Title:
2ALPHA-METHYL-19-NOR-(20S)-1ALPHA-HYDROXY-BISHOMOPREGNACALCIFEROL AND ITS USES
Document Type and Number:
WIPO Patent Application WO2006057899
Kind Code:
A3
Abstract:
This invention discloses 2a-methyl-19-nor-(20S)-vitamin D analogs, and specifically 2a-methyl-l9-nor-(20S)-1a-hydroxy-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
More Like This:
| WO/1985/003300 | 1alpha,25-DIHYDROXY-22Z-DEHYDROVITAMIN D COMPOUND |
Inventors:
DELUCA HECTOR F (US)
SICINSKI RAFAL R (PL)
PLUM LORI A (US)
CLAGETT-DAME MARGARET (US)
SICINSKI RAFAL R (PL)
PLUM LORI A (US)
CLAGETT-DAME MARGARET (US)
Application Number:
PCT/US2005/041817
Publication Date:
July 06, 2006
Filing Date:
November 18, 2005
Export Citation:
Assignee:
WISCONSIN ALUMNI RES FOUND (US)
DELUCA HECTOR F (US)
SICINSKI RAFAL R (PL)
PLUM LORI A (US)
CLAGETT-DAME MARGARET (US)
DELUCA HECTOR F (US)
SICINSKI RAFAL R (PL)
PLUM LORI A (US)
CLAGETT-DAME MARGARET (US)
International Classes:
C07C401/00; A61K31/59; A61P11/06; A61P17/06; A61P29/00; A61P35/00; A61P37/00
Domestic Patent References:
| WO2005051323A2 | 2005-06-09 | |||
| WO2004080922A2 | 2004-09-23 |
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