3-EPIVITAMIN D3 DERIVATIVE AND THERAPEUTIC AGENT CONTAINING THE SAME

Title:

3-EPIVITAMIN D3 DERIVATIVE AND THERAPEUTIC AGENT CONTAINING THE SAME

Document Type and Number:

WIPO Patent Application WO/2006/019169

Kind Code:

A1

Abstract:

A compound effective in the treatment of secondary hyperparathyroidism. It is a vitamin D₃ derivative represented by the following formula: [wherein R₁ represents hydrogen or C_1-4 alkyl; and R₂ represents any of the following groups: (wherein R_3a and R_3b each represents hydrogen or C_1-4 alkyl)].

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Inventors:

SAWAI YOSHIYUKI (JP)
OKADA KAZUHISA (JP)
SAITO HIROSHI (JP)
TAKENOUCHI KAZUYA (JP)
WATANABE KUNIHITO (JP)
TANOKURA AKIRA (JP)
NISHIGA MIYUKI (JP)
ISHIZUKA SEIICHI (JP)

Application Number:

PCT/JP2005/015177

Publication Date:

February 23, 2006

Filing Date:

August 16, 2005

Export Citation:

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Assignee:

TEIJIN PHARMA LTD (JP)
SAWAI YOSHIYUKI (JP)
OKADA KAZUHISA (JP)
SAITO HIROSHI (JP)
TAKENOUCHI KAZUYA (JP)
WATANABE KUNIHITO (JP)
TANOKURA AKIRA (JP)
NISHIGA MIYUKI (JP)
ISHIZUKA SEIICHI (JP)

International Classes:

C07C401/00; A61K31/59; A61K31/593; A61P3/02; A61P3/10; A61P3/14; A61P5/14; A61P9/12; A61P11/00; A61P17/00; A61P17/06; A61P17/10; A61P17/14

Domestic Patent References:

WO2002066424A1	2002-08-29
WO2000024712A1	2000-05-04
WO1998058909A1	1998-12-30

Foreign References:

JPS62502545A

1987-10-01

Other References:

POSNER G.H. ET AL: "2-Fluoroalkyl A-Ring Analogs of 1, 25-Dihydroxyvitamin D3. Stereocontrolled Total Synthesis via Intramolecular and Intermolecular Diels-Alder Cycloadditions. Preliminary Biological Testing", JOURNAL OF ORGANIC CHEMISTRY, vol. 60, no. 14, 1995, pages 4617 - 4628, XP002106463
CHO C-G. ET AL: "Asymmetric intramolecular Diels-Alder cycloadditions of 2-pyrone-3-carboxylates and synthesis of vitamin D3 A ring phosphine oxide", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 19, no. 9, 1998, pages 957 - 961, XP008056623

Attorney, Agent or Firm:

Mihara, Hideko c/o Teijin Intellectual Property Center Limited (1-1 Uchisaiwaicho 2-chom, Chiyoda-ku Tokyo 11, JP)

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