Title:
3-FLUOROPYRIDINE HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/167150
Kind Code:
A1
Abstract:
The present invention provides a 3-fluoropyridine heterocyclic compound. The 3-fluoropyridine heterocyclic compound and a pharmaceutically acceptable salt thereof have a structure as shown in formula I. Further provided in the present invention is a pharmaceutical composition, which comprises the 3-fluoropyridine heterocyclic compound in an therapeutically effective amount, and a pharmaceutically acceptable carrier. Also provided in the present invention is the use of the 3-fluoropyridine heterocyclic compound for preparing a medicament for treating or preventing an abnormality in Wnt signaling pathway. The 3-fluoropyridine heterocyclic compound of the present invention is able to effectively antagonize the Wnt signaling pathway, and therefore can be used to treat or prevent disorders caused by an abnormality in Wnt signaling pathway.
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Inventors:
ZHANG XIAOHU (CN)
Application Number:
PCT/CN2017/078305
Publication Date:
October 05, 2017
Filing Date:
March 27, 2017
Export Citation:
Assignee:
SUZHOU YUNXUAN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/14; A61K31/444; A61K31/4709; A61K31/502; A61K31/519; A61P7/06; A61P11/00; A61P35/00; C07D413/14; C07D471/04; C07D487/04
Domestic Patent References:
| WO2015140196A1 | 2015-09-24 | |||
| WO2015140195A1 | 2015-09-24 | |||
| WO2013185353A1 | 2013-12-19 | |||
| WO2014141038A2 | 2014-09-18 |
Foreign References:
| CN105254613A | 2016-01-20 | |||
| CN105142641A | 2015-12-09 | |||
| CN104876912A | 2015-09-02 |
Attorney, Agent or Firm:
WU, FENG & ZHANG CO. (CN)
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