Title:
4-AMINOPYRIMIDINE COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/196757
Kind Code:
A1
Abstract:
The present invention relates to the field of medicines, and specifically relates to a 4-aminopyrimidine compound having a structural feature represented by formula (I), or pharmaceutically acceptable salts thereof, a preparation method for the compound, and a use of the compound and the salts as a Bruton tyrosine kinase (BTK) inhibitor. A result of experiments shows that the compound in the present invention has a significant inhibition effect on the BTK, and can be used for treating thromboembolism, inflammatory disorders, autoimmune diseases, Waldenstrom macroglobulinemia, B cell lymphomas, and other diseases.
Inventors:
LAI YISHENG (CN)
GUO YI (CN)
ZHANG YINGYI (CN)
XIAO JIANHU (CN)
LI YUEZHEN (CN)
GUO YI (CN)
ZHANG YINGYI (CN)
XIAO JIANHU (CN)
LI YUEZHEN (CN)
Application Number:
PCT/CN2018/084300
Publication Date:
November 01, 2018
Filing Date:
April 24, 2018
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
C07D401/12; A61K31/506; A61P7/02; A61P9/10; A61P29/00; A61P37/00; C07D403/12
Domestic Patent References:
| WO2009055299A1 | 2009-04-30 |
Foreign References:
| CN104844573A | 2015-08-19 | |||
| CN105837576A | 2016-08-10 |
Attorney, Agent or Firm:
BEIJING TINGLI PATENT FIRM (ORDINARY PARTNERSHIP) (CN)
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