Title:
3-SUBSTITUTED PROLINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2013/118805
Kind Code:
A1
Abstract:
A compound represented by formula (1) or a pharmaceutically acceptable salt thereof has excellent FXIa inhibitory activity and is useful as a therapeutic agent for thromboembolism, thrombosis and the like.
(In the formula, ring D represents a phenyl ring, a five-membered or six-membered heteroaryl ring; m represents 0, 1 or 2; Ra represents an optionally substituted five- to ten-membered heteroaryl group or the like; if there are a plurality of Rb moieties, each Rb independently represents a halogen atom or the like; L represents -CR61=CR71-, -CR61R62-CR71CR72-, -NR61-C(=O)- or -CR61R62-NR71- (wherein each of R61, R62, R71 and R72 independently represents a hydrogen atom or the like); Rc represents an optionally substituted C6-10 aryl group or the like; Rd represents a hydrogen atom or the like; and ring Q represents a group represented by formula (3a') or the like.)
Inventors:
IKUMA YOHEI (JP)
KIMURA HIDENORI (JP)
FUKUDA NOBUHISA (JP)
NAKAI YOSHIO (JP)
SUZUKI KUNIKO (JP)
KIMURA HIDENORI (JP)
FUKUDA NOBUHISA (JP)
NAKAI YOSHIO (JP)
SUZUKI KUNIKO (JP)
Application Number:
PCT/JP2013/052821
Publication Date:
August 15, 2013
Filing Date:
February 07, 2013
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
International Classes:
C07D401/14; A61K31/41; A61K31/4184; A61K31/4439; A61K31/4709; A61K31/5377; A61P1/04; A61P7/02; A61P9/10; A61P19/02; A61P29/00; A61P31/04; A61P43/00; C07D403/10; C07D403/14
Foreign References:
| JP2006522033A | 2006-09-28 | |||
| JP2010506864A | 2010-03-04 | |||
| JP2010505896A | 2010-02-25 | |||
| JPH08509735A | 1996-10-15 | |||
| JP2010529991A | 2010-09-02 |
Attorney, Agent or Firm:
ASAMURA PATENT OFFICE, p. c. (JP)
Patent business corporation Asamura patent firm (JP)
Patent business corporation Asamura patent firm (JP)
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Claims: