Title:
(2'R)-2'-DEOXY-2'-HALO-2'-METHYL URIDINE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/177300
Kind Code:
A1
Abstract:
Disclosed are a compound of formula I, and preparation method and intermediate thereof; the use of the compound of formula I in preparing a drug for treating viral infections; the use of the compound of formula I in preparing sofosbuvir (SFBV) and the like, and a method of using the compound of formula I to prepare the SFBV and the like. The method claimed in the present invention prevents a side effect caused by using tertiary-butyl magnesium chloride in a phosphorylation reaction by a new design of reaction scheme, thus reducing impurity produced and complexity of a subsequent purification process. In addition, it has been proved by experiment that the method claimed in the present invention is easy to operate and has a mild reaction condition and a high yield, and the obtained product has stable quality and high purity, thus applicable to industrial-scale mass production.
More Like This:
WO/2017/040895 | ANTI-VIRAL COMPOUNDS |
JPH05186495 | CYCLIC OLIGONUCLEOTIDE PHOSPHOROTHIOATE |
Inventors:
JIANG XIANGRUI (CN)
HU TIANWEN (CN)
TIAN GUANGHUI (CN)
SHEN JINGSHAN (CN)
HU TIANWEN (CN)
TIAN GUANGHUI (CN)
SHEN JINGSHAN (CN)
Application Number:
PCT/CN2016/080742
Publication Date:
November 10, 2016
Filing Date:
April 29, 2016
Export Citation:
Assignee:
SUZHOU VIGONVITA LIFE SCIENCES CO LTD (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
TOPHARMAN SHANDONG CO LTD (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
TOPHARMAN SHANDONG CO LTD (CN)
International Classes:
C07H19/10; A61K31/7068; A61K31/7072; A61P31/12; C07H1/00; C07H19/073
Domestic Patent References:
WO2015017713A1 | 2015-02-05 | |||
WO2008121634A2 | 2008-10-09 | |||
WO2012040126A1 | 2012-03-29 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
北京金信知识产权代理有限公司 (CN)
北京金信知识产权代理有限公司 (CN)
Download PDF:
Previous Patent: DEVICE, NETWORK, AND METHOD FOR CSI FEEDBACK OF HYBRID BEAMFORMING
Next Patent: MICRO-TEXTURE ANTI-COUNTERFEIT METHOD
Next Patent: MICRO-TEXTURE ANTI-COUNTERFEIT METHOD