Title:
2,4-DISUBSTITUTED PHENYLENE-1,5-DIAMINE DERIVATIVES AND APPLICATIONS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM
Document Type and Number:
WIPO Patent Application WO/2015/127872
Kind Code:
A1
Abstract:
The present invention provides a class of 2,4-disubstituted phenylene-1,5-diamine derivatives, having an inhibiting effect on EGFR tyrosine kinases, and pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug of said derivatives. See the description for the definitions of each group in the formula. In addition, the present invention also discloses pharmaceutical compositions, pharmaceutically acceptable compositions, and applications thereof.
Inventors:
LAN JIONG (CN)
JIN YUNZHOU (CN)
ZHOU FUSHENG (CN)
XIE JING (CN)
SHEN SIDA (CN)
HU YI (CN)
LIU WEI (CN)
LV QIANG (CN)
JIN YUNZHOU (CN)
ZHOU FUSHENG (CN)
XIE JING (CN)
SHEN SIDA (CN)
HU YI (CN)
LIU WEI (CN)
LV QIANG (CN)
Application Number:
PCT/CN2015/073044
Publication Date:
September 03, 2015
Filing Date:
February 13, 2015
Export Citation:
Assignee:
SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO LTD (CN)
International Classes:
A61K31/506; C07D471/04; A61K31/53; A61K31/5377; A61K31/5386; A61K31/553; C07D239/48; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D413/04; C07D413/14; C07D491/08; A61P3/10; A61P9/00; A61P25/28; A61P35/00; A61P37/02
Domestic Patent References:
| WO2006021458A2 | 2006-03-02 |
Foreign References:
| CN101910152A | 2010-12-08 | |||
| CN102740847A | 2012-10-17 | |||
| CN103501612A | 2014-01-08 |
Other References:
See also references of EP 3112364A4
Attorney, Agent or Firm:
XU & PARTNERS,LLC. (CN)
上海一平知识产权代理有限公司 (CN)
上海一平知识产权代理有限公司 (CN)
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