Title:
2,4-DISUBSTITUTED AMIDO-6-SUBSTITUTED-[1,3,5]TRIAZINE OR 1,3-PYRIMIDINE COMPOUNDS, THEIR PROCESSES FOR PREPARATION, THEIR PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/071199
Kind Code:
A1
Abstract:
This invention discloses the 2,4-disubstituted amido-6-substituted [1,3,5] triazine
or 1,3-pyrimidine derivatives of the general formula (I), in which the definitions
of R1, R2, R3, R4, R5, R6,
A, B, X, Y and Z are described as the description, their preparations, their pharmaceutical
compositions and the pharmacological uses thereof. The compounds have high
incorporation activity with HIV-1 integrase, and may effectively inhibit the
incorporation of the integrase and the substrate in the substrate competition
test. So, the compounds are relatively strong HIV-1 integrase inhibitors and
are potential anti-HIV medicines.
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Inventors:
JIANG HUALIANG (CN)
SHEN XU (CN)
ZHENG YONGTANG (CN)
LI JIAN (CN)
DU LI (CN)
YANG LIUMENG (CN)
WANG RUIRUI (CN)
CHEN KAIXIAN (CN)
LIU HONG (CN)
WANG YIPING (CN)
SHEN XU (CN)
ZHENG YONGTANG (CN)
LI JIAN (CN)
DU LI (CN)
YANG LIUMENG (CN)
WANG RUIRUI (CN)
CHEN KAIXIAN (CN)
LIU HONG (CN)
WANG YIPING (CN)
Application Number:
PCT/CN2006/003546
Publication Date:
June 28, 2007
Filing Date:
December 22, 2006
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
KUNMING INST ZOOLOGY CAS (CN)
SHANGHAI PHARMACEUTICAL GROUP (CN)
JIANG HUALIANG (CN)
SHEN XU (CN)
ZHENG YONGTANG (CN)
LI JIAN (CN)
DU LI (CN)
YANG LIUMENG (CN)
WANG RUIRUI (CN)
CHEN KAIXIAN (CN)
LIU HONG (CN)
WANG YIPING (CN)
KUNMING INST ZOOLOGY CAS (CN)
SHANGHAI PHARMACEUTICAL GROUP (CN)
JIANG HUALIANG (CN)
SHEN XU (CN)
ZHENG YONGTANG (CN)
LI JIAN (CN)
DU LI (CN)
YANG LIUMENG (CN)
WANG RUIRUI (CN)
CHEN KAIXIAN (CN)
LIU HONG (CN)
WANG YIPING (CN)
International Classes:
C07D239/48; A61K31/18; A61K31/495; A61K31/53; A61K31/535; A61K31/5377; C07D239/50; C07D251/18; C07D251/54; C07D401/04; C07D413/04
Domestic Patent References:
WO1999036410A1 | 1999-07-22 | |||
WO2003062392A2 | 2003-07-31 |
Foreign References:
US20040167132A1 | 2004-08-26 | |||
GB2397301A | 2004-07-21 | |||
CN1295566A | 2001-05-16 | |||
CN1668305A | 2005-09-14 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (Block B KingSound International Center, 116 Zizhuyuan Roa, Haidian District Beijing 7, CN)
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