Title:
4-ARYLAMINO-QUINAZOLINES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS
Document Type and Number:
WIPO Patent Application WO2005003100
Kind Code:
A3
Abstract:
Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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Inventors:
CAI SUI XIONG (US)
SIRISOMA NILANTHA SUDATH (US)
PERVIN AZRA (US)
DREWE JOHN A (US)
KASIBHATLA SHAILAJA (US)
JAING SONGCHUN (US)
ZHANG HONG (US)
PLEIMAN CHRIS (US)
BAICHWAL VIJAY (US)
MANFREDI JOHN (US)
BHOITE LEENA (US)
SIRISOMA NILANTHA SUDATH (US)
PERVIN AZRA (US)
DREWE JOHN A (US)
KASIBHATLA SHAILAJA (US)
JAING SONGCHUN (US)
ZHANG HONG (US)
PLEIMAN CHRIS (US)
BAICHWAL VIJAY (US)
MANFREDI JOHN (US)
BHOITE LEENA (US)
Application Number:
PCT/US2004/021631
Publication Date:
May 12, 2005
Filing Date:
July 06, 2004
Export Citation:
Assignee:
MYRIAD GENETICS INC (US)
CYTOVIA INC (US)
CAI SUI XIONG (US)
SIRISOMA NILANTHA SUDATH (US)
PERVIN AZRA (US)
DREWE JOHN A (US)
KASIBHATLA SHAILAJA (US)
JAING SONGCHUN (US)
ZHANG HONG (US)
PLEIMAN CHRIS (US)
BAICHWAL VIJAY (US)
MANFREDI JOHN (US)
BHOITE LEENA (US)
CYTOVIA INC (US)
CAI SUI XIONG (US)
SIRISOMA NILANTHA SUDATH (US)
PERVIN AZRA (US)
DREWE JOHN A (US)
KASIBHATLA SHAILAJA (US)
JAING SONGCHUN (US)
ZHANG HONG (US)
PLEIMAN CHRIS (US)
BAICHWAL VIJAY (US)
MANFREDI JOHN (US)
BHOITE LEENA (US)
International Classes:
A61K31/517; A61K31/519; C07D239/94; C07D239/95; C07D401/12; C07D403/04; C07D403/12; C07D405/12; C07D471/04; C07D473/34; C07D487/04; (IPC1-7): A61K31/517; C07D239/95; A61P35/00; C07D403/04; C07D473/16; C07D239/94; C07D401/12; C07D473/34; C07D217/22; A61K31/47; C07D215/44; C07D471/04; C07D403/12; C07D475/06; C07D409/12
Domestic Patent References:
| WO1995015758A1 | 1995-06-15 | |||
| WO2004078114A2 | 2004-09-16 | |||
| WO2002047690A1 | 2002-06-20 |
Foreign References:
| GB2033894A | 1980-05-29 | |||
| US5707989A | 1998-01-13 | |||
| US5618814A | 1997-04-08 | |||
| GB2052481A | 1981-01-28 |
Other References:
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1960, XP002314666, Database accession no. 1960:131417 (AN)
DATABASE BEILSTEIN 1992, XP002314667, Database accession no. 636504 (CNR)
RIGBY J H.; LEE C-S: "Preparation of Highly Substituted 4-Aminopyridones via the Reaction of 2-Methylene Dihydrobenzimidazole with Vinyl Isocyanates", ORGANIC LETTERS., vol. 5, no. 7, 14 March 2003 (2003-03-14), USACS, WASHINGTON, DC., pages 1151 - 1153, XP002314664
BARLUENGA J ET AL: "Reaction of 3-amino-2-alkenimines with alkali metals: unexpected synthesis of substituted 4-(arylamino)quinolines", JOURNAL OF ORGANIC CHEMISTRY., vol. 54, no. 11, 1989, USAMERICAN CHEMICAL SOCIETY. EASTON., pages 2596 - 2598, XP002314665
DATABASE BEILSTEIN 1992, XP002314668, Database accession no. 329732 (BRN)
DATABASE BEILSTEIN 1992, XP002314667, Database accession no. 636504 (CNR)
RIGBY J H.; LEE C-S: "Preparation of Highly Substituted 4-Aminopyridones via the Reaction of 2-Methylene Dihydrobenzimidazole with Vinyl Isocyanates", ORGANIC LETTERS., vol. 5, no. 7, 14 March 2003 (2003-03-14), USACS, WASHINGTON, DC., pages 1151 - 1153, XP002314664
BARLUENGA J ET AL: "Reaction of 3-amino-2-alkenimines with alkali metals: unexpected synthesis of substituted 4-(arylamino)quinolines", JOURNAL OF ORGANIC CHEMISTRY., vol. 54, no. 11, 1989, USAMERICAN CHEMICAL SOCIETY. EASTON., pages 2596 - 2598, XP002314665
DATABASE BEILSTEIN 1992, XP002314668, Database accession no. 329732 (BRN)
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