Title:
3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
Document Type and Number:
WIPO Patent Application WO/2013/014204
Kind Code:
A3
Abstract:
The present invention relates to compounds of the formula I, wherein Ht, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
More Like This:
Inventors:
RUF SVEN (DE)
PERNERSTORFER JOSEF (DE)
SADOWSKI THORSTEN (DE)
HORSTICK GEORG (DE)
SCHREUDER HERMAN (DE)
BUNING CHRISTIAN (DE)
WIRTH KLAUS (DE)
PERNERSTORFER JOSEF (DE)
SADOWSKI THORSTEN (DE)
HORSTICK GEORG (DE)
SCHREUDER HERMAN (DE)
BUNING CHRISTIAN (DE)
WIRTH KLAUS (DE)
Application Number:
PCT/EP2012/064628
Publication Date:
April 04, 2013
Filing Date:
July 25, 2012
Export Citation:
Assignee:
SANOFI SA (FR)
RUF SVEN (DE)
PERNERSTORFER JOSEF (DE)
SADOWSKI THORSTEN (DE)
HORSTICK GEORG (DE)
SCHREUDER HERMAN (DE)
BUNING CHRISTIAN (DE)
WIRTH KLAUS (DE)
RUF SVEN (DE)
PERNERSTORFER JOSEF (DE)
SADOWSKI THORSTEN (DE)
HORSTICK GEORG (DE)
SCHREUDER HERMAN (DE)
BUNING CHRISTIAN (DE)
WIRTH KLAUS (DE)
International Classes:
C07D249/10; A61K31/341; A61K31/4196; A61K31/421; A61K31/4245; A61K31/433; A61P9/00; A61P11/00; A61P25/28; A61P37/00; C07D263/34; C07D271/06; C07D271/10; C07D277/32; C07D285/08; C07D307/68
Domestic Patent References:
| WO2009137338A1 | 2009-11-12 | |||
| WO2010136493A1 | 2010-12-02 | |||
| WO2000035285A1 | 2000-06-22 | |||
| WO2011092187A1 | 2011-08-04 | |||
| WO2011011232A1 | 2011-01-27 | |||
| WO2000020358A2 | 2000-04-13 | |||
| WO2008124838A1 | 2008-10-16 | |||
| WO1999023063A1 | 1999-05-14 | |||
| WO1998029387A1 | 1998-07-09 | |||
| WO1999000356A1 | 1999-01-07 | |||
| WO2001090095A1 | 2001-11-29 | |||
| WO2009033125A1 | 2009-03-12 | |||
| WO2009028280A1 | 2009-03-05 | |||
| WO2011005674A1 | 2011-01-13 |
Foreign References:
| US20070213302A1 | 2007-09-13 | |||
| US20100022599A1 | 2010-01-28 | |||
| EP1493740A1 | 2005-01-05 | |||
| EP1493739A1 | 2005-01-05 |
Other References:
NJUS, BEN H. ET AL: "Conformational mAb as a tool for integrin ligand discovery", ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, vol. 7, no. 5, October 2009 (2009-10-01), pages 507 - 515, XP002666149
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 26 March 2008 (2008-03-26), XP002669655, retrieved from STN Database accession no. 1010035-66-1
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 7 September 2010 (2010-09-07), XP002669656, retrieved from STN Database accession no. 1240065-00-2
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 28 May 2008 (2008-05-28), XP002669657, retrieved from STN Database accession no. 1023218-86-1
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 19 March 2003 (2003-03-19), XP002669658, retrieved from STN Database accession no. 500002-15-3
BADLAND M ET AL: "Thiophene and bioisostere derivatives as new MMP12 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 1, 1 January 2011 (2011-01-01), PERGAMON, ELSEVIER SCIENCE, GB, pages 528 - 530, XP027566699, ISSN: 0960-894X, [retrieved on 20101220]
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2002, GOTO, MAKOTO ET AL: "Preparation of diamides, agricultural and horticultural pesticides containing them, and their use", XP002669659, retrieved from STN Database accession no. 2002:866813
DUBLANCHET A C ET AL: "Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, no. 16, 15 August 2005 (2005-08-15), PERGAMON, ELSEVIER SCIENCE, GB, pages 3787 - 3790, XP025314160, ISSN: 0960-894X, [retrieved on 20050815], DOI: 10.1016/J.BMCL.2005.05.079
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GOLDFARB, DAVID SCOTT: "Method using lifespan-altering compounds for altering the lifespan of eukaryotic organisms, and screening for such compounds", XP002669660, retrieved from STN Database accession no. 2009:846102
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 19 March 2008 (2008-03-19), XP002669661, retrieved from STN Database accession no. 1008898-63-2
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 June 2008 (2008-06-25), XP002669662, retrieved from STN Database accession no. 1030684-64-0
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 13 May 2011 (2011-05-13), XP002669663, retrieved from STN Database accession no. 1294255-01-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 14 April 2011 (2011-04-14), XP002669664, retrieved from STN Database accession no. 1280129-81-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 6 April 2011 (2011-04-06), XP002669665, retrieved from STN Database accession no. 1275819-61-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 12 March 2009 (2009-03-12), XP002669666, retrieved from STN Database accession no. 1119379-63-3
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 March 2009 (2009-03-11), XP002669667, retrieved from STN Database accession no. 1118834-35-7
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 28 December 2008 (2008-12-28), XP002669668, retrieved from STN Database accession no. 1090892-16-2
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 22 September 2008 (2008-09-22), XP002669669, retrieved from STN Database accession no. 1051341-70-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 21 September 2008 (2008-09-21), XP002669670, retrieved from STN Database accession no. 1051301-70-2
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 16 March 2008 (2008-03-16), XP002669671, retrieved from STN Database accession no. 1008348-72-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 26 March 2008 (2008-03-26), XP002669655, retrieved from STN Database accession no. 1010035-66-1
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 7 September 2010 (2010-09-07), XP002669656, retrieved from STN Database accession no. 1240065-00-2
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 28 May 2008 (2008-05-28), XP002669657, retrieved from STN Database accession no. 1023218-86-1
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 19 March 2003 (2003-03-19), XP002669658, retrieved from STN Database accession no. 500002-15-3
BADLAND M ET AL: "Thiophene and bioisostere derivatives as new MMP12 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 1, 1 January 2011 (2011-01-01), PERGAMON, ELSEVIER SCIENCE, GB, pages 528 - 530, XP027566699, ISSN: 0960-894X, [retrieved on 20101220]
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2002, GOTO, MAKOTO ET AL: "Preparation of diamides, agricultural and horticultural pesticides containing them, and their use", XP002669659, retrieved from STN Database accession no. 2002:866813
DUBLANCHET A C ET AL: "Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, no. 16, 15 August 2005 (2005-08-15), PERGAMON, ELSEVIER SCIENCE, GB, pages 3787 - 3790, XP025314160, ISSN: 0960-894X, [retrieved on 20050815], DOI: 10.1016/J.BMCL.2005.05.079
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GOLDFARB, DAVID SCOTT: "Method using lifespan-altering compounds for altering the lifespan of eukaryotic organisms, and screening for such compounds", XP002669660, retrieved from STN Database accession no. 2009:846102
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 19 March 2008 (2008-03-19), XP002669661, retrieved from STN Database accession no. 1008898-63-2
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 June 2008 (2008-06-25), XP002669662, retrieved from STN Database accession no. 1030684-64-0
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 13 May 2011 (2011-05-13), XP002669663, retrieved from STN Database accession no. 1294255-01-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 14 April 2011 (2011-04-14), XP002669664, retrieved from STN Database accession no. 1280129-81-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 6 April 2011 (2011-04-06), XP002669665, retrieved from STN Database accession no. 1275819-61-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 12 March 2009 (2009-03-12), XP002669666, retrieved from STN Database accession no. 1119379-63-3
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 March 2009 (2009-03-11), XP002669667, retrieved from STN Database accession no. 1118834-35-7
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 28 December 2008 (2008-12-28), XP002669668, retrieved from STN Database accession no. 1090892-16-2
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 22 September 2008 (2008-09-22), XP002669669, retrieved from STN Database accession no. 1051341-70-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 21 September 2008 (2008-09-21), XP002669670, retrieved from STN Database accession no. 1051301-70-2
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 16 March 2008 (2008-03-16), XP002669671, retrieved from STN Database accession no. 1008348-72-8
Attorney, Agent or Firm:
THEN, Johann (Sanofi-Aventis Deutschland GmbHPatents Germany,,Industriepark Höchs, Geb. K 801 Frankfurt am Main, DE)
Download PDF: