Title:
3-ACETYL-5-HYDROXY-B-NORCHOLESTEROL-6-(N-METHYL)THIOSEMICARBAZONE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/016954
Kind Code:
A1
Abstract:
Disclosed are a 3-acetyl-5-hydroxy-B-norcholesterol-6-(N-methyl)thiosemicarbazone, a preparation method therefor and the use thereof, and structural formula (I) of the 3-acetyl-5-hydroxy-B-norcholesterol-6-(N-methyl)thiosemicarbazone. The prepared 3-acetyl-5-hydroxy-B-norcholesterol-6-(N-methyl)thiosemicarbazone has obvious inhibitory effects on various tumor cell lines such as liver cancer, lung cancer, gastric cancer, cervical cancer, prostate cancer and colon cancer, has a low toxicity, and is not prone to causing drug resistance. Also provided in the present invention are a preparation method for the compound and the use of the compound. The preparation method is simple, is easy to implement, and facilitates market promotion and application.
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Inventors:
YANG KUN (CN)
HUANG YANMIN (CN)
CUI JIANGUO (CN)
GAN CHUNFANG (CN)
PAN YUQIU (CN)
HUANG YANMIN (CN)
CUI JIANGUO (CN)
GAN CHUNFANG (CN)
PAN YUQIU (CN)
Application Number:
PCT/CN2019/098727
Publication Date:
February 04, 2021
Filing Date:
July 31, 2019
Export Citation:
Assignee:
GUANGXI WONDER PHARMACEUTICAL CO LTD (CN)
International Classes:
C07J9/00; A61P35/00
Foreign References:
| CN103214542A | 2013-07-24 | |||
| CN103214548A | 2013-07-24 |
Other References:
GAN, CHUNFANG ET AL.: "Synthesis and in vitro antiproliferative evaluation of some novel B-norcholesterols", STEROIDS, vol. 79, 5 November 2013 (2013-11-05), pages 37 - 43, XP028801877, DOI: 20200428213651X
Attorney, Agent or Firm:
NANNING SHENGRONG PATENT AGENCY (SPECIAL GENERAL PARTNERSHIP) (CN)
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