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Title:
3-ANILINO-2-CYCLOALKENONE DERIVATES
Document Type and Number:
WIPO Patent Application WO/1998/058901
Kind Code:
A1
Abstract:
3-anilino-2-cycloalkenone derivatives represented by general formula (I), optical isomers thereof, pharmaceutically acceptable salts thereof, or hydrates or solvates of these: wherein R¿1? represents optionally substituted C¿1-8? alkyl (excluding methyl), cycloalkyl, 3-tetrahydrofuryl, 2-indanyl, etc.; R¿2? represents C¿1-4? alkyl; R¿3? represents H, optionally substituted C¿1-5? alkyl, C¿3-7? cycloalkyl, etc.; R¿4? represents H, optionally substituted C¿1-5? alkyl, halogeno, etc.; R¿5?, R¿6?, R¿7? and R¿8? each independently represents H, optionally substituted C¿1-5? alkyl, etc.; and X represents -(CR¿11?R¿12?)¿n? - (where n is 0 to 2, and R¿11? and R¿12? each independently represents H, optionally substituted C¿1-5? alkyl, etc.) or -NR¿13?- (where R¿13? represents H or optionally substituted C¿1-5? alkyl).

Inventors:
INA SHINJI (JP)
YAMANA KENJIRO (JP)
NODA KYOJI (JP)
TAKAHAMA AKANE (JP)
AKIYAMA TOSHIHIKO (JP)
Application Number:
PCT/JP1997/004857
Publication Date:
December 30, 1998
Filing Date:
December 25, 1997
Export Citation:
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Assignee:
NIKKEN CHEMICALS CO LTD (JP)
INA SHINJI (JP)
YAMANA KENJIRO (JP)
NODA KYOJI (JP)
TAKAHAMA AKANE (JP)
AKIYAMA TOSHIHIKO (JP)
International Classes:
C07C225/20; C07C225/22; C07D211/86; C07D213/38; C07D215/12; C07D295/116; C07D307/20; (IPC1-7): C07C225/20; C07D215/12; C07D213/38; A61K31/135; A61K31/44; A61K31/47
Foreign References:
JPS495944A1974-01-19
JPH06100510A1994-04-12
JPH06100509A1994-04-12
JPH06100444A1994-04-12
JPH0597783A1993-04-20
JPH0551317A1993-03-02
Other References:
See also references of EP 0994100A4
Attorney, Agent or Firm:
Ishida, Takashi (Toramomon 37 Mori Building 5-1, Toranomon 3-chom, Minato-ku Tokyo 105, JP)
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