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Title:
4-AMINO-5-OXY-2,6,6-TRIMETHYL-2-CYCLOHEPTENE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/1996/032370
Kind Code:
A1
Abstract:
4-Amino-5-oxy-2,6,6-trimethyl-2-cycloheptene compounds represented by general formula (I), pharmacologically acceptable salts thereof, or solvates of these wherein R1 and R2 independently represent each hydrogen, optionally substituted alkyl or phenyl optionally having hydroxy, lower alkoxy, amino, nitro, carboxy, lower alkoxycarbonyl or halogeno on its ring, or R1 and R2 together with the nitrogen atom may form a nitrogen-containing heterocycle; R3 represents hydrogen, lower alkyl or lower aliphatic acyl; and W represents oxo, oxime or oxime ether. The compounds exert effects on a rat peripheral embolism model, a spontaneously hypertensive rat and a histamine-induced airway constriction model, which indicates that they are useful as a remedy for hypertension, peripheral embolism or bronchial asthma.

Inventors:
Yokura
Susumu, Yajima
Masao, Murakami
Kiyokazu, Matsunaga
Kouichi
Application Number:
PCT/JP1996/001023
Publication Date:
October 17, 1996
Filing Date:
April 12, 1996
Export Citation:
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Assignee:
TOKYO TANABE COMPANY LIMITED YOKURA
Susumu, Yajima
Masao, Murakami
Kiyokazu, Matsunaga
Kouichi
International Classes:
C07C225/20; C07C229/38; C07C229/60; C07C251/44; C07C251/66; C07D295/112; C07D295/116; C07D317/72; C07D491/10; (IPC1-7): C07C225/20; C07C229/60; C07C229/38; C07D295/10; C07D211/14; C07D211/74; C07D491/113; A61K31/13; A61K31/395
Foreign References:
EP0528699A21993-02-24
EP0443848A11991-08-28
Other References:
See also references of EP 0820982A4
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