3,5-DIMETHYL-1-ADAMANTYL-AMMONIUM POLYMERIC SALTS AND THE USE THEREOF IN THE FORM OF ANTIVIRAL AGENTS

Title:

3,5-DIMETHYL-1-ADAMANTYL-AMMONIUM POLYMERIC SALTS AND THE USE THEREOF IN THE FORM OF ANTIVIRAL AGENTS

Document Type and Number:

WIPO Patent Application WO/2005/028528

Kind Code:

A1

Abstract:

The invention relates to polymeric salts of 3,5-dimethyl-1-adamantyl-ammonium and of carboxyl-containing (co) polymers and to the use of the thus obtained salts in the form of antiviral agents. The aim of said invention is to synthesise the novel salts of 3,5-dimethyl-1-adamantyl-ammonium and of carboxyl-containing (co) polymers and in selecting thereamong compounds exhibiting an antiviral activity and durable action. Said aim is achieved by synthesising the 3,5-dimethyl-1-adamantyl-ammonium salts and water-soluble carboxyl-containing (co) polymers of general formula (1), wherein m and n are mol. %, m=100-n, the carboxyl-containing (co) polymers are selected from a group of polyvinyl-amino-succinic acid, vinyl alcohol and N-vinyl-amino-succinic acid copolymer, N-vinyl-pyrrolidone and N-vinyl-amino-succinic acid copolymer, N-vinyl-pyrrolidone and crotonic acid copolymer, N-vinyl-succinimide and maleinic anhydride copolymer, N-vinyl-pyrrolidone and maleinic anhydride copolymer and polyacrylic acid. A general synthesis method and synthesis examples for each inventive compound, toxicity test results and results of determination of the comparative antiviral activity are also disclosed. The obtained compounds are uniquely identifiable by IR-spectroscopy methods, element analysis and potentiometric titrimetric analysis, exhibit a sufficiently high antiviral activity with respect to A-type and B-type influenza viruses, they are characterised by a long (durable) activity, thereby making it possible to use the obtained salts not only as antiviral agents for sparing therapy but also for preventing viral diseases.

Inventors:

MARCHUKOV VALERY ALEKSANDROVIC (RU)
PLATONOV VITALY GEORGIEVICH (RU)
SELKOV SERGEI ALEKSEEVICH (RU)
CHERNOBROVY ALEKSANDR NIKOLAEV (LV)

Application Number:

PCT/RU2003/000417

Publication Date:

March 31, 2005

Filing Date:

September 23, 2003

Export Citation:

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Assignee:

AKCIJU SABIEDRIBA OLAINES KIMI (LV)
MARCHUKOV VALERY ALEKSANDROVIC (RU)
PLATONOV VITALY GEORGIEVICH (RU)
SELKOV SERGEI ALEKSEEVICH (RU)
CHERNOBROVY ALEKSANDR NIKOLAEV (LV)

International Classes:

A61K31/13; A61P31/12; C08F8/44; (IPC1-7): C08F220/04; C08F120/06; C08F126/02; C08F216/06; C08F226/02; C08F226/10; A61K31/13; A61K47/32; A61P31/12

Foreign References:

RU2071323C1	1997-01-10
US6517847B2	2003-02-11
US5726284A	1998-03-10

Other References: