4'-C-SUBSTITUTED 2-HALOADENOSINE DERIVATIVE

Title:

4'-C-SUBSTITUTED 2-HALOADENOSINE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2005/090349

Kind Code:

A1

Abstract:

A compound which has excellent anti-HIV activity, is effective also against polypharmacy-resistant HIV strains having resistance to two or more anti-HIV drugs, especially AZT, DDI, DDC, D4T, 3TC, etc., is lowly cytotoxic, and has resistance to deactivation by adenosine deaminase. It is a 4'-C-substituted 2-haloadenosine derivative represented by the following formula [I], [II], or [III]. Also provided is a medicinal composition comprising the derivative and a pharmaceutically acceptable support. [Chemical formula 1] (In the formulae, X represents halogeno; R¹ represents ethynyl or cyano; and R² represents hydrogen or the atoms of a residue of phosphoric acid or a derivative thereof.)

More Like This:

WO/2001/090130	PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACCEPTABLE SALTS OF (SS-RS)-S-ADENOSYL-L-METHIONINE
JPWO2003068794	An oligonucleotide derivative containing a nucleoside analog in which the nucleic acid sugar portion is bound to an S type and a nucleotide analog thereof.
JP2870704	[Title of Invention] Homocysteine assay

Inventors:

KOHGO SATORU (JP)
OHRUI HIROSHI (JP)
KODAMA EIICHI (JP)
MATSUOKA MASAO (JP)
MITSUYA HIROAKI (JP)

Application Number:

PCT/JP2005/005374

Publication Date:

September 29, 2005

Filing Date:

March 24, 2005

Export Citation:

Click for automatic bibliography generation Help

Assignee:

YAMASA CORP (JP)
KOHGO SATORU (JP)
OHRUI HIROSHI (JP)
KODAMA EIICHI (JP)
MATSUOKA MASAO (JP)
MITSUYA HIROAKI (JP)

International Classes:

C07H19/16; (IPC1-7): C07D473/40; A61K31/52; A61K31/7076; A61P31/18; C07H19/173

Domestic Patent References:

WO2000069876A1	2000-11-23
WO2003068796A1	2003-08-21

Foreign References:

US5192749A

1993-03-09

Other References:

SALVATORI D. ET AL: "Adenine and Deayaadenine Nucleoside and Deoxynucleoside Analogus: Inhibition of Viral Replication of Sheep MVV (In Vitro Model for HIV) and Bovine BHV-1.", BIOOGANIC & MEDICINAL CHEMISTRY, vol. 10, no. 9, 2002, pages 2973 - 2980, XP002989446

Attorney, Agent or Firm:

The, Patent Corporate Body Aruga Patent Office (3-6 NIHONBASHININGYOCHO 1-CHOM, CHUO-KU Tokyo 13, JP)

Download PDF:

View/Download PDF PDF Help

Previous Patent: ARYL AND HETEROARYL-PIPERIDINECARBOXYLATE DERIVATIVES, THE PREPARATION AND THE USE THEREOF IN THE FO...

Next Patent: PYRAZOLO[3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS