Title:
(2E,4E)-5-PHENYL-PENTA-2,4-DIEN-1-ONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2019/190177
Kind Code:
A1
Abstract:
The present application relates to a novel pentadieonyl compound and a pharmaceutical composition comprising same. Functioning to restrain intracellular adipogenesis and fat accumulation within cells and to activate fat metabolism, the pentadieonyl compound of the present application can be used for prevention or treatment of fatty liver and diseases associated with fatty liver. In addition, the pentadieonyl compound of the present application upregulates the expression of SIRT1 or increases the activity of SIRT1 within cells and thus can be used for prevention or treatment of diseases associated with SIRT1. Furthermore, the pentadieonyl compound of the present application downregulates the expression of CK2 or decreases the activity of CK2 within cells and thus can be used for prevention or treatment of diseases associated with CK2.
Inventors:
KIM JONG WOO (KR)
LEE CHI WOO (KR)
KIM HAK SUNG (KR)
DIRGHA RAJ JOSHI (KR)
KWON SANG HOON (KR)
LEE CHI WOO (KR)
KIM HAK SUNG (KR)
DIRGHA RAJ JOSHI (KR)
KWON SANG HOON (KR)
Application Number:
PCT/KR2019/003525
Publication Date:
October 03, 2019
Filing Date:
March 26, 2019
Export Citation:
Assignee:
BIOWAY INC (KR)
International Classes:
C07D211/22; A23L33/10; A61K31/4453; A61K31/496; A61K31/5375; A61P3/04; A61P3/10; C07D241/04; C07D265/30
Domestic Patent References:
| WO2003070713A1 | 2003-08-28 |
Foreign References:
| KR101498218B1 | 2015-03-12 | |||
| KR101186500B1 | 2012-09-27 | |||
| KR20090031735A | 2009-03-27 | |||
| KR20180053032A | 2018-05-21 | |||
| KR101078376B1 | 2011-10-31 | |||
| KR101186500B1 | 2012-09-27 | |||
| KR101498218B1 | 2015-03-12 |
Other References:
DATABASE Registry 3 September 2009 (2009-09-03), retrieved from STN Database accession no. RN 1181623-88-0
DATABASE Registry 19 December 2007 (2007-12-19), retrieved from STN Database accession no. RN 958823-18-2
KOUL, S.: "Structure-activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome P450 activities", BIOORGANIC & MEDICINAL CHEMISTRY, 2000, pages 251 - 268, XP002207113, doi:10.1016/S0968-0896(99)00273-4
LU , Y. ET AL.: "Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice", HEPATOLOGY, vol. 47, no. 5, 2008, pages 1483 - 1494, XP055639217
DING RBBAO JDENG CX, INT J BIOL SCI., vol. 13, no. 7, 2017, pages 852 - 867
PURUSHOTHAM A ET AL., CELL METAB., vol. 9, no. 4, 2009, pages 327 - 38
CHOI SEKWON SSEOK S ET AL., MOL CELL BIOL., vol. 37, no. 15, 2017, pages e00006 - 17
VISCARRA JAWANG YHONG IHSUL HS, SCI SIGNAL., vol. 10, no. 467, 2017, pages eaai8596
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
DATABASE Registry 19 December 2007 (2007-12-19), retrieved from STN Database accession no. RN 958823-18-2
KOUL, S.: "Structure-activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome P450 activities", BIOORGANIC & MEDICINAL CHEMISTRY, 2000, pages 251 - 268, XP002207113, doi:10.1016/S0968-0896(99)00273-4
LU , Y. ET AL.: "Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice", HEPATOLOGY, vol. 47, no. 5, 2008, pages 1483 - 1494, XP055639217
DING RBBAO JDENG CX, INT J BIOL SCI., vol. 13, no. 7, 2017, pages 852 - 867
PURUSHOTHAM A ET AL., CELL METAB., vol. 9, no. 4, 2009, pages 327 - 38
CHOI SEKWON SSEOK S ET AL., MOL CELL BIOL., vol. 37, no. 15, 2017, pages e00006 - 17
VISCARRA JAWANG YHONG IHSUL HS, SCI SIGNAL., vol. 10, no. 467, 2017, pages eaai8596
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
Attorney, Agent or Firm:
IPS PATENT FIRM (KR)
Download PDF:
Previous Patent: GLYCYRRHIZIN-GLYCOL CHITOSAN CONJUGATE-COATED IRON OXIDE NANOPARTICLES AND USE THEREOF
Next Patent: HAIR COLORING APPLICATOR
Next Patent: HAIR COLORING APPLICATOR