4-HYDROXY-2-CYCLOPENTENONE DERIVATIVE AND CARCINOSTATIC AND OSTEOGENESIS PROMOTER CONTAINING THE SAME

Title:

4-HYDROXY-2-CYCLOPENTENONE DERIVATIVE AND CARCINOSTATIC AND OSTEOGENESIS PROMOTER CONTAINING THE SAME

Document Type and Number:

WIPO Patent Application WO/1994/005619

Kind Code:

A1

Abstract:

An optically active compound represented by general formula (I), a mixture thereof, and a carcinostatic and osteogenesis promoter each containing the same as the active ingredient, wherein Y represents hydrogen or halogen; A represents hydroxy, C2-C7 acyloxy, C2-C5 alkoxycarbonyloxy or C1-C7 sulfonyloxy and B represents hydrogen, or alternatively A and B are combined together to represent a bond; R2 represents a C4-C10 alicyclic hydrocarbon, C6-C10 aromatic hydrocarbon or C1-C9 heterocyclic hydrocarbon group each of which may be substituted; R3 represents hydrogen or a C1-C10 aliphatic hydrocarbon, C4-C10 alicyclic hydrocarbon or C6-C10 aromatic hydrocarbon group each of which may be substituted; R4 represents hydrogen, C1-C4 alkyl, C2-C7 acyl, C2-C5 alkoxycarbonyl, tri(C1-C7 hydrocarbyl)silyl or a group which forms an acetal bond together with the oxygen atom to which the R4 is bonded; and R5 represents hydrogen or a C1-C10 aliphatic hydrocarbon or C4-C10 alicyclic hydrocarbon group each of which may be substituted.

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Inventors:

FURUYA MINORU (JP)
SUGIURA SATOSHI (JP)
HAZATO ATSUO (JP)

Application Number:

PCT/JP1993/001266

Publication Date:

March 17, 1994

Filing Date:

September 07, 1993

Export Citation:

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Assignee:

TEIJIN LTD (JP)
FURUYA MINORU (JP)
SUGIURA SATOSHI (JP)
HAZATO ATSUO (JP)

International Classes:

C07C45/67; C07C49/707; C07C49/723; C07C49/743; C07C49/747; C07C49/753; C07C69/007; C07C69/738; C07C69/76; C07C69/96; C07C205/45; C07C225/22; C07C405/00; C07D213/50; C07D277/16; C07D309/12; C07D333/22; C07F7/18; C07H13/04; C07H13/06; (IPC1-7): C07C49/707; C07C49/753; C07C69/76; C07C69/738; C07C205/45; C07C225/22; C07C69/16; C07C69/96; C07C59/90; C07F7/18; C07D309/12; C07D213/50; C07D333/16; C07D407/08; C07D277/16; C07H13/04; A61K31/12; A61K31/215; A61K31/44; A61K31/135

Foreign References:

JPS6296438A	1987-05-02
JPS6013755A	1985-01-24
EP0448726A1	1991-10-02
JPS62234060A	1987-10-14

Other References:

Tetrahedron Letters, Vol. 31, No. 26, 1990, Great Britain, MANAT POHMAKOTR, "A General Synthesis of 5-Alkylidene-4-Hydroxy-2-Cyclopentenones", p. 3783-3784, Compound 5.
Chemistry Letters, 1972, Japan, AKIRA KAWAMOTO, "2 (7H)-Oxepinones : Photochemical Oxidation of 6-Monosubstituted Fulvenes", p. 807-810, Compound 5.
See also references of EP 0659728A4

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