4-AMINO-5-OXY-2,6,6-TRIMETHYL-2-CYCLOHEPTENE COMPOUNDS

Title:

4-AMINO-5-OXY-2,6,6-TRIMETHYL-2-CYCLOHEPTENE COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/1996/032370

Kind Code:

A1

Abstract:

4-Amino-5-oxy-2,6,6-trimethyl-2-cycloheptene compounds represented by general formula (I), pharmacologically acceptable salts thereof, or solvates of these wherein R1 and R2 independently represent each hydrogen, optionally substituted alkyl or phenyl optionally having hydroxy, lower alkoxy, amino, nitro, carboxy, lower alkoxycarbonyl or halogeno on its ring, or R1 and R2 together with the nitrogen atom may form a nitrogen-containing heterocycle; R3 represents hydrogen, lower alkyl or lower aliphatic acyl; and W represents oxo, oxime or oxime ether. The compounds exert effects on a rat peripheral embolism model, a spontaneously hypertensive rat and a histamine-induced airway constriction model, which indicates that they are useful as a remedy for hypertension, peripheral embolism or bronchial asthma.

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Inventors:

YOKURA SUSUMU (JP)
YAJIMA MASAO (JP)
MURAKAMI KIYOKAZU (JP)
MATSUNAGA KOUICHI (JP)

Application Number:

PCT/JP1996/001023

Publication Date:

October 17, 1996

Filing Date:

April 12, 1996

Export Citation:

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Assignee:

TOKYO TANABE CO (JP)
YOKURA SUSUMU (JP)
YAJIMA MASAO (JP)
MURAKAMI KIYOKAZU (JP)
MATSUNAGA KOUICHI (JP)

International Classes:

C07C225/20; C07C229/38; C07C229/60; C07C251/44; C07C251/66; C07D295/112; C07D295/116; C07D317/72; C07D491/10; (IPC1-7): C07C225/20; C07C229/60; C07C229/38; C07D295/10; C07D211/14; C07D211/74; C07D491/113; A61K31/13; A61K31/395

Foreign References:

EP0528699A2	1993-02-24
EP0443848A1	1991-08-28

Other References: