(2'R)-2'-DEOXY-2'-HALO-2'-METHYL URIDINE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF

WIPO Patent Application WO/2016/177300

A1

Disclosed are a compound of formula I, and preparation method and intermediate thereof; the use of the compound of formula I in preparing a drug for treating viral infections; the use of the compound of formula I in preparing sofosbuvir (SFBV) and the like, and a method of using the compound of formula I to prepare the SFBV and the like. The method claimed in the present invention prevents a side effect caused by using tertiary-butyl magnesium chloride in a phosphorylation reaction by a new design of reaction scheme, thus reducing impurity produced and complexity of a subsequent purification process. In addition, it has been proved by experiment that the method claimed in the present invention is easy to operate and has a mild reaction condition and a high yield, and the obtained product has stable quality and high purity, thus applicable to industrial-scale mass production.

WO/2017/040895	ANTI-VIRAL COMPOUNDS
JPH05186495	CYCLIC OLIGONUCLEOTIDE PHOSPHOROTHIOATE

JIANG XIANGRUI (CN)
HU TIANWEN (CN)
TIAN GUANGHUI (CN)
SHEN JINGSHAN (CN)

PCT/CN2016/080742

November 10, 2016

April 29, 2016

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SUZHOU VIGONVITA LIFE SCIENCES CO LTD (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
TOPHARMAN SHANDONG CO LTD (CN)

C07H19/10; A61K31/7068; A61K31/7072; A61P31/12; C07H1/00; C07H19/073

WO2015017713A1	2015-02-05
WO2008121634A2	2008-10-09
WO2012040126A1	2012-03-29

KINGSOUND & PARTNERS (CN)
北京金信知识产权代理有限公司 (CN)

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