Title:
3, 4-DIHYDROISOQUINOLIN-1 (2H) -ONES DERIVATIVES AS STING ANTAGONISTS AND THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/109912
Kind Code:
A1
Abstract:
Provided are compounds as well as their compositions and methods of use. The compounds disclosed herein modulate, eg., antagonize, stimulator of interferon genes (STING) activity and are useful in the treatment of various inflammatory diseases including systemic lupus erythematosus.
Inventors:
LI JING (CN)
SONG FENGTAO (CN)
XU SANJIA (CN)
XU WENQING (CN)
WANG ZHIWEI (CN)
SONG FENGTAO (CN)
XU SANJIA (CN)
XU WENQING (CN)
WANG ZHIWEI (CN)
Application Number:
PCT/CN2022/139360
Publication Date:
June 22, 2023
Filing Date:
December 15, 2022
Export Citation:
Assignee:
BEIGENE LTD (GB)
LI JING (CN)
LI JING (CN)
International Classes:
C07D403/04; A61K31/4704; A61P31/00; C07C311/21; C07D215/00; C07D513/02
Domestic Patent References:
| WO2021161230A1 | 2021-08-19 | |||
| WO2020150417A2 | 2020-07-23 |
Foreign References:
| CN112409223A | 2021-02-26 | |||
| CN110446503A | 2019-11-12 | |||
| CN103958478A | 2014-07-30 |
Other References:
RICKARD DAVID J., SEHON CLARK A., KASPARCOVA VIERA, KALLAL LORENA A., HAILE PAMELA A., ZENG XIN, MONTOUTE MONICA N., POORE DEREK D: "Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway", PLOS ONE, vol. 9, no. 5, 7 May 2014 (2014-05-07), pages e96737, XP093040206, DOI: 10.1371/journal.pone.0096737
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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