2,4-DISUBSTITUTED AMIDO-6-SUBSTITUTED-[1,3,5]TRIAZINE OR 1,3-PYRIMIDINE COMPOUNDS, THEIR PROCESSES FOR PREPARATION, THEIR PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Title:

2,4-DISUBSTITUTED AMIDO-6-SUBSTITUTED-[1,3,5]TRIAZINE OR 1,3-PYRIMIDINE COMPOUNDS, THEIR PROCESSES FOR PREPARATION, THEIR PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2007/071199

Kind Code:

A1

Abstract:

This invention discloses the 2,4-disubstituted amido-6-substituted [1,3,5] triazine or 1,3-pyrimidine derivatives of the general formula (I), in which the definitions of R1, R2, R3, R4, R5, R6, A, B, X, Y and Z are described as the description, their preparations, their pharmaceutical compositions and the pharmacological uses thereof. The compounds have high incorporation activity with HIV-1 integrase, and may effectively inhibit the incorporation of the integrase and the substrate in the substrate competition test. So, the compounds are relatively strong HIV-1 integrase inhibitors and are potential anti-HIV medicines.

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Inventors:

JIANG HUALIANG (CN)
SHEN XU (CN)
ZHENG YONGTANG (CN)
LI JIAN (CN)
DU LI (CN)
YANG LIUMENG (CN)
WANG RUIRUI (CN)
CHEN KAIXIAN (CN)
LIU HONG (CN)
WANG YIPING (CN)

Application Number:

PCT/CN2006/003546

Publication Date:

June 28, 2007

Filing Date:

December 22, 2006

Export Citation:

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Assignee:

SHANGHAI INST MATERIA MEDICA (CN)
KUNMING INST ZOOLOGY CAS (CN)
SHANGHAI PHARMACEUTICAL GROUP (CN)
JIANG HUALIANG (CN)
SHEN XU (CN)
ZHENG YONGTANG (CN)
LI JIAN (CN)
DU LI (CN)
YANG LIUMENG (CN)
WANG RUIRUI (CN)
CHEN KAIXIAN (CN)
LIU HONG (CN)
WANG YIPING (CN)

International Classes:

C07D239/48; A61K31/18; A61K31/495; A61K31/53; A61K31/535; A61K31/5377; C07D239/50; C07D251/18; C07D251/54; C07D401/04; C07D413/04

Domestic Patent References:

WO1999036410A1	1999-07-22
WO2003062392A2	2003-07-31

Foreign References:

US20040167132A1	2004-08-26
GB2397301A	2004-07-21
CN1295566A	2001-05-16
CN1668305A	2005-09-14

Attorney, Agent or Firm:

KINGSOUND & PARTNERS (Block B KingSound International Center, 116 Zizhuyuan Roa, Haidian District Beijing 7, CN)

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