Title:
4-PHENYLSULFONAMIDOPIPERIDINES AS CALCIUM CHANNEL BLOCKERS
Document Type and Number:
WIPO Patent Application WO2006040181
Kind Code:
A3
Abstract:
The invention relates to piperidinyl compounds of Formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to an assay useful for identifying such compounds as N-type calcium channel modulators or blockers. The invention is also directed to the compounds of Formula (I) and compounds identified by the above assay, and the use of such compounds to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
Inventors:
BENJAMIN ELFRIDA R (US)
CHEN ZHENGMING (US)
SHA DEYOU (US)
TAFESSE LAYKEA (US)
VICTORY SAMUEL F (US)
WHITEHEAD JOHN W F (US)
ZHOU XIAOMING (US)
CHEN ZHENGMING (US)
SHA DEYOU (US)
TAFESSE LAYKEA (US)
VICTORY SAMUEL F (US)
WHITEHEAD JOHN W F (US)
ZHOU XIAOMING (US)
Application Number:
PCT/EP2005/011105
Publication Date:
November 09, 2006
Filing Date:
October 14, 2005
Export Citation:
Assignee:
EURO CELTIQUE SA (LU)
BENJAMIN ELFRIDA R (US)
CHEN ZHENGMING (US)
SHA DEYOU (US)
TAFESSE LAYKEA (US)
VICTORY SAMUEL F (US)
WHITEHEAD JOHN W F (US)
ZHOU XIAOMING (US)
BENJAMIN ELFRIDA R (US)
CHEN ZHENGMING (US)
SHA DEYOU (US)
TAFESSE LAYKEA (US)
VICTORY SAMUEL F (US)
WHITEHEAD JOHN W F (US)
ZHOU XIAOMING (US)
International Classes:
C07D211/58; A61K31/4468; A61P29/02; C07D211/98; C07D401/06
Domestic Patent References:
| WO2002042257A1 | 2002-05-30 | |||
| WO2003051868A1 | 2003-06-26 | |||
| WO2000037059A2 | 2000-06-29 | |||
| WO2001049670A1 | 2001-07-12 | |||
| WO2003079025A2 | 2003-09-25 |
Foreign References:
| EP1254895A1 | 2002-11-06 | |||
| US6294533B1 | 2001-09-25 |
Other References:
W. L. CAULFIELD ET AL.: "The First Potent and Selective Inhibitors of the Glycine Transporter Type 2", J. MED. CHEM., vol. 44, no. 17, 16 August 2001 (2001-08-16), pages 2679 - 2682, XP002369779
DATABASE CHEMCATS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 May 2004 (2004-05-03), XP002375661, retrieved from STN Database accession no. 2004:992806
DATABASE CHEMCATS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 May 2004 (2004-05-03), XP002375662, retrieved from STN Database accession no. 2004:992362
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 9 May 2004 (2004-05-09), XP002375663, retrieved from STN Database accession no. 680874-24-2
DATABASE CHEMCATS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 May 2004 (2004-05-03), XP002375664, retrieved from STN Database accession no. 2004:992822
DATABASE CHEMCATS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 May 2004 (2004-05-03), XP002375665, retrieved from STN Database accession no. 2004:992813
DATABASE CHEMCATS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 May 2004 (2004-05-03), XP002375661, retrieved from STN Database accession no. 2004:992806
DATABASE CHEMCATS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 May 2004 (2004-05-03), XP002375662, retrieved from STN Database accession no. 2004:992362
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 9 May 2004 (2004-05-09), XP002375663, retrieved from STN Database accession no. 680874-24-2
DATABASE CHEMCATS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 May 2004 (2004-05-03), XP002375664, retrieved from STN Database accession no. 2004:992822
DATABASE CHEMCATS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 May 2004 (2004-05-03), XP002375665, retrieved from STN Database accession no. 2004:992813
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