Title:
3'-PRODRUGS OF 2'-DEOXY- beta -L-NUCLEOSIDES
Document Type and Number:
WIPO Patent Application WO2001096353
Kind Code:
A3
Abstract:
The present invention relates to compounds, compositions and methods for the treatment of a host infected with a hepatitis B virus. Specifically, compounds and compositions of 3'-esters of 2'-deoxy- beta -L-nucleosides are disclosed, which can be administered either alone or in combination with other anti-hepatitis B agents. Compounds and compositions of 3',5'-esters of 2'-deoxy-ss-L-nucleosides are disclosed, which can be administered either alone or in combination with other anti-hepatitis B agents, are also disclosed.
Inventors:
BRYANT MARTIN L (US)
GOSSELIN GILLES (FR)
IMBACH JEAN-LOUIS (FR)
GOSSELIN GILLES (FR)
IMBACH JEAN-LOUIS (FR)
Application Number:
PCT/US2001/019147
Publication Date:
April 18, 2002
Filing Date:
June 15, 2001
Export Citation:
Assignee:
NOVIRIO PHARMACEUTICALS LTD (KY)
CT NAT DA LA RECH SCIENT CNRS (FR)
BRYANT MARTIN L (US)
GOSSELIN GILLES (FR)
IMBACH JEAN LOUIS (FR)
CT NAT DA LA RECH SCIENT CNRS (FR)
BRYANT MARTIN L (US)
GOSSELIN GILLES (FR)
IMBACH JEAN LOUIS (FR)
International Classes:
C07D239/47; A61K31/513; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K45/00; A61P31/12; A61P31/20; A61P43/00; C07H19/06; C07H19/073; C07H19/16; C07H19/173; (IPC1-7): C07H19/06; C07H19/16; A61K31/7068; A61P31/12
Domestic Patent References:
| WO2000009531A2 | 2000-02-24 | |||
| WO1992008727A1 | 1992-05-29 |
Foreign References:
| US5559101A | 1996-09-24 |
Other References:
V. SKARIC ET AL.: "Aminoacyl derivatives of 4-thiothymidine, cytosine and cytidine", CROATICA CHEMICA ACTA, vol. 48, no. 3, 1976, pages 351 - 359, XP001034973
WANG P ET AL: "RECENT ADVANCES IN L-NUCLEOSIDES: CHEMISTRY AND BIOLOGY", ANTIVIRAL RESEARCH, ELSEVIER SCIENCE BV., AMSTERDAM, NL, vol. 46, no. 1/2, 1998, pages 19 - 44, XP000944025, ISSN: 0166-3542
BOUDOU V ET AL: "A new and convenient approach for the synthesis of ribo- and 2'-deoxyribo-beta-L-furanonucleosides starting from beta-L-xylofuranonucleosides", NUCLEOSIDES & NUCLEOTIDES, MARCEL DEKKER, INC, US, vol. 18, no. 45, 1999, pages 607 - 609, XP002164642, ISSN: 0732-8311
RYU E K ET AL: "AMINOACYL DERIVATIVES OF NUCLEOSIDES, NUCLEOTIDES, AND POLYNUCLEOTIDES. XXVII GENERAL SYNTHESIS OF 2'(3')-O-AMINOACYL DINUCLEOSIDE PHOSPHATES DERIVED FROM THE AA-TRNA TERMINUS", JOURNAL OF CARBOHYDRATES. NUCLEOSIDES NUCLEOTIDES, MARCEL DEKKER, BASEL, CH, vol. 4, no. 6, 1977, pages 387 - 408, XP000564974, ISSN: 0094-0585
WANG P ET AL: "RECENT ADVANCES IN L-NUCLEOSIDES: CHEMISTRY AND BIOLOGY", ANTIVIRAL RESEARCH, ELSEVIER SCIENCE BV., AMSTERDAM, NL, vol. 46, no. 1/2, 1998, pages 19 - 44, XP000944025, ISSN: 0166-3542
BOUDOU V ET AL: "A new and convenient approach for the synthesis of ribo- and 2'-deoxyribo-beta-L-furanonucleosides starting from beta-L-xylofuranonucleosides", NUCLEOSIDES & NUCLEOTIDES, MARCEL DEKKER, INC, US, vol. 18, no. 45, 1999, pages 607 - 609, XP002164642, ISSN: 0732-8311
RYU E K ET AL: "AMINOACYL DERIVATIVES OF NUCLEOSIDES, NUCLEOTIDES, AND POLYNUCLEOTIDES. XXVII GENERAL SYNTHESIS OF 2'(3')-O-AMINOACYL DINUCLEOSIDE PHOSPHATES DERIVED FROM THE AA-TRNA TERMINUS", JOURNAL OF CARBOHYDRATES. NUCLEOSIDES NUCLEOTIDES, MARCEL DEKKER, BASEL, CH, vol. 4, no. 6, 1977, pages 387 - 408, XP000564974, ISSN: 0094-0585
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