4-diamine;

N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(oxazol-5-ylmethyl)pyrimid ine-2,4-diamine;

N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(thiazol-4-ylmethyl)pyrimi dine-2,4-diamine;

N4.-((1 H-Pyrazol-3-yl)methyl)-N4.-(4-fluoro-2-(2,2,2-trifluoroethox y)phenyl)pyrimidin diamine;

N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol-4-y lmethyl)pyrimidine-2 _^ diamine;

N4.-(4-Bromo-2-(trifluoromethyl)phenyl)-N4.-isopropylpyrimid ine-2,4-diamine;

N4.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-ethylpyrimid ine-2,4-diamine;

N4.-Ethyl-N4.-(2-methyl-4-(pentafluorosulfanyl)phenyl)pyrimi dine-2,4-diamine;

N4.-[2-Ethyl-4-(pentafluorosulfanyl)phenyl]-N4.-(oxazol-4-yl methyl)pyrimidine-2,4- diamine;

N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(pyridazin- 3-ylmethyl)pyrimidine-2,4- diamine;

N4.-[2-Ethyl-4-(pentafluorosulfanyl)phenyl]-N4.-(1 H-pyrazol-5-ylmethyl)pyrimidine-2,4- diamine;

N4.-[2-Ethyl-4-(pentafluorosulfanyl)phenyl]-N4.-(1 ,3,4-oxadiazol-2-ylmethyl)pyrimidine- 2,4-diamine;

N4.-lsopropyl-N4.-(2-(2-methylprop-1 -en-1 -yl)-4-(pyrrolidin-1 -ylsulfonyl)phenyl)pyrimidine- 2,4-diamine;

N4.-(2-Cyclobutyl-4-(pyrrolidin-1 -ylsulfonyl)phenyl)-N4.-isopropylpyrimidine-2,4-diamine; N4.-(4-((Difluoromethyl)sulfonyl)-2-ethylphenyl)-N4.-(oxazol -4-ylmethyl)pyrimidine-2,4- diamine;

N4.-lsopropyl-N4.-(2-methyl-4-(pentafluorosulfanyl)phenyl)py rimidine-2,4-diamine;

N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(2-methoxye thyl)pyrimidine-2,4- diamine; N4. -(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(pyrimidin-2-y lmethyl)pyrimi diamine;

N4. -[(5-Methyloxazol-4-yl)methyl]-N4.-[2-methyl-4-(pentafluoros ulfanyl)phenyl]pyrim 2,4-diamine;

N4. -(lsoxazol-3-ylmethyl)-N4.-(2-methyl-4-(pentafluorosulfanyl) phenyl)pyrimidine-2,^ diamine;

N4. -(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol-5-ylme thyl)pyrimidine-2,4- diamine;

N4. -(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol-2-ylme thyl)pyrimidine-2,4- diamine;

N4. -[(3-Chloro-2-pyridyl)methyl]-N4.-[2-methyl-4-(pentafluorosu lfanyl)phenyl]pyrimidine- 2,4-diamine;

N4. -(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(thiazol-4-ylm ethyl)pyrimidine-2,4- diamine;

N4. -[(4-Fluoro-1 H-pyrazol-3-yl)methyl]-N4.-[2-methyl-4- (pentafluorosulfanyl)phenyl]pyrimidine-2,4-diamine;

N4. -((4-Chloro-1 H-pyrazol-3-yl)methyl)-N4.-(2-methyl-4- (pentafluorosulfanyl)phenyl)pyrimidine-2,4-diamine;

N4. -[2-Methyl-4-(pentafluorosulfanyl)phenyl]-N4.-(1 H-pyrazol-3-ylmethyl)pyrimidine-2,4- diamine;

N4. -Ethyl-N4.-(2-ethyl-4-((trifluoromethyl)sulfonyl)phenyl)pyri midine-2,4-diamine;

N4. -(2-Cyclobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-ethy lpyrimidine-2,4-diamine;N4. -(2-Cyclobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(oxa zol-4-ylmethyl)pyrimidine- 2,4-diamine;

N4. -(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-isopropylpyrimi dine-2,4-diamine;

N4. -(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(oxazol-2 -ylmethyl)pyrimidine-2,4- diamine;

N4. -(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-((3-fluor opyridin-4- yl)methyl)pyrimidine-2,4-diamine; N4. -(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-((6-(trifluorom ethyl)pyridin-2- yl)methyl)pyrimidine-2,4-diamine;

N4. -((3,5-Dimethylisoxazol-4-yl)methyl)-N4.-(2-ethyl-4- ((trifluoromethyl)sulfonyl)phenyl)pynmidine-2,4-diamine;

N4. -(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(pyrimidi n-2-ylmethyl)py^

diamine;

N4. -(2-Cyclobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-isop ropylpyrimidine-2,4- diamine;

N4. -lsopropyl-N4.-(2-methyl-4-(trifluoromethoxy)phenyl)pyrimidi ne-2,4-diamine;

N4. -(2-Ethyl-4-(trifluoromethoxy)phenyl)-N4.-(oxazol-4-ylmethyl )pyrimidine-2,4-diN4. -(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-propylpyrimidin e-2,4-diamine;

N4. -(2-Cyclopropyl-4-(methylsulfonyl)phenyl)-N4.-ethylpyrimidin e-2,4-diamine;

N4. -(2-Cyclopropyl-4-(methylsulfonyl)phenyl)-N4.-propylpyrimidi ne-2,4-diamine;

N4. -(2-Cyclopropyl-4-(ethylsulfonyl)phenyl)-N4.-ethylpyrimidine -2,4-diamine;

N4. -Ethyl-N4.-(2-isobutyl-4-(methylsulfonyl)phenyl)pyrimidine-2 ,4-diami

N4. -(2-Cyclobutyl-4-methylsulfonylphenyl)-N4.-(oxazol-4-ylmethy l)pyrimidine-2,4-diamN4. -(2-Cyclobutyl-4-methylsulfonylphenyl)-N4.-(2-methoxyethyl)p yrimidine-2,4-diamN4. -Ethyl-N4.-(2-ethyl-4-(methylsulfonyl)phenyl)pyrimidine-2,4- diamine;

N4. -(2-lsobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(oxazo l-4-ylmethyl)pyrimidi diamine;

N4. -(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-isopropyl pyrimidine-2,4-diamine; N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-/\/ ⁴ -(oxazol-4-ylmethyl)pynmidine-2,4- diamine;

N4. -(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-((6-(trifluoromethyl )pyridin-2- yl)methyl)pyrimidine-2,4-diamine;

N4. -(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-(2-methoxyethyl)pyri midine-2,4-diamine;N4. -(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-(pyrimidin-4-ylmethy l)pynmidine-2,4-diaN4. -(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-(oxazol-4-ylmethyl)p yrimidine-2,4-diamine;N4. -((1 H-Pyrazol-5-yl)methyl)-N4.-(2-cyclobutyl-4-(methylsulfonyl)p henyl)pyrimidine-2,4- diamine; N4. -(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-(pyrimidin-4-yl methyl)pyrimid diamine;

N4. -(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-isopropylpyrimidine- 2,4-diam

N4. -(2-lsobutyl-4-(methylsulfonyl)phenyl)-N4.-propylpyrimidine- 2,4-diamine;

N4. -(2-Ethyl-4-((trifluoromethyl)sulfo^

yl)methyl)pyrimidine-2,4-diamine;

N4. -(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(pyrimidi n-4-ylmethyl)pyri

diamine;

N4. -(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(2-methox yethyl)pyrimidine-2,4- diamine;

N4. -(4-((Difluoromethyl)sulfonyl)-2-ethylphenyl)-N4.-ethylpyrim idine-2,4-diamine;

N4. -(2-Cyclobutyl-4-(ethylsulfonyl)phenyl)-N4.-ethylpyrimidine- 2,4-diamine;

N4. -(2-Ethoxy-4-fluorophenyl)-N4.-(imidazo[1 ,2-a]pyridin-2-ylmethyl)pyrimidine-2,4- diamine;

N4. -(2-Ethoxy-4-fluorophenyl)-N4.-((2-methyloxazol-4-yl)methyl) pyrimidine-2,4-diamine; 4-((2-Am inopyrim idin-4-yl)(ethyl)am ino)-3-cyclobutyl-N-ethyl-N- methylbenzenesulfonamide;

4-((2-Am inopyrim idin-4-yl)(propyl)amino)-3-cyclobutyl-N-methyl-N- propylbenzenesulfonamide;

N4. -(4-Bromo-2-(trifluoromethoxy)phenyl)-N4.-(oxazol-4-ylmethyl )pyrimidine-2,4-diamine;N4. -Ethyl-N4.-(4-(methylsulfonyl)-2-(prop-1 -en-2-yl)phenyl)pyrimidine-2,4-diamine;

N4. -Ethyl-N4.-(2-isopropyl-4-(methylsulfonyl)phenyl)pyrimidine- 2,4-diamine;

N4. -(4-Bromo-2-(trifluoromethoxy)phenyl)-N4.-isopropylpyrimidin e-2,4-diamine;

N4. -(4-Bromo-2-isopropoxyphenyl)-N4.-isopropylpyrimidine-2,4-di amine;

N4. -(4-Bromo-2-(2,2,2-trifluoroethoxy)phenyl)-N4.-isopropylpyri midine-2,4-diamine;

N4. -(4-Bromo-2-methylphenyl)-N4.-isopropylpynmidine-2,4-diamine ;

4-((2-Am inopyrim idin-4-yl)(isopropyl)amino)-3-(trifluoromethoxy)benzonitrile ;

N4. -(4-(Ethylsulfonyl)-2-(trifluoromethoxy)phenyl)-N4.-isopropy lpyrimidine-2,4-diamine;N4. -(4-Bromo-2-methylphenyl)-N4.-(oxazol-4-ylmethyl)pyrimidine- 2,4-diamine;

N4. -(4-(Ethylsulfonyl)-2-methylphenyl)-N4.-(oxazol-4-ylmethyl)p yrimidine-2,4-diamine; N4. -lsopropyl- N4.-(4-(methylsulfonyl)-2-(trifluoromethyl)phenyl)pyrimidine -2,4-d

N4. -lsopropyl-N4.-(4-(isopropylsulfonyl)-2-(trifluoromethyl)phe nyl)pyrimidine-2,4-diamN4. -(2-Ethoxy-4-fluorophenyl)-N4.-(isoxazol-5-ylmethyl)pyrimidi ne-2,4-diamine;

N4. -((1 ,3,4-Oxadiazol-2-yl)methyl)-N4.-(2-ethoxy-4-fluorophenyl)pyr imidine-2,4-d

4-((2-Aminopynmidin-4-yl)(isopropyl)amino)-3-propylbenzon itrile;

(E)-4-((2-Aminopyrimidin-4-yl)(oxazol-4-ylmethyl)amino)-3-(p rop-1 -en-1 -yl)benzamide; (E)-4-((2-Aminopyrimidin-4-yl)(isopropyl)amino)-3-(prop-1 -en-1 -yl)benzonitnle;

(E)-4-((2-Aminopyrimidin-4-yl)(isopropyl)amino)-3-(prop-1 -en-1 -yl)benzamide;

(E)-N4.-(4-Chloro-2-(prop-1 -en-1 -yl)phenyl)-N4.-(oxazol-4-ylmethyl)pyrimidine-2,4- diamine;

N4. -(2-Cyclobutyl-4-(isopropylsulfonyl)phenyl)-N4.-isopropylpyr imidine-2,4-diamine;N4. -(4-Fluoro-2-(trifluoromethoxy)phenyl)-N4.-isopropylpynmidin e-2,4-diamine;

N4. -((2H-1 ,2,3-Triazol-4-yl)methyl)-N4.-(2-ethoxy-4-fluorophenyl)pynmi din

N4. -Ethyl-N4.-(4-(methylsulfonyl)-2-propylphenyl)pyrimidine-2,4 -diamine;

N4. -(2-Cyclobutyl-4-(cyclopropylsulfonyl)phenyl)-N4.-ethylpyrim idine-2,4-diamine;

N4. -(2-Cyclobutyl-4-(cyclopropylsulfonyl)phenyl)-N4.-propylpyri midine-2,4-diamine;N4. -((4H-1 ,2,4-Triazol-3-yl)methyl)-N4.-(2-ethoxy-4-fluorophenyl)pyrim idine-2,4-^N4. -(2-Ethyl-4-(trifluoromethyl)phenyl)-N4.-(oxazol-4-ylmethyl) pyrimidine-2,4-dia

N4. -(Oxazol-4-ylmethyl)-N4.-(4-(trifluoromethyl)phenyl)pyrimidi ne-2,4-diamin

4-((2-Am inopyrim idin-4-yl)(ethyl)am ino)-3-cyclobutylbenzam ide;

4-((2-Am inopyrim idin-4-yl)(isopropyl)am ino)-3-cyclobutylbenzam ide;

4-((2-Am inopyrim idin-4-yl)(ethyl)am ino)-3-isobutylbenzam ide;

(E)-N4.-lsopropyl-N4.-(2-(prop-1 -en-1 -yl)-4-(trifluoromethyl)phenyl)pynmidine-2,4- diamine;

N4. -lsopropyl-N4.-(2-propyl-4-(trifluoromethyl)phenyl)pyrimidin e-2,4-diamine;

N4. -lsopropyl-N4.-(2-methyl-4-(trifluoromethyl)phenyl)pyrimidin e-2,4-diamine;

4-((2-Aminopyrimidin-4-yl)(oxazol-4-ylmethyl)amino)-3-propyl benzonitnle;

(E)-N4.-(4-Fluoro-2-(prop-1 -en-1 -yl)phenyl)-N4.-isopropylpyrimidine-2,4-diamine;

N4. -(4-Fluoro-2-propylphenyl)-N4.-isopropylpyrimidine-2,4-diami ne;

N4. -(4-Fluoro-2-(prop-1 -en-2-yl)phenyl)-N4.-isopropylpyrimidine-2,4-diamine; N4. -(4-Fluoro-2-isopropylphenyl)-N4.-isopropylpyrimidine-2,4-di amine; and

(E)-4-((2-Aminopyrimidin-4-yl)(oxazol-4-ylm

Additional illustrative embodiments of this invention are compounds or a pharmaceutically acceptable salt thereof selected from the group consisting of:

N4.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-ethylpyri midine-2,4-diamine;

N4.-lsopropyl-N4.-(2-(2-methylprop-1 -en-1 -yl)-4-(pyrrolidin-1 -ylsulfonyl)phenyl)pyrimidine- 2,4-diamine;

N4.-(2-Cyclobutyl-4-(pyrrolidin-1 -ylsulfonyl)phenyl)-N4.-isopropylpyrimidine-2,4-diamine; N4.-(4-((Difluoromethyl)sulfonyl)-2-ethylphenyl)-N4.-(oxazol -4-ylmethyl)pyrimidine-2,4- diamine;

N4.-Ethyl-N4.-(2-ethyl-4-((trifluoromethyl)sulfonyl)pheny l)pyrimidine-2,4-diamine;

N4.-(2-Cyclobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4 .-ethylpyrimidine-2,4-diamine; N4.-(2-Cyclobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-( oxazol-4-ylmethyl)pyrimidine- 2,4-diamine;

N4.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-isopropyl pyrimidine-2,4-diamine;

N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(ox azol-2-ylmethyl)pyrimidine-2,4- diamine;

N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-((3 -fluoropyridin-4- yl)methyl)pyrimidine-2,4-diamine;

N4.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-((6-(trif luoromethyl)pyridin-2- yl)methyl)pyrimidine-2,4-diamine;

N4.-((3,5-Dimethylisoxazol-4-yl)methyl)-N4.-(2-ethyl-4- ((trifluoromethyl)sulfonyl)phenyl)pyrimidine-2,4-diamine;

N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(py rimidin-2-ylmethyl)pyrimidine-2,4- diamine;

N4.-(2-Cyclobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4 .-isopropylpyrimidine-2,4-diamine; N4.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-propylpyrimi dine-2,4-diamine;

N4.-(2-Cyclopropyl-4-(methylsulfonyl)phenyl)-N4.-ethylpyr imidine-2,4-diamine;

N4.-(2-Cyclopropyl-4-(methylsulfonyl)phenyl)-N4.-propylpy rimidine-2,4-diamine;

N4.-(2-Cyclopropyl-4-(ethylsulfonyl)phenyl)-N4.-ethylpyri midine-2,4-diamine; N4.-Ethyl-N4.-(2-isobutyl-4-(methylsulfonyl)phenyl)pyrimidin e-2,4-diam

N4.-(2-Cyclobutyl-4-methylsulfonylphenyl)-N4.-(oxazol-4-y lmethyl)pyrimidine-2,4-diam N4.-(2-Cyclobutyl-4-methylsulfonylphenyl)-N4.-(2-methoxyethy l)pyrimidine-2,4-diami N4.-Ethyl-N4.-(2-ethyl-4-(methylsulfonyl)phenyl)pyrimidine-2 ,4-diamin

N4.-(2-lsobutyl-4-((trifluoromethyl)sulfo^

diamine;

N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-iso propylpyrimidine-2,4-diam

N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(ox azol-4-ylmethyl)pyrimidi diamine;

N4.-(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-((6-(trifluoro methyl)pyridin-2- yl)methyl)pyrimidine-2,4-diamine;

N4.-(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-(2-methoxyethy l)pyrimidine-2,4-diamine; N4.-(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-(pyrimidin-4-ylme thyl)pynmidine-2,4-diami N4.-(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-(oxazol-4-ylmethy l)pyrimidine-2,4-diamine; N. ⁴ -((1 /-/-Pyrazol-5-yl)methyl)-N4.-(2-cyclobutyl-4-(methylsulfonyl )phenyl)pyrimidine-2,4- diamine;

N4.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-(pyrimidi n-4-ylmethyl)pyrimidine-2,4- diamine;

N4.-(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-isopropylpyrim idine-2,4-diamine;

N4.-(2-lsobutyl-4-(methylsulfonyl)phenyl)-N4.-propylpyrim idine-2,4-diamine;

N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-((6 -(trifluoromethyl)pyndin-2- yl)methyl)pyrimidine-2,4-diamine;

N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(py rimidin-4-ylmethyl)pyrimidine-2,4- diamine;

N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(2- methoxyethyl)pyrimidine-2,4- diamine;

N4.-(4-((Difluoromethyl)sulfonyl)-2-ethylphenyl)-N4.-ethy lpyrimidine-2,4-diamine;

N4.-(2-Cyclobutyl-4-(ethylsulfonyl)phenyl)-N4.-ethylpyrim idine-2,4-diamine;

4-((2-Am inopyrim idin-4-yl)(ethyl)am ino)-3-cyclobutyl-N.-ethyl-N.- methylbenzenesulfonamide; 4-((2-Aminopyrimidin-4-yl)(propyl)amino)-3-cyclobutyl-N.-met hyl-N.- propylbenzenesulfonamide;

N4.-Ethyl-N4.-(4-(methylsulfonyl)-2-(prop-1 -en-2-yl)phenyl)pyrimidine-2,4-diam

N4.-Ethyl-N4.-(2-isopropyl-4-(methylsulfonyl)phenyl)pyrim idine-2,4-diamin

N4.-(4-(Ethylsulfonyl)-2-(trifluoromethoxy)phenyl)-N4.-is opropylpyrimidine-2,4-diami N4.-(4-(Ethylsulfonyl)-2-methylphenyl)-N4.-(oxazol-4-ylmethy l)pyrimidine-2,4-diami N4.-lsopropyl-N4.-(4-(methylsulfonyl)-2-(trifluoromethyl)phe nyl)pyrimidine-2,4-diam

N4.-lsopropyl-N4.-(4-(isopropylsulfonyl)-2-(trifluorometh yl)phenyl)pyrimidine-2,4-diami N4.-(2-Cyclobutyl-4-(isopropylsulfonyl)phenyl)-N4.-isopropyl pyrimidine-2,4-diamine;

N4.-Ethyl-N4.-(4-(methylsulfonyl)-2-propylphenyl)pyrimidi ne-2,4-diamine;

N4.-(2-Cyclobutyl-4-(cyclopropylsulfonyl)phenyl)-N4.-ethy lpyrimidine-2,4-diamine; and N4.-(2-Cyclobutyl-4-(cyclopropylsulfonyl)phenyl)-N4.-propylp yrimidine-2,4-diamine.

Additional illustrative embodiments of this invention are compounds selected from the group consisting of:

N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol- 4-ylmethyl)pyrimidine-2,4- diamine;

N4.-Ethyl-N4.-(2-methyl-4-(pentafluorosulfanyl)phenyl)pyr imidine-2,4-diamine;

N4.-[2-Ethyl-4-(pentafluorosulfanyl)phenyl]-N4.-(oxazol-4 -ylmethyl)pyrimidine-2,4-diamine; N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(pyridazin- 3-ylmethyl)pyrimidine-2,4- diamine;

N4.-[2-Ethyl-4-(pentafluorosulfanyl)phenyl]-N4.-(1 /-/-pyrazol-5-ylmethyl)pyrimidine-2,4- diamine;

N4.-[2-Ethyl-4-(pentafluorosulfanyl)phenyl]-N4.-(1 ,3,4-oxadiazol-2-ylmethyl)pyrimidine- 2,4-diamine;

N4.-lsopropyl-N4.-(2-methyl-4-(pentafluorosulfanyl)phenyl )pyrimidine-2,4-diamine;

N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(2-metho xyethyl)pyrimidine-2,4-diamine; N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(pyrimidin- 2-ylmethyl)pyrimidine-2,4- diamine;

N4.-[(5-Methyloxazol-4-yl)methyl]-N4.-[2-methyl-4-(pentaf luorosulfanyl)phenyl]pyrimidine- 2,4-diamine; N4.-(lsoxazol-3-ylmethyl)-N4.-(2-methyl-4-(pentafluorosulfan yl)phenyl)pyrimidine-2,4- diamine;

N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol- 5-ylmethyl)pyrimidine-2,4- diamine;

N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol- 2-ylmethyl)pyrimidine-2,4- diamine;

N4.-[(3-Chloro-2-pyridyl)methyl]-N4.-[2-m

2,4-diamine;

N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(thiazol -4-ylmethyl)pyrimidine-^ diamine;

N4.-[(4-Fluoro-1 H-pyrazol-3-yl)methyl]-N4.-[2-methyl-4-

(pentafluorosulfanyl)phenyl]pyrimidine-2,4-diamine; and

N4.-((4-Chloro-1 H-pyrazol-3-yl)methyl)-N4.-(2-methyl-4-

(pentafluorosulfanyl)phenyl)pyrimidine-2,4-diamine; and

N4.-[2-Methyl-4-(pentafluorosulfanyl)phenyl]-N4.-(1 H-pyrazol-3-ylmethyl)pyrimidine-2,4- diamine.

An embodiment of the invention are compounds or a pharmaceutically acceptable salt thereof selected from the group consisting of:

(2-Ethoxy-4-fluorophenyl)-N4.-isopropylpyrimidine-2,4-dia mine;

N4.-(2-Cyclobutyl-4-(trifluoromethoxy)phenyl)-N4.-(oxazol -4-ylmethyl)pyrimidine-2,4- diamine;

N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol- 4-ylmethyl)pyrimidine-2,4- diamine;

N4.-(2-Cyclobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4 .-(oxazol-4-ylmethyl)pyrimidine- 2,4-diamine and

N4.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-ethylpyri midine-2,4-diamine.

Additional illustrative embodiments of this invention are compounds or a pharmaceutically acceptable salt thereof selected from the group consisting ofN4. -(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-ethylpyrimidine -2,4-diamine; N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol-4-y lmethyl)pyrimidi diamine;

N4.-(2-Cyclobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4 .-(oxazol-4-ylmethyl)pyrimidine- 2,4-diamine;

N4.-(2-Cyclobutyl-4-(trifluoromethoxy)phenyl)-N4.-(oxazol -4-ylmethyl)pyrimidine-2,4- diamine; and

(2-Ethoxy-4-fluorophenyl)-N4.-isopropylpyrimidine-2,4-diamin e.

Additional embodiments of this invention are pharmaceutical compositions each comprising an effective amount of at least one of the compounds illustratively given above.

An additional embodiment of the invention is directed to a method of treating a subject suffering from or diagnosed with a disease, disorder, or medical condition mediated by H ₄ R activity, comprising administering to the subject in need of such treatment an effective amount of at least one of the above compounds or a

pharmaceutically acceptable salt thereof, pharmaceutically acceptable prodrug, or pharmaceutically active metabolite of such compounds. In certain embodiments of the inventive method, the disease, disorder, or medical condition is inflammation.

Inflammation herein refers to the response that develops as a consequence of histamine release, which in turn is caused by at least one stimulus. Examples of such stimuli are immunological stimuli and non-immunological stimuli.

An additional embodiment of the invention is directed to a method for modulating H ₄ R activity, comprising exposing a H ₄ R to an effective amount of at least one of the above compounds.

An additional embodiment of the invention is a method of treating a subject suffering from or diagnosed with a disease, disorder, or medical condition mediated by H ₄ R activity, comprising administering to a subject in need of such treatment an effective amount of at least one compound of Formula I, or a pharmaceutically acceptable salt thereof.

An additional illustrative embodiment of the invention is a method, wherein the disease, disorder, or medical condition is inflammation. An additional illustrative embodiment of the invention is a method, wherein the disease, disorder, or medical condition is selected from the group consisting of:

inflammatory disorders, allergic disorders, dermatological disorders, autoimmune disease, lymphatic disorders, and immunodeficiency disorders.

An additional illustrative embodiment of the invention is a method, wherein the disease, disorder, or medical condition is selected from allergy, asthma, eosinophilic asthma, dry eye, chronic obstructive pulmonary disease (COPD), atherosclerosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, psoriasis, pruritus, itchy skin, atopic dermatitis, urticaria, ocular inflammation, conjunctivitis, nasal polyps, allergic rhinitis, nasal itch, parasitic or fungal infections, hidradenitis suppurativa, malignancy, such as lymphoma, jaundice, polycythemia, punctate palmoplantar keratoderma, thyroid illness/hyperparathyroidism, diabetes, chicken pox, iron deficiency anemia, psychiatric diseases, medication-induced itch; cholestasis; pregnancy-related itch, xerosis, sunburn, dandruff, scab/scars, insect bites, poison ivy, poison oak, hemorrhoids, contact dermatitis, age associated itch, itch associated with dialysis , scleroderma, autoimmune thyroid diseases, immune-mediated diabetes mellitus, lupus, myasthenia gravis, autoimmune neuropathies, autoimmune uveitis, autoimmune hemolytic anemia, pernicious anemia, autoimmune thrombocytopenia, temporal arteritis, anti-phospholipid syndrome, vasculitides, Behcet's disease, dermatitis herpetiformis, pemphigus vulgaris, vitiligo, primary biliary cirrhosis, autoimmune hepatitis, autoimmune oophoritis and orchitis, autoimmune disease of the adrenal gland, polymyositis, dermatomyositis, spondyloarthropathy, Sjogren's syndrome, pruritus, and diabetic nephropathy.

An additional illustrative embodiment of the invention is a method, wherein the disease, disorder, or medical condition is selected from allergy, asthma, autoimmune diseases, and pruritus.

An additional illustrative embodiment of the invention is a method, wherein said inflammatory bowel disease is one of colitis, Crohn's disease, and ulcerative colitis.

An additional illustrative embodiment of the invention is a method, wherein said parasitic or fungal infections is a parasitic infection. An additional illustrative embodiment of the invention is a method, wherein said parasitic or fungal infections is a fungal infection.

An additional illustrative embodiment of the invention is a method, wherein said parasitic or fungal infections is one of lice infection, scabies, swimmer's itch, jock itch, athlete's foot.

An additional illustrative embodiment of the invention is a method, wherein said malignancy is lymphoma.

An additional illustrative embodiment of the invention is a method, wherein said malignancy is Hodgkin's disease.

An additional illustrative embodiment of the invention is a method, wherein said medication-induced itch is one of photodermatitis, morphine-induced itch, opiate- induced itch, and chloroquine-induced itch).

An additional illustrative embodiment of the invention is a method, wherein said pregnancy-related itch is one of obstetric cholestasis, pruritic urticarial, papules and plaques of pregnancy, and gestational pemphigoid.

An additional illustrative embodiment of the invention is a method, wherein said autoimmune neuropathy is Guillain-Barre neuropathy.

An additional illustrative embodiment of the invention is a method, wherein said vasculitides is Wegener's granulomatosis.

An additional illustrative embodiment of the invention is a method, wherein said spondyloarthropathy is ankylosing spondylitis.

An embodiment of the invention is directed to the making, including purifying the above compounds.

Additional embodiments, features, and advantages of the invention will be apparent from the following detailed description and through practice of the invention. Table 1

Table of abbreviations and acronyms used herein include those listed in the following table.

Illustrative compounds useful in methods of this invention are be described below by reference to the illustrative synthetic schemes ("Schemes") and specific examples for their preparation. One of ordinary skill in the art will recognize that, to obtain the various compounds herein, starting materials may be suitably selected so that the ultimately desired substituents will be carried through the reaction scheme with or without protection as appropriate to yield the desired product. Alternatively, it may be

necessary or desirable to employ, in the place of the ultimately desired substituent, a suitable group that may be carried through the reaction scheme and replaced as appropriate with the desired substituent. Unless otherwise specified, the variables are as defined above in reference to Formula I. If no temperature or temperature range is stated, it is to be understood that the reaction is to be run at room temperature.

Schemes given below describe general preparation procedures.

Scheme 1

Compound IV is converted to compound V through the reduction of the nitro group. One of ordinary skill in the art will realize that this reduction is accomplished through a variety of methods. Some methods include catalytic hydrogenation conditions such as H2 gas and a catalytic amount of a metal catalyst such as Pd or Pt, wherein the Pd and Pt catalyst used may be 5-10% Pd on carbon and 5-10% Pt on carbon, respectively. This reduction may be conventionally run in a flask wherein the

atmosphere above the reaction mixture is H2 gas or wherein H2 gas is bubbled through the solution. Alternatively, the reaction may be run through a continuous hydrogenation flow reactor. The nitro group can also be reduced with, Fe, Zn or SnCb in solvents such as methanol, ethanol, isopropanol, THF or mixtures of some of such solvents.

Depending on specific substituent assignments for R ¹ and R ² , starting compound IV in the foregoing transformation is available commercially or it is prepared from commercially available forms through known transformations such as those illustratively described in processes (a) - (c) below.

(a) When compound IV is desired in the form in which R ² is OCi-C4 alkyl, then compound IV in the form in which R ² is OH is reacted with Ci-C4 alkyl-LG, wherein LG is a leaving group such as CI, Br, I, mesylate or tosylate, with a base such as K2CO3 or CS2CO3 in a solvent such as acetone or THF.

(b) When compound IV is desired in the form in which R ² is OC1-C3 perhaloalkyi, then compound IV in the form in which R ² is F is reacted with HOC1-C3 perhaloalkyi and NaH in a solvent such as toluene at a temperature ranging from -20 °C to 0 °C.

(c) When compound IV is desired in the form in which R ¹ is NO2, then compound IV in the form in which R ¹ is H is treated with H2SO4, fuming HNO3 at a temperature of about -10 °C.

Compound V with certain R ¹ and/or R ² assignments are transformed to other forms of compound V that have different R ¹ and/or R ² assignments as illustratively described in processes (d)-(i) below.

(d) When compound V is desired in the form in which R ² is C ₁ -C ₄ alkyl or

C ₃ -C ₄ cycloalkyl, then compound V in which R ² is CI, Br or I is treated with an alkyl or cycloalkyl boronic acid, a trialkyl or tricycloalkylborane, or an alkyl 1 ,3,5,2,4,6- trioxatriborinane, a metal catalyst such as Pd(Ph3)4, Pd(dppf)Cl2, 2- dicyclohexylphosphino-2',6'-diisopropoxybiphenyl, palladium(ll) phenethylamine chloride (1 : 1 MTBE solvate), Pd(dppf)Cl2-CH2Cl2 or chloro-(2-dicyclohexylphosphino-2',6'- diisopropoxy-1 , 1 '-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)-methyl-i-bu tyl ether adduct and a base such as CS2CO3 or K2CO3 in a solvent such as MeOH, DMF, benzene, toluene or mixtures thereof at a temperature of about 60 °C-125 °C for a time from about 1 hour to 24 hours. An alternative method to convert compound V (R ² is CI, Br or I) to compound V (R ² is C ₁ -C ₄ alkyl or C3-C4 cycloalkyl) is treating compound V (R ² is CI, Br or I) with a palladium catalyst such as Pd(t-Bu3P)2 or bis(tri-fe/f- butylphosphine)palladium(O) and C ₁ -C ₄ alkyl-zinc bromide or C3-C4 cycloalkylzinc bromide in a solvent such as THF at a temperature of about 50 °C for a time from about 1 hour to 24 hours.

(e) When compound V is desired in the form in which R ² is C ₁ -C ₄ alkyl, then compound V in which R ² is OH is treated with Ci-C4 alkyl-LG, wherein LG is a leaving group such as CI, Br, I, mesylate or tosylate, with a base such as K2CO3 or CS2CO3 in a solvent such as acetone or THF at a temperature of about rt to the reflux temperature of the solvent.

(f) When compound V is desired in the form in which R ² is 0 C1 -C4 alkyl, then compound V in which R ² is F is treated with C ₁ -C ₄ alkyl-OH and NaH in a solvent such as toluene wherein the reaction is run at a temperature between 0 °C and 45 °C for a time of about 15 h.

(g) When compound V is desired in the form in which R ² is Br, then compound V in which R ² is H) is treated with a brominating agent such as 1 ,3-dibromo-5,5- dimethylhydantoin or NBS in a solvent such as dichloromethane at a temperature of about 0 °C to rt for a time of approximately 15 minutes to 1 hour.

(h) When compound V is desired in the form in which R ² is CI, then compound V in which R ² is H is treated with a chlorinating agent such as NCS in a solvent such as acetonitrile at a temperature of about 50 °C to 75 °C for a time ranging from 1 hour to 22 hours.

(i) When compound V is desired in the form in which R ¹ is -S02-cyclopropyl and

R ² is H, then compound V in which R ¹ is I and R ² is H is treated with sodium

cyclopropanesulfinate, trifluoromethanesulfonate benzene complex, and

dimethylethylenediamine in a solvent such as DMSO with heating to a temperature of about 120 °C for approximately 16 h.

Reacting compound V with compound VI and an acid, such as concentrated HCI or p-toluene sulfonic acid hydrate, in a solvent such as iPrOH at a temperature of about

50 - 80 °C for about 15-22 hours yields compound VII.

Furthermore, reacting compound VII with a base such as NaH in a solvent such as DMF, ACN or THF, and a compound such as R ³ -LG, wherein LG is a leaving group such as CI, Br, I, mesylate or tosylate at a temperature of about 0 - 50 °C for a time ranging from 15 minutes to 22 hours yields compound VIII.

Compound VIII with certain R ¹ or R ² assignments is transformed to other forms of compound VIII that have different R ¹ or R ² assignments as illustratively described in processes (j), (k) and (m) below. (j) When compound VIII is desired in the form in which R ¹ is CN, then compound VIII in which R ¹ is Br is cyanized through a palladium catalyzed cyanation. Typical conditions include treatment with a cyanide source such as Zn(CN)2, NaCN or KCN, a metal such as zinc powder, ligands such as X-Phos and tBuBrettPhos, a palladium source such as Pd2dba3 in a solvent such as DMSO or DMA with heating to a

temperature of about 120 °C.

(k) When compound VIII is desired in the form in which R ² is (E)-prop-1 -en-1 -yl, then compound VIII in which R ² is I is treated with [(E)-prop-1 -enyl]boronic acid, chloro- (2-dicyclohexylphosphino-2',6'-diisopropoxy-1 , 1 '-biphenyl)[2-(2- aminoethyl)phenyl]palladium(ll)-methyl-f-butyl ether adduct, and degassed 0.5 M phosphate solution in a solvent such as dioxane with heating to a temperature of about 120 °C. This reaction may be heated in a microwave reactor or may be heated in the conventional manner.

(m) When compound VIII is desired in the form in which R ¹ is S-iPr, then compound VIII in which R ¹ is Br is treated with n-butyllithium (2.5 M in hexanes) in a solvent such as THF at -73 °C followed by treatment with isopropyl disulfide at a temperature from -73 C to rt for a time from about 15 minutes to 24 hours.

Compound VIII is converted to compound of formula I through a two-step process wherein in the first step the -SChta group is initially oxidized to a -SO2CH3 group upon treatment with an oxidizing agent such as a monopersulfate, for example potassium monopersulfate, sometimes available in the form of a triple salt combination, and found under the tradename oxone, in methanol and water at a temperature of about 0 °C to rt or MCPBA. The second step of the two-step process comprises treatment of the -SO2CH3 intermediate (structure not shown) with NH ₄ OH in iPrOH at a temperature of about 140 °C for about 40 minutes. The reaction may be run in a microwave reactor or may be heated in the conventional manner.

Compound of formula I with certain R ¹ or R ² assignments are transformed to other forms of compound of formula I that have different R ¹ or R ² assignments as illustratively described in processes (n)-(w) below. (n) When compound of formula I is desired in the form in which R ¹ is SO2R ⁴ , where R ⁴ is Ci-C4 alkyl, C1-C2 perhaloalkyl or C3-C4 cycloalkyl, then compound of formula I in which R ¹ is Br is treated with NaS02R ⁴ , a catalyst such as Cul or

(CF3S03Cu)2C6H6, in a solvent or mixtures thereof such as DMA and DMSO, with heating to a temperature of about 120-140 °C.

(o) When compound of formula I is desired in the form in which R ¹ is

-CH=CH-CH3 then compound of formula I in which R ¹ is Br is treated with prop-1 - enylboronic acid, CS2CO3, Pd(Ph3)4 in a solvent mixture such as dioxane and water at a temperature of about 100 °C for approximately 15 minutes.

(p) When compound of formula I is desired in the form in which R ¹ is propyl then compound of formula I in which R ¹ is -CH=CH-CH3 is subjected to hydrogenation conditions which include catalytic hydrogenation conditions such as H2 gas and a catalytic amount of a metal catalyst such as Pd or Pt, wherein the Pd and Pt used may be 5-10% Pd on carbon and 5-10% Pt on carbon, respectively. This reduction may be run in the conventional manner in a flask wherein the atmosphere above the reaction mixture is H2 gas or wherein H2 gas is bubbled through the solution. Alternatively, the reaction may be run through a continuous hydrogenation flow reactor.

(q) When compound of formula I is desired in the form in which R ¹ is

-CH=CH-CH3 (trans)) then compound of formula I in which R ¹ is CI is treated with trans- 1 -propen-1 -ylboronic acid, K3PO4 solution (0.5 M), and 2-dicyclohexylphosphino-2',6'- diisopropoxybiphenyl, palladium(ll) phenethylamine chloride in a solvent mixture such as dioxane and water at a temperature of about 140 °C for approximately 20 minutes.

(r) When compound of formula I is desired in the form in which R ¹ -C(CH3)=CH2 then compound of formula I in which R ¹ is CI is treated with isopropenylboronic acid pinacol ester, K3PO4 solution (0.5 M), and 2-dicyclohexylphosphino-2',6'- diisopropoxybiphenyl, palladium(ll) phenethylamine chloride in a solvent mixture such as dioxane and water at a temperature of about 140 °C for approximately 20 minutes.

(s) When compound of formula I is desired in the form in which R ¹ is isopropyl then compound of formula I in which R ¹ is -C(CH3)=CH2 is subjected to hydrogenation conditions which include catalytic hydrogenation conditions such as H2 gas and a catalytic amount of a metal catalyst such as Pd or Pt, wherein the Pd and Pt used may be 5-10% Pd on carbon and 5-10% Pt on carbon, respectively. This reduction may be run in the conventional manner in a flask wherein the atmosphere above the reaction mixture is H2 gas or wherein H2 gas is bubbled through the solution. Alternatively, the reaction may be run through a continuous hydrogenation flow reactor.

(t) When compound of formula I is desired in the form in which R ¹ is -CH=CH2 then compound of formula I in which R ¹ is Br is treated with chloro-(2- dicyclohexylphosphino-2',6'-diisopropoxy-1 , 1 '-biphenyl)[2-(2- aminoethyl)phenyl]palladium(ll)-methyl-f-butyl ether adduct, K3PO4 (0.5 M in H2O,), and 4,4,5,5-tetramethyl-2-vinyl-1 ,3,2-dioxaborolane in a solvent such as dioxane at a temperature of about 120 °C for 1 h in a microwave reactor.

(u) When compound of formula I is desired in the form in which R ¹ is ethyl then compound of formula I in which R ¹ is -CH=CH2 is subjected to hydrogenation conditions which include catalytic hydrogenation conditions such as H2 gas and a catalytic amount of a metal catalyst such as Pd or Pt, wherein the Pd and Pt used may be 5-10% Pd on carbon and 5-10% Pt on carbon, respectively. This reduction may be run in the conventional manner in a flask wherein the atmosphere above the reaction mixture is H2 gas or wherein H2 gas is bubbled through the solution. Alternatively, the reaction may be run through a continuous hydrogenation flow reactor.

(v) When compound of formula I is desired in the form in which R ¹ is CH3 then compound of formula I in which R ¹ is CI is treated with 2,4,6-trimethyl-1 ,3,5,2,4,6- trioxatriborinane, 1 , 1 '-bis(diphenylphosphino)ferrocene-palladium(ll)dichloride

dichloromethane complex, a 0.5 M degassed phosphate solution at a temperature of about 140 °C for approximately 30 m in in a microwave reactor.

(w) When compound of formula I is desired in the form in which R ¹ is CN then compound of formula I in which R ¹ is CI is treated with zinc cyanide, 2- dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl, Zn powder, and Pd2(dba)3 in a solvent such as DMA at a temperature of about 120 °C for approximately 1 h.

Scheme 2

Compound V is converted to compound X through a variety of methods.

Reductive amination of the aniline is accomplished through treatment with an appropriately substituted aldehyde, a reducing agent such as NaBH(OAc)3, NaCNBhh, and NaBH ₄ , in a suitable solvent such as DCM and DCE, for a period of 1 -24 h, optionally an acid, such as acetic acid, may be added.

Alternatively, compound V is converted to compound X through a two-step procedure (not expressly shown in Scheme 2) wherein compound V is coupled first with a carboxylic acid using amide bond coupling conditions. The resulting amide is then fully reduced by using reduction conditions such as LiAIH ₄ in ether and BH3-THF or BH3-DMS in a solvent such as THF at a temperature of about 40 °C.

Compound X is converted to compound of formula I through treatment with compound XI and an acid such as p-toluenesulfonic acid in a solvent such as dioxane and water or mixtures thereof at a temperature of about 60 °C.

Compound VII is converted to compound XII by treating it with 2-bromoacetate and NaH in a solvent such as DMF wherein the reaction in conducted at a temperature between 0 °C and room temperature. Compound XII is then converted to compound XIII by treating it with NH2NH2-H2O in a solvent such as ethanol at a temperature of about 80 °C. Compound XIII is converted to compound XIV by treating it with TsOH and trimethoxymethane at a temperature at or close to the reflux temperature. Compound XIV then is converted to compound of formula I using the conditions described to convert compound VIII to compound of formula I in Scheme 1 .

Compound XV is converted to compounds XVI and XVII by treating it with [(E)- prop-1 -enyl]boronic acid, 2-dicyclohexylphosphino-2',6'-diisopropoxybiphenyl and a palladium(ll) phenethylamine chloride, and degassed 0.5 M phosphate solution in a solvent such as dioxane. Compounds XVI and XVII are compounds of formula I. The mixture of compounds XVI and XVII is separated into individual constituent compounds by HPLC using a gradient mobile phase of 5% ACN in H2O (containing 0.05% TFA) to 95% ACN in H ₂ O (containing 0.05% TFA), over 8 minutes using a 30mm X 100mm InertSil ODS-3 column, which was kept at 46°C with 80 ml/min flow rate.

Compound VII is converted to compound XVIII by treating it with NaH in DMF at a temperature starting at 10 C, followed by addition of 3-bromoprop-1 -yne wherein the temperature is raised to rt for about 2 h. Compound XVIII is converted to compound XIX by treating it with formalin, acetic acid, CuS04, L-ascorbic acid sodium salt and NalSh in a solvent such as dioxane at a temperature of about 0 °C to rt. Compound XIX then is converted to compound of formula I by using the conditions described to convert compound VIII to compound of formula I in Scheme 1 .

Compound XX is converted to compound XXI by treating it with concentrated HCI in a solvent such as MeOH at a temperature of about 45 °C for a time period of about 15 h. Compound XXI is a compound of formula I.

Examples In obtaining the compounds described in the examples below and the corresponding analytical data, the following experimental and analytical protocols were followed unless otherwise indicated.

Reaction mixtures were magnetically stirred at room temperature. Where solutions are characterized as "dried," they were generally dried over a drying agent such as Na2S04 or MgS04. Where mixtures, solutions, and extracts were

"concentrated", they were typically concentrated on a rotary evaporator under reduced pressure.

Thin-layer chromatography was performed using Merck silica gel 60 F254 2.5 cm x 7.5 cm, 250 pm or 5.0 cm x 10.0 cm, 250 pm pre-coated silica gel plates.

Normal-phase flash column chromatography (FCC) was performed on silica gel (S1O2) eluting with 2 M NH3 in MeOH/ CH2CI2, unless otherwise noted.

Mass spectra (MS) were obtained on an Agilent series 1 100 MSD using electrospray ionization (ESI) in positive mode unless otherwise indicated. Calculated (calcd.) mass corresponds to the exact mass.

Compound purification was made in some cases by acidic HPLC that entailed purification on a reverse phase HPLC system using different mobile phases that started initially with a mobile phase of 5% ACN in H2O (both with 0.05% TFA) that was held for 1 min, then changed to a gradient of 5-99% ACN over 6 min, which was held at 99% ACN for 3 min, with a flow rate of 80 mL/min. Columns that were used include: Inertsil ODS-3 column (3 μητι, 30 x 100mm, T = 45 °C), XBridge C18 OBD column (5 μητι, 50 x 100mm), and Phenomenex Luna C18 column (5 pm, 100 x 30 mm).

Nuclear magnetic resonance (NMR) spectra were obtained on Bruker model DRX spectrometers. The format of the 1 H NMR data below is: chemical shift in ppm downfield of the tetramethylsilane reference (multiplicity, coupling constant J in Hz, integration).

Chemical names were generated by either using ChemDraw (CambridgeSoft, Cambridge, MA) or ACD/Name Version 9 (Advanced Chemistry Development, Toronto, Ontario, Canada). To provide a more concise description, some of the quantitative expressions given herein are not qualified with the term "about". It is understood that, whether the term "about" is used explicitly or not, every quantity given herein is meant to refer to the actual given value, and it is also meant to refer to the approximation to such given value that would reasonably be inferred based on the ordinary skill in the art, including equivalents and approximations due to the experimental and/or measurement conditions for such given value.

Whenever a yield is given as a percentage, such yield refers to a mass of the entity for which the yield is given with respect to the maximum amount of the same entity that could be obtained under the particular stoichiometric conditions. Reagent concentrations that are given as percentages refer to mass ratios, unless indicated differently.

The following examples are provided to further illustrate aspects of the invention and various embodiments.

Intermediate 1 : 2-propyl-4-(trifluoromethoxy)aniline

A solution of 2-bromo-4-(trifluoromethoxy)aniline (256 mg, 1 .00 mmol), [(E)-prop-1 - enyl]boronic acid (172 mg, 2.00 mmol), 1 , 1 '-bis(diphenylphosphino)ferrocene- palladium(ll)dichloride dichloromethane complex (29.0 mg, 0.0400 mmol), and K2C03(aq) (1 M, 2 equiv) in MeOH (0.5 ml_)/toluene (0.5 ml_) was stirred at 125 °C for 4 h. The organic layer was separated, concentrated to dryness, and purified by FCC (S1O2) to give (E)-2-(prop-1 -en-1 -yl)-4-(trifluoromethoxy)aniline. (E)-2-(Prop-1 -en-1 -yl)-4- (trifluoromethoxy)aniline and Pd/C (10% on carbon, 30 mg) in MeOH (10 ml_) was stirred under H2 (1 atm) for 3 h. After filtration on diatomaceous earth such as Celite ^® , the filtrate was collected and concentrated to dryness to give 2-propyl-4-

(trifluoromethoxy)aniline. MS (ESI): mass calcd. for C10H12F3NO, 219.1 ; m/z found, 220.1 [M+H] ⁺ . Intermediate 2: 2-Ethoxy-4-fluoro-1 -nitrobenzene

To a 100 mL round-bottomed flask were added a mixture of 5-fluoro-2-nitrophenol (3.14 g, 20.0 mmol), iodoethane (3.43 g, 22.0 mmol), K2CO3 (5.52 g, 40.0 mmol), and acetone (30.0 mL). The mixture was heated at reflux for 15 h, and then concentrated under vacuum to dryness. Water (30 mL) was added to the residue and the resulting mixture was extracted with EtOAc (3 x 20 mL). The combined organic phases were washed with saturated NaCI(aq) (30 mL), dried over anhydrous Na2S04, and

concentrated to dryness to give the title compound (3.7 g, 100%) as a yellow oil. ¹ H

NMR (300 MHz, CDCb): δ 7.92 (dd, J = 9.0, 6.0 Hz, 1 H), 6.80 - 6.65 (m, 2H), 4.17 (q, J = 7.0 Hz, 2H), 1 .51 (t, J = 7.0 Hz, 3H).

Intermediate 3: 2-Ethoxy-4-fluorobenzenamine

To a 250 mL round-bottomed flask were added 2-ethoxy-4-fluoro-1 -nitrobenzene (3.70 g, 20.0 mmol) and 10% Pd/C (370 mg) in MeOH (80.0 mL). The mixture was stirred at rt for 3 h under a H2 atmosphere. The mixture was filtered and the filtrate was concentrated to dryness to give the title product (2.8 g, crude, 90%) as a dark oil. MS (ESI): mass calcd. for CsHioFNO 155.07, m/z found 156.2 [M+H] ⁺ .

Intermediate 4: 4-Fluoro-1 -nitro-2-(2,2,2-trifluoroethoxy)benzene

To a 100 ml_ round-bottomed flask were added 2, 4-difluoro-1 -nitrobenzene (1 .6 g, 10 mmol), 2,2,2-trifluoroethanol (1 .4 g, 14 mmol), and toluene (20 ml_) and the mixture cooled to 0 °C. The reaction was treated with NaH (60% in mineral oil, 0.48 g, 12 mmol) in four portions over 5 min and was stirred at 45 °C for 15 h. The mixture was cooled to rt, diluted with water (30 ml_), and extracted with EtOAc (3 ^χ 20 ml_). The combined organic phases were washed with saturated aqueous NaCI, dried over anhydrous Na2S04, filtered, and concentrated to dryness to give the title compound (1 .2 g, 50%) as a red oil, which was used in the next reaction without any further purification. 1 H NMR (300 MHz, CDCb): δ 8.00 (dd, J = 9.3 Hz, 6.0 Hz, 1 H), 6.92 - 6.86 (m, 1 H), 6.82 (dd, J = 9.3 Hz, 2.4 Hz, 1 H), 4.48 (q, J = 7.8 Hz, 2H).

Intermediates 5, 6 and 10-16, whose characterization is provided in Table 2, were made in a manner analogous to the procedure described below for intermediate 17, substituting the appropriate reagents where necessary.

2-Cyclobutyl-4-(methylsulfonyl)aniline (Intermediate 17).

To a 500 ml_ round-bottomed flask were added 2-bromo-4-methanesulfonylaniline (10 g, 40 mmol) and 1 , 1 '-bis(diphenylphosphino)ferrocene-palladium(ll)dichloride

dichloromethane complex (820 mg, 1 .0 mmol) as solids. The round-bottomed flask was equipped with a 125 mL addition funnel and the system was evacuated, then backfilled with N2 (3x). The addition funnel was removed briefly to add THF (80 ml_, 0.50 M, 40 mmol) and the round-bottomed flask was placed into an ice/water bath to cool with stirring to ~0 °C. To the addition funnel was added cyclobutylzinc bromide (0.12 L, 0.50 M, 60 mmol) via cannula transfer. After cooling the reaction for ~15 min, cyclobutylzinc bromide was added dropwise at a rate of ~20 mL/5 min. After the reaction began to turn to a dark brown color, the addition rate was increased to add the remainder of material over 5 min. The round-bottomed flask was removed from the cold bath, and placed into a preheated 60 °C heating block. The reaction was stirred under a blanket of N2 at 60 °C for 30 minutes than cooled to room temperature. The reaction mixture was then poured onto saturated aqueous NH ₄ CI (200 ml_) and EtOAc (200 ml_). The aqueous layer was found to contain a small amount of insoluble solids, therefore water (100 ml_) was added to afford two distinct layers. The aqueous layer was extracted further with EtOAc (100 ml_). The combine organics were washed with brine (100 ml_), dried over anhydrous MgS04, and concentrated to dryness. The residue was purified by FCC (330 g S1O2, 5-50% EtOAc/hexane). Fractions were combined and

concentrated to dryness to give the title compound (6.90 g, 75.8% yield) as an off-white powder. ¹ H NMR (400 MHz, CDCb): δ 7.63 - 7.53 (m, 2H), 6.67 (d, J = 8.2 Hz, 1 H), 4.11 (s, 2H), 3.53 - 3.33 (m, 1 H), 3.01 (s, 3H), 2.49 - 2.30 (m, 2H), 2.26 - 2.01 (m, 3H), 1 .94 - 1 .80 (m, 1 H).

Table 2

Intermediates 9 and 15, whose characterization is provided in Table 3, were made in a manner analogous to the procedure described below for intermediate 7, substituting the appropriate reagents where necessary.

2-ethyl-4-((trifluoromethyl)sulfonyl)aniline (Intermediate 7)

A 20 ml_ vial was charged 2-bromo-4-((trifluoromethyl)sulfonyl)aniline (505 mg, 1 .66 mmol), 1 , 1 '-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride dichloromethane complex (100 mg, 0.122 mmol), CS2CO3 (3.16 g, 9.70 mmol), and DMF (10 ml_). The vial was capped and the resulting mixture was sparged with N2 for 15 min.

Triethylborane (1 M in hexanes) (4.57 ml_, 4.57 mmol) was then added via syringe to the vial and the contents again sparged with N2 for 15 min. The vial was placed into a preheated 50 °C heating block. At 18 h, the contents were cooled to room temperature, filter cake was rinsed with ethyl acetate and the resulting filtrate was washed with water then brine. The organics were dried using MgS04 and then concentrated to dryness. Purification by FCC (40 g S1O2, 30% EA/hexanes) afforded 331 mg of 2-ethyl-4- ((trifluoromethyl)sulfonyl)aniline. 1 H NMR (400 MHz, Chloroform-d) δ 7.72 - 7.59 (m, 2H), 6.81 - 6.63 (m, 1 H), 4.46 (s, 2H), 2.53 (q, J = 7.5 Hz, 2H), 1 .30 (t, J = 7.5 Hz, 3H).

Table 3

Example 1 : (2-Ethoxy-4-fluorophenyl)-N4.-isopropylpyrimidine-2,4-diamin e.

Step A: 2-Ethoxy-4-fluoro-N.-isopropylaniline. To a 100 mL round-bottomed flask were added 2-ethoxy-4-fluoroaniline (Intermediate 3, 1 .0 g, 6.1 mmol), 2-methoxypropene (0.70 mL, 7.3 mmol) and 1 ,2-dichloroethane (20 mL). To the resulting solution was added acetic acid (0.35 mL, 6.1 mmol) and NaBH(OAc)3 (2.7 g, 12 mmol). The mixture was stirred at rt for 16 h. The mixture was diluted with water (30 mL) and extracted with CH2CI2 (30 mL). The organic layer was separated then dried over anhydrous Na2S04, filtered, and concentrated under vacuum to dryness. The residue was purified by FCC to give the title compound (680 g, 56%) as a yellow oil. MS (ESI): mass calcd. for C11 H16FNO 197.1 , m/z found 198.1 [M+H] ⁺ .

Step B: N4.-(2-Ethoxy-4-fluorophenyl)-N4.-isopropylpyrimidine-2,4-di amine. To a 10 mL microwave vial were added 2-ethoxy-4-fluoro-N.-isopropylaniline (200 mg, 1 .0 mmol), 4- chloropyrimidin-2-amine (260 mg, 2.0 mmol), 1 ,4-dioxane (0.66 mL) and water (0.33 mL). p-Toluenesulfonic acid monohydrate (190 mg, 1 .0 mmol) was added to the mixture and the resulting mixture was heated at 150 °C using microwave heating for 90 min. Additional 4-chloropyrimidin-2-amine (130 mg, 1 .0 mmol) was added and heated further using microwave heating at 150 °C for 30 min. After cooling to rt, the mixture was neutralized with a saturated aqueous NaHC03 solution and extracted with DCM (2x). The organic phase was dried over anhydrous Na2S04, and concentrated under vacuum to dryness. The residue was purified by FCC (4 g S1O2 column: 100% hexane for 5 min, then 0 to 100% EtOAc/hexane with 10 min gradient) to give the title compound (78 mg, 27%) as a yellow solid. MS (ESI): mass calcd. for C15H19FN4O, 290.3; m/z found, 291 .1 [M+H] ⁺ . ¹ H NMR (500 MHz, CDsOD): δ 7.58 - 7.46 (m, 1 H), 7.15 - 7.10 (m, 1 H), 6.93 (dd, J = 10.8, 2.7 Hz, 1 H), 6.81 - 6.74 (m, 1 H), 5.39 - 5.00 (m, 2H), 4.08 - 3.96 (m, 2H), 1 .28 (t, J = 7.0 Hz, 3H), 1 .20 (d, J = 6.6 Hz, 3H), 1 .05 (d, J = 6.7 Hz, 3H).

Example 2: N4. -((1 H-Pyrazol-5-yl)methyl)-N4.-(4-fluoro-2-methylphenyl)pyrimidi ne-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 1 and using 1 /-/-pyrazole-5-carbaldehyde and 4-fluoro-2-methylbenzenamine in place of 2-methoxypropene and 2-ethoxy-4-fluoroaniline, respectively, in step A. MS (ESI): mass calcd. for C15H15FN6 298.1 , m/z found 299.1 [M+H] ⁺ . ¹ H NMR (400 MHz, DMSO-de): δ 8.39 (d, J = 2.6 Hz, 1 H), 8.32 (d, J = 5.4 Hz, 1 H), 7.00 (d, J = 5.4 Hz, 1 H), 6.89 - 6.84 (m, 3H), 6.81 - 6.75 (m, 1H), 6.52 (dd, J = 8.8, 4.9 Hz, 1H), 6.47 (d, J = 2.6 Hz, 1H), 5.41 (t, J = 6.0 Hz, 1H), 4.34 (d, J = 6.0 Hz, 2H), 2.15 (s, 3H).

Example 3:N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(isoxazol-4-ylmethyl)pyr imidine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 1, using isoxazole-4-carbaldehyde in place of 2-methoxypropene in step A. MS (ESI): mass calcd. for

Hz, 1H), 6.71 - 6.61 (m, 2H), 5.42 (d, J = 6.0 Hz, 1H), 5.07 - 4.58 (m, 4H), 3.93 (q, J = 7.0 Hz, 2H), 1.24 (t, J = 7.0 Hz, 3H).

Exam le 4:N4.-Benzyl-N4.-(2-ethoxy-4-fluorophenyl)pyrimidine-2,4-dia mine.

The title compound was prepared using analogous conditions described in Example 1 using benzaldehyde in place of 2-methoxypropene in Step A. MS (ESI): mass calcd. for

= 7.4 Hz, 1H), 7.28-7.19 (m, 5H), 7.03 (dd, J = 8.7, 6.1Hz, 1H), 6.92 (dd, J= 10.7, 2.7 Hz, 1H), 6.73-6.67 (m 1H), 5.67 (d, J =7.4 Hz, 1H), 5.34 (d, J = 14.4 Hz, 1H), 4.99 (d, J= 14.3 Hz, 1H), 4.04-3.96 (m, 1H), 3.91 -3.83 (m, 1H), 1.21 (t, J = 7.0 Hz, 3H). Example 5: N4.-(Oxazol-4-ylmethyl)-N4.-(2-propyl-4-(trifluoromethoxy)ph enyl)pyrimidine- 2,4-diamine.

The title compound was prepared using analogous conditions described in Example 1 , using 2-propyl-4-(trifluoromethoxy)aniline (Intermediate 1 ) and oxazole-4-carbaldehyde in place of 2-ethoxy-4-fluoroaniline and 2-methoxypropene, respectively, in step A. MS (ESI): mass calcd. for C18H18F3N5O2, 393.4; m/z found, 394.1 [M+H] ⁺ . ¹ H NMR (500 MHz, CD3OD): δ 8.11 (s, 1 H), 7.92 (s, 1 H), 7.63 (d, J = 6.0 Hz, 1 H), 7.28 (d, J = 2.5 Hz, 1 H), 7.25 - 7.01 (m, 2H), 5.36 - 5.22 (m, 2H), 4.64 - 4.51 (m, 1 H), 2.55 - 2.25 (m, 2H), 1 .70 - 1 .38 (m, 2H), 0.88 (t, J = 7.3 Hz, 3H).

Example 6: N4.-(2-Cyclobutyl-4-(trifluoromethoxy)phenyl)-N4.-(oxazol-4- lmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 1 using 2-cyclobutyl-4-(trifluoromethoxy)aniline (Intermediate 5) in place of 2-ethoxy-4- fluoroaniline and oxazole-4-carbaldehyde in place of 2-methoxypropene in Step A. MS (ESI): mass calcd. for C19H18F3N5O2, 405.4; m/z found, 406.1 [M+H] ⁺ . ¹ H NMR (600 MHz, CD3OD): δ 8.11 (s, 1 H), 7.91 (s, 1 H), 7.63 (d, J = 6.3 Hz, 1 H), 7.45 - 7.32 (m, 1 H), 7.26 - 7.10 (m, 2H), 5.51 - 5.05 (m, 2H), 4.53 (d, J = 15.3 Hz, 1 H), 3.55 - 3.40 (m, 1 H), 2.30 - 1 .68 (m, 6H). Example 7: N4.-(2-Methyl-4-(trifluoromethoxy)phenyl)-N4.-(oxazol-4-ylme thyl)pyrimidine- 2,4-diamine.

The title compound was prepared using analogous conditions described in Example 1 using 2-methyl-4-(trifluoromethoxy)aniline and oxazole-4-carbaldehyde in place of 2- ethoxy-4-fluoroaniline and 2-methoxypropene in Step A, respectively. MS (ESI): mass calcd. for CieHuFsNsCte, 365.3; m/z found, 366.1 [M+H] ⁺ . ¹ H NMR (500 MHz, CDsOD): δ 8.19 - 8.06 (m, 1 H), 7.93 (s, 1 H), 7.66 (d, J = 5.9 Hz, 1 H), 7.32 - 7.12 (m, 3H), 5.56 - 5.08 (m, 2H), 4.73 (d, J = 15.2 Hz, 1 H), 2.10 (s, 3H).

Example 8: N4.-(2-lsobutyl-4-(trifluoromethoxy)phenyl)-N4.-(oxazol-4-yl methyl)pyrimidine- 2,4-diamine.

The title compound was prepared using analogous conditions described in Example 1 using 2-isobutyl-4-(trifluoromethoxy)aniline and oxazole-4-carbaldehyde in place of 2- ethoxy-4-fluoroaniline and 2-methoxypropene, respectively in Step A. MS (ESI): mass calcd. for C19H20F3N5O2, 407.4; m/z found, 408.1 [M+H] ⁺ . ¹ H NMR (500 MHz, CDsOD): δ 8.12 (d, J = 0.7 Hz, 1 H), 7.95 (s, 1 H), 7.70-7.56 (m, 1 H), 7.29 (s, 1 H), 7.25 - 7.11 (m, 2H), 5.56 - 5.12 (m, 2H), 4.43 (d, J = 15.2 Hz, 1 H), 2.51 - 2.22 (m, 2H), 1 .90 (m, 1 H), 0.86 (d, J = 6.6, 6H). Example 9: 2-(4-((2-Aminopynmidin-4-yl)(oxazol-4-ylmethyl)amino)-3-ethy lphenyl)- 1,1,1 ,3,3,3-hexafluoropropan-2-ol.

The title compound was prepared using analogous conditions described in Example 1 using 2-(4-amino-3-ethylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol and oxazole-4- carbaldehyde in place of 2-ethoxy-4-fluoroaniline and 2-methoxypropene, respectively. MS (ESI): mass calcd. for C19H17F6N5O2, 461.4; m/z found, 462.1 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCl ₃ ): δ 7.84 - 7.44 (m, 4H), 6.97 (d, J = 8.4 Hz, 1H), 6.80 - 6.49 (m, 1H), 5.46 - 5.14 (m, 1H), 5.01 -4.70 (m, 3H), 4.43 (d, J= 15.2 Hz, 1H), 2.45 -2.14 (m, 2H), 1.04- 0.80 (m, 3H).

Example 10:N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(oxazol-2-ylmethyl)pyri midine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 1 using oxazole-2-carbaldehyde in place of 2-methoxypropene in step A. MS (ESI): mass calcd. for C16H16FN5O2, 329.1; m/z found, 330.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.74 (d, J = 6.0 Hz, 1H), 7.57 (s, 1H), 7.17 (dd, J = 8.6, 6.3 Hz, 1H), 7.02 (s, 1H), 6.69 (dd, J = 10.4, 2.7 Hz, 1H), 6.66-6.59 (m, 1H), 5.80-5.60 (m, 1H), 5.51 (d, J = 5.4 Hz, 1H), 4.8 (br s, 2H), 4.66-4.52 (m, 1H), 3.99 (q, J = 7.0 Hz, 2H), 1.31 (t, J = 7.0 Hz, 3H). Example 11 : N. ⁴ -((1 /-/-Pyrazol-3-yl)methyl)-N4.-(2-ethoxy-4-fluorophenyl)pynmid ine-2,4- diamine.

Step A: N.-((1 H --yrazol-3-yl)methyl)-2-ethoxy-4-fluorobenzenamine. The title compound was prepared using analogous conditions described in Example 1 , Step A, using 1 A7- pyrazole-3-carbaldehyde in place of 2-methoxypropene to give the title compound as a yellow oil. MS (ESI): mass calcd. for C12HHFN3O, 235.11 , m/z found 236.2 [M+H] ⁺ . Step B: N. ⁴ -((1 H- PPrazol-3-yl)methyl)-N4.-(2-ethoxy-4-fluorophenyl)pyrimidine -2,4- diamine. The title compound was prepared using analogous conditions described in Example 1 , Step B using N.-((1 /-/-pyrazol-3-yl)methyl)-2-ethoxy-4-fluorobenzenamine in place of 2-ethoxy-4-fluoro- N.-isopropylaniline in step B, to give the title compound as a yellow solid. MS (ESI): mass calcd. for CieHiyFNeO, 328.14, m/z found 329.1 [M+H] ⁺ . 1 H NMR (400 MHz, CDCb): δ 10.98 (br s, 1 H), 7.68 (d, J = 6.2 Hz, 1 H), 7.45 (d, J = 1 .7 Hz, 1 H), 6.94 (dd, J = 8.6, 6.2 Hz, 1 H), 6.69 (dd, J = 10.4, 2.7 Hz, 1 H), 6.66 - 6.59 (m, 1 H), 6.06 (s, 1 H), 5.52 - 5.05 (m, 4H), 4.72 (s, 1 H), 3.95 (q, J = 6.9 Hz, 2H), 1 .27 (t, J = 7.0 Hz, 3H).

Example 12: N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(oxazol-4-ylmethyl)pyrimid ine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 1 using oxazole-4-carbaldehyde in place of 1 /-/-pyrazole-3-carbaldehyde. MS (ESI): mass calcd. for C16H16FN5O2, 329.1; m/z found, m/z = 330.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.80 (s, 1H), 7.73 (d, J= 6.1 Hz, 1H), 7.60 (s, 1H), 7.08 (dd, J = 8.6, 6.3 Hz, 1H), 6.71 (dd, J = 10.4, 2.6 Hz, 1H), 6.68-6.61 (m, 1H), 5.57-5.28 (m, 2H), 4.84 (brs, 2H), 4.66-4.46 (m, 1H), 4.01 (q, J = 6.9 Hz, 2H), 1.31 (t, J = 7.0 Hz, 3H).

Examplel 3:N4.-((4-Chloro-1H-pyrazol-3-yl)methyl)-N4.-(2-ethoxy-4- fluoro henyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 11 using 4-chloro-1 /-/-pyrazole-3-carbaldehyde in place of 2-methoxypropene in step A and using concentrated H2SO4 in place of p-toluenesulfonic acid monohydrate in step B to give the title compound. MS (ESI): mass calcd. for C16H16CIFN6O, 362.1 ; m/z found, 363.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 11.28 (br s, 1H), 7.72 (d, J = 6.1Hz, 1H), 7.41 (s, 1H), 7.01 (dd, J = 8.5, 6.2 Hz, 1H), 6.72 - 6.63 (m, 2H), 5.48 (d, J = 6.1Hz, 1H), 5.14 (br s, 2H), 5.02 - 4.80 (m, 2H), 3.95 (q, J = 7.0 Hz, 2H), 1.24 (t, J = 7.0 Hz, 3H).

Example 14:N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(isoxazol-3-ylmethyl)py rimidine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 11 using isoxazole-3-carbaldehyde in place of 2-methoxypropene in step A and using concentrated H2SO4 in place of p-toluenesulfonic acid monohydrate in step B to give the title compound. MS (ESI): mass calcd. for C16H16FN5O2, 329.1 ; m/z found, 330.1

[M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.30 (d, J = 1 .1 Hz, 1 H), 7.74 (d, J = 6.0 Hz, 1 H), 6.98 (dd, J = 8.6, 6.3 Hz, 1 H), 6.68 (dd, J = 10.4, 2.6 Hz, 1 H), 6.64 - 6.58 (m, 1 H), 6.44 (d, J = 1.4 Hz, 1 H), 5.52 - 5.36 (m, 2H), 4.90 - 4.75 (m, 3H), 3.96 (q, J = 7.0 Hz, 2H), 1 .28 (t, J = 7.0 Hz, 3H).

Example 15: N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(thiazol-5-ylmethyl)pyrimi dine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 11 using thiazole-5-carbaldehyde in place of 2-methoxypropene in step A and using concentrated H2SO4 in place of p-toluenesulfonic acid monohydrate in Step B to give the title compound. MS (ESI): mass calcd. for CieHieFNsOS, 345.1 ; m/z found, 346.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDsOD): δ 8.89 (s, 1 H), 7.66 - 7.61 (m, 2H), 7.04 (dd, J = 8.6, 6.3 Hz, 1 H), 6.91 (dd, J = 10.7, 2.7 Hz, 1 H), 6.75 - 6.69 (m, 1 H), 5.50 - 5.29 (m, 2H), 5.08 (d, J = 14.7 Hz, 1 H), 4.00 - 3.91 (m, 2H), 1 .19 (t, J = 7.0 Hz, 3H).

Example 16: N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(oxazol-5-ylmethyl)pyrimid ine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 1 using oxazole-5-carbaldehyde in place of 2-methoxypropene in step A and using concentrated H2SO4 in place of p-toluenesulfonic acid monohydrate in Step B to give the title compound. MS (ESI): mass calcd. for CieHieFNsOS, 329.1 ; m/z found, 330.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): 7.75 (s, 1 H), 7.72 (d, J = 6.1 Hz, 1 H), 6.97 (dd, J = 8.5, 6.3 Hz, 1 H), 6.90 (s, 1 H), 6.69 (dd, J = 10.4, 2.6 Hz, 1 H), 6.66 - 6.59 (m, 1 H), 5.52 - 5.40 (m, 2H), 4.88 (br s, 2H), 4.76-4.60 (m, 1 H), 3.97 (q, J = 7.0 Hz, 2H), 1 .28 (t, J = 7.0 Hz, 3H)

Example 17: N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(thiazol-4-ylmethyl)pyrimi dine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 1 using thiazole-4-carbaldehyde in place of 2-methoxypropene in step A and using concentrated H2SO4 in place of p-toluenesulfonic acid monohydrate in Step B to give the title compound. MS (ESI): mass calcd. for CieHieFNsOS, 345.1 ; m/z found, 346.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): 8.71 (d, J = 1.9 Hz, 1 H), 7.72 (d, J = 6.0 Hz, 1 H), 7.25 (d, J = 1 .6 Hz, 1 H), 7.02 (dd, J = 8.6, 6.4 Hz, 1 H), 6.68 (dd, J = 10.5, 2.7 Hz, 1 H), 6.63 - 6.57 (m, 1 H), 5.67 - 5.43 (m, 2H), 4.92 - 4.76 (m, 3H), 3.98 (q, J = 7.0 Hz, 2H), 1 .29 (t, J = 7.0 Hz, 3H).

Example 18: N4.-((1 H-Pyrazol-3-yl)methyl)-N4.-(4-fluoro-2-(2,2,2- trifluoroethoxy)phenyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 1 using N-((1 H-pyrazol-3-yl)methyl)-4-fluoro-2-(2,2,2-trifluoroethoxy)ani line derived from 4-fluoro-1 -nitro-2-(2,2,2-trifluoroethoxy)benzene (Intermediate 4) in place of 2-ethoxy-4- fluoronitrobenzene in step B and using concentrated H2SO4 in place of p-toluenesulfonic acid monohydrate in Step B to give the title compound. MS (ESI): mass calcd. for

C16H14F4N6O 382.12, m/z found 383.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 11 .00 (br s, 1 H), 7.74 (d, J = 6.1 H z, 1 H), 7.45 (d, J = 1 .8 Hz, 1 H), 6.99 (dd, J = 8.4, 6.2 Hz, 1 H), 6.79 - 6.70 (m, 2H), 6.08 (s, 1 H), 5.50 - 5.23 (m, 2H), 5.09 (s, 2H), 4.65 - 4.45 (m, 1 H), 4.25 (q, J = 7.9 Hz, 2H).

Example 19: N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol-4- ylmethyl)pyrimidine-2,4-diamine.

Step A: 2-Bromo-4-(pentafluorosulfanyl)aniline. To a 500 mL round-bottomed flask were added 4-aminophenylsulfur pentafluoride (4.4 g, 20 mmol) and dichloromethane (120 mL). The solution was cooled to 0 °C, then 1 ,3-dibromo-5,5-dimethylhydantoin (2.8 g, 9.8 mmol) was added. The mixture was stirred at 0 °C for 1 h, then warmed to rt and stirred for 1 h. The mixture was filtered through a pad of diatomaceous earth such as Celite ^® . The filtrate was concentrated to dryness and the residue was purified by FCC to give the title compound (5.8 g, 97% yield) as yellow oil. MS (ESI): mass calcd. for CeHsBrFsNS, 296.92, m/z found 297.9 [M+H] ⁺ .

Step B: 2-Methyl-4-(pentafluorosulfanyl)benzenamine. To a 1 L round-bottomed flask were added 2-bromo-4-(pentafluorosulfanyl)aniline (13.4 g, 44.9 mmol), 2,4,6-trimethyl- 1 , 3,5,2, 4,6-trioxatriborinane (6.80 g, 53.9 mmol), CS2CO3 (29.2 g, 89.8 mmol),

Pd(dppf)Cl2 (3.30 g, 4.50 mmol), H2O (50.0 mL), and toluene (200 mL). The mixture was degassed and refilled with Ar. The reaction mixture was heated at 95 °C for 15 h, and then allowed to cool to rt. The reaction was extracted with EtOAc (2 ^χ 250 mL) and the combined organic layers were washed with saturated aqueous NaCI solution (250 mL), dried over anhydrous Na2S04, concentrated to dryness, and purified by FCC to give the title compound (6.5 g, 62% yield) as yellow oil. MS (ESI): mass calcd. for CyHsFsNS, 233.03, m/z found 234.0 [M+H] ⁺ .

Step C: N.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-2-(methylthio)py rimidin-4-amine. To a 500 mL round-bottomed flask were added 2-methyl-4-

(pentafluorosulfanyl)benzenamine (4.6 g, 20 mmol), 4-chloro-2-(methylthio)pyrimidine (4.8 g, 30 mmol), / ^' -PrOH (45 mL), and concentrated HCI (3.0 mL). The mixture was stirred at 85 °C for 15 h. The mixture was cooled and concentrated to dryness. The residue was dissolved in dichloromethane (500 mL) and washed with saturated

NaHC03 aqueous solution (100 mL), saturated NaCI aqueous solution (100 mL), dried over anhydrous Na2S04, filtered, and concentrated to dryness. The residue was purified by FCC to give the title compound (5.8 g, 54% yield) as yellow oil. MS (ESI): mass calcd. for

Step D: N.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-2-(methylthio)-N .-(oxazol-4- ylmethyl)pyrimidin-4-amine. To a 100 mL round-bottomed flask were added N-(2- methyl-4-(pentafluorosulfanyl)phenyl)-2-(methylthio)pyrimidi n-4-amine (1 .43 g, 4.00 mmol) and DMF (25.0 mL). The solution was cooled to 0 °C, then NaH (60% in mineral oil, 480 mg, 12.0 mmol) was added. The mixture was stirred at 0 °C for 0.5 h, then 4- (bromomethyl)oxazole (HBr salt, 1 .45 g, 6.0 mmol) was added to the reaction mixture and stirred at rt for 15 h. The mixture was diluted with brine (60 mL) and extracted with EtOAc (2 x 200 mL). The organic layers were combined, washed with saturated NaCI (100 mL), filtered, and concentrated to dryness. The residue was purified by FCC to give the title compound (1 .45 g, 83% yield) as colorless oil. MS (ESI): mass calcd. for C16H15F5N4OS2, 438.06, m/z found 439.0 [M+H] ⁺ .

Step E: N.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-2-(methylsulfony l)-N.-(oxazol-4- ylmethyl) pyrimidin-4-amine. To a 1 L round-bottomed flask were added N.-(2-methyl-4- (pentafluorosulfanyl)phenyl)-2-(methylthio)-N.-(oxazol-4-ylm ethyl)pyrimidin-4-amine (1 .45 g, 3.31 mmol), dichloromethane (100 mL), and m-CPBA (85%, 1 .95 g, 9.91 mmol), in sequence at 0 °C. The reaction mixture was stirred at 0 °C for 3 h. The mixture was diluted with dichloromethane (300 ml_), washed with saturated aqueous NaHC03 solution (80.0 ml_), saturated aqueous NaCI solution (80.0 ml_), and

concentrated to dryness. The residue was purified by FCC to give the title compound (1 .25 g, 81 .0% yield) as a yellow solid. MS (ESI): mass calcd. for Ci6Hi5F5N ₄ 03S2, 470.05, m/z found 470.9 [M+H] ⁺ .

Step F: N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol-4-y lmethyl)pyrimidine- 2,4-diamine. To a 100 ml_ sealed vessel were added N.-(2-methyl-4- (pentafluorosulfanyl)phenyl)-2-(methylsulfonyl)-N.-(oxazol-4 -ylmethyl)pyrimidin-4-amine (1 .25 g, 2.65 mmol), NH ₄ OH (25 wt%, 6.00 ml_), and /-PrOH (4.00 ml_). The mixture was stirred at 100 °C for 4 h. The mixture was cooled to rt and concentrated to dryness and the residue was purified by FCC to give the title compound as a white solid (582 mg, 52.3%). MS (ESI): mass calcd. for C15H14F5N5OS, 407.08, m/z found 408.0 [M+H] ⁺ . 1 H NMR (400 MHz, CDsOD) δ 8.13 (s, 1 H), 7.96 (s, 1 H), 7.84 (d, J = 2.2 Hz, 1 H), 7.75 (dd, J = 8.7, 2.5 Hz, 1 H), 7.70 (d, J = 5.9 Hz, 1 H), 7.38 (d, J = 8.7 Hz, 1 H), 5.54 - 5.30 (m, 1 H), 5.28 - 5.10 (m, 1 H), 4.85 - 4.70 (m, 1 H), 2.17 (s, 3H).

Exam le 20: N4.-(4-Bromo-2-(trifluoromethyl)phenyl)-N4.-isopropylpyrimid ine-2,4-diamine

The title compound was prepared using analogous conditions described in Example 19, Steps C-F starting with 2-amino-5-bromobenzotrifluoride in place of 2-methyl-4- (pentafluorosulfanyl)benzenamine in step C and 2-iodopropane in place of 4- (bromomethyl)oxazole hydrobromide in step D. MS (ESI): mass calcd. for Hz, 1 H), 5.22 (d, J = 6.1 Hz, 1 H), 4.86 (s, 2H), 4.75 (hept, J = 6.7 Hz, 1 H), 1 .33 (d, J = 6.5 Hz, 3H), 1 .06 (d, J = 6.9 Hz, 3H).

Example 21 : N4-.(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-ethylpyrimid ine-2,4-diamine

Step A: N.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-2-(methylthio)pyr imidin-4-amine. To a 1 L round-bottomed flask were added 4-chloro-2-(methylthio)pyrimidine (30.2 g, 188 mmol), 2-cyclobutyl-4-(methylsulfonyl)aniline (Intermediate 17, 26.4 g, 1 17 mmol) and / ^' - PrOH (300 mL) under nitrogen, followed by the addition of pTsOH ^» H20 (1 .20 g, 6.31 mmol). The contents were warmed gradually to 70 °C over 40 min and allowed to react at 70 °C for approximately 22 hours, then stirred at room temperature overnight. The reaction was cooled to 0 °C and saturated aqueous sodium bicarbonate (200 mL) and deionized water (400 mL) were added and stirred for approximately 30 minutes. The precipitate was collected via vacuum filtration and rinsed with deionized water (~150 mL) and dried under reduced pressure to yield the title compound (40.5 g, 99.0% yield). MS (ESI): mass calcd. for C16H19N3O2S2, 349.48, m/z found 349.9 [M+H] ⁺ .

Step B: N.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N.-ethyl-2-(methy lthio)pyrimidin-4- amine.

Step B: To a 2 L, 3-neck round-bottomed flask containing a stir bar, condenser, and septa with N2 inlet were added N.-(2-cyclobutyl-4-(methylsulfonyl)phenyl)-2-

(methylthio)pyrimidin-4-amine (68.1 g, 195 mmol), ACN (1.00 L), CS2CO3 (159 g, 487 mmol) and 1 -iodoethane (24.0 mL, 295 mmol) under a nitrogen atmosphere and was immersed in an oil bath 70 °C for one hour, then cooled to room temperature. The reaction mixture was diluted with deionized water (300 mL) and ethyl acetate (300 mL), the layers were separated and the aqueous layer extracted twice with ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. The crude product was filtered prior to purification by FCC (silica gel, 30-40% hexanes/ethyl acetate) to yield the title compound (57.2 g, 77.8% yield). MS (ESI): mass calcd. for C18H23N3O2S2, 377.53, m/z found 377.9 [M+H] ⁺ . ¹ H NMR (400 MHz, CDsOD): δ 8.10 (d, J = 2.2 Hz, 1 H), 7.92 - 7.83 (m, 2H), 7.29 (d, J = 8.2 Hz, 1 H), 5.48 (s, 1 H), 4.30 (s, 1 H), 3.57 - 3.44 (m, 2H), 3.14 (s, 3H), 2.54 (s, 3H), 2.33 - 2.24 (m, 1 H), 2.25 - 2.11 (m, 2H), 2.11 - 2.03 (m, 1 H), 2.03 - 1.92 (m, 1 H), 1 .90 - 1.79 (m, 1 H), 1.23 (t, J = 7.0 Hz, 3H).

Step C: N.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N.-ethyl-2-(methy lsulfonyl)pyrimidin-4- amine. To a 1 L round-bottomed flask were added N.-(2-cyclobutyl-4- (methylsulfonyl)phenyl)-N.-ethyl-2-(methylthio)pyrimidin-4-a mine (28.3 g, 74.8 mmol) followed by DCM (600 mL). The reaction mixture was cooled to 0 °C then treated with m- CPBA (43.4 g, 176 mmol) in small portions over 0.5 h. The reaction mixture was removed from the ice bath and the reaction was stirred an additional 45 min. The reaction mixture was poured onto a stirred solution of 0.5 M Na2S203 (500 mL) then treated with saturated aqueous sodium bicarbonate (500 mL). DCM (250 mL) was added, the mixture was extracted, and the organic layer was separated. The aqueous layer was extracted again with DCM (400 mL). The combined organic layers were dried over anhydrous MgS04 and concentrated to dryness to give a yellow oil/foam. The residue was dissolved in isopropanol (100 mL) and water (100 mL). The resulting emulsion was stirred vigorously at rt. After about 20 minutes, a solid began to form. The mixture was stirred for an additional 15 minutes, filtered, dried under reduced pressure for 16 h, and then dried for an additional 2 h under high vacuum while being heated at 60 °C to give the title compound (21 .8 g, 71.1 % yield) as an off-white solid. MS (ESI): mass calcd. for C18H23N3O4S2, 409.52; m/z found, 410.1 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.17 (s, 1 H), 8.12 (d, J = 6.2 Hz, 1 H), 7.92 (dd, J = 8.4, 2.2 Hz, 1 H), 7.29 (d, J = 8.1 H z, 1 H), 5.90 (d, J = 6.1 H z, 1 H), 4.45 - 4.33 (m, 1 H), 3.64 - 3.53 (m, 1 H), 3.53 - 3.45 (m, 1 H), 3.35 (s, 3H), 3.15 (s, 3H), 2.31 (s, 1 H), 2.26 - 2.17 (m, 1 H), 2.15 - 1 .97 (m, 3H), 1 .93 - 1 .82 (m, 1 H), 1 .26 (t, J = 7.1 Hz, 3H).

Step D: N4.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-ethylpyrimid ine-2,4-diamine. N- (2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N.-ethyl-2-(methylsu lfonyl)pyrimidin-4-amine (1.77 g, 4.33 mmol) was added to a 25 mL microwave vial and then NH ₄ OH (1.0 M in /-PrOH, 8.00 mL, 4.50 mmol) was added. The vial was capped and heated at 130 °C for 1.25 h in the microwave. The contents of the reaction vessel were transferred to a round bottom flask, evaporated to dryness, dissolved in DCM, and purified by FCC (S1O2, EtOAc with 0.1 % EteN) to give the title compound (986 mg, 65.7% yield) as a white solid. MS (ESI): mass calcd. for

1H NMR (600 MHz, CDCb): δ 8.07 (d, J = 2.3 Hz, 1H), 7.84 (dd, J = 8.2, 2.2 Hz, 1H), 7.72 (br s, 1H), 7.29 (d, J = 8.2 Hz, 1H), 5.21 (br s, 1H), 4.84 (s, 2H), 4.22 (br s, 1H), 3.53 (p, J =8.9 Hz, 1H), 3.46-3.38 (m, 1H), 3.15 (s, 3H), 2.32-2.23 (m, 1H), 2.21 - 2.12 (m, 2H), 2.11 -2.03 (m, 1H), 2.02 - 1.92 (m, 1H), 1.86- 1.79 (m, 1H), 1.18 (t, J = 7.1Hz, 3H).

Example 22:N4.-Ethyl-N4.-(2-methyl-4-(pentafluorosulfanyl)phenyl)pyr imidine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 19 using iodoethane in place of 4-(bromomethyl)oxazole hydrobromide in step D. MS (ESI): mass calcd. for

(400 MHz, CDCb): δ 7.73 (d, J = 2.7 Hz, 2H), 7.69-7.64 (m, 1H), 7.22 (d, J = 8.6 Hz, 1H), 5.41-5.18 (m, 1H), 4.88 (br s, 2H), 4.20-4.00 (m, 1H), 3.75-3.53 (m, 1H), 2.21 (s, 3H), 1.19 (t, J = 7.1Hz, 3H).

Example 23:N4.-[2-Ethyl-4-(pentafluorosulfanyl)phenyl]-N4.-(oxazol-4 - ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 2-ethyl-4-(pentafluorothio)aniline in place of 2-methyl-4-

(pentafluorosulfanyl)benzenamine in step C. MS (ESI): mass calcd. for C16H16F5N5OS, 421.4; m/z found, 422.0 [M+H] ⁺ . ¹ H N MR (500 MHz, CD3OD): δ 8.11 (s, 1H), 7.94 (s, 1H), 7.83 (d, J = 2.5 Hz, 1H), 7.72 (dd, J = 8.7, 2.7 Hz, 1H), 7.66 (d, J = 5.8 Hz, 1H), 7.33 (d, J = 8.6 Hz, 1H), 5.43 - 5.04 (m, 2H), 4.67 (d, J = 15.5 Hz, 1H), 2.52 (q, J = 7.6 Hz, 2H), 1.14 (t, J = 7.6 Hz, 3H). Example 24:N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(pyridaz in-3- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 employing 3-(bromomethyl)pyridazine in place of 4-bromomethyloxazole hydrobromide salt in step D. MS (ESI): mass calcd. for CieHisFsNeS, 418.1, m/z found 419.0 [M+H] ⁺ . ¹ H NMR(400MHz, CDCb): δ 9.13 (dd, J = 4.9, 1.6 Hz, 1H), 7.77 (d, J = 6.1 Hz, 1H), 7.74 (dd, J = 8.5, 1.5 Hz, 1H), 7.72 (d, J = 2.5 Hz, 1H), 7.61 (dd, J = 8.7, 2.5 Hz, 1H), 7.49 (dd, J = 8.5, 4.9 Hz, 1H), 7.23 (d, J = 8.7 Hz, 1H), 5.71 (br s, 1H), 5.43 (d, J = 6.0 Hz, 1H), 5.09 (brs, 2H), 4.99 (brs, 1H), 2.18 (s, 3H).

Example 25:N4.-[2-Ethyl-4-(pentafluorosulfanyl)phenyl]-N4.-(1H-pyraz ol-5- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 2-ethyl-4-(pentafluorothio)aniline in place of 2-methyl-4- (pentafluorosulfanyl)benzenamine in step C and 5-(chloromethyl)-1 /-/-pyrazole hydrochloride in place of 4-(bromomethyl)oxazole hydrobromide in step D. MS (ESI): mass calcd. for

CDsOD): 6 7.81 (s, 1 H), 7.75 - 7.62 (m, 2H), 7.54 (s, 1 H), 7.16 (d, J = 8.6 Hz, 1 H), 6.32 (s, 1 H), 5.48 - 5.07 (m, 2H), 4.82 (d, J = 15.6 Hz, 1 H), 2.54 - 2.35 (m, 2H), 1 .08 (t, J = 7.6 Hz, 3H).

Example 26: N4.-[2-Ethyl-4-(pentafluorosulfanyl)phenyl]-N4.-(1 ,3,4-oxadiazol-2- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 2-ethyl-4-(pentafluorothio)aniline in place of 2-methyl-4-

(pentafluorosulfanyl)benzenamine in step C and 2-(chloromethyl)-1 ,3,4-oxadiazole in place of 4-(bromomethyl)oxazole hydrobromide in step D. MS (ESI): mass calcd. for CisHisFsNeOS, 422.4; m/z found, 422.9 [M+H] ⁺ . ¹ H NMR (400 MHz, CDsOD): δ 8.91 (s, 1 H), 7.89 (d, J = 2.5 Hz, 1 H), 7.78 (dd, J = 8.7, 2.6 Hz, 1 H), 7.72 (d, J = 6.0 Hz, 1 H), 7.57 (d, J = 8.7 Hz, 1 H), 5.63 (d, J = 16.4 Hz, 1 H), 5.54 - 5.39 (m, 1 H), 4.98 (d, J = 16.4 Hz, 1 H), 2.62 (q, J = 7.5 Hz, 2H), 1 .20 (t, J = 7.6 Hz, 3H). Example 27: N4.-lsopropyl-N4.-(2-(2-methylprop-1 -en-1 -yl)-4-(pyrrolidin-1 - ylsulfonyl)phenyl)pyrimidine-2,4-diamine.

Step A. 2-chloro-4-(pyrrolidin-1 -ylsulfonyl)aniline. The title compound was prepared as described in Example 29, step A, MS (ESI): mass calcd. for C10H13CIN2O2S, 260.0; m/z found, 260.9 [M+H] ⁺ . ¹ H NMR (400 MHz, Methanol^) δ 7.62 (d, J = 2.1 H z, 1 H), 7.46 (dd, J = 8.6, 2.1 Hz, 1 H), 6.88 (d, J = 8.5 Hz, 1 H), 3.21 - 3.13 (m, 4H), 1 .79 - 1 .71 (m, 4H).

Step B: N-(2-chloro-4-(pyrrolidin-1 -ylsulfonyl)phenyl)-2-(methylthio)pyrimidin-4-amine. The title compound was prepared using analogous conditions described in Example 19. MS (ESI): mass calcd. for

Step C: N4-(2-chloro-4-(pyrrolidin-1 -ylsulfonyl)phenyl)-N4-isopropylpyrimidine-2,4- diamine. 2-lodopropane (0.55 ml_, 5.5 mmol) was added to a stirring mixture of N-(2- chloro-4-(pyrrolidin-1 -ylsulfonyl)phenyl)-2-(methylthio)pyrimidin-4-amine (1 .16 g, 2.8 mmol) and cesium carbonate (2.7 g, 8.3 mmol) in acetonitrile (9 ml_, 2.8 mmol). The mixture was heated at 85 °C for 1 hr then worked-up with DCM and water. The separated organic layer was dried over Na2S04, filtered, and concentrated. The crude material was dissolved in DCM (18.4 ml_, 2.8 mmol) and submerged in an ice bath. 3- Chloroperoxybenzoic acid (1.90 g, 1 1 .0 mmol) was added to the mixture and allowed to stir for 1 hr. The reaction was quenched with sodium thiosulfate (500 mg) and water (10 ml_), then extracted with DCM/sat'd NaHC03. Separated the crude material into 4 separate sealed tubes (for safety reasons), then added 2ml_ IPA and 2ml_ 33% ammonia in H2O in each vial. Heated all 4 vials at 120 °C for 16 hr, then carefully released the pressure for each. A batch work-up with DCM/brine was performed after combining the 4 vials in a separatory funnel. Purified crude over silica gel (0 to 100% EtOAc in hexane) to yield the title product (715. mg, 66% yield). MS (ESI): mass calcd. for C17H22CIN5O2S, 395.1 ; m/z found, 395.9 [M+H] ⁺ . 1 H NMR (400 MHz, Chloroform-d) δ 8.00 (d, J = 2.1 H z, 1 H), 7.80 (dd, J = 8.2, 2.1 Hz, 1 H), 7.75 (d, J = 6.0 Hz, 1 H), 7.39 (d, J = 8.2 Hz, 1 H), 5.20 (d, J = 5.9 Hz, 1 H), 5.15 - 5.04 (m, 1 H), 4.73 (s, 2H), 3.42 - 3.28 (m, 4H), 1 .89 - 1.82 (m, 4H), 1 .33 - 0.97 (m, 6H).

Step D. N ⁴ -lsopropyl-N4.-(2-(2-methylprop-1 -en-1 -yl)-4-(pyrrolidin-1 - ylsulfonyl)phenyl)pyrimidine-2,4-diamine. This title compound was prepared using analogous conditions described in Example 98, step B, using 2,2- dimethylethenylboronic acid. MS (ESI): mass calcd. for C21 H29N5O2S, 415.6; m/z found, 416.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.82 (d, J = 2.1 Hz, 1 H), 7.74 (dd, J = 8.2, 2.2 Hz, 1 H), 7.67 (d, J = 6.1 H z, 1 H), 7.24 (d, J = 8.2 Hz, 1 H), 6.00 (s, 1 H), 5.10 (d, J = 5.9 Hz, 1 H), 5.07 - 4.97 (m, 1 H), 4.78 (s, 2H), 3.36 - 3.29 (m, 4H), 2.08 - 1 .89 (m, 1 H), 1 .85 - 1 .77 (m, 10H), 1 .24 - 1 .00 (m, 5H).

Example 28: N4.-(2-Cyclobutyl-4-(pyrrolidin-1 -ylsulfonyl)phenyl)-N4.-isopropylpyrimidine- -diamine.

The title compound was prepared using analogous conditions described in Example 21 using 2-cyclobutyl-4-(pyrrolidine-1 -sulfonyl)phenylamine in place of 2-cyclobutyl-4- (methylsulfonyl)aniline (Intermediate 17) in step A and 2-iodopropane in place of 1 - iodoethane in step C. MS (ESI): mass calcd. for C21 H29N5O2S, 415.6; m/z found, 416.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDsOD): δ 8.07 (d, J = 2.1 H z, 1 H), 7.77 (dd, J = 8.2, 2.2 Hz, 1 H), 7.57 (d, J = 6.2 Hz, 1 H), 7.33 (d, J = 8.2 Hz, 1 H), 5.30 - 4.99 (m, 2H), 3.67 - 3.52 (m, 1 H), 2.32 - 1.85 (m, 8H), 1 .84 - 1 .72 (m, 4H), 1.39 - 1.20 (m, 5H), 0.94 (d, J = 6.9 Hz, 3H).

Example 29: N4.-(4-((Difluoromethyl)sulfonyl)-2-ethylphenyl)-N4.-(oxazol -4- ylmethyl)pyrimidine-2,4-diamine.

Step A: 2-Chloro-4-((difluoromethyl)sulfonyl)aniline. To a round-bottomed flask were added 4-((difluoromethyl)sulfonyl)aniline (1 .98 g, 9.54 mmol) and ACN (25.0 ml_) and was stirred to dissolve at 50 °C. To this mixture was added NCS (1.26 g, 9.22 mmol) and was stirred for 3 h at 50 °C. The reaction temperature was increased to 75 °C and stirred overnight. The reaction mixture was cooled to rt, washed with DCM, H2O, and saturated NaHC03, and collecting the organic phase. The aqueous phase was extracted again with DCM. The combined organics were dried over anhydrous Na2S04, filtered, and concentrated to dryness. The residue was purified by FCC (120 g S1O2 column, eluent = 0-30 % ethyl acetate/hexanes) to give the title compound (740 mg, 32.0% yield) of an off-white solid.

Step B: N4.-(4-((Difluoromethyl)sulfonyl)-2-ethylphenyl)-N4.-(oxazol -4- ylmethyl)pyrimidine-2,4-diamine. The title compound was prepared using analogous conditions described in Example 21 using 2-chloro-4-(trifluoromethylsulfonyl)aniline in place of 2-bromo-4-(pentafluorosulfanyl)aniline and triethylborane in place of

cyclobutylzinc bromide in step A. MS (ESI): mass calcd. for C17H17F2N5O3S, 409.4; m/z found, 410.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCIs): δ 7.97 (d, J = 2.2 Hz, 1 H), 7.86 (dd, J = 8.3, 2.2 Hz, 1 H), 7.85 - 7.74 (m, 2H), 7.69 - 7.60 (m, 1 H), 7.44 (d, J = 8.3 Hz, 1 H), 6.23 (t, J = 53.4 Hz, 1 H), 5.51 - 5.18 (m, 2H), 4.98 (s, 2H), 4.59 (s, 1 H), 2.56 (q, J = 7.5 Hz, 2H), 1 .19 (t, J = 7.6 Hz, 3H). Example 30: N4.-lsopropyl-N4.-(2-methyl-4-(pentafluorosulfanyl)phenyl)py rimidine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 19 using 2-iodopropane in place of 4-(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for found, m/z = 369.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.73 (d, J = 2.4 Hz, 1 H), 7.70 (d, J = 6.1 Hz, 1 H), 7.66 (dd, J = 8.6, 2.5 Hz, 1 H), 7.19 (d, J = 8.6 Hz, 1 H), 5.26-5.02 (m, 2H), 4.82 (br s, 2H), 2.21 (s, 3H), 1 .38-1 .27 (m, 3H), 1 .06-0.97 (m, 3H).

Example 31 : N4-.(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(2- methoxyethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 1 -bromo-2-methoxyethane in place of 4-(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for C14H17F5N4OS, 384.1 ; m/z found, m/z = 385.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.74 (d, J = 6.0 Hz, 1 H), 7.70 (d, J = 2.2 Hz, 1 H), 7.66 (dd, J = 8.6, 2.4 Hz, 1 H), 7.31 (d, J = 8.6 Hz, 1 H), 5.38 - 5.24 (m, 1 H), 4.88 (br s, 2H), 4.28 - 4.14 (m, 1 H), 3.88 - 3.72 (m, 1 H), 3.68 - 3.54 (m, 2H), 3.31 (s, 3H), 2.20 (s, 3H).

Example 32: N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(pyrimidin- 2- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 2-(chloromethyl)pyrimidine in place of 4-(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for

(400 MHz, CDCb): δ 8.70 (d, J = 4.9 Hz, 2H), 7.82-7.68 (m, 3H), 7.63 (dd, J = 8.7, 2.5 Hz, 1 H), 7.20 (t, J = 4.9 Hz, 1 H), 5.82 - 5.64 (m, 1 H), 5.58 - 5.45 (m, 1 H), 5.30 (br s, 2H), 4.67 (d, J = 14.7 Hz, 1 H), 2.33 (s, 3H).

Example 33: N4.-[(5-Methyloxazol-4-yl)methyl]-N4.-[2-methyl-4- (pentafluorosulfanyl)phenyl]pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 4-(chloromethyl)-5-methyloxazole in place of 4-(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for

NMR (400 MHz, CDCb): δ 7.78 - 7.60 (m, 4H), 7.31 (d, J = 8.6 Hz, 1 H), 5.40 - 5.08 (m, 4H), 4.63 (d, J = 13.6 Hz, 1 H), 2.28 (s, 3H), 2.14 (s, 3H).

Example 34: N4.-(lsoxazol-3-ylmethyl)-N4.-(2-methyl-4- (pentafluorosulfanyl)phenyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 3-(chloromethyl)isoxazole (which was prepared according to Hughes, L. R., era/., Eur. Pat. Appl., EP373891A2) in place of 4-(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for

MHz, CDsOD): 68.62 (d, J= 1.1 Hz, 1H), 7.87 (d, J = 2.3 Hz, 1H), 7.79- 7.68 (m, 2H), 7.34 (d, J=8.6 Hz, 1H), 6.63 (s, 1H), 5.48-5.30 (m, 2H), 5.01-4.91 (m, 1H), 2.17 (s, 3H). Example 35:N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol- 5- lmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 5-(chloromethyl)oxazole, (which was prepared according to Bull, J. A.; era/., Chemistry - A European Journal, 2007, 13(19), 5515-5538) in place of 4-

(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for CisHuFsNsOS, 407.1; m/z found, m/z = 408.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDsOD): δ 8.15 (s, 1H), 7.87 (d, J = 2.4 Hz, 1H), 7.77 (dd, J = 8.7, 2.6 Hz, 1H), 7.72 (d, J = 5.9 Hz, 1H), 7.33 (d, J = 8.6 Hz, 1H), 7.14 (s, 1H), 5.50-5.23 (m, 2H), 5.12-5.00 (m, 1H), 2.13 (s, 3H).

Example 36:N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(oxazol- 2- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 2-(chloromethyl)oxazole in place of 4-(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for

Example 37: N4.-[(3-Chloro-2-pyridyl)methyl]-N4.-[2-methyl-4- (pentafluorosulfanyl)phenyl]pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 2-(bromomethyl)-3-chloropyridine in place of 4-(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for C17H15CIF5N5S, 451.1 ; m/z found, m/z = 452.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.42 (dd, J = 4.7, 1 .4 Hz, 1 H), 7.76 (d, J = 6.0 Hz, 1 H), 7.70 - 7.62 (m, 3H), 7.59 (dd, J = 8.8, 2.5 Hz, 1 H), 7.14 (dd, J = 8.0, 4.7 Hz, 1 H), 5.76 (d, J = 10.4 Hz, 1 H), 5.44 (d, J = 4.6 Hz, 1 H), 4.77 (br s, 2H), 4.68 (d, J = 15.2 Hz, 1 H), 2.30 (s, 3H). Example 38: N4.-(2-Methyl-4-(pentafluorosulfanyl)phenyl)-N4.-(thiazol-4- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 4-(chloromethyl)thiazole in place of 4-(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for C15HMF5N5S2, 423.1; m/z found, m/z = 424.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CD3OD): δ 8.93 (d, J = 1.8 Hz, 1H), 7.82 (d, J = 2.1 Hz, 1H), 7.74 - 7.68 (m, 2H), 7.61 (s, 1H), 7.33 (d, J= 8.7 Hz, 1H), 5.50-5.30 (m, 2H), 5.15-5.00 (m, 1H), 2.10 (s, 3H).

Example 39:N4.-[(4-Fluoro-1H-pyrazol-3-yl)methyl]-N4.-[2-methyl-4- entafluorosulfanyl)phenyl]pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 using 3-(chloromethyl)-4-fluoro-1H-pyrazole in place of 4-(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for CisHuFeNeS, 424.1 ; m/z found, m/z = 425.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 10.94 (br s, 1H), 7.80-7.71 (m, 2H), 7.66 (dd, J = 8.6, 2.4 Hz, 1H), 7.36 (d, J = 4.6 Hz, 1H), 7.15 (d, J = 8.8 Hz, 1H), 5.67 (brs, 2H), 5.41-5.32 (m, 1H), 5.23-5.10 (m, 1H), 4.78-4.65 (m, 1H), 2.13 (s, 3H).

Example 40:N4.-((4-Chloro-1H-pyrazol-3-yl)methyl)-N4.-(2-methyl-4- (pentafluorosulfanyl)phenyl)pyrimidine-2,4-diamine.

Step A. N4.-((4-Chloro-1 -((2-(trimethylsilyl)ethoxy)methyl)-1 H-pyrazol-3-yl)methyl)-N4.-(2- methyl-4-(pentafluorosulfanyl)phenyl)pyrimidine-2,4-diamine. The title compound was prepared using analogous conditions described in Example 19 using 4-chloro-3- (chloromethyl)-l -((2-(trimethylsilyl)ethoxy)methyl)-1 H-pyrazole in place of 4-

(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for C21 H28CIF5N6OSS1, 570.14, m/z found 571 .0 [M+H] ⁺ .

Step B. N4.-((4-Chloro-1 H-pyrazol-3-yl)methyl)-N4.-(2-methyl-4-

(pentafluorosulfanyl)phenyl)pyrimidine-2,4-diamine. To a 100 mL round-bottomed flask were addedN4.-((4-chloro-1 -((2-(trimethylsilyl)ethoxy)methyl)-1 /-/-pyrazol-3-yl)methyl)- N4.-(2-methyl-4-(pentafluorosulfanyl)phenyl)pyrimidine-2,4-d iamine (260 mg, 0.45 mmol), MeOH (20 mL), and concentrated HCI (2mL). The reaction mixture was stirred at 45 °C for 15 h, and then concentrated to dryness. The residue was dissolved in DCM (150 mL), washed with saturated aqueous NaHC03 solution (30 mL), water (30 mL), and concentrated to dryness. The residue was purified by FCC to give the title compound as a white solid (95 mg). MS (ESI): mass calcd. for C15HMCIF5N6S, 440.06, m/z found 441 .0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 11 .38 (br s, 1 H), 7.78 (d, J = 6.0 Hz, 1 H), 7.71 (d, J = 2.3 Hz, 1 H), 7.63 (dd, J = 8.7, 2.4 Hz, 1 H), 7.46 (s, 1 H), 7.11 (d, J = 8.6 Hz, 1 H), 5.34 (d, J = 5.8 Hz, 1 H), 5.28 - 5.06 (m, 3H), 4.75 (br s, 1 H), 2.09 (s, 3H).

Example 41 : N4-.[2-Methyl-4-(pentafluorosulfanyl)phenyl]-N4.-(1 /-/-pyrazol-3- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 40 steps A-D, using 3-(chloromethyl)-1 -((2-(trimethylsilyl)ethoxy)methyl)-1 /-/-pyrazole . MS (ESI): mass calcd. for

(400 MHz, CDCb): δ 11 .03 (br s, 1 H), 7.78 (d, J = 6.0 Hz, 1 H), 7.69 (d, J = 2.4 Hz, 1 H), 7.60 (dd, J = 8.6, 2.4 Hz, 1 H), 7.49 (d, J = 1 .8 Hz, 1 H), 7.05 (d, J = 8.6 Hz, 1 H), 6.14 (s, 1 H), 5.25 (m, 2H), 5.02 (br s, 2H), 4.79-4.64 (m, 1 H), 2.05 (s, 3H).

Example 42: N4. -Ethyl-N4.-(2-ethyl-4-((trifluoromethyl)sulfonyl)phenyl)pyri midine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 19 starting with 4-((trifluoromethyl)sulfonyl)aniline in step A, and 2,4,6-triethyl-1 ,3,5,2,4,6- trioxatriborinane in place of 2,4, 6-trimethyl-1 , 3,5,2, 4,6-trioxatriborinane in step B, and iodoethane in place of 4-(bromomethyl)oxazole in step D. MS (ESI): mass calcd. for

10.94 (br s, 1 H), 7.80-7.71 (m, 2H), 7.66 (dd, J = 8.6, 2.4 Hz, 1 H), 7.36 (d, J = 4.6 Hz, 1 H), 7.15 (d, J = 8.8 Hz, 1 H), 5.67 (br s, 2H), 5.41 -5.32 (m, 1 H), 5.23-5.10 (m, 1 H), 4.78-4.65 (m, 1 H), 2.13 (s, 3H).

Example 43: N4. -(2-Cyclobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-ethy lpyrimidine- 2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting with 2-cyclobutyl-(4-(trifluoromethyl)sulfonyl)aniline in place of 2-cyclobutyl-4- (methylsulfonyl)aniline (Intermediate 17) MS (ESI): mass calcd. for Ci7Hi9F3N ₄ 02S, 400.4; m/z found, 401 .1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.12 (d, J = 2.4 Hz, 1 H), 7.93 (dd, J = 8.2, 2.2 Hz, 1 H), 7.77 (d, J = 6.0 Hz, 1 H), 7.38 (d, J = 8.3 Hz, 1 H), 5.32 (s, 1 H), 4.91 (s, 2H), 4.19 (s, 1 H), 3.63 - 3.39 (m, 2H), 2.38 - 1 .80 (m, 6H), 1.20 (t, J = 7.0 Hz, 3H). Example 44: N4. -(2-Cyclobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(oxa zol-4- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting with 2-cyclobutyl-(4-(trifluoromethyl)sulfonyl)aniline in place of 2-cyclobutyl-4- (methylsulfonyl)aniline (Intermediate 17) and using 4-bromomethyloxazole in place of 1 - iodoethane in Step C. MS (ESI): mass calcd. for C19H18F3N5O3S, 453.4; m/z found, 453.9 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.09 - 8.02 (m, 1 H), 7.90 (dd, J = 8.3, 2.2 Hz, 1 H), 7.84 - 7.77 (m, 2H), 7.65 (s, 1 H), 7.52 (d, J = 8.3 Hz, 1 H), 5.53 - 5.21 (m, 2H), 4.83 (s, 2H), 4.49 - 4.29 (m, 1 H), 3.51 (p, J = 8.9 Hz, 1 H), 2.28 - 2.16 (m, 2H), 2.16 - 2.03 (m, 2H), 2.03 - 1.92 (m, 1 H), 1 .90 - 1 .77 (m, 1 H). Example 45: N4. -(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-isopropylpyrimi dine-2,4-

The title compound was prepared using analogous conditions described in Example 21 employing 2-iodopropane in place of 1 -iodoethane in step C. MS (ESI): mass calcd. for Ci8H24N ₄ 0 ₂ S, 360.5; m/z found, 361 .0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.20 (d, J = 2.2 Hz, 1 H), 7.82 (dd, J = 8.2, 2.3 Hz, 1 H), 7.66 (d, J = 6.1 Hz, 1 H), 7.23 (d, J = 8.2 Hz, 1 H), 5.23 - 4.87 (m, 2H), 4.81 (s, 2H), 3.62 - 3.50 (m, 1 H), 3.16 (s, 3H), 2.27 - 2.14 (m, 2H), 2.14 - 1 .99 (m, 2H), 1 .99 - 1 .78 (m, 2H), 1.28 (d, J = 6.6 Hz, 3H), 0.89 (d, J = 6.9 Hz, 3H).

Example 46: N4. -(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(oxazol-2 - ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 4-amino-3-ethylphenyl trifluoromethanesulfonate (Intermediate 7) and 2-(bromomethyl)oxazole in place of 1 -iodoethane in Step C. MS (ESI): mass calcd. for C17H16F3N5O3S, 427.4; m/z found, 427.9 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.03 (d, J = 2.1 H z, 1 H), 7.93 (dd, J = 8.3, 2.2 Hz, 1 H), 7.84 (d, J = 6.0 Hz, 1 H), 7.65 (d, J = 8.3 Hz, 1 H), 7.61 (d, J = 0.8 Hz, 1 H), 7.06 (d, J = 0.8 Hz, 1 H), 5.81 - 5.20 (m, 2H), 4.98 - 4.51 (m, 3H), 2.62 (q, J = 7.5 Hz, 2H), 1 .22 (t, J = 7.5 Hz, 3H). Example 47: N4. -(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-((3-fluor opyndin-4- yl)methyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 4-amino-3-ethylphenyl trifluoromethanesulfonate (Intermediate 7) and 4-(bromomethyl)-3-fluoropyridine in place of 1 -iodoethane in Step C. MS (ESI): mass calcd. for

Example 48: N4. -(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-((6-(trifluorom ethyl)pyridin- 2- l)methyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 employing 2-(chloromethyl)-6-(trifluoromethyl)pyridine in place of 1 -iodoethane. MS (ESI): mass calcd. for C22H22F3N5O2S, 477.5; m/z found, 478.15 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.03 (d, J = 2.2 Hz, 1 H), 7.86 (t, J = 7.8 Hz, 1 H), 7.83 - 7.74 (m, 2H), 7.66 (d, J = 7.9 Hz, 1 H), 7.57 (dd, J = 7.7, 1 .0 Hz, 1 H), 7.44 (d, J = 8.2 Hz, 1 H), 5.70 (d, J = 15.6 Hz, 1H), 5.37 (s, 1H), 5.02 (s, 2H), 4.53 (d, J = 15.9 Hz, 1H), 3.62 - 3.50 (m, 1H), 3.11 (s, 3H), 2.29-1.90 (m, 5H), 1.88-1.77 (m, 1H).

Example 49:N4.-((3,5-Dimethylisoxazol-4-yl)methyl)-N4.-(2-ethyl-4- ((trifluoromethyl)sulfonyl)phenyl)pynmidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 4-amino-3-ethylphenyl trifluoromethanesulfonate (Intermediate 7) and subsequently using 4-(chloromethyl)-3,5-dimethylisoxazole in place of 1- iodoethane in Step C. MS (ESI): mass calcd. for C19H20F3N5O3S, 455.5; m/z found,

456.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.05 (d, J = 2.1Hz, 1H), 7.93 (dd, J = 8.3, 2.2 Hz, 1H), 7.79 (d, J = 5.1 Hz, 1H), 7.22 (d, J = 8.3 Hz, 1H), 5.19 (d, J = 5.9 Hz, 1H), 5.10 (s, 1H), 4.96 - 4.72 (m, 3H), 2.57-2.28 (m, 2H), 2.00 (s, 3H), 1.98 (s, 3H), 1.13 (t, J = 7.6 Hz, 3H).

Example 50:N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(py rimidin-2- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 4-amino-3-ethylphenyl trifluoromethanesulfonate (Intermediate 7) and subsequently using 2-(chloromethyl)pyrimidine in place of 1 -iodoethane. MS (ESI): mass calcd. for C18H17F3N6O2S, 438.4; m/z found, 438.9 [M+H] ⁺ . 1 H NMR (400 MHz, CDCb): δ 8.69 (d, J = 4.9 Hz, 2H), 8.02 (dd, J = 5.3, 3.1 Hz, 2H), 7.91 (dd, J = 8.4, 2.2 Hz, 1 H), 7.82 (s, 1 H), 7.19 (t, J = 4.9 Hz, 1 H), 6.07 - 5.35 (m, 2H), 5.16 - 4.30 (m, 3H), 2.72 (q, J = 7.4 Hz, 2H), 1 .26 (t, J = 7.6 Hz, 3H).

Example 51 : N4.-(2-Cyclobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.- isopropylpyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting with 2-bromo-4-(trifluoromethylsulfonyl)aniline in place of 2-bromo-4- (pentafluorosulfanyl)aniline and 2-iodopropane in place of 1 -iodoethane. MS (ESI): mass calcd. for Ci8H2iF ₃ N ₄ 0 ₂ S, 414.5; m/z found, 415.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.25 (d, J = 2.2 Hz, 1 H), 7.93 (dd, J = 8.3, 2.3 Hz, 1 H), 7.72 (d, J = 6.0 Hz, 1 H), 7.34 (d, J = 8.3 Hz, 1 H), 5.14 - 4.97 (m, 2H), 4.76 (s, 2H), 3.58 (p, J = 8.9 Hz, 1 H), 2.19 (s, 3H), 2.08 - 1.83 (m, 3H), 1.32 (s, 3H), 0.94 (s, 3H).

Example 52: N4.-lsopropyl-N4.-(2-methyl-4-(trifluoromethoxy)phenyl)pyrim idine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 19 starting with 2-methyl-4-(trifluoromethoxy)aniline in place of 2-methyl-4- (pentafluorosulfanyl)aniline in step C and 2-iodopropane in place of 1 -iodoethane in step D. MS (ESI): mass calcd. for

(500 MHz, CDsOD): δ 7.58 (d, J = 6.3 Hz, 1 H), 7.37 - 7.25 (m, 1 H), 7.24 (d, J = 1 .1 H z, 2H), 5.35 - 4.96 (m, 2H), 2.17 (s, 3H), 1 .31 (d, J = 6.6 Hz, 3H), 1 .00 (d, J = 6.9 Hz, 3H).

Example 53: N4.-(2-Ethyl-4-(trifluoromethoxy)phenyl)-N4.-(oxazol-4-ylmet hyl)pyrimidine- 2,4-diamine.

N4.-(2-bromo-4-(trifluoromethoxy)phenyl)- N4.-(oxazol-4-ylmethyl)pyrimidine-2,4-diamine (structure not shown) was prepared using analogous conditions described in Example 21 . N4. -(2-bromo-4-(trifluoromethoxy)phenyl)- N4.-(oxazol-4-ylmethyl)pyrimidine-2,4- diamine was then converted to the title compound using conditions analogous to those described in the synthesis of 2-cyclobutyl-4-(methylsulfonyl)aniline (Intermediate 17). MS (ESI): mass calcd. for C17H16F3N5O2, 379.3; m/z found, 380.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CD3OD): δ 8.11 (d, J = 1 .0 Hz, 1 H), 7.92 (d, J = 1 .0 Hz, 1 H), 7.63 (d, J = 6.1 Hz, 1 H), 7.33 - 7.27 (m, 1 H), 7.23 - 7.15 (m, 2H), 5.33 - 5.24 (broad, 2H), 4.61 (d, J = 15.2 Hz, 1 H), 2.46 (q, J = 7.6 Hz, 2H), 1 .12 (t, J = 7.6 Hz, 3H).

Example 54: N4.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-propylpyrimi dine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 21 employing 1-iodopropane in place of 1-iodoethane. MS (ESI): mass calcd. for

Ci8H24N ₄ 0 ₂ S, 360.5; m/z found, 361.2 [M+H] ⁺ . ¹ H NMR (500 MHz, CDsOD): 68.10 (s, 1H), 7.89 (dd, J = 8.2, 1.7 Hz, 1H), 7.62 (s, 1H), 7.40 (d, J = 8.2 Hz, 1H), 5.34 (br s, 1H), 4.13 (s, 1H), 3.68-3.52 (m, 1H), 3.40-3.32 (m, 1H), 3.19 (s, 3H), 2.36-2.26 (m, 1H), 2.25-2.18 (m, 1H), 2.17-2.04 (m, 2H), 2.03-1.94 (m, 1H), 1.91 -1.81 (m, 1H), 1.76 - 1.66 (m, 1H), 1.65 - 1.57 (m, 1H), 0.92 (t, J = 7.4 Hz, 3H). Example 55:N4.-(2-Cyclopropyl-4-(methylsulfonyl)phenyl)-N4.-ethylpyr imidine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 2-cyclopropyl-4-(ethylsulfonyl)aniline (Intermediate 12). MS (ESI): mass calcd. for C16H20N4O2S, 332.4; m/z found, 333.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.78 (dd, J = 8.2, 2.2 Hz, 1H), 7.74 (d, J = 5.9 Hz, 1H), 7.46 (d, J = 2.2 Hz, 1H), 7.31 (d, J = 8.2 Hz, 1H), 5.37 (s, 1H), 4.78 (s, 2H), 4.16 (s, 1H), 3.72 (s, 1H), 3.09 (s, 3H), 1.94-1.81 (m, 1H), 1.21 (t, J = 7.1Hz, 3H), 1.09-0.95 (m, 2H), 0.87- 0.68 (m, 2H).

Example 56:N4.-(2-Cyclopropyl-4-(methylsulfonyl)phenyl)-N4.-propylpy rimidine-2,4- The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 2-cyclopropyl-4-(ethylsulfonyl)aniline (Intermediate 13) and 1 - iodopropane in place of 1 -iodoethane in Step C. MS (ESI): mass calcd. for

Ci7H22N ₄ 0 ₂ S, 346.5; m/z found, 347.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.77 (dd, J = 8.2, 2.2 Hz, 1 H), 7.74 (d, J = 6.1 Hz, 1 H), 7.45 (d, J = 2.2 Hz, 1 H), 7.31 (d, J = 8.2 Hz, 1 H), 5.36 (s, 1 H), 4.76 (s, 2H), 4.05 (s, 1 H), 3.58 (s, 1 H), 3.09 (s, 3H), 1 .92 - 1 .77 (m, 1 H), 1 .78 - 1 .53 (m, 2H), 1 .12 - 0.96 (m, 2H), 0.92 (t, J = 7.4 Hz, 3H), 0.86 - 0.67 (m,

2H). Example 57: N4.-(2-Cyclopropyl-4-(ethylsulfonyl)phenyl)-N4.-ethylpyrimid ine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A Example 58: N4.-Ethyl-N4.-(2-isobutyl-4-(methylsulfonyl)phenyl)pyrimidin e-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 2-isobutyl-4-(methylsulfonyl)aniline (Intermediate 14). MS (ESI): mass calcd. for

CDCb): δ 7.94 (d, J = 2.2 Hz, 1H), 7.84 (dd, J = 8.2, 2.3 Hz, 1H), 7.73 (d, J = 6.0 Hz, 1H), 7.32 (d, J = 8.2 Hz, 1H), 4.94 (s, 2H), 4.32 (s, 1H), 3.34 (s, 1H), 3.12 (s, 3H), 2.48 - 2.38 (m, 3H), 1.99 (dq, J= 13.6, 6.8 Hz, 1H), 1.21 (t, J = 7.0 Hz, 3H), 0.87 (s, 6H).

Example 59:N4.-(2-Cyclobutyl-4-methylsulfonylphenyl)-N4.-(oxazol-4- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 using 4-bromomethyloxazole in place of 1-iodoethane, in Step C. MS (ESI): mass calcd. for C19H21N5O3S, 399.5; m/z found, 400.2 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.03 (d, J = 2.2 Hz, 1H), 7.88 - 7.72 (m, 3H), 7.67 (s, 1H), 7.42 - 7.31 (m, 1H), 5.41 (d, J= 15.6 Hz, 1H), 5.33-5.27 (m, 1H), 5.09 (s, 2H), 4.38 (d, J= 15.3 Hz, 1H), 3.56- 3.44 (m, 2H), 3.13 (s, 3H), 2.48 (s, 1H), 2.25 - 2.04 (m, 2H), 2.02 - 1.89 (m, 1H), 1.87 - 1.76 (m, 1H).

Example 60:N4.-(2-Cyclobutyl-4-methylsulfonylphenyl)-N4.-(2-methoxye thyl)pyrimidine- 2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 using 2-bromoethyl methyl ether in place of 1-iodoethane in step C. MS (ESI): mass calcd. for C18H24N4O3S, 376.5; m/z found, 377.05 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.04 (d, J = 2.2 Hz, 1 H), 7.84 (dd, J = 8.2, 2.2 Hz, 1 H), 7.72 (d, J = 5.9 Hz, 1 H), 7.42 (d, J = 8.2 Hz, 1 H), 5.24 (s, 1 H), 4.94 (s, 2H), 4.39 (s, 1 H), 3.72 - 3.66 (m, 1 H), 3.61 - 3.44 (m, 4H), 3.31 (s, 3H), 3.13 (s, 3H), 2.32 - 2.23 (m, 2H), 2.21 - 1.91 (m, 4H), 1 .88 - 1 .78 (m, 1 H).

Example 61 : N4-.Ethyl-N4.-(2-ethyl-4-(methylsulfonyl)phenyl)pyrimidine-2 ,4-diamine

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 2-ethyl-4-(methylsulfonyl)aniline (Intermediate 9). MS (ESI): mass calcd. for Ci ₅ H2oN ₄ 0 ₂ S, 320.4; m/z found, 320.95 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.98 (d, J = 2.2 Hz, 1 H), 7.87 (dd, J = 8.3, 2.2 Hz, 1 H), 7.73 (d, J = 6.0 Hz, 1 H), 7.33 (d, J = 8.2 Hz, 1 H), 5.31 (s, 1 H), 5.20 (s, 2H), 4.18 (s, 1 H), 3.55 (s, 1 H), 3.15 (s, 3H), 2.58 (q, J = 7.6 Hz, 2H), 1 .21 (q, J = 7.5 Hz, 6H).

Example 62: N4. -(2-lsobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(oxazo l-4- ylmethyl)pyrimidine-2,4-diamine.

Step A. N4. -(2-(2-methylprop-1 -en-1 -yl)-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(oxazol-4- ylmethyl)pyrimidine-2,4-diamine. The title compound was prepared using analogous conditions described in Example 19 starting with 4-((trifluoromethyl)sulfonyl)aniline in place of 4-(pentafluorosulfanyl)aniline in step A and 2,2-dimethylenylboronic acid pinacol ester in place of 2,4,6-trimethyl-1 ,3,5,2,4,6-trioxatriborinane in step B. MS (ESI): mass calcd. for C19H18F3N5O3, 453.11 ; m/z found, 453.9 [M+H] ⁺ .

Step B: N4. -(2-lsobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(oxazo l-4- ylmethyl)pyrimidine-2,4-diamine. To a 10 mL microwave vial was charged a solution of N4-(2-(2-methylprop-1 -en-1 -yl)-4-((trifluoromethyl)sulfonyl)phenyl)-N4-(oxazol-4- ylmethyl)pyrimidine-2,4-diamine (31 mg, 0.068 mmol) in ethanol (1 .4 mL). Resulting solution was sparged with nitrogen for 15 min then 10% Pd/C was added. The resulting mixture was gain sparged with nitrogen for 15 min, then hydrogen gas (1 atm) was introduced by sparging mixture for 15 min then maintain under a static 1 atm. The mixture was heated to 50 °C. After 3 h, the mixture was sparged with nitrogen to remove the hydrogen gas and the mixture was filtered through a pad of diatomaceous earth such as Celite ^® . The filter cake was rinsed with copious amount of ethanol and ethyl acetate. The filtrate was concentrated to dryness. Purification by acidic HPLC afforded 13 mg of N4.-(2-lsobutyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(ox azol-4- ylmethyl)pyrimidine-2,4-diamine. MS (ESI): mass calcd. for C19H20F3N5O3S, 455.5; m/z found, 456.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCIs): δ 7.98 (d, J = 2.2 Hz, 1 H), 7.91 (dd, J = 8.4, 2.3 Hz, 1 H), 7.82 (d, J = 1.0 Hz, 1 H), 7.79 (d, J = 6.0 Hz, 1 H), 7.68 (d, J = 1 .0 Hz, 1 H), 7.52 (d, J = 8.3 Hz, 1 H), 5.62 - 5.21 (m, 2H), 4.91 (s, 2H), 4.57 - 4.18 (m, 1 H), 2.44 (d, J = 7.2 Hz, 2H), 1 .93 (dp, J = 13.6, 6.9 Hz, 1 H), 0.84 (d, J = 6.6 Hz, 6H). Example 63: N4. -(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-isopropyl pyrimidine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 4-amino-3-ethylphenyl trifluoromethanesulfonate (Intermediate 7) and 2-iodopropane in place of 1 -iodoethane. MS (ESI): mass calcd. for

Ci6Hi9F ₃ N ₄ 0 ₂ S, 388.4; m/z found, 388.9 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCIs): δ 8.06 (d, J = 2.2 Hz, 1H), 7.94 (dd, J = 8.3, 2.2 Hz, 1H), 7.74 (d, J = 6.0 Hz, 1H), 7.39 (d, J Hz, 1H), 5.15 (d, J = 6.0 Hz, 1H), 5.11 -4.96 (m, 1H), 4.81 (s, 2H), 2.60 (q, J =7.

2H), 1.51 -0.80 (m, 9H).

Example 64:N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(ox azol-4- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 4-amino-3-ethylphenyl trifluoromethanesulfonate (Intermediate 7) and 4-bromomethyloxazole in place of 1-iodoethane. MS (ESI): mass calcd. for

C17H16F3N5O3S, 427.4; m/z found, 427.9 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.01 (d, J = 2.1Hz, 1H), 7.96-7.88 (m, 1H), 7.84-7.77 (m, 2H), 7.69-7.62 (m, 1H), 7.49 (d, J = 8.3 Hz, 1H), 5.34 (s, 1H), 4.83 (s, 2H), 2.57 (q, J= 7.6 Hz, 2H), 1.19 (t, J= 7.5 Hz, 3H).

Example 65:N4.-(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-((6-(trifluoro methyl)pyridin-2- yl)methyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 2-ethyl-4-(methylsulfonyl)aniline (Intermediate 9) and 2- (chloromethyl)-6-(trifluoromethyl)pyridine in place of 1-iodoethane. MS (ESI): mass calcd. for C20H20F3N5O2S, 451.5; m/z found, 452.2 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.96 (d, J = 2.2 Hz, 1 H), 7.90 - 7.74 (m, 3H), 7.70 (d, J = 7.9 Hz, 1 H), 7.57 (d, J = 7.7 Hz, 1 H), 7.45 (d, J = 8.3 Hz, 1 H), 5.63 (d, J = 14.0 Hz, 1 H), 5.38 (s, 1 H), 5.14 (d, J = 3.5 Hz, 2H), 4.70 (d, J = 15.7 Hz, 1 H), 3.10 (s, 3H), 2.58 (q, J = 7.5 Hz, 2H), 1 .19 (t, J = 7.5 Hz, 3H).

Example 66: N4.-(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-(2-methoxyethyl)p yrimidine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 2-ethyl-4-(methylsulfonyl)aniline (Intermediate 9) and 2- bromoethyl methyl ether in place of 1 -iodoethane. MS (ESI): mass calcd. for

Ci6H22N ₄ 0 ₃ S, 350.4; m/z found, 351 .0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.95 (d, J = 2.2 Hz, 1 H), 7.85 (dd, J = 8.2, 2.3 Hz, 1 H), 7.76 - 7.68 (m, 1 H), 7.43 (d, J = 8.2 Hz, 1 H), 5.28 (s, 1 H), 5.11 (s, 2H), 4.32 (s, 1 H), 3.71 - 3.56 (m, 3H), 3.30 (s, 3H), 3.13 (s, 3H), 2.57 (p, J = 7.6 Hz, 2H), 1 .22 (t, J = 7.6 Hz, 3H).

Example 67: N4.-(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-(pyrimidin-4-ylme thyl)pyrimidine- 2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 employing starting at Step A using 2-ethyl-4-(methylsulfonyl)aniline (Intermediate 9) and 4-(bromomethyl)pyrimidine hydrobromide in place of 1 -iodoethane. MS (ESI): mass calcd. for C18H20N6O2S, 384.5; m/z found, 385.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 9.12 (d, J = 1 .4 Hz, 1 H), 8.70 (d, J = 5.2 Hz, 1 H), 7.97 (d, J = 2.2 Hz, 1 H), 7.85 - 7.73 (m, 2H), 7.52 - 7.43 (m, 2H), 5.57 (d, J = 16.8 Hz, 1 H), 5.40 (d, J = 6.0 Hz, 1 H), 5.01 (s, 2H), 4.56 (d, J = 17.0 Hz, 1 H), 3.10 (d, J = 7.1 Hz, 3H), 2.60 (q, J = 7.6 Hz, 2H), 1 .22 (t, J = 7.5 Hz, 3H).

Example 68: N4.-(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-(oxazol-4-ylmethy l)pyrimidine- 2 4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 2-ethyl-4-(methylsulfonyl)aniline (Intermediate 9) and 4- (bromomethyl)oxazole in place of 1 -iodoethane. MS (ESI): mass calcd. for

= 2.2 Hz, 1 H), 7.87 - 7.79 (m, 2H), 7.75 (d, J = 6.0 Hz, 1 H), 7.69 (d, J = 1 .1 Hz, 1 H), 7.34 (d, J = 8.2 Hz, 1 H), 5.32 (d, J = 11 .2 Hz, 2H), 5.22 (s, 2H), 4.55 (d, J = 15.3 Hz, 1 H), 3.12 (s, 3H), 2.54 (q, J = 7.6 Hz, 2H), 1.18 (q, J = 7.4 Hz, 3H).

Example 69: N4.-((1 /-/-Pyrazol-5-yl)methyl)-N4.-(2-cyclobutyl-4- methylsulfonyl)phenyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 employing 5-(chloromethyl)-1 /-/-pyrazole hydrochloride in place of 1 -iodoethane. MS (ESI): mass calcd. for C19H22N6O2S, 398.5; m/z found, 399.1 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.04 (d, J = 2.2 Hz, 1H), 7.80 - 7.70 (m, 2H), 7.51 - 7.46 (m, 1H), 7.09 -7.03 (m, 1H), 6.14 (s, 1H), 5.42 (d, J = 14.5 Hz, 1H), 5.23 (s, 1H), 5.14 (s, 2H), 4.46 (d, J= 15.2 Hz, 1H), 3.50-3.39 (m, 1H), 3.12 (s, 3H), 2.21 - 1.99 (m, 4H), 2.00-1.87 (m, 1H), 1.86 -1.75 (m, 1H).

Example 70:N4.-(2-Cyclobutyl-4-(methylsulfonyl)phenyl)-N4.-(pyrimidi n-4- ylmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 employing 4-(bromomethyl)pyrimidine hydrobromide in place of 1-iodoethane. MS (ESI): mass calcd. for C20H22N6O2S, 410.5; m/z found, 411.2 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 9.12 (d, J = 1.5 Hz, 1H), 8.70 (d, J = 5.2 Hz, 1H), 8.07 - 7.98 (m, 1H), 7.83 - 7.74 (m, 2H), 7.50 - 7.40 (m, 2H), 5.62 (d, J = 16.1 Hz, 1H), 5.41 - 5.37 (m, 1H), 4.91 (s, 2H), 4.42 (d, J= 16.5 Hz, 1H), 3.68-3.50 (m, 1H), 3.09 (d, J= 18.4 Hz, 3H), 2.28 - 2.06 (m, 4H), 2.07 - 1.79 (m, 2H).

Example 71 : N4-.(2-Ethyl-4-(methylsulfonyl)phenyl)-N4.-isopropylpyrimidi ne-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 2-ethyl-4-(methylsulfonyl)aniline (Intermediate 9) and 2- iodopropane in place of 1-iodoethane. MS (ESI): mass calcd. for Ci6H22N ₄ 02S, 334.4; m/z found,

(dd, J = 8.2, 2.2 Hz, 1 H), 7.67 - 7.62 (m, 1 H), 7.30 (d, J = 8.2 Hz, 1 H), 5.16 (s, 1 H), 5.05 (d, J = 21 .0 Hz, 2H), 3.36 (s, 1 H), 3.16 (s, 3H), 2.58 (qd, J = 7.6, 4.0 Hz, 2H), 1 .33 (d, J = 6.6 Hz, 3H), 1 .23 (t, J = 7.6 Hz, 3H), 0.99 (d, J = 6.9 Hz, 3H). Exam le 72: N4.-(2-lsobutyl-4-(methylsulfonyl)phenyl)-N4.-propylpyrimidi ne-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 2-isobutyl-4-(methylsulfonyl)aniline (Intermediate 14) and 1 - iodopropane in place of 1 -iodoethane. MS (ESI): mass calcd. for Ci8H26N ₄ 02S, 362.5; m/z found, 363.0 [M+H] ⁺ . ¹ H N MR (400 MHz, CDCb): δ 7.94 (d, J = 2.2 Hz, 1 H), 7.84 (dd, J = 8.2, 2.2 Hz, 1 H), 7.73 (d, J = 6.1 Hz, 1 H), 7.33 (d, J = 8.2 Hz, 1 H), 5.34 - 5.28 (m, 1 H), 5.05 (s, 2H), 4.21 (s, 1 H), 3.13 (s, 4H), 2.43 (dd, J = 15.5, 7.6 Hz, 2H), 2.05 - 1 .92 (m, 1 H), 1 .58 (d, J = 9.7 Hz, 2H), 0.94 - 0.83 (m, 9H). Example 73: N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-((6- trifluoromethyl)pyridin-2-yl)methyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 4-amino-3-ethylphenyl trifluoromethanesulfonate (Intermediate

7) and 2-(chloromethyl)-6-(trifluoromethyl)pyridine in place of 1 -iodoethane. MS (ESI): mass calcd. for C20H17F6N5O2S, 505.4; m/z found, 505.9 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.02 (d, J = 2.2 Hz, 1 H), 7.94 - 7.89 (m, 1 H), 7.89 - 7.83 (m, 1 H), 7.83 - 7.77 (m, 1 H), 7.69 - 7.55 (m, 3H), 5.77 - 5.23 (m, 2H), 5.00 - 4.53 (m, 3H), 2.62 (q, J Hz, 2H), 1 .21 (t, J = 7.6 Hz, 3H).

Example 74: N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(pynmi din-4- lmethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 4-amino-3-ethylphenyl trifluoromethanesulfonate (Intermediate 7) and 4-(brornomethyl)pyridine hydrobromide in place of 1 -iodoethane. MS (ESI): mass calcd. for C18H17F3N6O2S, 438.4; m/z found, 438.9 [M+H] ⁺ . ¹ H NMR (400 MHz, , CDCb): 6 9.13 (d, J = 1 .4 Hz, 1 H), 8.71 (d, J = 5.2 Hz, 1 H), 8.04 (d, J = 2.1 Hz, 1 H), 7.93 (dd, J = 8.3, 2.2 Hz, 1 H), 7.84 (d, J = 5.9 Hz, 1 H), 7.66 (d, J = 8.3 Hz, 1 H), 7.43 (dd, J = 5.2, 1 .4 Hz, 1 H), 5.81 - 5.18 (m, 2H), 5.07 - 4.34 (m, 3H), 2.64 (q, J = 7.5 Hz, 2H), 1 .23 (t, J = 7.6 Hz, 3H).

Example 75: N4.-(2-Ethyl-4-((trifluoromethyl)sulfonyl)phenyl)-N4.-(2- methox ethyl)pyrimidine-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 4-amino-3-ethylphenyl trifluoromethanesulfonate (Intermediate 7) and 2-bromoethyl methyl ether in place of 1 -iodoethane. MS (ESI): mass calcd. for C16H19F3N4O3S, 404.4; m/z found, 405.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.02 (d, J = 2.1 H z, 1 H), 7.94 (dd, J = 8.2, 2.2 Hz, 1 H), 7.77 (d, J = 6.0 Hz, 1 H), 7.54 (d, J = 8.3 Hz, 1 H), 5.30 (s, 1 H), 4.87 (s, 2H), 4.26 (s, 1 H), 3.64 (s, 3H), 3.29 (s, 3H), 2.58 (q, J = 7.5 Hz, 2H), 1 .22 (t, J = 7.4 Hz, 3H).

Example 76: N4.-(4-((Difluoromethyl)sulfonyl)-2-ethylphenyl)-N4.-ethylpy rimidine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 4-((difluoromethyl)sulfonyl)-2-ethylaniline (Intermediate 15). MS (ESI): mass calcd. for

Hz, 1 H), 7.39 (d, J = 8.3 Hz, 1 H), 6.24 (t, J = 53.4 Hz, 1 H), 5.32 (s, 1 H), 4.77 (s, 2H), 4.47 - 3.38 (m, 2H), 2.59 (q, J = 7.6 Hz, 2H), 1 .30 - 1 .14 (m, 6H).

Exam le 77: N4.-(2-Cyclobutyl-4-(ethylsulfonyl)phenyl)-N4.-ethylpyrimidi ne-2,4-diamine.

The title compound was prepared using analogous conditions described in Example 21 starting at Step A using 2-cyclobutyl-4-(ethylsulfonyl)aniline (Intermediate 11 ). MS (ESI): mass calcd. for

(q, J = 7.4 Hz, 2H), 2.41 - 1 .88 (m, 5H), 1.88 - 1 .74 (m, 1 H), 1 .36 (t, J = 7.4 Hz, 3H), 1 .17 (t, J = 7.1 Hz, 3H).

Example 78: N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(imidazo[1 ,2-a]pyridin-2- ylmethyl)pyrimidine-2,4-diamine.

MS (ESI): mass calcd. for C20H19FN6O, 378.2; m/z found, 379.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CD ₃ OD): δ 8.35 - 8.32 (m, 1 H), 7.79 (s, 1 H), 7.63 (d, J = 6.0 Hz, 1 H), 7.50 - 7.39 (m, 1 H), 7.29 - 7.23 (m, 1 H), 7.12 (dd, J = 8.5, 6.4 Hz, 1 H), 6.93 - 6.84 (m, 2H), 6.68 - 6.62 (m, 1 H), 5.68 - 5.38 (m, 2H), 4.78 (d, J = 14.9 Hz, 1 H), 4.02 (q, J = 7.0 Hz, 2H), 1 .24 (t, J = 7.0 Hz, 3H).

Example 79: N4.-(2-Ethoxy-4-fluorophenyl)-N4.-((2-methyloxazol-4-yl)meth yl)pyrimidine- 2,4-diamine.

Step A: N.-(2-Ethoxy-4-fluorophenyl)-2-(methylthio)pyrimidin-4-amine . The title compound was prepared using analogous conditions described in Example 19 starting with 2-ethoxy-4-fluoroaniline in place of 2-methyl-4-(pentafluorosulfanyl)benzenamine in step C.

Step B: N4.-(2-Ethoxy-4-fluorophenyl)-N4.-((2-methyloxazol-4-yl)meth yl)pyrimidine-2,4- diamine. The title compound was prepared using analogous conditions described in step D of example 102 using N.-(2-ethoxy-4-fluorophenyl)-2-(methylthio)pyrimidin-4- amine and 4-(chloromethyl)-2-methyloxazole instead of N.-(4-bromo-2- cyclobutylphenyl)-2-methylsulfanylpyrimidin-4-amine and 2-iodopropane, respectively. Step C: N4. -(2-Ethoxy-4-fluorophenyl)-N4.-((2-methyloxazol-4-yl)methyl) pyrimidine-2,4- diamine. The title compound was prepared using analogous conditions described in step F-G in example of 102. MS (ESI): mass calcd. for C17H18FN5O2, 343.1 ; m/z found, 344.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.70 (d, J = 6.0 Hz, 1 H), 7.40 (s, 1 H), 7.06 (dd, J = 8.6, 6.3 Hz, 1 H), 6.68 (dd, J = 10.5, 2.7 Hz, 1 H), 6.66 - 6.59 (m, 1 H), 5.52 - 5.42 (m, 1 H), 5.39 - 5.21 (m, 1 H), 4.83 (br s, 2H), 4.46 (d, J = 12.9 Hz, 1 H), 3.98 (q, J = 7.0 Hz, 2H), 2.40 (s, 3H), 1 .29 (t, J = 7.0 Hz, 3H).

Example 80: 4-((2-Aminopyrimidin-4-yl)(ethyl)amino)-3-cyclobutyl-N.-ethy l-N.- methylbenzenesulfonamide.

Step A: 3-cyclobutyl-N-methyl-4-((2-(methylthio)pyrimidin-4- yl)amino)benzenesulfonamide. The title compound was prepared using analogous conditions described in Example 21 , step A starting with 4-amino-3-cyclobutyl-N- methylbenzenesulfonamide (Intermediate 15) in place of 2-cyclobutyl-4- (methylsulfonyl)aniline (Intermediate 17). MS (ESI): mass calcd. for Ci6H2oN ₄ 02S2, 364.1 ; m/z found, 364.9 [M+H] ⁺ .

Step B: 3-cyclobutyl-N-ethyl-4-(ethyl(2-(methylsulfonyl)pyrimidin-4- yl)amino)-N- methylbenzenesulfonamide. To a 100 mL round bottom flask was charged a solution of 3-cyclobutyl-N-methyl-4-((2-(methylthio)pyrimidin-4-yl)amino )benzenesulfonamide (350 mg, 0.96 mmol) in CAN (48 mL). 1 -iodoethane (0.12 mL, 1 .44 mmol) and Cs2C03 (0.78 g, 2.4 mmol) were added, then the reaction vessel was flushed with N2. The reaction mixture was heated to 70 °C. The reaction was run for a total of 1 h, then cooled to room temperature. The reaction mixture was diluted with water, and an oil collected at the bottom of the flask. EtOAc was added and the mixture was extracted, then the organic layer was separated. The aqueous layer was extracted again with EtOAc, and the combined organic layers were dried (MgS04) and concentrated to dryness. The residue was purified (FCC, 120 g column, 30-40% EtOAc/hexanes), to afford the title compound. MS (ESI): mass calcd. for C19H27N5O2S, 389.5; m/z found, 390.0 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.90 (d, J = 2.2 Hz, 1 H), 7.76 - 7.64 (m, 2H), 7.22 (d, J = 8.2 Hz, 1 H), 6.44 (s, 1 H), 5.20 (s, 1 H), 4.95 (s, 2H), 4.20 (s, 1 H), 3.57 - 3.37 (m, 2H), 3.19 (q, J = 7.1 H z, 2H), 2.82 (s, 3H), 2.32 - 2.23 (m, 1 H), 2.21 - 1 .89 (m, 4H), 1 .22 - 1 .15 (m, 6H).

Example 81 : 4-((2-Aminopyrimidin-4-yl)(propyl)amino)-3-cyclobutyl-N.-met hyl-N.- propylbenzenesulfonamide.

The title compound was prepared using analogous conditions described in Example 80 using 1 -iodopropane in place of 1 -iodoethane. MS (ESI): mass calcd. for C21 H31 N5O2S, 417.6; m/z found, 418.1 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.90 (d, J = 2.2 Hz, 1 H), 7.74 - 7.65 (m, 2H), 5.25 (s, 2H), 4.14 - 4.08 (m, 1 H), 3.58 - 3.42 (m, 2H), 3.34 - 3.25 (m, 1 H), 3.07 (t, J = 7.2 Hz, 2H), 2.81 (s, 3H), 2.33 - 2.24 (m, 1 H), 2.21 - 1 .90 (m, 4H), 1 .87-1 .78 (m, 1 H), 1.74 - 1 .52 (m, 4H), 0.96 (t, J = 7.4 Hz, 1 H), 0.90 (t, J = 7.4 Hz, 1 H).

Example 82: N4.-(4-Bromo-2-(trifluoromethoxy)phenyl)-N4.-(oxazol-4-ylmet hyl)pyrimidine- 2,4-diamine.

The title compound was prepared using analogous conditions described in Example 19 starting with 4-bromo-2-(trifluoromethoxy)aniline in place of 2-methyl-4- (pentafluorosulfanyl)benzenamine in step C. MS (ESI): mass calcd. for

Ci5HiiBrF ₃ N502, 430.2; m/z found, 429.7 [M+H] ⁺ . ¹ H NMR (600 MHz, DMSO-de): δ 8.27 (d, J = 1.0 Hz, 1 H), 8.08 (d, J = 0.9 Hz, 1 H), 7.76 - 7.71 (m, 2H), 7.68 (dd, J = 8.5, 2.2 Hz, 1 H), 7.49 (d, J = 8.5 Hz, 1 H), 6.20 (s, 2H), 5.51 (br s, 1 H), 4.84 (br s, 2H).

Example 83: N4.-Ethyl-N4.-(4-(methylsulfonyl)-2-(prop-1 -en-2-yl)phenyl)pyrimidine-2,4- diamine.

Step A: N4.-(2-Bromo-4-(methylsulfonyl)phenyl)-N4.-ethylpyrimidine-2 ,4-diamine. The title compound was prepared using analogous conditions described in Example 19 starting with 2-bromo-4-(methylsulfonyl)aniline in place of 2-methyl-4- (pentafluorosulfanyl)benzenamine in step C and iodoethane in place of 4- (bromomethyl)oxazole hydrobromide in step D. MS (ESI): mass calcd. for

Step B: N4.-Ethyl-N4.-(4-(methylsulfonyl)-2-(prop-1 -en-2-yl)phenyl)pyrimidine-2,4- diamine.N4. -(2-Bromo-4-(methylsulfonyl)phenyl)-N4.-ethylpyrimidine-2,4- diamine (200 mg, 0.539 mmol), 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl (10.0 mg, 0.0140 mmol), and 2-isopropenyl-4,4, 5, 5-tetramethyl-1 ,3,2-dioxaborolane (453 mg, 2.69 mmol) were added to a microwave vial. The vial was evacuated and purged with N2. THF (2.00 mL) was added via syringe, followed by K3PO4 (0.5 M, 4.00 mL, 2.00 mmol). The entire reaction mixture was evacuated for 30 seconds, then purged with N2. The mixture was heated at 130 °C for 1 h. The reaction mixture was poured onto saturated aqueous NaHC03 (50 mL) then extracted with DCM (2 x 50 mL). The combined organic layers were dried over anhydrous MgS04, filtered, and concentrated to dryness. The residue was purified by FCC to give the title compound (167 mg, 93% yield) as a clear oil. MS (ESI): mass calcd. for C16H20N4O2S, 332.4; m/z found, 333.1 [M+H] ⁺ . ¹ H NMR (500 MHz, DMSO): 6 7.91 (dd, J = 2.31 , 8.22 Hz, 1 H), 7.87 (d, J = 2.29 Hz, 1 H), 7.70 (d, J = 5.92 Hz, 1 H), 7.46 (d, J = 8.26 Hz, 1 H), 6.12 (s, 2H), 5.45 (s, 1 H), 5.21 (s, 1 H), 5.05 (s, 1 H), 4.67 - 3.46 (m, 2H), 3.30 (s, 3H), 1.94 (s, 3H), 1 .1 1 - 1 .07 (m, 3H).

Example 84: N4.-Ethyl-N4.-(2-isopropyl-4-(methylsulfonyl)phenyl)pyrimidi ne-2,4-diamine.

A solution of N4-.ethyl-N4.-(4-(methylsulfonyl)-2-(prop-1 -en-2-yl)phenyl)pyrimidine-2,4- diamine (as prepared in Example 83, 150 mg, 0.451 mmol) in MeOH (5 mL) was treated with Pd/C (15 mg) then evacuated and backfilled with hydrogen using a balloon which was attached to the reaction flask. The reaction mixture was stirred for 48 h at room temperature. The mixture was filtered and rinsed with additional MeOH (3 mL). The solution was concentrated to dryness and the residue was purified by FCC to give a clear oil. The oil was dissolved in DCM (1 mL) and treated with hexanes (10 mL). The resulting precipitate was isolated by filtration to give the title compound (26 mg, 17% yield) as a white solid. MS (ESI): mass calcd. for C16H22N4O2S, 334.4; m/z found, 335.1 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.00 (d, J = 2.2 Hz, 1 H), 7.82 (dd, J = 8.2, 2.2 Hz, 1 H), 7.73 (d, J = 6.0 Hz, 1 H), 7.29 (d, J = 8.2 Hz, 1 H), 5.29 (br s, 1 H), 4.74 (s, 2H), 4.24 (br s, 1 H), 3.50 - 3.38 (m, 1 H), 3.12 (s, 3H), 3.08 - 2.99 (m, 1 H), 1 .25 (d, J = 6.9 Hz, 3H), 1 .21 (t, J = 7.1 Hz, 3H), 1.15 (d, J = 6.8 Hz, 3H).

Example 85: N4.-(4-Bromo-2-(trifluoromethoxy)phenyl)-N4.-isopropylpyrimi dine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 19 starting with 4-bromo-2-(trifluoromethoxy)aniline in place of 2-methyl-4- (pentafluorosulfanyl)benzenamine in step C and using 2-iodopropane in place of 4- (bromomethyl)oxazole hydrobromide in step D. MS (ESI): mass calcd. for

Ci ₄ Hi ₄ BrF ₃ N ₄ 0, 391 .2; m/z found, 390.0 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.72 (d, J = 6.1 H z, 1 H), 7.58 - 7.52 (m, 1 H), 7.48 (dd, J = 8.4, 2.1 Hz, 1 H), 7.09 (d, J = 8.4 Hz, 1 H), 5.28 (d, J = 6.0 Hz, 1 H), 5.13 - 4.99 (m, 1 H), 4.72 (s, 2H), 1 .13 (d, J = 6.4 Hz, 6H).

Example 86: N4.-(4-Bromo-2-isopropoxyphenyl)-N4.-isopropylpyrimidine-2,4 -diamine.

Step A: 4-Bromo-2-isopropoxyaniline. To a 100 ml_ round-bottomed flask was added NaH (60% in mineral oil, 215 mg, 5.38 mmol) and DMF (55 ml_) affording a white suspension. The round-bottomed flask was placed into an ice/water bath and cooled for 10 min. 2-Amino-5-bromophenol (1.00 g, 5.30 mmol) was dissolved in DMF (6 ml_) and was added dropwise over 10 min. After 35 min, 2-iodopropane (0.537 ml_, 5.32 mmol) was added dropwise slowly to the reaction. After 1.5 h, the reaction was concentrated to remove most of the DMF. The resulting brown solution was diluted with EtOAc (150 mL) and poured onto saturated NaHC03 (50 mL). The aqueous layer was removed and the organic layer was washed sequentially with water (50 mL), brine (50 mL), and then dried over anhydrous MgS04. The organics were concentrated to dryness to afford a dark brown solid/oil mixture. The residue was purified by FCC (120 g silica gel, eluent = 0-15% ethyl acetate/hexanes) to give the title compound (660 mg, 53% yield) as a light brown/red oil.

Step B: N4.-(4-Bromo-2-isopropoxyphenyl)-N4.-isopropylpyrimidine-2,4 -diamine. The title compound was prepared using analogous conditions described in Example 19 starting with 4-bromo-2-isopropoxyaniline in place of 2-methyl-4- (pentafluorosulfanyl)benzenamine in step C and using 2-iodopropane in place of 4-

(bromomethyl)oxazole hydrobromide in step D. MS (ESI): mass calcd. for Ci6H2iBrN ₄ 0, 365.3; m/z found, 364.9 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.62 (d, J = 6.1 Hz, 1 H), 7.11 - 7.03 (m, 2H), 6.96 - 6.88 (m, 1 H), 5.22 (s, 1 H), 5.12 (s, 1 H), 4.68 (s, 2H), 4.48 (hept, J = 6.0 Hz, 1 H), 1 .36 - 0.92 (m, 12H).

Example 87: N4.-(4-Bromo-2-(2,2,2-trifluoroethoxy)phenyl)-N4.-isopropylp yrimidine-2,4- diamine.

Step A: 4-Bromo-2-(2,2,2-trifluoroethoxy)aniline. The title compound (343 mg, 24%) was prepared using the method for Example 86, step A, and using 2-iodo-1 , 1 , 1 - trifluoroethane in place of 2-iodopropane. MS (ESI): mass calcd. for CsHyBrFsNO, 270.05; m/z found, 269.8 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.00 (dd, J = 8.4, 2.0 Hz, 1 H), 6.89 (d, J = 2.1 Hz, 1 H), 6.62 (d, J = 8.4 Hz, 1 H), 4.35 (q, J = 8.0 Hz, 2H), 3.91 - 3.77 (m, 2H).

Step B: N4.-(4-Bromo-2-(2,2,2-trifluoroethoxy)phenyl)-N4.-isopropylp yrimidine-2,4- diamine. The title compound was prepared using analogous conditions described in Example 19 starting with 4-bromo-2-(2,2,2-trifluoroethoxy)aniline in place of 2-methyl-4- (pentafluorosulfanyl)benzenamine in step C and using 2-iodopropane in place of 4- (bromomethyl)oxazole hydrobromide in step D. MS (ESI): mass calcd. for

CisHieBrFsNUO, 405.2; m/z found, 404.8 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.68 (d, J = 6.1 H z, 1 H), 7.31 - 7.23 (m, 1 H), 7.13 (d, J = 2.1 Hz, 1 H), 7.01 (d, J = 8.3 Hz, 1 H), 5.25 (s, 1 H), 5.10 (s, 1 H), 4.68 (s, 2H), 4.26 (d, J = 8.8 Hz, 2H), 1 .11 (s, 6H).

Example 88: N4.-(4-Bromo-2-methylphenyl)-N4.-isopropylpyrimidine-2,4-dia mine.

The title compound was prepared using analogous conditions described in Example 19 starting with 4-bromo-2-methylaniline in place of 2-methyl-4- (pentafluorosulfanyl)benzenamine in step C and using 2-iodopropane in place of 4- (bromomethyl)oxazole hydrobromide in step D. MS (ESI): mass calcd. for Ci4Hi7BrN ₄ , 321.2; m/z found, 321 .0 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.66 (d, J = 6.0 Hz, 1 H), 7.48 (dd, J = 2.2, 0.9 Hz, 1 H), 7.42 - 7.35 (m, 1 H), 6.95 (d, J = 8.4 Hz, 1 H), 5.20 - 5.00 (m, 2H), 4.70 (s, 2H), 2.10 (s, 3H), 1 .26 (d, J = 6.6 Hz, 3H), 0.97 (d, J = 6.9 Hz, 3H).

Example 89: 4-((2-Aminopyrimidin-4-yl)(isopropyl)amino)-3- trifluoromethoxy)benzonitrile.

Step A: N.-(4-Bromo-2-(trifluoromethoxy)phenyl)-N.-isopropyl-2-(meth ylthio)pyrimidin-4- amine. The title compound was prepared using analogous conditions described in Example 19 starting with 4-bromo-2-(trifluoromethoxy)aniline in place of 2-methyl-4- (pentafluorosulfanyl)benzenamine in step C and using 2-iodopropane in place of 4- (bromomethyl)oxazole hydrobromide in step D. MS (ESI): mass calcd. for

CisHisBrFsNsOS, 422.26; m/z found, 422.8 [M+H] ⁺ .

Step B: 4-(lsopropyl(2-(methylthio)pyrimidin-4-yl)amino)-3-

(trifluoromethoxy)benzonitrile. To a 20 mL vial were added N.-(4-bromo-2- (trifluoromethoxy)phenyl)-N.-isopropyl-2-(methylthio)pyrimid in-4-amine (302 mg, 0.715 mmol), zinc cyanide (190 mg, 1 .62 mmol), 2-dicyclohexylphosphino-2',4',6'- triisopropylbiphenyl (81 .0 mg, 0.170 mmol), zinc powder (1 1 .0 mg, 0.17 mmol), and Pd2(dba)3 (105 mg, 0.1 15 mmol) as solids. The reaction vessel was then evacuated and backfilled with N2 twice. DMA (7 mL) was added in one portion and the reaction mixture was heated at 120 °C in a heating block for 1 h. The vial was removed from the heat and allowed to cool to rt. The reaction was diluted with EtOAc (15 mL) and filtered through a pad of diatomaceous earth such as Celite ^® to remove the insoluble

particulates. The cake was rinsed with EtOAc (2 x 5 mL). The filtrate was washed with saturated NaHCO3 (20 mL), water (20 mL), brine (20 mL), and dried over anhydrous MgSO4, filtered and concentrated to dryness. The residue was purified by FCC to give the title compound (221 mg, 84% yield) as a colorless residue. MS (ESI): mass calcd. for C16H15F3N4OS, 368.38; m/z found, 369.0 [M+H] ⁺ .

Step C: 4-((2-Aminopyrimidin-4-yl)(isopropyl)amino)-3-(trifluorometh oxy)benzonitrile. The title compound (222 mg) was prepared using analogous conditions described in Example 19, step E starting with 4-(isopropyl(2-(methylthio)pyrimidin-4-yl)amino)-3- (trifluoromethoxy)benzonitrile in place of N.-(2-methyl-4-(pentafluorosulfanyl)phenyl)-2- (methylthio)-N.-(oxazol-4-ylmethyl)pyrimidin-4-amine. MS (ESI): mass calcd. for C15H14F3N5O, 337.3; m/z found, 337.9 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCIs): δ 7.79 (d, J = 6.0 Hz, 1 H), 7.70 - 7.66 (m, 1 H), 7.65 (dd, J = 8.1 , 1 .8 Hz, 1 H), 7.37 (d, J = 8.1 Hz, 1 H), 5.37 (d, J = 6.0 Hz, 1 H), 4.96 (hept, J = 6.9 Hz, 1 H), 4.72 (s, 2H), 1 .17 (d, J = 6.7 Hz, 6H). Example 90: N4.-(4-(Ethylsulfonyl)-2-(trifluoromethoxy)phenyl)-N4.-isopr opylpyrimidine-

To a 20 mL vial were added N4.-(4-bromo-2-(trifluoromethoxy)phenyl)-N4.- isopropylpyrimidine-2,4-diamine (Example 20, 194 mg, 0.496 mmol), ethanesulfinic acid, sodium salt (154 mg, 1 .33 mmol), and Cul (230 mg, 1 .21 mmol). The vial was sealed, evacuated, and backfilled with N2 (2x). DMSO (5.5 mL), which was degassed using argon for 30 min, was added. The vial was heated at 130 °C on a heating block for 22 h. The reaction was cooled to rt and diluted with EtOAc (50 mL) and poured into water resulting in an inseparable emulsion. The emulsion was filtered through a pad of diatomaceous earth, such as diatomaceous earth such as Celite ^® , and the biphasic mixture was separated. The aqueous layer was extracted further with EtOAc (50 mL). The combined organics were washed with water (50 mL) and brine (50 mL), dried over anhydrous MgSO4, and concentrated to dryness. The residue was purified by acidic HPLC to give the title compound (56 mg, 28% yield) as a colorless powder. MS (ESI): mass calcd. for C16H19F3N4O3S, 404.4; m/z found, 405.1 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.93 - 7.90 (m, 1 H), 7.88 (dd, J = 8.2, 2.0 Hz, 1 H), 7.78 (s, 1 H), 7.45 (d, J = 8.2 Hz, 1 H), 5.36 (d, J = 5.9 Hz, 1 H), 5.07 - 4.92 (m, 1 H), 4.78 (s, 2H), 3.21 (q, J = 7.4 Hz, 2H), 1 .37 (t, J = 7.4 Hz, 3H), 1 .18 (d, J = 6.8 Hz, 6H). Example 91 : N4-.(4-Bromo-2-methylphenyl)-N4.-(oxazol-4-ylmethyl)pyrimidi ne-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 19 starting with 4-bromo-2-(trifluoromethoxy)aniline in place of 2-methyl-4- (pentafluorosulfanyl)benzenamine in step C. MS (ESI): mass calcd. for

360.2; m/z found, 360.1 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.82 - 7.79 (m, 1H), 7.74 (d, J = 6.0 Hz, 1H), 7.63 - 7.57 (m, 1H), 7.48 - 7.41 (m, 1H), 7.37 - 7.31 (m, 1H), 6.95 (d, J=8.4 Hz, 1H), 5.34 (s, 1H), 5.26 (d, J = 15.1Hz, 1H), 4.77 (s, 2H), 4.59 (d, J = 15.1 Hz, 1H), 2.05 (s, 3H).

Example 92:N4.-(4-(Ethylsulfonyl)-2-methylphenyl)-N4.-(oxazol-4-ylme thyl)pyrimidine- -diamine.

The title compound was prepared using analogous conditions described in Example 90, usingN4.-(4-(ethylsulfonyl)-2-methylphenyl)-N4.-(oxazol-4-yl methyl)pyrimidine-2,4- diamine (Example 91) instead of N4-.(4-bromo-2-(trifluoromethoxy)phenyl)-N4.- isopropylpyrimidine-2,4-diamine. MS (ESI): mass calcd. for

found, 373.9 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.84 (d, J = 2.1Hz, 1H), 7.82 - 7.80 (m, 1H), 7.80 - 7.73 (m, 2H), 7.64 (s, 1H), 7.35 (d, J = 8.2 Hz, 1H), 5.44 - 5.20 (m, 2H), 4.92 (s, 2H), 4.79-4.52 (m, 1H), 3.15 (q, J = 7.4 Hz, 2H), 2.18 (s, 3H), 1.33 (t, J = 7.4 Hz, 3H).

Example 93:N4.-lsopropyl-N4.-(4-(methylsulfonyl)-2-(trifluoromethyl) phenyl)pyrimidine- 2,4-diamine.

To a 10 mL vial were addedN4.-(4-bromo-2-(trifluoromethyl)phenyl)-N4.- isopropylpyrimidine-2,4-diamine (Example 20, 108 mg, 0.288 mmol), sodium

methanesulfinate (85.0 mg, 0.710 mmol), and DMSO (0.58 mL). The vial was sealed and heated to 130 °C using a heating block. After 20 h, an additional 2.5 equivalents of sodium methanesulfinate (85.0 mg, 0.710 mmol) was added and the heat was increased to 150 °C for 2 d. The reaction was poured into water (20 mL) and extracted with EtOAc (50 mL). The layers were separated and the organic layer was washed with water, brine, dried over anhydrous MgS04, and concentrated to dryness. The residue was purified by acidic HPLC to give the title compound (48 mg, 44% yield) as a white powder. MS (ESI): mass calcd. for C15H17F3N4O2S, 374.4; m/z found, 375.0 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.35 (d, J = 2.2 Hz, 1 H), 8.21 (dd, J = 8.3, 2.2 Hz, 1 H), 7.88 - 7.70 (m, 1 H), 7.47 (d, J = 8.2 Hz, 1 H), 5.32 (d, J = 6.0 Hz, 1 H), 4.78 - 4.63 (m, 3H), 3.18 (s, 3H), 1 .50 - 0.99 (m, 6H).

Example 94: N4.-lsopropyl-N4.-(4-(isopropylsulfonyl)-2-(trifluoromethyl) phenyl)pyrimidine- -diamine.

To a 10 mL vial were addedN4.-(4-bromo-2-(trifluoromethyl)phenyl)-N4.- isopropylpyrimidine-2,4-diamine (Example 20, 150 mg, 0.40 mmol), the sodium salt of isopropylsulfinic acid (81 mg, 0.62 mmol), and copper(l) trifluoromethanesulfonate benzene complex (45 mg, 0.080 mmol) as solids. The vial was sealed, evacuated, and backfilled with N2 (3x). N.,N.'-Dimethylethylenediamine (16 mg, 0.18 mmol) was dissolved in degassed DMSO (1.0 mL) and the solution was added to the vial. The vial was heated to 120 °C in a microwave for 2.5 h. The reaction mixture was poured into water (20 mL) and extracted with EtOAc (30 mL). The layers were separated and the aqueous phase was back extracted with EtOAc (25 mL). The combined organics were washed with water (20 mL), brine (20 mL), dried over anhydrous MgS04, filtered, and concentrated to dryness. The residue was purified by FCC (24 g silica gel, 0-5% 2N NH3-MeOH/DCM as eluent) and by acidic HPLC to give the title compound (42 mg, 26% yield) as a white powder. MS (ESI): mass calcd. for C17H21 F3N4O2S, 402.4; m/z found, 403.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.29 (d, J = 2.2 Hz, 1 H), 8.15 (dd, J = 8.2, 2.2 Hz, 1 H), 7.77 (d, J = 6.0 Hz, 1 H), 7.46 (d, J = 8.2 Hz, 1 H), 5.27 (d, J = 6.0 Hz, 1 H), 4.81 - 4.62 (m, 3H), 3.38 - 3.19 (m, 1 H), 1 .44 - 1 .32 (m, 9H), 1 .16 (d, J = 41 .0 Hz, 3H).

Example 95: N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(isoxazol-5-ylmethyl)pyrim idine-2,4- diamine.

Step A: N.-(2-Ethoxy-4-fluorophenyl)isoxazole-5-carboxamide. To a 100 mL round- bottomed flask was added, in sequence, isoxazole-5-carboxylic acid (0.34 g, 3.0 mmol), HATU (1 .4 g, 3.6 mmol), TEA (0.92 g, 9.1 mmol), DCM (40 mL), and 2-ethoxy-4- fluoroanaline (0.60 g, 3.9 mmol) at 0 °C. The reaction mixture was warmed to rt and stirred for 15 h. The reaction mixture was concentrated to dryness and the residue was purified by FCC to give the title compound (0.32 g, 43% yield) as a yellow solid. MS (ESI): mass calcd. for C12H11 FN2O3 250.1 , m/z found 251 .1 [M+H] ⁺ .

Step B: 2-Ethoxy-4-fluoro-N.-(isoxazol-5-ylmethyl)aniline. To a 100 mL round-bottomed flask were added N.-(2-ethoxy-4-fluorophenyl)isoxazole-5-carboxamide (0.47 g, 1 .9 mmol), BH3 (1 M in THF, 30 mL), and THF (30 mL). The reaction was heated at 40 °C for 4 h, and then concentrated to dryness. The residue was dissolved in MeOH (30 mL) and stirred for 5 min. The mixture was concentrated to dryness and the residue was purified by FCC to give the title compound (0.37 g, 83% yield) as a colorless oil. MS (ESI): mass calcd. for C12H13FN2O2 236.1 , m/z found 237.1 [M+H] ⁺ .

Step C: N4.-(2-Ethoxy-4-fluorophenyl)-N4.-(isoxazol-5-ylmethyl)pyrim idine-2,4-diamine. To a 50 mL round-bottomed flask were added 2-ethoxy-4-fluoro-N.-(isoxazol-5- ylmethyl)aniline (1 .3 mmol), 4-chloropyrimidin-2-amine (200 mg, 1 .5 mmol), and /-PrOH (10 mL). Concentrated H2SO4 (2 drops) was added to the mixture and heated at 60 °C for 15 h. After cooling to rt, the mixture was diluted with water (20 mL), neutralized with a saturated aqueous NaHC03 (10 mL), and extracted with EtOAc (50 mL). The organic phase was washed with saturated aqueous NaCI (20 mL), dried over anhydrous

Na2S04, and concentrated under vacuum to dryness. The residue was purified by FCC to give the title compound. MS (ESI): mass calcd. for C16H16FN5O2 329.1 , m/z found 330.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.14 (s, 1 H), 7.75 (d, J = 6.0 Hz, 1 H), 7.07 (dd, J = 8.6, 6.3 Hz, 1 H), 6.70 (dd, J = 10.4, 2.6 Hz, 1 H), 6.67 - 6.61 (m, 1 H), 6.19 (s, 1 H), 5.55 - 5.40 (m, 2H), 4.88 - 4.72 (m, 3H), 3.98 (q, J = 6.9 Hz, 2H), 1 .29 (t, J = 7.0 Hz, 3H).

Example 96: N. ⁴ -((1 ,3,4-Oxadiazol-2-yl)methyl)-N4.-(2-ethoxy-4-fluorophenyl)pyr imidine- 2,4-diamine.

Step A: N.-(2-Ethoxy-4-fluorophenyl)-2-(methylthio)pyrimidin-4-amine . To a 100 mL round-bottomed flask were added in sequence 2-ethoxy-4-fluoroaniline (0.50 g, 3.2 mmol), 4-chloro-2-(methylthio)pyrimidine (1.2 g, 7.5 mmol), /-PrOH (20 mL), and concentrated HCI (2 drops). The reaction was heated at 80 °C for 4 h then cooled to rt. The reaction mixture was diluted with water (20 mL), neutralized with saturated aqueous NaHCO3, and extracted with EtOAc (3 ^χ 20 mL). The combined organic phase was washed with saturated aqueous NaCI, dried over anhydrous Na2S04, and concentrated to dryness under vacuum. The residue was purified by FCC to give the title compound (0.83 g, 93% yield) as a yellow oil. MS (ESI): mass calcd. for C13H14FN3OS 279.1 , m/z found 280.1 [M+H] ⁺ .

Step B: Ethyl 2-((2-ethoxy-4-fluorophenyl)(2-(methylthio)pyrimidin-4-yl)am ino)acetate. To a 50 mL round-bottomed flask were added N.-(2-ethoxy-4-fluorophenyl)-2- (methylthio)pyrimidin-4-amine (1 .05 g, 3.70 mmol) and DMF (10 mL). The reaction was cooled to 0 °C and NaH (60% in mineral oil, 0.180 g, 4.50 mmol) was added. The reaction was stirred at 0 °C for 10 min, and then 2-bromoacetate (1 .00 g, 5.90 mmol) was added and was stirred at rt for 15 h. The reaction was diluted with EtOAc (60 mL), washed with water (2 ^χ 30 mL) and saturated aqueous NaCI (30 mL), dried over anhydrous Na2S04, filtered, and concentrated to dryness to give the title compound (1 .5 g) as a yellow solid, which was used directly in the next step without further purification. MS (ESI): mass calcd. for C17H20FN3O3S 365.1 , m/z found 366.1 [M+H] ⁺ .

Step C: 2-((2-Ethoxy-4-fluorophenyl)(2-(methylthio)pyrimidin-4-yl)am ino)acetohydrazide. To a 100 mL round-bottomed flask were added ethyl 2-((2-ethoxy-4-fluorophenyl)(2- (methylthio)pyrimidin-4-yl)amino)acetate (1 .5 g), ΝΗ2ΝΗ2Ή2Ο (80%, 5.0 mL), and EtOH (30 mL). The reaction was heated at 80 °C for 15 h, and then cooled to rt. The reaction was concentrated to dryness, diluted with DCM (50 mL), washed with water (2 ^χ 20 mL) and saturated aqueous NaCI, dried over anhydrous Na2SO4, filtered, and concentrated to dryness under vacuum to give the title compound (1 .5 g) as a yellow solid. MS (ESI): mass calcd. for C15H18FN5O2S 351 .12, m/z found 352.1 [M+H] ⁺ .

Step D: N.-((1 ,3,4-Oxadiazol-2-yl)methyl)-N.-(2-ethoxy-4-fluorophenyl)-2- (methylthio)pyrimidin-4-amine. To a 100 mL round-bottomed flask were added 2-((2- ethoxy-4-fluorophenyl)(2-(methylthio)pyrimidin-4-yl)amino)ac etohydrazide (1 .5 g), TsOH (100 mg, 0.60 mmol), and trimethoxymethane (30 mL). The reaction was heated at reflux for 6 h and then cooled to rt. The reaction was concentrated to dryness, diluted with DCM (60 mL), washed with saturated K2CO3 (30 mL) and saturated aqueous NaCI, dried over anhydrous Na2SO4, filtered, and concentrated to dryness under vacuum. The residue was purified by FCC to give the title compound (0.50 g, 37% yield over 3 steps) as a yellow solid. MS (ESI): mass calcd. for C16H16FN5O2S 361.1 , m/z found 362.1 [M+H] ⁺ .

Step E: N. ⁴ -((1 ,3,4-Oxadiazol-2-yl)methyl)-N4.-(2-ethoxy-4-fluorophenyl)pyr imidine-2,4- diamine. The title compound was prepared using analogous conditions described in Example 19, steps E and F, and using N.-((1 ,3,4-oxadiazol-2-yl)methyl)-N.-(2-ethoxy-4- fluorophenyl)-2-(methylthio)pyrimidin-4-amine in place of N.-(2-methyl-4- (pentafluorosulfanyl)phenyl)-2-(methylthio)-N.-(oxazol-4-ylm ethyl)pyrimidin-4-amine. MS (ESI): mass calcd. for C16H16FN5O2 330.1 , m/z found 331 .1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.35 (s, 1 H), 7.76 (d, J = 6.0 Hz, 1 H), 7.23 (dd, J = 8.4, 6.5 Hz, 1 H), 6.74 - 6.63 (m, 2H), 5.70 (d, J = 15.5 Hz, 1 H), 5.55 (d, J = 5.9 Hz, 1 H), 4.93 - 4.80 (m, 3H), 3.99 (dd, J = 13.7, 6.8 Hz, 2H), 1 .30 (t, J = 6.9 Hz, 3H).

Exam le 97: 4-((2-Aminopyrimidin-4-yl)(isopropyl)amino)-3-propylbenzonit rile.

The title compound was prepared using analogous conditions described in Example 19, beginning at step C using with 4-amino-3-propylbenzonitrile (Intermediate 16) in place of 2-methyl-4-(pentafluorosulfanyl)benzenamine and 2-iodopropane in place of 4- bromomethyloxazole in step D. MS (ESI): mass calcd. for C17H21 N5, 295.4; m/z found, 296.1 [M+H] ⁺ . ¹ H NMR (600 MHz, CDCb): δ 7.69 (d, J = 6.0 Hz, 2H), 7.57 (dd, J = 8.2, 2.0 Hz, 1 H), 7.20 (d, J = 8.1 H z, 1 H), 5.14 - 5.10 (m, 1 H), 5.03 (h, J = 6.8, 6.3 Hz, 1 H), 4.95 (s, 2H), 2.47 (td, J = 8.0, 2.8 Hz, 2H), 1 .61 (td, J = 16.5, 15.0, 7.6 Hz, 2H), 1 .32 - 1 .28 (m, 3H), 0.99 (d, J = 7.0 Hz, 3H), 0.92 (t, J = 7.3 Hz, 3H).

Example 98: (E)-4-((2-Aminopyrimidin-4-yl)(oxazol-4-ylmethyl)amino)-3-(p rop-1 -en-1 - yl)benzamide.

Step A: 4-((2-Aminopyrimidin-4-yl)(oxazol-4-ylmethyl)amino)-3-chloro benzonitrile. The title compound was prepared using analogous conditions described in Example 19 starting with 4-amino-3-chlorobenzonitrile in place of 2-methyl-4- (pentafluorosulfanyl)aniline in step C. MS (ESI): mass calcd. for CisHnCINeO, 326.74; m/z found, 327.0 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.86 - 7.79 (m, 4H), 7.66 (d, J = 1 .1 H z, 1 H), 7.61 (dd, J = 8.2, 1 .9 Hz, 1 H), 7.46 (d, J = 8.2 Hz, 1 H), 5.45 (s, 1 H), 5.13 (d, J = 4.1 Hz, 3H).

Step B: (E)-4-((2-Aminopyrimidin-4-yl)(oxazol-4-ylmethyl)amino)-3-(p rop-1 -en-1 - yl)benzamide. To a 25 mL vial were added 4-((2-aminopyrimidin-4-yl)(oxazol-4- ylmethyl)amino)-3-chlorobenzonitrile (200 mg, 0.612 mmol), [(E)-prop-1 -enyl]boronic acid (131 mg, 1 .53 mmol), and 2-dicyclohexylphosphino-2',6'-diisopropoxybiphenyl, palladium(ll) phenethylamine chloride (13.0 mg, 0.0180 mmol). The vial was sealed and evacuated and backfilled with N2 (2x). Dioxane (2.08 mL) and degassed phosphate solution (0.5 M, 3.67 mL, 1 .84 mmol) were added. The resulting mixture was heated to 120 °C in a microwave reactor for 30 min. The reaction was cooled to rt, then diluted with EtOAc (30 mL). The mixture was poured into water (20 mL) and the layers separated. The aqueous layer was extracted with EtOAc (30 mL). The combined organics were washed with brine (20 mL), dried over anhydrous MgS04, and

concentrated to dryness. The residue was purified by HPLC to give the title compound (95 mg, 44% yield). MS (ESI): mass calcd. for Ci8Hi ₈ N ₆ 02, 350.4; m/z found, 351 .0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.09 (d, J = 2.0 Hz, 1 H), 7.83 (d, J = 1.0 Hz, 1 H), 7.66 (dd, J = 8.1 , 2.1 Hz, 1 H), 7.59 (s, 1 H), 7.49 - 7.42 (m, 1 H), 7.14 (d, J = 8.2 Hz, 1 H), 6.40 (dq, J = 15.7, 6.6 Hz, 1 H), 6.12 (dq, J = 15.6, 1 .6 Hz, 1 H), 5.80 (s, 1 H), 5.41 (d, J = 17.1 Hz, 2H), 4.65 (d, J = 14.9 Hz, 1 H), 3.49 (s, 1 H), 1 .87 (dd, J = 6.6, 1 .7 Hz, 3H). Example 99: (E)-4-((2-Aminopyrimidin-4-yl)(isopropyl)amino)-3-(prop-1 -en-1 - yl)benzonitrile.

The title compound was prepared using the method for Example 98 employing 4-((2- aminopyrimidin-4-yl)(isopropyl)amino)-3-bromobenzonitrile in place of 4-((2- aminopyrimidin-4-yl)(oxazol-4-ylmethyl)amino)-3-chlorobenzon itrile. A second compound was also isolated: (E)-4-((2-Aminopyrimidin-4-yl)(isopropyl)amino)-3-(prop- 1 -en-1 -yl)benzamide (Example 100). MS (ESI): mass calcd. for Ci7Hi9N5, 293.4; m/z found, 294.2 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.95 (d, J = 1 .9 Hz, 1 H), 7.70 - 7.48 (m, 2H), 7.37 - 7.06 (m, 1 H), 6.58 - 6.09 (m, 4H), 5.39 - 4.96 (m, 2H), 1 .88 (dd, J = 6.7, 1 .6 Hz, 3H), 1 .30 (s, 3H), 0.99 (s, 3H).

Example 100: (E)-4-((2-Aminopyrimidin-4-yl)(isopropyl)amino)-3-(prop-1 -en-1 - l)benzamide.

The title compound was isolated in combination with Example 99. MS (ESI): mass calcd. for C17H21 N5O, 311 .4; m/z found, 312.0 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.14 (d, J = 2.1 Hz, 1 H), 7.72 (dd, J = 8.1 , 2.1 Hz, 1 H), 7.49 (d, J = 6.6 Hz, 1 H), 7.20 7.09 (m, 1 H), 6.54 - 6.48 (m, 1 H), 6.38 (dq, J = 15.7, 6.6 Hz, 2H), 6.23 (dq, J = 15.8, 1 .7 Hz, 1 H), 6.14 (d, J = 13.9 Hz, 2H), 5.14 (dt, J = 20.8, 6.3 Hz, 2H), 1.90 - 1.81 (m, 3H), 1 .29 (d, J = 6.5 Hz, 3H), 0.98 (d, J = 6.9 Hz, 3H). Example 101 : (E)-N4.-(4-Chloro-2-(prop-1 -en-1 -yl)phenyl)-N4.-(oxazol-4- ylmethyl)pyrimidine-2,4-diamine.

Step A: N.-(4-Chloro-2-iodophenyl)-2-(methylthio)pyrimidin-4-amine. The title compound was prepared using analogous conditions described in Example 19, Step C and D starting with 4-chloro-2-iodoaniline in place of 2-methyl-4-(pentafluorosulfanyl)aniline in step C. MS (ESI): mass calcd. for C11 H9CIIN3S, 377.63; m/z found, 377.8 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.16 (d, J = 5.8 Hz, 1 H), 7.87 - 7.78 (m, 2H), 7.35 (dd, J = 8.7, 2.4 Hz, 1 H), 6.72 (s, 1 H), 6.30 (d, J = 5.8 Hz, 1 H), 2.53 (s, 3H).

Step B: (E)-N.-(4-Chloro-2-(prop-1 -en-1 -yl)phenyl)-2-(methylthio)pyrimidin-4-amine. To a 25 mL vial were added N.-(4-chloro-2-iodophenyl)-2-(methylthio)pyrimidin-4-amine (1 .0 g, 2.6 mmol), [(E)-prop-1 -enyl]boronic acid (210 mg, 2.4 mmol), and chloro-(2- dicyclohexylphosphino-2',6'-diisopropoxy-1 , 1 '-biphenyl)[2-(2- aminoethyl)phenyl]palladium(ll)-methyl-f-butyl ether adduct (56.0 mg, 0.077 mmol). The vial was sealed then evacuated and backfilled with N2 (2x). Dioxane (9.0 mL) and degassed phosphate solution (0.5 M, 16 mL, 7.9 mmol) were added. The resulting mixture was heated to 120 °C in a microwave reactor for 60 min. The reaction was cooled to rt, then diluted with EtOAc (30 mL). The mixture was poured into water (20 mL) and the layers separated. The aqueous layer was extracted further with EtOAc (30 mL). The combined organics were washed with brine (20 mL), dried over anhydrous MgS04, and concentrated to dryness. The residue was purified by FCC to give the title compound (500 mg, 65% yield). MS (ESI): mass calcd. for C14H14CIN3S, 291 .80; m/z found, 292.0 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.06 (d, J = 5.9 Hz, 1 H), 7.47 (d, J = 2.4 Hz, 1 H), 7.37 - 7.26 (m, 1 H), 7.20 (ddd, J = 8.4, 3.7, 2.3 Hz, 1 H), 6.75 (s, 1 H), 6.41 (dq, J = 15.6, 1 .7 Hz, 1 H), 6.31 - 6.16 (m, 1 H), 6.08 (d, J = 5.9 Hz, 1 H), 2.52 (d, J = 5.7 Hz, 3H), 1 .86 (dd, J = 6.6, 1 .7 Hz, 3H).

Step C: (E)-N4.-(4-Chloro-2-(prop-1 -en-1 -yl)phenyl)-N4.-(oxazol-4-ylmethyl)pyrimidine- 2,4-diamine. The title compound was prepared using the method for Example 19, steps E-F, and using (E)-N.-(4-chloro-2-(prop-1 -en-1 -yl)phenyl)-2-(methylthio)pyrimidin-4- amine in place of N.-(2-methyl-4-(pentafluorosulfanyl)phenyl)-2-(methylsulfony l)-N.- (oxazol-4-ylmethyl) pyrimidin-4-amine in step E. MS (ESI): mass calcd. for

C17H16CIN5O, 341.8; m/z found, 342.1 [M+H] ⁺ . ¹ H N MR (500 MHz, CDCb): δ 7.79 (d, J = 1 .0 Hz, 1 H), 7.72 (d, J = 6.0 Hz, 1 H), 7.60 - 7.52 (m, 2H), 7.17 (dd, J = 8.4, 2.5 Hz, 1 H), 6.96 (d, J = 8.4 Hz, 1 H), 6.31 - 6.10 (m, 2H), 5.39 - 5.28 (m, 2H), 5.02 (s, 2H), 4.53 (d, J = 15.3 Hz, 1 H), 1 .81 (dd, J = 6.4, 1 .5 Hz, 3H).

Example 102: N4. -(2-Cyclobutyl-4-(isopropylsulfonyl)phenyl)-N4.-isopropylpyr imidine-2,4- diamine.

Step A: 2-Cyclobutylaniline. To a round-bottomed flask were added 2-bromoaniline (10.3 g, 58.4 mmol), bis(tri-ierf-butylphosphine)palladium(0) (1 .79 g, 52.6 mmol), and THF (195 ml_). The reaction was stirred and purged with N2 gas for 30 min.

Cyclobutylzinc bromide (105 ml_, 52.6 mmol) was added by syringe to the reaction mixture and heated at 50 °C for 20 h. After cooling to room temperature, the reaction was then poured onto saturated aqueous NH ₄ CI and EtOAc. The layers were separated and aqueous layer was extracted further with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered, and concentrated to dryness. The residue was purified by FCC to yield the title compound as a brown oil (3.28 g, 38% yield).

Step B: 4-Bromo-2-cyclobutylaniline. To a round-bottomed flask was added 2- cyclobutylaniline (4.75 g, 32.3 mmol), followed by ammonium acetate (250 mg, 3.23 mmol) and ACN (160 mL). The reaction mixture was stirred in an ice bath. Next, N- bromosuccinimide (5.80 g, 32.3 mmol) was added slowly and stirred for 15 min at 0 °C. The reaction was quenched by the addition of water and concentrated to dryness. The aqueous layer was extracted with DCM (2x). The combined organic layers were dried over anhydrous Na2S04, filtered, and concentrated to dryness. The residue was purified by FCC to yield the title compound as a red oil (5.76 g, 78.9% yield).

Step C: N.-(4-Bromo-2-cyclobutylphenyl)-2-methylsulfanylpyrimidin-4- amine. To a round-bottomed flask were added 4-bromo-2-cyclobutylaniline (5.76 g, 25.5 mmol), p- toluenesulfonic acid monohydrate (0.984 g, 5.09 mmol), and /-PrOH (25.5 mL) with stirring. The reaction was heated to 50 °C to dissolve all reagents, then 4-chloro-2- (methylthio)pyrimidine (3.17 mL, 26.7 mmol) was added. The reaction was stirred at 50 °C overnight. The reaction was quenched by the addition of water and extracted with DCM (2x), separating the organic layers. The combined organic phases were dried over anhydrous Na2S04, filtered, and concentrated to dryness to yield the title compound as a brown oil (10.2 g, 114% yield).

Step D: N.-(4-Bromo-2-cyclobutylphenyl)-N.-isopropyl-2-methylsulfany lpyrimidin-4- amine. To a round-bottomed flask were added N.-(4-bromo-2-cyclobutylphenyl)-2- methylsulfanylpyrimidin-4-amine (5.34 g, 15.2 mmol), cesium carbonate (15.0 g, 45.7 mmol), 2-iodopropane (3.00 mL, 30.5 mmol), and ACN (50.0 mL) and the resulting reaction mixture was heated at 50 °C for 2 h. After 2 h, additional 2-iodopropane (1 .00 mL, 10.2 mmol) was added and the resulting reaction mixture heated at 65 °C for an additional 40 min. The reaction mixture was quenched by the addition of water and extracted with DCM (2x). The combined organic layers were dried over anhydrous Na2S04, filtered, and concentrated to dryness. The residue was purified by FCC to yield the title compound as an amber oil (5.81 g, 97.2% yield).

Step E: N.-(2-Cyclobutyl-4-isopropylsulfanylphenyl)-N.-isopropyl-2- methylsulfanylpyrimidin-4-amine. To a 20 mL microwave reaction vial were added N-(4- bromo-2-cyclobutylphenyl)-N.-isopropyl-2-methylsulfanylpyrim idin-4-amine (270 mg, 0.70 mmol) and THF (2.3 mL). The reaction vial was placed into a dry ice//-PrOH bath and cooled to ~ -73 °C for 15 min. With stirring, n-butyllithium (2.5 M in hexanes, 0.30 ml_, 0.77 mmol) was then added dropwise over 5 min and stirred at -73 °C for an additional 10 min, then isopropyl disulfide (0.12 ml_, 0.77 mmol) was added in one portion. The reaction was allowed to warm slowly to rt. The reaction was stirred at room temperature for 3 h, then quenched by pouring into a solution of water and extracted with EtOAc (2x). The combined organic layer was washed with brine, dried over anhydrous MgS04, filtered and concentrated to dryness. The residue was purified by FCC to yield the title compound as a colorless oil (135 mg, 49.9% yield).

Step F: N4. -(2-Cyclobutyl-4-(isopropylsulfonyl)phenyl)-N4.-isopropylpyr imidine-2,4- diamine. The title compound was prepared using analogous conditions described in Example 19 using N.-(2-cyclobutyl-4-isopropylsulfanylphenyl)-N.-isopropyl-2- methylsulfanylpyrimidin-4-amine in place of N.-(2-methyl-4-(pentafluorosulfanyl)phenyl)- 2-(methylsulfonyl)-N.-(oxazol-4-ylmethyl)pyrimidin-4-amine in step E and an increased amount of mCPBA (418 mg, 2.42 mmol, 7 eq). MS (ESI): mass calcd. for C20H28N4O2S, 388.5; m/z found, 389.0 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 8.13 (d, J = 2.2 Hz, 1 H), 7.77 (dd, J = 8.1 , 2.2 Hz, 1 H), 7.67 (d, J = 6.0 Hz, 1 H), 7.22 (d, J = 8.2 Hz, 1 H), 5.23 - 4.91 (m, 2H), 4.74 (s, 2H), 3.65 - 3.51 (m, 1 H), 3.32 - 3.19 (m, 1 H), 2.27 - 2.07 (m, 3H), 2.07 - 1 .79 (m, 3H), 1 .36 (d, J = 6.7 Hz, 6H), 1 .29 (d, J = 6.5 Hz, 3H), 0.91 (d, J = 6.9 Hz, 3H).

Example 103: N4.-(4-Fluoro-2-(trifluoromethoxy)phenyl)-N4.-isopropylpyrim idine-2,4- diamine.

Step A: 4-Fluoro-1 -nitro-2-(trifluoromethoxy)benzene. To a 100 ml_ round-bottomed flask were added concentrated H2SO4 (25 ml_), fuming HNO3 (25 ml_), and 1 -fluoro-3- (trifluoromethoxy)benzene (9.0 g, 50 mmol) at -10 °C in sequence. The mixture was stirred at rt for 30 min then poured onto ice and extracted with EtOAc (3 ^χ 20 mL). The combined organic layers were washed with saturated aqueous NaHC03 solution (30 mL), brine (30 mL), dried over anhydrous Na2S04, concentrated to dryness, and purified by FCC to give the title compound as a pale-yellow oil (0.50 g). ¹ H NMR (300 MHz, CDCIs): 6 8.21 - 8.14 (m, 1 H), 7.21 -7.12 (m, 2H).

Step B: 4-Fluoro-2-(trifluoromethoxy)benzenamine. The title compound was prepared using analogous conditions described in the preparation of Intermediate 3 using 4- fluoro-1 -nitro-2-(trifluoromethoxy)benzene in place of 2-ethoxy-4-fluoro-1 -nitrobenzene. MS (ESI): mass calcd. for C7H5F4NO, 195.03, m/z found 196.1 [M+H] ⁺ .

Step C: N.-(4-Fluoro-2-(trifluoromethoxy)phenyl)-2-(methylthio)pyrim idin-4-amine. To a 50 mL round-bottomed flask were added 4-fluoro-2-(trifluoromethoxy)benzenamine (0.39 g, 2.0 mmol), 2-chloro-4-(methylthio)pyrimidine (0.39 g, 2.4 mmol), concentrated HCI (0.25 mL), and /-PrOH (10 mL). The mixture was heated at 80 °C for 15 h, then neutralized with saturated aqueous NaHC03 solution (5 mL) and concentrated to dryness. The residue was diluted with water (10 mL) and extracted with EtOAc (3 x 10 mL). The combined organic layers were washed with brine (10 mL), dried over anhydrous Na2S04, concentrated to dryness, and purified by FCC to give the title compound as a pale-yellow oil (0.59 g). MS (ESI): mass calcd. for C12H9F4N3OS, 319.04, m/z found 320.0 [M+H] ⁺ .

Step D: N.-(4-Fluoro-2-(trifluoromethoxy)phenyl)-N.-isopropyl-2-(met hylthio)pyrimidin-4- amine. To a 50 mL round-bottomed flask were added N.-(4-fluoro-2- (trifluoromethoxy)phenyl)-2-(methylthio)pyrimidin-4-amine (0.59 g, 1 .8 mmol) and DMF (10 mL). To the mixture was added NaH (60% in mineral oil, 0.14 g, 3.6 mmol) at 0 °C. The mixture was stirred at 0 °C for 30 min, then 2-iodopropane (0.46 g, 2.7 mmol) was added. The mixture was stirred at rt for 15 h. The mixture was quenched with water (20 mL) and extracted with EtOAc (3 ^χ 20 mL). The combined organic layers were washed with water (20 mL) and saturated aqueous NaCI solution (20 mL), dried over anhydrous Na2SO4, and concentrated to dryness. The residue was purified by FCC to give the title compound as an off-white solid (0.54 g). MS (ESI): mass calcd. for C15H15F4N3OS, 361.09, m/z found 362.0 [M+H] ⁺ . Step E: N.-(4-Fluoro-2-(trifluoromethoxy)phenyl)-N.-isopropyl-2-(met hylsulfonyl)pyrimidi 4-amine. To a 50 mL round-bottomed flask were added N.-(4-fluoro-2- (trifluoromethoxy)phenyl)-N.-isopropyl-2-(methylthio)pyrimid in-4-amine (0.54 g, 1 .5 mmol), MeOH (5 mL), and water (5 mL). The mixture was cooled to 0 °C, and then Oxone (1 .8 g, 3.0 mmol) was added. The mixture was stirred at rt for 3 h, then saturated aqueous NaHC03 solution (5.0 mL) was added and the mixture extracted with EtOAc (3 x 10 mL). The combined organic layers were washed with saturated aqueous NaCI solution (10 mL), dried over anhydrous Na2S04, and concentrated to dryness. The residue was purified by FCC to give the title compound as a pale-yellow oil (0.28 g). MS (ESI): mass calcd. for C15H15F4N3O3S, 393.08, m/z found 394.1 [M+H] ⁺ .

Step F: N4.-(4-Fluoro-2-(trifluoromethoxy)phenyl)-N4.-isopropylpyrim idine-2,4-diamine. To a 25 mL microwave tube were added N.-(4-fluoro-2-(trifluoromethoxy)phenyl)-N.- isopropyl-2-(methylsulfonyl)pyrimidin-4-amine (0.28 g, 0.71 mmol), /-PrOH (4.0 mL), and NH4OH (6.0 mL). The mixture was heated at 140 °C for 40 min in a microwave reactor. After cooling to rt, the reaction mixture was concentrated to dryness and the residue was purified by FCC to give the title compound as a yellow solid (0.12 g). MS (ESI): mass calcd. for Ci4Hi ₄ F ₄ N ₄ O, 330.28, m/z found 331.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.72 (d, J = 6.1 Hz, 1 H), 7.21 (t, J = 8.6 Hz, 1 H), 7.12 (d, J = 9.5 Hz, 2H), 5.31 (d, J = 5.9 Hz, 1 H), 5.25 - 5.11 (m, 1 H), 4.83 (br s, 2H), 1 .13 (d, J = 6.7 Hz, 6H).

Example 104: N. ⁴ -((2/-/-1 ,2,3-Triazol-4-yl)methyl)-N4.-(2-ethoxy-4-fluorophenyl)pyrim idine- 2,4-diamine.

Step A: N.-(2-Ethoxy-4-fluorophenyl)-2-(methylthio)-N.-(prop-2-ynyl) pyrimidin-4-amine. To a 50 mL round-bottomed flask were added N.-(2-ethoxy-4-fluorophenyl)-2- (methylthio)pyrimidin-4-amine (as prepared in Example 96, step A)1 .0 g, 3.6 mmol) and DMF (10 mL). The mixture was cooled to 0 °C and NaH (60% in mineral oil, 170 mg, 4.3 mmol) was added. The mixture was stirred at 0 °C for 10 min and then 3- bromoprop-1 -yne (650 mg, 5.4 mmol) was added dropwise and the resulting reaction mixture was stirred at rt for 2 h. The mixture was diluted with EtOAc (50 mL), washed with water (3 χ 30 mL) and brine (30 mL), dried over anhydrous Na2S04, filtered, and concentrated to dryness. The residue was purified by FCC to give the title compound (1.0 g, 87% yield) as a brown oil. MS (ESI): mass calcd. for CieHieFNsOS 317.10, m/z found 318.0 [M+H] ⁺ .

Step B: N.-((2Η-1 ,2,3-Triazol-4-yl)methyl)-N.-(2-ethoxy-4-fluorophenyl)-2- (methylthio)pyrimidin-4-amine. To a 100 mL round-bottomed flask were added formalin (25%, 5.0 mL), AcOH (0.92 g, 15 mmol), and dioxane (30 mL). The solution was cooled to 0 °C and NaN3 (1.0 g, 15 mmol) was added. The mixture was stirred at 0 °C for 15 min and then N.-(2-ethoxy-4-fluorophenyl)-2-(methylthio)-N.-(prop-2-ynyl) pyrimidin-4- amine (1.1 g, 3.5 mmol) was added and was stirred at 0 °C for another 20 min. CuSO4 (100 mg, 0.63 mmol) and L-ascorbic acid sodium salt (500 mg, 2.7 mmol) were added and stirred at rt for 15 h. The reaction mixture was filtered and concentrated to dryness. The residue was purified by FCC to give title compound (0.60 g, 47% yield) as a colorless oil. MS (ESI): mass calcd. for CieHiyFNeOS 360.12, m/z found 361 .1 [M+H] ⁺ . Step C: N. ⁴ -((2Η-1 ,2,3-Triazol-4-yl)methyl)-N4.-(2-ethoxy-4-fluorophenyl)pyrim idine-2,4- diamine. The title compound was prepared using analogous conditions described in Example 19, step E and F starting with N.-((2/-/-1 ,2,3-triazol-4-yl)methyl)-N.-(2-ethoxy-4- fluorophenyl)-2-(methylthio)pyrimidin-4-amine in place of N.-(2-methyl-4- (pentafluorosulfanyl)phenyl)-2-(methylthio)-N.-(oxazol-4-ylm ethyl)pyrimidin-4-amine. MS (ESI): mass calcd. for C15H16FN7O, 329.1 , m/z found 330.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CD3OD): δ 7.76 (s, 1 H), 7.62 (d, J = 6.2 Hz, 1 H), 7.08 (dd, J = 8.7, 6.2 Hz, 1 H), 6.90 (dd, J = 10.8, 2.8 Hz, 1 H), 6.71 (td, J = 8.4, 2.7 Hz, 1 H), 5.43 (s, 1 H), 5.31 (d, J = 15.5 Hz, 1 H), 4.98 - 4.87 (m, 1 H), 3.98 (q, J = 7.0 Hz, 2H), 1.23 (t, J = 7.0 Hz, 3H).

Example 105: N4.-Ethyl-N4.-(4-(methylsulfonyl)-2-propylphenyl)pyrimidine- 2,4-diamine.

Step A: N4.-Ethyl-N4.-(4-(methylsulfonyl)-2-(prop-1 -enyl)phenyl)pyrimidine-2,4-diamine. To a 100 mL round-bottomed flask were addedN4.-(2-bromo-4-(methylsulfonyl)phenyl)- N4.-ethylpyrimidine-2,4-diamine hydrochloride (as prepared in Example 83, step A, 160 mg, 0.392 mmol), prop-1 -enylboronic acid (50.0 mg, 0.580 mmol), CS2CO3 (350 mg, 1 .07 mmol), Pd(PPh3)4 (50.0 mg, 0.0430 mmol), dioxane (30 mL), and water (10 mL). The reaction mixture was degassed, back filled with Argon and heated at 100 °C for 15 h. After cooling to rt, the reaction mixture was diluted with EtOAc (30 mL), washed with saturated aqueous NaCI (30 mL), dried over anhydrous Na2S04, filtered, and

concentrated to dryness. The residue was purified by FCC to give title compound (100 mg, 76.0% yield) as a white solid. MS (ESI): mass calcd. for C16H20N4O2S, 332.13, m/z found 332.9 [M+H]+.

Step B: N4.-Ethyl-N4.-(4-(methylsulfonyl)-2-propylphenyl)pyrimidine- 2,4-diamine. To a 100 mL round-bottomed flask were added N4.-ethyl-N4.-(4-(methylsulfonyl)-2-(prop-1 - enyl)phenyl)pyrimidine-2,4-diamine (130 mg, 0.301 mmol), MeOH (30 mL), and Pd/C (10% w/w, 30 mg). The reaction was degassed under vacuum and back filled with H2 using a balloon and was stirred for 15 h. The reaction mixture was filtered and concentrated to dryness and the residue was purified by FCC to give title compound (70 mg, 69% yield) as a white solid. MS (ESI): mass calcd. for C16H22N4O2S, 334.2, m/z found 334.9 [M+H] ⁺ . ¹ H NMR (400 MHz, CDsOD): δ 8.02 (d, J = 2.0 Hz, 1 H), 7.91 (dd, J = 8.2, 2.2 Hz, 1 H), 7.66 (s, 1 H), 7.45 (d, J = 8.2 Hz, 1 H), 5.36 (br s, 1 H), 4.27 (br s, 1 H), 3.55 (br s, 1 H), 3.19 (s, 3H), 2.56 (dd, J = 8.8, 7.0 Hz, 2H), 1.77 - 1 .58 (m, 2H), 1 .24 (t, J = 7.1 H z, 3H), 0.95 (t, J = 7.3 Hz, 3H). Example 106: N4.-(2-Cyclobutyl-4-(cyclopropylsulfonyl)phenyl)-N4.-ethylpy rimidine-2,4- diamine.

Step A: 4-(Cyclopropylsulfonyl)aniline. To a 50 mL sealed vessel were added 4- iodoaniline (2.19 g, 10.0 mmol), sodium cyclopropanesulfinate (1.54 g, 12.0

mmol), trifluoromethanesulfonate benzene complex (251 mg, 0.500 mmol),

dimethylethylenediamine (88.0 mg, 1.00 mmol), and DMSO (50 mL). The reaction vessel was heated at 120 °C for 16 h. The reaction was then poured into a mixture of H2O (50 mL) and EtOAc (500 mL). The organic layer was washed with water (3 ^χ 30 mL) and saturated aqueous NaCI (20 mL), dried over anhydrous Na2S04, filtered, and concentrated to dryness. The residue was purified by FCC to give the title compound (1.80 g, 91.0%) as yellow solid. MS (ESI): mass calcd. for C9H11NO2S, 197.05, m/z found 198.0 [M+H] ⁺ .

Step B:N4.-(2-Cyclobutyl-4-(cyclopropylsulfonyl)phenyl)-N4.-ethyl pyrimidine-2,4-diamine. The title compound was prepared using analogous conditions described in Example 21 starting with 4-(cyclopropylsulfonyl)aniline in place of 4-(methylsulfonyl)aniline. MS (ESI): mass calcd. for C19H24N4O2S, 372.2, m/z found 372.9 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.03 (d, J = 2.1 Hz, 1H), 7.79 (dd, J = 8.2, 2.2 Hz, 1H), 7.74-7.67 (m, 1H), 7.27-7.24 (m, 1H), 5.26 (br s, 1H), 4.85 (br s, 2H), 4.22 (br s, 1H), 3.59 - 3.36 (m, 2H), 2.58-2.50 (m, 1H), 2.35-2.23 (m, 1H), 2.18- 1.91 (m, 4H), 1.88- 1.78 (m, 1H), 1.45- 1.39 (m, 2H), 1.18 (t, J = 7.1 Hz, 3H), 1.14-1.07 (m, 2H).

Example 107:N4.-(2-Cyclobutyl-4-(cyclopropylsulfonyl)phenyl)-N4.-pro pylpyrimidine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 21 employing 4-(cyclopropylsulfonyl)aniline in place of 4-(methylsulfonyl)aniline and 1- iodopropane in place of 1-iodoethane. MS (ESI): mass calcd. for C2oH26N ₄ 02S, 386.2, m/z found 386.9 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.03 (d, J = 2.0 Hz, 1H), 7.78 (dd, J = 8.2, 2.2 Hz, 1H), 7.75-7.68 (m, 1H), 7.29 (s, 1H), 5.26 (brs, 1H), 5.18-4.51 (m, 2H), 4.11 (brs, 1H), 3.56-3.45 (m, 1H), 3.31 -3.22 (m, 1H), 2.58-2.50 (m, 1H), 2.33 - 2.24 (m, 1H), 2.22 - 1.92 (m, 4H), 1.87 - 1.77 (m, 1H), 1.73 - 1.51 (m, 2H), 1.45 - 1.39 (m, 2H), 1.14 - 1.08 (m, 2H), 0.91 (t, J = 7.4 Hz, 3H).

Example

24-diamine.

The title compound was prepared using analogous conditions described in Example 19 starting with 2-ethoxy-4-fluoroaniline in place of 2-methyl-4-

(pentafluorosulfanyl)benzenamine in step C, and 3-(chloromethyl)-4/-/-1 ,2,4-triazole in place of 4-bromomethyloxazole hydrobromide salt in step D. MS (ESI): mass calcd. for C15H16FN7O, 329.1, m/z found 330.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDsOD): δ 8.86 (s, 1H), 7.92 (s, 1H), 7.71 (d, J = 6.1 Hz, 1H), 7.22 (dd, J = 8.7, 6.2 Hz, 1H), 6.92 (dd, J = 10.7, 2.7 Hz, 1H), 6.81 -6.75 (m, 1H), 6.22 (d, J = 13.9 Hz, 1H), 6.09 (d, J = 13.6 Hz, 1H), 5.46 (d, J = 5.9 Hz, 1H), 3.93 (q, J = 7.0 Hz, 2H), 1.16 (t, J = 7.0 Hz, 3H). Example 109: N4.-(2-Ethyl-4-(trifluoromethyl)phenyl)-N4.-(oxazol-4-ylmeth yl)pyrimidine- 2,4-diamine.

Step A: N4.-(2-Bromo-4-(trifluoromethyl)phenyl)-N4.-(oxazol-4-ylmeth yl)pyrimidine-2,4- diamine. The title compound was prepared using analogous conditions described in Example 102, steps C-D, and F-G, and using 2-bromo-4-(trifluoromethyl)aniline in place of 4-bromo-2-cyclobutylaniline in step C, and using 4-bromomethyloxazole in place of 2- iodopropane in step D.

Step B: N4.-(Oxazol-4-ylmethyl)-N4.-(4-(trifluoromethyl)-2-vinylphen yl)pyrimidine-2,4- diamine. To a 35 ml_ microwave vial were added N4.-(2-bromo-4-

(trifluoromethyl)phenyl)-N4.-(oxazol-4-ylmethyl)pyrimidin e-2,4-diamine (207 mg, 0.500 mmol), chloro-(2-dicyclohexylphosphino-2',6'-diisopropoxy-1 , 1 '-biphenyl)[2-(2- aminoethyl)phenyl]palladium(ll)-methyl-f-butyl ether adduct (20 mg, cat.), K3PO4 (0.5 M in H2O, 2.00 ml_, 1.00 mmol), 4,4,5,5-tetramethyl-2-vinyl-1 ,3,2-dioxaborolane (308 mg, 2.00 mmol), and dioxane (10.0 ml_) under N2. The reaction was heated at 120 °C for 1 h in a microwave reactor. The mixture was cooled to rt and diluted with EtOAc (50 ml_), washed with water (3 x 30 ml_) and saturated aqueous NaCI (20 ml_), dried over anhydrous Na2S04, filtered, and concentrated to dryness. The residue was purified by FCC to give the title compound (160 mg, 89% yield) as a yellow oil. MS (ESI): mass calcd. for C17H14F3N5O, 361 .12, m/z found 362.1 [M+H] ⁺ .

Step C: N4.-(2-Ethyl-4-(trifluoromethyl)phenyl)-N4.-(oxazol-4-ylmeth yl)pyrimidine-2,4- diamine. To a 100-mL round-bottomed flask were addedN4.-(oxazol-4-ylmethyl)-N4.-(4- (trifluoromethyl)-2-vinylphenyl)pyrimidine-2,4-diamine (160 mg, 0.443 mmol), Pd/C (10% on activated carbon, 20 mg), and MeOH (20 ml_). The flask was degassed under vacuum and refilled with hydrogen gas using a balloon. The reaction mixture was stirred at rt for 14 h under a H2 atmosphere. The mixture was filtered through a pad of diatomaceous earth such as Celite ^® and the filtrate was concentrated to dryness. The residue was purified by FCC to give the title compound (112 mg, 70% yield) as a yellow solid. MS (ESI): mass calcd. for C17H16F3N5O, 363.1 , m/z found 364.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.81 (s, 1 H), 7.73 (d, J = 5.4 Hz, 1 H), 7.63 (d, J = 8.7 Hz, 2H), 7.50 (d, J = 8.1 Hz, 1 H), 7.20 (d, J = 8.2 Hz, 1 H), 5.44 - 5.24 (m, 2H), 4.96 (br s, 2H), 4.53 (d, J = 15.2 Hz, 1 H), 2.50 (q, J = 7.5 Hz, 2H), 1 .16 (t, J = 7.6 Hz, 3H).

Example 110: N4.-(Oxazol-4-ylmethyl)-N4.-(4-(trifluoromethyl)phenyl)pyrim idine-2,4- diamine.

The title compound was prepared using analogous conditions described in Example 102, steps C-D, and F-G, and using 2-methyl-4-(trifluoromethyl)aniline in place of 4- bromo-2-cyclobutylaniline in step C, and using 4-bromomethyloxazole in place of 2- iodopropane in step D. MS (ESI): mass calcd. for C16HHF3N5O, 349.1 , m/z found 350.1 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.82 (s, 1 H), 7.73 (d, J = 6.1 H z, 1 H), 7.64 (s, 1 H), 7.57 (s, 1 H), 7.51 (d, J = 8.2 Hz, 1 H), 7.24 (d, J = 8.2 Hz, 1 H), 5.42 - 5.20 (m, 2H), 5.07 (br s, 2H), 4.64 (d, J = 14.9 Hz, 1 H), 2.15 (s, 3H).

Exam le 111 : 4-((2-Aminopyrimidin-4-yl)(ethyl)amino)-3-cyclobutylbenzamid e.

The title compound was prepared using analogues conditions as described in example 1 13, steps A-E wherein, methyl 4-amino-3-cyclobutylbenzoate was used in place of methyl 4-amino-3-bromobenzoate in step A. Purification by column chromatography (DCM: MeOH, 20:1) afforded the title compound. MS (ESI): mass calcd. for C17H21N5O, 311.2, m/z found 312.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDC ): δ 8.01 (d, J= 1.9 Hz, 1H), 7.71 -7.59 (m, 2H), 7.15(d, J = 8.1 Hz, 1H), 6.15(brs, 1H), 5.79 (brs, 1H), 5.23 (brs, 1H), 4.94 (br s, 2H), 4.22 (br s, 1H), 3.55 - 3.38 (m, 2H), 2.25 - 2.07 (m, 4H), 2.02 - 1.89 (m, 1H), 1.87 - 1.77 (m, 1H), 1.17 (t, J= 7.1 Hz, 3H).

Exam le 112: 4-((2-Aminopyrimidin-4-yl)(isopropyl)amino)-3-cyclobutylbenz amide.

The title compound was prepared using analogous conditions described in Example 102, steps A, C-D, and F-G, and using methyl 4-amino-3-bromobenzoate in place of 2- bromoaniline in step A, and using methyl 4-amino-3-cyclobutylbenzoate in place of 4- bromo-2-cyclobutylaniline in step C. MS (ESI): mass calcd. for C18H23N5O, 325.4, m/z found 326.0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 8.14 (d, J = 2.1Hz, 1H), 7.66 (dd, J =8.1, 2.1 Hz, 1H), 7.59 (d, J = 6.2 Hz, 1H), 7.10 (d, J =8.1 Hz, 1H), 6.20 (br s, 1H),

5.89 (br s, 1H), 5.17 - 4.93 (m, 4H), 3.57 - 3.46 (m, 1H), 2.29 - 2.16 (m, 2H), 2.14 - 1.97 (m, 2H), 1.96 - 1.80(m, 2H), 1.28 (d, J = 6.5 Hz, 3H), 0.92 (d, J = 6.9 Hz, 3H).

Exam ie 113: 4-((2-Am inopyrim idin-4-yl)(ethyl)am ino)-3-isobutylbenzam ide.

Step A: Methyl 3-bromo-4-((2-(methylthio)pyrimidin-4-yl)amino)benzoate. To a solution of methyl 4-amino-3-bromobenzoate (920 mg, 4.00 mmol) and 4-chloro-2- (methylthio)pyrimidine (964 mg, 6.00 mmol) in isopropanol (20 mL) was added p- toluene sulphonic acid (100 mg, 0.580 mmol) at rt. The mixture was stirred for 2 h at 100 °C using microwave irradiation in a microwave reactor. The mixture was

concentrated in vacuo and purified by a column chromatography (DCM : CH3OH = 20 : 1 ) to afford 1 .1 g of the title compound. MS (ESI): mass calcd. for Ci3Hi2BrN302S, 354.2; m/z found, 355.1 [M+H] ⁺ .

Step B: Methyl 3-bromo-4-(ethyl(2-(methylthio)pyrimidin-4-yl)amino)benzoate .

To a 50 mL sealed tube was added methyl 3-bromo-4-((2-(methylthio)pyrimidin-4- yl)amino)benzoate (1 .1 g, 3.1 mmol), iodoethane (0.97 g, 6.2 mmol) and cesium carbonate (2.0 g, 6.2 mmol) in acetonitrile (100 mL). The vessel was heated to 65 °C for 3h, then cooled to rt and filtered. The reaction mixture was concentrated in vacuo and purified by column chromatography (DCM : CH3OH = 20 : 1 ) to afford 1.0 g of the title compound. MS (ESI): mass calcd. for Ci5Hi6BrN302S, 382.3; m/z found, 383.1 [M+H] ⁺ .

Step C: Methyl 3-bromo-4-(ethyl(2-(methylsulfonyl)pyrimidin-4-yl)amino)benz oate To a 200 mL round-bottomed flask was added methyl 3-bromo-4-(ethyl(2- (methylthio)pyrimidin-4-yl)amino)benzoate (1 .0 g, 2.6 mmol) in dichloromethane (100 mL), then m-CPBA (1 .5 g, 8.5 mmol) was added to the solution. The mixture was stirred at 0 °C for 3h, then NaHC03/H20 and DCM were added and the layers separated. The organic layer was dried and concentrated in vacuo, then purified by column

chromatography (DCM : CH3OH = 50 : 1 ) to afford 900 mg of the title compound. MS (ESI): mass calcd. for Ci5Hi ₆ BrN ₃ 04S, 414.2; m/z found, 415.7 [M+H] ⁺ .

Step D: 4-((2-aminopyrimidin-4-yl)(ethyl)amino)-3-bromobenzamide

To a round-bottomed flask was charged methyl 3-bromo-4-(ethyl(2-

(methylsulfonyl)pyrimidin-4-yl)amino)benzoate (900 mg, 2.17 mg) which was dissolved into 1 ,4-dioxane (10 mL) then ammonium hydroxide (5 mL) was added. The resulting mixture was stirred for 14 h at 105 °C, then DCM and water were added. The layers were separated and the organic layers were dried and concentrated. Purification by column chromatography (DCM : CH3OH = 15 : 1 ) afforded 150 mg of the title compound. MS (ESI): mass calcd. for CisHuBrNsO, 336.2; m/z found, 336.0 [M+H] ⁺ . Step E: 4-((2-aminopyrimidin-4-yl)(ethyl)amino)-3-(2-methylprop-1 -en-1 -yl)benzamide To a 15 mL reaction vessel was added 4-((2-aminopyrimidin-4-yl)(ethyl)amino)-3- bromobenzamide (150 mg, 0.446 mmol), 4,4,5,5-tetramethyl-2-(2-methylprop-1 -en-1 - yl)-1 ,3,2-dioxaborolane (255 mg, 1 .40 mmol), chloro-(2-dicyclohexylphosphino-2',6'- diisopropoxy-1 , 1 '-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)-methyl-i-bu tyl ether adduct (50 mg) and 0.5 M K3PO4 (aq.) (1 .84 mL, 0.920 mmol) in 1 ,4-dioxane (10 mL) under N2. The resulting mixture was stirred at 120 °C for 1 h. The mixture was filtered, concentrated in vacuo, and purified by column chromatography (petroleum ether : ethyl acetate = 100 : 1 ) to afford 1 10 mg of the title compound. MS (ESI): mass calcd. for C17H21 N5O, 311 .4; m/z found, 312.0 [M+H] ⁺ .

Step F: 4-((2-aminopyrimidin-4-yl)(ethyl)amino)-3-isobutylbenzamide

To a 100 mL round-bottomed flask was added 4-((2-aminopyrimidin-4-yl)(ethyl)amino)-

3-(2-methylprop-1 -en-1 -yl)benzamide (110 mg, 0.35 mmol) and palladium on carbon (10 mg) in methanol (20 mL). The resulting mixture was stirred for 14 hours under 2 atm of H2, filtered and concentrated in vacuo. Purification by preparative HPLC afforded 29 mg of the title compound. MS (ESI): mass calcd. for C17H23N5O, 313.2; m/z found, 313.9 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.85 (d, J = 2.0 Hz, 1 H), 7.71 - 7.60 (m, 2H), 7.18 (d, J = 8.1 Hz, 1 H), 6.11 (br s, 1 H), 5.77 (br s, 1 H), 5.29 (br s, 1 H), 4.94 (br s, 2H), 4.36 (br s, 1 H), 3.37 - 3.25 (m, 1 H), 2.47 - 2.30 (m, 2H), 2.07 - 1.89 (m, 1 H), 1 .21 (t, J = 7.1 Hz, 3H), 0.86 (dd, J = 8.3, 6.8 Hz, 6H).

Example 114: (E)-N4.-lsopropyl-N4.-(2-(prop-1 -en-1 -yl)-4- trifluoromethyl)phenyl)pyrimidine-2,4-diamine.

Step A:N4.-(2-Chloro-4-(trifluoromethyl)phenyl)-N4.-isopropylpyri midine-2,4-diamine. The title compound was prepared using the method for Example 102, steps C-D and F- G, and using 2-chloro-4-(trifluoromethyl)aniline in place of 4-bromo-2-cyclobutylaniline in step C, to give the title compound. MS (ESI): mass calcd. for Ci4Hi ₄ CIF3N ₄ , 330.74; m/z found, 331 .0 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.81 (d, J = 2.1 Hz, 1 H), 7.74 (d, J = 6.0 Hz, 1 H), 7.62 (dd, J = 8.3, 2.1 Hz, 1 H), 7.37 (dd, J = 8.2, 1 .0 Hz, 1 H), 5.24 - 5.18 (m, 1 H), 5.12 (p, J = 6.9 Hz, 1 H), 4.89 (s, 2H), 1.10 (s, 6H).

Step B: (E)-N4.-isopropyl-N4.-(2-(prop-1 -en-1 -yl)-4-(trifluoromethyl)phenyl)pyrimidine-2,4- diamine. To a microwave vial were addedN4.-(2-chloro-4-(trifluoromethyl)phenyl)-N4.- isopropylpyrimidine-2,4-diamine (590 mg, 3.57 mmol), 4,4,5,5-tetramethyl-2-[(E)-prop-1 - enyl]-1 ,3,2-dioxaborolane (600 mg, 3.57 mmol), chloro-(2-dicyclohexylphosphino-2',6'- diisopropoxy-1 , 1 '-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)-methyl-i-bu tyl ether adduct (260 mg, 0.357 mmol), potassium phosphate tribasic solution (0.5 M, 10.0 ml_), and dioxane (5.4 ml_). The mixture was degassed with N2 for 15 min, then heated in a microwave reactor at 1 10 °C for 60 min. The reaction was purified by acidic HPLC (0- 100% acetonitrile/water using trifluoroacetic acid as modifier) to give the title compound (570 mg, 95.0% yield). MS (ESI): mass calcd. for C17H19F3N4, 336.35; m/z found, 337.2 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.89 (d, J = 2.2 Hz, 1 H), 7.67 (d, J = 6.0 Hz, 1 H), 7.52 (dd, J = 8.2, 2.1 Hz, 1 H), 7.18 (d, J = 8.1 Hz, 1 H), 6.33 (d, J = 4.0 Hz, 2H), 5.14 (dt, J = 21 .0, 6.8 Hz, 2H), 4.91 (s, 2H), 1 .84 (d, J = 4.4 Hz, 3H), 1 .27 (d, J = 6.6 Hz, 3H), 0.97 (d, J = 7.0 Hz, 3H).

Example 115: N4.-lsopropyl-N4.-(2-propyl-4-(trifluoromethyl)phenyl)pyrimi dine-2,4- diamine.

A solution of (E)-N4.-isopropyl-N4.-(2-(prop-1 -en-1 -yl)-4-

(trifluoromethyl)phenyl)pyrimidine-2,4-diamine (Example 114, 500 mg, 1.49 mmol) in MeOH (30 mL) was subjected to atmospheric H2 at rt for 5 h. The reaction was concentrated to dryness and the residue was purified by acidic HPLC to give the title compound. MS (ESI): mass calcd. for Ci7H ₂ i F ₃ N ₄ , 338.1 ; m/z found, 339.0 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.71 (dd, J = 2.0, 1 .0 Hz, 1 H), 7.59 (dd, J = 8.2, 2.1 H z, 1 H), 7.42 (d, J = 7.4 Hz, 1 H), 7.20 (d, J = 8.2 Hz, 1 H), 5.49 - 4.86 (m, 2H), 2.56 - 2.36 (m, 2H), 1 .76 - 1 .58 (m, 2H), 1.35 (d, J = 6.6 Hz, 3H), 1 .04 (d, J = 6.9 Hz, 3H), 0.98 (t, J = 7.3 Hz, 3H).

Example 116: N4.-lsopropyl-N4.-(2-methyl-4-(trifluoromethyl)phenyl)pyrimi dine-2,4- diamine.

N4.-lsopropyl-N4.-(2-methyl-4-(trifluoromethyl)phenyl)pyr imidine-2,4-diamine. To a 25 mL vial were added N4.-(2-chloro-4-(trifluoromethyl)phenyl)-N4.-isopropylpyrimi dine-2,4- diamine (as prepared in Example 1 14, step A, 250 mg, 0.756 mmol), 2,4,6-trimethyl- 1 , 3,5,2, 4,6-trioxatriborinane (82.0 mg, 0.660 mmol), and 1 , 1 '- bis(diphenylphosphino)ferrocene-palladium(ll)dichloride dichloromethane complex (55.0 mg, 0.0760 mmol). The vial was sealed then evacuated and backfilled with N2 (2x). Dioxane (10.0 mL) and degassed phosphate solution (0.5 M, 16.0 mL, 7.90 mmol) were added. The resulting mixture was heated to 140 °C in a microwave reactor for 30 min. The reaction was cooled to rt, then diluted with EtOAc (30 mL) and poured into water (20 mL). The aqueous layer was extracted further with EtOAc (30 mL). The combined organics were washed with brine (20 mL), dried over anhydrous MgS04, and

concentrated to dryness. The residue was purified by FCC to give the title compound (80 mg, 34% yield). MS (ESI): mass calcd. for C15H17F3N4, 310.1 ; m/z found, 311 .0 [M+H] ⁺ . ¹ H NMR (400 MHz, CDCb): δ 7.71 - 7.56 (m, 2H), 7.45 (d, J = 7.1 Hz, 1 H), 7.23 (d, J = 8.2 Hz, 2H), 5.30 (s, 1 H), 5.21 (dd, J = 23.2, 7.4 Hz, 2H), 2.22 (s, 3H), 1 .35 (d, J = 6.6 Hz, 3H), 1.03 (d, J = 6.9 Hz, 3H). Exam le 117: 4-((2-Aminopynmidin-4-yl)(oxazol-4-ylmethyl)amino)-3-propylb enzonitrile.

Step A: (E)-4-((2-Aminopyrimidin-4-yl)(oxazol-4-ylmethyl)amino)-3-(p rop-1 -en-1 - yl)benzonitrile. To a 20 mL microwave vial were added (E)-N4.-(4-chloro-2-(prop-1 -en-1 - yl)phenyl)-N4.-(oxazol-4-ylmethyl)pyrimidine-2,4-diamine (Example 101 , 500 mg, 1.46 mmol), zinc cyanide (388 mg, 3.31 mmol), X-Phos (166 mg, 0.348 mmol), Zn powder (22 mg, 0.34 mmol), and Pd2(dba)3 (215 mg, 0.235 mmol). The reaction vessel was then evacuated and backfilled with N2 (2x). DMA (15 mL) was added in one portion and the resulting brown mixture was placed into a preheated 120 °C heating block and heated for 1 h. The vial was removed from the heat and cooled to rt. The reaction was diluted with EtOAc (15 mL) and was filtered through a pad of diatomaceous earth such as Celite ^® to remove the insoluble particulates. The cake was rinsed with EtOAc (2 x 5 mL). The filtrate was transferred to a 125 mL separatory funnel and washed with saturated NaHCO3 (20 mL), water (20 mL), and brine (20 mL), then dried over anhydrous MgSO4. The organics were concentrated to dryness to afford a yellow semi solid. The residue was purified by FCC to give the title compound as a colorless residue (370 mg, 76% yield). MS (ESI): mass calcd. for CisHieNeO, 332.36; m/z found, 333.1 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.79 (d, J = 1 .0 Hz, 1 H), 7.72 (d, J = 6.0 Hz, 1 H), 7.60 - 7.52 (m, 2H), 7.17 (dd, J = 8.4, 2.5 Hz, 1 H), 6.96 (d, J = 8.4 Hz, 1 H), 6.31 - 6.10 (m, 2H), 5.39 - 5.28 (m, 2H), 5.02 (s, 2H), 4.53 (d, J = 15.3 Hz, 1 H), 1 .81 (dd, J = 6.4, 1 .5 Hz, 3H).

Step B: 4-((2-Aminopyrimidin-4-yl)(oxazol-4-ylmethyl)amino)-3-propyl benzonitrile. A solution of (E)-4-((2-aminopyrimidin-4-yl)(oxazol-4-ylmethyl)amino)-3-(p rop-1 -en-1 - yl)benzonitrile (300 mg, 0.903 mmol) in MeOH (18 mL) was hydrogenated using a H2 balloon at rt for 5 h. The reaction was concentrated to dryness and the residue was purified by HPLC (0-100% acetonitrile/water using trifluoroacetic acid as modifier) to give the title compound (90 mg, 30% yield). MS (ESI): mass calcd. for ΟΐδΗΐδΝβΟ, 334.4; m/z found, 335.1 [M+H] ⁺ . ¹ H N MR (500 MHz, CDCb): δ 9.71 (s, 1 H), 7.85 (s, 1 H), 7.77 (s, 1 H), 7.72 (d, J = 1 .9 Hz, 1 H), 7.61 (dd, J = 8.2, 1 .9 Hz, 1 H), 7.50 (d, J = 7.2 Hz, 1 H), 7.32 (d, J = 8.2 Hz, 1 H), 6.48 (s, 1 H), 5.50 (d, J = 14.8 Hz, 1 H), 5.39 (d, J = 7.2 Hz, 1 H), 4.50 (d, J = 14.8 Hz, 1 H), 2.49 - 2.39 (m, 2H), 1 .70 - 1 .53 (m, 2H), 0.94 (t, J = 7.3 Hz, 3H).

Example 118: (E)-N4.-(4-Fluoro-2-(prop-1 -en-1 -yl)phenyl)-N4.-isopropylpyrimidine-2,4- diamine.

Step A: N4.-(2-Chloro-4-fluorophenyl)-N4.-isopropylpyrimidine-2,4-di amine. The title compound was prepared using the method for Example 102 steps C-D and F-G, and using 2-chloro-4-fluoroaniline in place of 4-bromo-2-cyclobutylaniline in step C (2300 mg). 1 H NMR (400 MHz, Methanol-d4) d 7.63 - 7.56 (m, 1 H), 7.48 - 7.40 (m, 1 H), 7.40 - 7.31 (m, 1 H), 7.28 - 7.17 (m, 1 H), 5.38 - 5.03 (m, 2H), 1 .28 (d, J = 6.5 Hz, 3H), 1 .05 (d, J = 6.8 Hz, 3H). MS (ESI): mass calcd. for Ci ₃ Hi ₄ CIFN ₄ , 280.7; m/z found, 281.1 [M+H] ⁺ .

Step B: (E)-N4.-(4-Fluoro-2-(prop-1 -en-1 -yl)phenyl)-N4.-isopropylpyrimidine-2,4-diamine. A microwave vial containing N4.-(2-chloro-4-fluorophenyl)-N4.-isopropylpyrimidine-2,4- diamine (1 12 mg, 0.399 mmol), 2-dicyclohexylphosphino-2',6'-diisopropoxybiphenyl, palladium(ll) phenethylamine chloride (7.3 mg, 0.010 mmol), K3PO4 solution (0.5 M 2.39 mL), dioxane (1.21 mL), and frans-1 -propen-1 -ylboronic acid (103 mg, 1 .20 mmol) was stirred and degassed with N2 for 15 min, and then the reaction was heated in a microwave for 20 min at 140 °C. The reaction mixture was filtered, added DCM and

H2O, collected the organic layer, and extracted the aqueous layer again with DCM. The combined organic fractions were dried over anhydrous Na2S04, filtered, and concentrated to dryness. The residue was purified by FCC to give the title compound (57.9 mg). MS (ESI): mass calcd. for C16H19FN4, 286.4; m/z found, 287.1 [M+H] ⁺ . ¹ H N MR (500 MHz, CDC ): δ 7.65 (d, J = 6.1Hz, 1H), 7.31 (dd, J = 10.0, 2.8 Hz, 1H), 7.04 - 6.93 (m, 2H), 6.26 - 6.22 (m, 2H), 5.19 - 5.05 (m, 2H), 4.72 (s, 2H), 1.84 - 1.81 (m, 3H), 1.23 (d, J = 6.6 Hz, 3H), 0.95 (d, J = 6.9 Hz, 3H).

Exam le 119:N4.-(4-Fluoro-2-propylphenyl)-N4.-isopropylpyrimidine-2, 4-diamine

A solution of (E)-N4.-(4-fluoro-2-(prop-1 -en-1 -yl)phenyl)-N4.-isopropylpyrimidine-2,4- diamine (Example 118, 108 mg, 0.377 mmol) in MeOH (7.5 mL) was hydrogentated (H2, 1 atm, 80 °C) over 10% Pd/C for 2 h. The reaction was concentrated to dryness and the residue was purified by FCC to give the title compound (87.7 mg, 80.6% yield). MS (ESI): mass calcd. for C16H21FN4, 288.4; m/z found, 289.2 [M+H] ⁺ . ¹ H NMR (400 MHz, CD3OD): δ 7.56-7.51 (m, 1H), 7.26 (dd, J = 9.8, 2.8 Hz, 1H), 7.22-7.16 (m, 1H), 7.13 -7.07 (m, 1H), 5.36 (s, 1H), 5.12 (s, 1H), 2.52-2.35 (m, 2H), 1.72-1.59 (m, 2H), 1.33 (d, J = 6.6 Hz, 3H), 1.04 (d, J = 6.8 Hz, 3H), 0.95 (t, J = 7.3 Hz, 3H).

Example 120:N4.-(4-Fluoro-2-(prop-1 -en-2-yl)phenyl)-N4.-isopropylpyrimidine-2,4- diamine.

The title compound was prepared using the method for Example 118, steps A-B, and using isopropenyiboronic acid pinacol ester in place of frans-1-propen-1-ylboronic acid in step B (65.3 mg). MS (ESI): mass calcd. for C16H19FN4, 286.4; m/z found, 287.3

[M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.68 (d, J = 6.1 Hz, 1 H), 7.09 (dd, J = 9.5, 2.7 Hz, 1 H), 7.04 - 6.95 (m, 2H), 5.28 (d, J = 6.0 Hz, 1 H), 5.12 - 5.08 (m, 1 H), 5.01 - 4.97 (m, 1 H), 4.91 - 4.82 (m, 1 H), 4.69 (s, 2H), 1 .95 (s, 3H), 1 .19 (d, J = 6.6 Hz, 3H), 1 .06 (d, J = 6.9 Hz, 3H).

Exam le 121 : N4-.(4-Fluoro-2-isopropylphenyl)-N4.-isopropylpyrimidine-2,4 -diamine.

A solution of N4-.(4-fluoro-2-(prop-1 -en-2-yl)phenyl)-N4.-isopropylpyrimidine-2,4-diamine (Example 120, 60 mg, 0.21 mmol) in MeOH (4.2 ml_) was hydrogenated (H2, 1 atm) using an H-Cube machine and a 10% Pd/C cartridge for 2 h. The reaction mixture was concentrated to dryness and the residue purified by HPLC. The HPLC fractions were washed with saturated NaHC03 and DCM, collected the organic phase, and extracted the aqueous phase again with DCM. The pooled organic layers were dried over anhydrous Na2S04, filtered, and concentrated to dryness to give the title compound (38.7 mg, 64% yield). MS (ESI): mass calcd. for C16H21 FN4, 288.4; m/z found, 289.2 [M+H] ⁺ . ¹ H NMR (400 MHz, CDsOD): δ 7.54 (d, J = 6.2 Hz, 1 H), 7.20 (dd, J = 10.0, 2.9 Hz, 1 H), 7.13 - 7.08 (m, 1 H), 7.06 - 6.99 (m, 1 H), 5.23 - 5.01 (m, 2H), 3.03 - 2.91 (m, 1 H), 1 .26 (d, J = 6.6 Hz, 3H), 1 .22 (d, J = 6.9 Hz, 3H), 1 .09 (d, J = 6.8 Hz, 3H), 1 .02 (d, J = 6.9 Hz, 3H).

Example 122: (E)-4-((2-Aminopyrimidin-4-yl)(oxazol-4-ylmethyl)amino)-3-(p rop-1 -en-1 - yl)benzonitrile.

The title compound was prepared using the method for Example 117, steps A-B (370 mg). MS (ESI): mass calcd. for CisHieNeO, 332.4; m/z found, 333.10 [M+H] ⁺ . ¹ H NMR (500 MHz, CDCb): δ 7.79 (d, J = 1 .0 Hz, 1 H), 7.72 (d, J = 6.0 Hz, 1 H), 7.60 - 7.52 (m, 2H), 7.17 (dd, J = 8.4, 2.5 Hz, 1 H), 6.96 (d, J = 8.4 Hz, 1 H), 6.31 - 6.10 (m, 2H), 5.39 - 5.28 (m, 2H), 5.02 (s, 2H), 4.53 (d, J = 15.3 Hz, 1 H), 1 .81 (dd, J = 6.4, 1 .5 Hz, 3H).

Binding Assay on Recombinant Human Histamine H ₄ Receptor.

Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H ₄ receptor. To isolate plasma membrane enriched in recombinant human H4 receptor, cells were collected from 100 culture dishes (150mm) in PBS-EDTA. The cells were pellet by centrifugation (800g) and resuspended in 5X TE buffer (50mM Tris/5mM EDTA). The cells were then homogenized and centrifuged at 1000g for 10 min. The supernatant was collected and centrifuged for an additional 26000g for 30 min. The supernatant was removed and the pellet was gently resuspended in 30ml of 5X TE buffer. Protein concentration was then determined using Bradford protein assay (Bradford, M.M., Anal. Biochem., 1976, 72: 248-254). Isolated cell membranes were incubated with 2x KD (10 nM), [ ³ H] histamine (Specific activity: 23 Ci/mmol), with or without test compounds for 45 min at 25 °C. Nonspecific binding was defined with 100 μΜ cold histamine. K values were calculated based on an experimentally determined appropriate Kb values according to Cheng and Prusoff {Biochem. Pharmacol. 1973, 22(23):3099-3108). Membranes were harvested by rapid filtration using the 96 well Brandel system or a cell harvester using a Whatman GF/C filter or filter plates treated with 0.5% polyethylenimine (PEI), and washed 4 times with ice-cold 50 mM Tris/5 mM EDTA buffer. Filters were then dried, mixed with scintillant and radioactive counts were determined. Results for the compounds tested in theses assays are presented in Table 4 as an average of results obtained.